Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 16, Issue 4, Pages 7133-7142Publisher
MDPI AG
DOI: 10.3390/ijms16047133
Keywords
cardiac arrest; brain ischemia; unfolded protein response; PKR-Like Endoplasmic Reticulum Kinase (PERK); Inositol Requiring Enzyme 1 (IRE1); Activating Transcription Factor 6 (ATF6); Glucose-Regulated Protein 78; Binding Protein (GRP78; BiP)
Funding
- National Institutes of Health [R01NS076715]
Ask authors/readers for more resources
The endoplasmic reticulum (ER) is responsible for processing of proteins that are destined to be secreted, enclosed in a vesicle, or incorporated in the plasma membrane. Nascent peptides that enter the ER undergo a series of highly regulated processing steps to reach maturation as they transit the ER. Alterations in the intracellular environment that induce ER stress are thought to interrupt these processing steps, and result in unfolding of proteins in the ER. Accumulation of unfolded proteins concurrently activates three transmembrane stress sensors, IRE1, ATF6 and PERK, and is referred to as the Unfolded Protein Response (UPR). Our understanding of the mechanisms of UPR induction has been assembled primarily from experiments inducing ER stress with chemical and genetic manipulations. However, physiological stress often induces activation of ER stress sensors in a distinct manner from the canonical UPR. The unique activation profiles in vivo have prompted us to examine the mechanism of UPR activation in neurons following cerebral ischemia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available