Article
Chemistry, Multidisciplinary
Bhavesh Premdjee, Asser S. Andersen, Mark Larance, Kilian W. Conde-Frieboes, Richard J. Payne
Summary: The text discusses the successful assembly of a 31.5 kDa phosphorylated IGFBP-2 protein using two ligation manifolds, incorporating phosphoserine post-translational modification and nine disulfide bonds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Rafael Fernandez-Martinez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: This study aimed to evaluate whether the alterations in insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) in schizophrenia patients are related to the psychiatric disorder itself or are a result of antipsychotic treatment. The results showed that drug-naive first episode patients had lower levels of IGF-2 compared to controls, but no significant change in IGFBP-7 levels. However, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment in these patients. Chronic patients, on the other hand, had higher levels of both proteins compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Review
Biochemistry & Molecular Biology
Shiva Nasr, Athar Nakisa, Setareh Jandaghian, Monireh Kouhi, Erfan Sadeghi, Jaleh Varshosaz
Summary: This systematic review found that flavonoid supplements do not have a significant effect on IGF-1 and IGFBP-3. However, a high soy diet has beneficial effects on components of the IGF system, which may be useful in breast cancer.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Geriatrics & Gerontology
Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei
Summary: Exogenous recombinant human IGF-1 attenuated cisplatin-induced muscle atrophy by restoring IGF-1/PI3K/Akt signaling pathway activity, inhibiting muscle protein degradation, and reducing muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
Huong Thuy Le, Ho Jin Lee, Jaebeom Cho, Hye-Young Min, Ji-Sun Lee, Su-Jae Lee, Ho-Young Lee
Summary: The study demonstrates the anti-metastatic effects of IGFBP-3 in inhibiting migration and invasion of NSCLC and HNSCC cells, as well as the development of metastasized tumors in vivo. Mechanistically, IGFBP-3 disrupts the protein stability of vimentin via direct binding, providing a molecular explanation for its IGF-independent anti-metastatic and anti-tumor activities.
Article
Cell & Tissue Engineering
Haijian Sun, Shuang Wang, Zheng Yang, Lijie Tian, Xiaoxia Li, Jie Zhou, Baoli Wang
Summary: In this study, the researchers found that CHRDL1 acts as an antagonist of BMPs by binding to them and blocking their interaction with BMP receptors. They revealed that CHRDL1 suppresses osteoblast differentiation while promoting adipocyte differentiation. Mechanistic exploration showed that CHRDL1 stabilizes IGFBP3 and differentially modulates AKT/mTORC1 signaling, thereby regulating the differentiation of osteoblasts and adipocytes.
Article
Agriculture, Dairy & Animal Science
Mengying Dou, Md. Abul Kalam Azad, Yating Cheng, Sujuan Ding, Yang Liu, Bo Song, Xiangfeng Kong
Summary: Animal growth after weaning is influenced by various factors, including breed, nutrition, growth hormones, physiological stage, and environment. This study investigated the insulin-like growth factor (IGF) system components in different pig breeds during weaning and found that expressions of IGF system components were affected by weaning stress and differed among the breeds.
Article
Medicine, General & Internal
Barbara Wlodarczyk, Lukasz Durko, Przemyslaw Wlodarczyk, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: Differentiating between pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) poses a challenge. This study assessed the usability of IGF-1, IGFBP-2, and IGF-1/IGFBP-2 ratio in differentiating PDAC and CP. The results indicate that CA 19-9 demonstrates high potential as a marker for PDAC and CP differentiation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rikke Hjortebjerg, Maja R. Kristiansen, Ivan Brandslund, Dorte Aa. Olsen, Jacob V. Stidsen, Jens S. Nielsen, Jan Frystyk
Summary: In individuals with type 2 diabetes, high levels of IGFBP-2 are associated with low glucose and insulin secretion, are unaffected by metformin treatment, and are associated with the risk of prior comorbidity and mortality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Chloe Rauzier, Dominic J. Chartrand, Natalie Almeras, Isabelle Lemieux, Eric Larose, Patrick Mathieu, Philippe Pibarot, Benoit Lamarche, Caroline Rheaume, Paul Poirier, Jean-Pierre Despres, Frederic Picard
Summary: This study found that low levels of IGFBP-2 are associated with fat accumulation and metabolic alterations in individuals with obesity. However, it remains unclear whether IGFBP-2 affects energy metabolism in the early stages of these disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, General & Internal
Xiaohui Wang, Jia Li, Wei Zhang, Feng Wang, Yunzi Wu, Yulin Guo, Dong Wang, Xinfeng Yu, Ang Li, Fei Li, Yibin Xie
Summary: This study reveals that tumor-derived IGFBP-3 plays a critical role in cancer-associated cachexia by causing lipid loss in mature adipocytes. IGFBP-3 antagonizes insulin/IGF-like signaling and impairs the balance between lipolysis and lipogenesis. The findings suggest that tumor-derived IGFBP-3 may serve as a biomarker for the diagnosis of cachexia in cancer patients.
CHINESE MEDICAL JOURNAL
(2023)