Article
Food Science & Technology
Jing Wan, Peng He, Yuanshan Chen, Qiujin Zhu
Summary: A practical, efficient, and rapid method for quantifying 19 pyrethroids in tea and orange samples was developed. Out of 262 tea samples, 11 pyrethroids were detected positive with concentrations below maximum residue limits. No pyrethroid was found in 209 peeled orange samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Cell Biology
Chandranayaka Siddaiah, Anil Kumar BM, Saligrama Adavigowda Deepak, Syed Salman Lateef, Saurabh Nagpal, Kanchugarakoppal S. Rangappa, Chakrabhavi D. Mohan, Shobith Rangappa, Madan S. Kumar, Minaxi Sharma, Vijai Kumar Gupta
Summary: This study focused on metabolite profiling and identification from the bark of Alangium salviifolium by using organic and aqueous solvents. Eighty-one secondary metabolites with therapeutic potential were identified, showcasing the therapeutic value of this plant.
Review
Chemistry, Analytical
Hugo M. Santos, Luis B. Carvalho, Carlos Lodeiro, Goncalo Martins, Ines L. Gomes, Wilson D. T. Antunes, Vanessa Correia, Maria M. Almeida-Santos, Helena Rebelo-de-Andrade, Antonio P. A. Matos, J. L. Capelo
Summary: This work presents a tutorial on the capabilities of bioanalytical mass spectrometry in detecting and differentiating viruses at the peptide level, as well as providing diagnosis and prognosis for infected patients. It offers insights into the possibilities of current high-resolution mass spectrometry technology and bioinformatics.
MICROCHEMICAL JOURNAL
(2023)
Review
Food Science & Technology
Minke Yang, Juan Li, Chengying Zhao, Hang Xiao, Xiang Fang, Jinkai Zheng
Summary: Flavonoids have gained increasing attention for their various health-promoting effects. Liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS) has become a widely used technique for detecting flavonoids, providing efficient separation and structural information. This review comprehensively summarizes the principles and methodologies of LC-Q-TOF-MS/MS for detecting flavonoids in food, including qualitative and quantitative determination. It also discusses recent applications in agricultural products, food processing, and in vivo metabolism, as well as suggesting technological improvements and potential applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Guo-Ming Dong, Hang Yu, Li-Bin Pan, Shu-Rong Ma, Hui Xu, Zheng-Wei Zhang, Pei Han, Jie Fu, Xin-Yu Yang, Adili Keranmu, Hai-Tao Niu, Jian-Dong Jiang, Yan Wang
Summary: The study revealed that gut microbiota plays a significant role in the metabolism of timosaponin BII, resulting in the production of various metabolites, including three newly identified structures in the gut microbiota. The metabolic behavior of timosaponin BII in gut microbiota system was found to be unique compared to rat liver homogenate and a rat liver microsome incubation system.
Article
Food Science & Technology
Nannan Li, Shuqin Li, Qirou Wang, Shuyu Yang, Yinuo Hou, Yan Gao, Xiangyang Zhang, Min Zhang, Haixia Chen
Summary: This study applied MALDI-TOF MSI and QTOF LC-MS/MS techniques to investigate the spatial distribution changes of low molecular weight compounds in garlic tissue during Laba garlic processing. It was found that some bioactive compounds were transformed or leached out during the processing, while new compounds related to pigments emerged. This study provides a basis for understanding the spatial distributions and changes of compounds in garlic tissue during Laba garlic processing, which may affect the bioactivities of garlic.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Daseul Jeong, Sanggil Choe, Sooyeun Lee, Kang Min Kim, Jaesung Pyo
Summary: The metabolites of five major illegal anti-obesity drugs were analyzed for the first time, providing a tool for toxicological detection and metabolite identification in forensic cases. The study revealed that these drugs were metabolized into multiple constituents in in vivo and in vitro models.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yan He, Weiwei Su, Xiang He, Taobin Chen, Xuan Zeng, Zenghao Yan, Weijian Zhang, Wei Yang, Jianmin Guo, Hao Wu
Summary: This study identified and characterized the components of Naoxintong Capsule in beagle dog plasma, as well as proposed the in vivo bio-transformation pathways. By developing a quantitative method for crucial components and conducting plasma pharmacokinetic study, insights into the absorbed components profiling and in vivo transformation behaviors of NXTC were provided for future investigations on efficacy-contributing critical components and mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Jiameng Qu, Fan Ke, Ziru Liu, Xiao Yang, Xianzhe Li, Huarong Xu, Qing Li, Kaishun Bi
Summary: This study comprehensively demonstrates the multi-target mechanisms of dandelion against TNBC using network pharmacology, molecular pharmacology, and metabolomics approaches. The findings indicate that dandelion can treat TNBC by regulating cell cycle and metabolism-related biological processes. These findings are of great importance for further mechanism investigations and the development of highly effective dandelion-based treatments for TNBC.
Article
Chemistry, Analytical
Sylvia K. Neef, Ute Hofmann, Thomas E. Muerdter, Matthias Schwab, Mathias Haag
Summary: The suitability of a capillary hydrophilic interaction chromatography (CapHILIC) -QTOF-MS system for non-targeted metabolomics was evaluated and compared with a narrow-bore hydrophilic interaction chromatography (HILIC) -QTOF-MS system. Both platforms detected a similar number of features and performed well in terms of retention time stability, analytical repeatability, and signal intensity. The use of CapHILIC increased the signal areas of all metabolites, though the signal-to-noise ratio was only improved for 50% of the metabolites. Further optimization of CapHILIC conditions improved reproducibility and signal intensity.
Article
Food Science & Technology
Aicha El Jai, Abdellah Zinedine, Ana Juan-Garcia, Jordi Manes, Samira Etahiri, Cristina Juan
Summary: Aromatic and medicinal plants (AMPs) as herbal materials are often contaminated by various mycotoxin-producing fungi. This study investigated the co-occurrence of 15 mycotoxins in 40 AMP samples consumed in Morocco. Results showed that while multiple mycotoxins were present in the samples, the dietary exposure of mycotoxins through AMP beverages does not pose a risk to the population.
Article
Construction & Building Technology
Stepanka Kuckova, Gabriela Rambouskova, Petra Junkova, Jiri Santrucek, Pavel Cejnar, Tatiana Anatolievna Smirnova, Ondrej Novotny, Radovan Hynek
Summary: The enrichment of mortar mixtures with natural organic materials has a long history, with protein additives proven to enhance mortar durability and strength. This study aimed to identify and quantify proteins in model mortars with various protein additives using mass spectrometry techniques. The results confirmed the possibility of identifying protein additives in century-old mortars, shedding light on traditional recipes.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Biochemical Research Methods
Jie Tang, Mengge Shi, Yan Xu, Zhengcai Ju, Huida Guan, Jun Lin, Gan Li, Han Han, Tong Zhang
Summary: A rapid and highly sensitive LC-MS/MS method was established and validated for simultaneous determination of multiple components in rat plasma, providing useful information for the further study of active ingredients of SGZT.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Analytical
Laximan Velip, Vivek Dhiman, Bhoopendra Singh Kushwah, Vijaya Madhyanapu Golla, S. Gananadhamu
Summary: Urapidil, an antihypertensive drug, was investigated under various stress conditions according to ICH guidelines. A stability indicating HPLC method and LC-Q-TOF-MS were used to separate, identify, and evaluate the toxicity of five impurities. The study findings are important for understanding the stability of the drug and the mechanism of impurity formation.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Kyoung-Moon Han, You Kyung Kim, Sowoon Seo, Jun Hyoung Kim, Ji Hyun Lee, Hyung Il Kim, Sooyeul Cho
Summary: High-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) were used to detect and characterize banned synthetic colorants in cosmetics. A validated HPLC method was applied to 120 distributed cosmetic products, revealing the presence of three illegal synthetic colorants in one product. The fragmentation pattern of synthetic colorants was predicted based on their fragment ions obtained using LC-Q-TOF-MS.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Medicinal
Takuma Kobayashi, Takeshi Toyoda, Yuya Tajima, Shinji Kishimoto, Yuta Tsunematsu, Michio Sato, Kohei Matsushita, Takanori Yamada, Yuko Shimamura, Shuichi Masuda, Masako Ochiai, Kumiko Ogawa, Kenji Watanabe, Takeji Takamura-Enya, Yukari Totsuka, Keiji Wakabayashi, Noriyuki Miyoshi
Summary: The study suggests that a novel metabolite MxMxBD may increase the risk of bladder carcinogenesis by exhibiting stronger mutagenicity and genotoxicity compared to o-Ans. Additionally, heterodimerizations were observed when o-Ans was coincubated with o-Tol or aniline, highlighting the importance of considering both homodimerizations and heterodimerizations in evaluating the combined exposure risk of bladder carcinogenesis.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Applied
Yoji Kato, Yui Kishi, Yayako Okano, Masaki Kawai, Michiyo Shimizu, Naoko Suga, Chisato Yakemoto, Mai Kato, Akika Nagata, Noriyuki Miyoshi
Summary: Reports on the thermal stability of manuka honey in terms of food processing have been limited. This study found that heating resulted in significant decreases in MGO and MAP in manuka honey. The mechanism for the decrease in MGO involves an amino-carbonyl reaction, while the decrease in MAP is influenced by the volume of headspace in a vessel. Additionally, heating can cause signature molecules in honey to vaporize.
Article
Microbiology
Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Kikue Todoroki-Mori, Yuta Tsunematsu, Michio Sato, Yuji Ogata, Noriyuki Miyoshi, Naoto Kubota, Jun Kunisawa, Keiji Wakabayashi, Tetsuya Kubota, Kenji Watanabe, Motohiko Miyachi
Summary: This study found that stool patterns may help evaluate the presence of tumorigenic bacteria and fecal fatty acids without the need for specialist technology or skill. Specifically, a certain stool pattern was found to be associated with pks(+)E. coli and had significant correlations with specific fecal fatty acids.
Article
Multidisciplinary Sciences
Nanami Senoo, Takumi Akahori, Hiyori Ichida, Noriyuki Miyoshi, Akihito Morita, Takao Shimizu, Hideo Shindou, Shinji Miura
Summary: The study found that fasting led to a decrease in 22:6-phosphatidylcholines (PCs) and an increase in 18:2-PCs in skeletal muscle phospholipid profiles. This increase in 18:2-PCs during fasting was able to compensate for the loss of 22:6-PCs, maintaining the total amount of polyunsaturated fatty acid (PUFA)-containing PCs. Similar phospholipid alterations were observed in insulin-deficient mice, indicating that these perturbations were characteristic of catabolic skeletal muscle. In muscles lacking 22:6-PCs, such as lysophosphatidic acid acyltransferase 3 knockout mice, accumulation of other PUFA-containing PCs, mainly 18:2-PCs, suggests a compensatory mechanism for maintaining PUFA-containing PCs in skeletal muscle.
Article
Chemistry, Multidisciplinary
Tomoharu Motoyama, Shogo Nakano, Fumihito Hasebe, Ryo Miyata, Shigenori Kumazawa, Noriyuki Miyoshi, Sohei Ito
Summary: Pyrazines, such as 3-ethyl-2,5-dimethylpyrazine, can be synthesized from L-Thr by a simple bacterial operon. The process involves condensation reaction of aminoacetone and acetaldehyde supplied by specific enzymes. A moderate reaction temperature is crucial for the synthesis of pyrazines.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Yudai Shioji, Takuma Kobayashi, Takuya Yoshida, Tomoka Otagiri, Keita Onoda, Yasukiyo Yoshioka, Tatsuya Sasada, Noriyuki Miyoshi
Summary: Research shows that both dried and raw spirulina diets have lower digestibility coefficients but higher biological values in Wistar rats as compared to the casein diet. The protein digestibility-corrected amino acid score of raw spirulina is significantly higher than that of dried spirulina, indicating their potential as effective protein and amino acid supplements. Additionally, amino acid profiling of blood in spirulina-fed rats suggests a positive impact on protein/amino acid bioavailability.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Food Science & Technology
Tomokazu Ohishi, Sumio Hayakawa, Noriyuki Miyoshi
Summary: Epidemiological studies have shown that consumption of green tea, coffee, wine, and curry may reduce the risk of various cancers, although the effects can differ depending on the specific cancer site. Compounds found in these foods, such as chlorogenic acid, curcumin, epigallocatechin gallate, and resveratrol, can act as antioxidants or prooxidants to modulate reactive oxygen species (ROS) and miRNA expression, thereby exerting anticancer effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Yasukiyo Yoshioka, Tomokazu Ohishi, Yoriyuki Nakamura, Ryuuta Fukutomi, Noriyuki Miyoshi
Summary: Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of cancer. Polyphenols play a major role in the anticancer effects of these foods, influencing ROS-mediated pathways and miR expression. Further research can provide more convincing evidence.
Article
Chemistry, Medicinal
Takuma Kobayashi, Shinji Kishimoto, Shogo Watanabe, Yasukiyo Yoshioka, Takeshi Toyoda, Kumiko Ogawa, Kenji Watanabe, Yukari Totsuka, Keiji Wakabayashi, Noriyuki Miyoshi
Summary: This study identifies the formation of several p-semidine-type dimers, including MMBD and MxMxBD, during the metabolic conversion of o-Tol and o-Ans. The dimers containing the o-Ans moiety showed faster dimerization rates but decreased levels with prolonged incubation. These findings suggest the potential significance of the homo-and hetero-dimers of monocyclic aromatic amines in bladder carcinogenesis and the combined exposure risk.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tomokazu Ohishi, Noriyuki Miyoshi, Mari Mori, Miki Sagara, Yukio Yamori
Summary: Plant polyphenols, such as genistein and epigallocatechin-3-gallate, have been studied for their potential health benefits, particularly in relation to cancer and cardiovascular diseases. However, there are conflicting findings regarding the effects of these flavonoids, with some studies showing positive effects while others do not. Factors such as recall bias and the measurement of metabolites in urine samples can contribute to these inconsistencies. Further clinical studies considering different confounding factors are needed to provide evidence for the actual impact of dietary flavonoids on human diseases. One possible mechanism involves the regulation of reactive oxygen species and 5'-adenosine monophosphate-activated protein kinase by flavonoids.
Review
Biochemistry & Molecular Biology
Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, Noriyuki Miyoshi
Summary: Polyphenols have anticancer effects by acting as antioxidants and modulating cell signaling pathways, with ncRNA modulation enhancing these effects.
Article
Nutrition & Dietetics
Kazuaki Iguchi, Koji Nagashima, Jun Mochizuki, Hiroyuki Yamamoto, Keiko Unno, Noriyuki Miyoshi
Summary: Several studies have shown that the consumption of certain mushroom species can affect testosterone production in animals. Enokitake mushrooms and vegetables containing adenosine might influence testosterone production. This study investigated the effects of enokitake and adenosine on testosterone production in testicular cells in mice models. The results suggest that intake of adenosine-containing mushrooms and vegetables, particularly enokitake, may be beneficial for increasing testicular testosterone production and combating aging and fatigue.
Article
Biochemistry & Molecular Biology
Yasukiyo Yoshioka, Shiori Oishi, Keita Onoda, Katsumi Shibata, Noriyuki Miyoshi
Summary: The study found that diosgenin is an effective functional food for preventing glucocorticoid-induced skeletal muscle atrophy. It acts by inhibiting protein expression, improving phosphorylation levels, and blocking nuclear translocation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Takuji Suzuki, Tomokazu Ohishi, Hiroki Tanabe, Noriyuki Miyoshi, Yoriyuki Nakamura
Summary: Matrix metalloproteinases (MMPs) are zinc-dependent metalloproteinases that are involved in various diseases. Polyphenols have been demonstrated to have beneficial effects on these diseases by suppressing MMP gene expression and enzyme activity, as well as inhibiting reactive oxygen species and directly binding to MMPs. Molecular docking analyses can provide a structural basis for the development of polyphenol-based drugs with anti-inflammatory properties.
Article
Biochemistry & Molecular Biology
Shunsuke Yamamoto, Shigeki Kato, Nanami Senoo, Noriyuki Miyoshi, Akihito Morita, Shinji Miura
Summary: The study found significant differences in PC profiles between different meat animal species and cut sites, with pork meat having high amounts of PCs containing ether bonds and beef and lamb meats containing PCs with an odd number of carbon atoms. Additionally, PC profiles varied based on muscle location in chicken and pork, suggesting that skeletal muscle PC profiles can be indicators of animal species and muscle location.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemical Research Methods
Saranya Krishnan, Shina Sasi, Preshobha Kodakkattumannil, Salima Al Senaani, Geetha Lekshmi, Martin Kottackal, Khaled M. A. Amiri
Summary: This study aimed to develop an efficient DNA extraction protocol suitable for diverse plant species and tissues. A reliable and consistent protocol was described for the extraction of high-quality DNA from difficult-to-extract plant species. The optimized protocol was successful in extracting high-quality DNA from various plant species and tissues, making it useful for genomic studies of recalcitrant plants.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Eisaku Hokazono, Saori Fukumoto, Takeshi Uchiumi, Susumu Osawa
Summary: This study proposes a method for detecting nucleic acid amplification using pyrophosphate, which requires only two reagents and an automated analyzer. The technique has high sensitivity and reproducibility, and can detect pyrophosphate within 10 minutes. Therefore, this method has the potential to be a new, rapid, and simple detection technique for amplified nucleic acids.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Drew S. Sowersby, L. Kevin Lewis
Summary: SURE electrophoresis is a new method for concentrating samples in gels, which allows efficient detection of highly dilute DNA samples. This approach generates single bands with enhanced signal intensities and minimal band broadening.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Hongyi Liang, Guoliang Yin, Guangxi Shi, Zhiyong Liu, Xiaofei Liu, Jingwei Li
Summary: The mechanism of Echinacoside (ECH) in treating breast cancer (BC) was explored through network pharmacology and experimental validation. It was found that ECH plays an important role in anti-BC by regulating the PI3K/AKT/HIF-1 alpha/VEGF signaling pathway, and it exhibits multi-target and multi-pathway effects.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Daniel S. Kantner, Emily Megill, Anna Bostwick, Vicky Yang, Carmen Bekeova, Alexandria Van Scoyk, Erin L. Seifert, Michael W. Deininger, Nathaniel W. Snyder
Summary: This study compared the results of different methods for measuring the amount of acetyl-Coenzyme A. The colorimetric ELISA kit did not produce interpretable results, while the fluorometric enzymatic kit showed comparable results to the LC-MS-based methods depending on the matrix and extraction conditions. LC-MS/MS and LC-HRMS methods produced well-aligned results, especially when using stable isotope-labeled internal standards.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Jingyan Xu, Hanying Tan, Xionghui Ma, Linjing Su, Zhi Zhang, Yuhao Xiong
Summary: This study investigates the co-catalytic capabilities of MoO3 nanosheets in enhancing the enzyme-like catalytic activity of a two-dimensional ultrathin Fe(III)-modified covalent triazine framework (Fe-CTF) under neutral pH conditions. The Fe-CTF/MoO3 co-catalytic system exhibits enzyme-mimicking activity and enables the development of a colorimetric method for glucose detection. Furthermore, a straightforward one-pot colorimetric method is established for screening XOD inhibitors.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Lichao Zhang, Kang Xiao, Xueting Wang, Liang Kong
Summary: A novel fusion technology was designed to identify FAD-binding sites, achieving the best results on two independent test datasets and outperforming existing methods significantly. The high performance and certainty of the method were demonstrated through statistical tests and cross-entropy loss analysis.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Abdulkadir Kilic, Mehmet Aslan, Abdulkadir Levent
Summary: This study developed a simple, rapid, sensitive, and selective voltammetric technique for the electrochemical characterization and detection of the highly risky drug Edoxaban. The optimized voltammetric method showed good analytical working range and was successfully applied to urine and tablet samples.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Su Hyun Kim, Nara Shin, Jong-Min Jeon, Jeong-Jun Yoon, Jeong Chan Joo, Hee Taek Kim, Shashi Kant Bhatia, Yung-Hun Yang
Summary: To address environmental issues caused by traditional plastics, bioplastics have gained attention as alternatives. Although bioplastics have better degradability, their degradation still takes longer than anticipated. This study proposes a novel screening method to identify bioplastic degraders faster, saving time and providing more quantitative data.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Irem Okman Kocoglu, Pinar Esra Erden, Esma Kilic
Summary: In this study, an electrochemical biosensor based on carbon nanofibers and ionic liquid modification was constructed for tyramine detection. The biosensor showed linear response, low detection limit, high sensitivity, and exhibited good reproducibility, stability, and anti-interference ability.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Liana U. Akhmetzianova, Timur M. Davletkulov, Assol R. Sakhabutdinova, Alexey Chemeris, Irek M. Gubaydullin, Ravil R. Garafutdinov
Summary: A new program called LAMPrimers iQ has been developed for high-quality LAMP primer design, and its advantages in providing higher specificity and reliable detection of viral RNA were validated using SARS-CoV-2 coronavirus RNA as a model target.
ANALYTICAL BIOCHEMISTRY
(2024)
Article
Biochemical Research Methods
Tommaso Pileri, Alberto Sinibaldi, Agostino Occhicone, Norbert Danz, Elena Giordani, Matteo Allegretti, Frank Sonntag, Peter Munzert, Patrizio Giacomini, Francesco Michelotti
Summary: This study developed a biosensing device based on one-dimensional photonic crystal to detect HER2 in breast cancer. The device combines label-free and fluorescence operation modes, allowing for real-time and accurate detection in less than 20 minutes. It offers a promising technique for combined label-free and fluorescence detection in disease diagnosis and therapeutic monitoring.
ANALYTICAL BIOCHEMISTRY
(2024)
