Article
Chemistry, Analytical
Yue Luo, Gang Chen, Xiuqing Deng, Hanqing Cai, Xueheng Fu, Fujian Xu, Xiaonian Xiao, Yumeng Huo, Jin Luo
Summary: A method using high performance liquid chromatography-inductively coupled plasma-tandem mass spectrometry (HPLC-ICP-MS/MS) was developed for the speciation of six selenium species. The six species could be completely separated within 20 minutes under optimized conditions, and the method showed low detection limits and good recovery for selenium-enriched foods.
Article
Food Science & Technology
Lena Ruzik, Malgorzata Jakubowska
Summary: The popularity of plant-based food products has grown in response to the increasing demand for plant foods. This study analyzed the total arsenic content and its species in plant-based beverages purchased in Poland. The research validated a method for analyzing arsenic using high-performance liquid chromatography combined with inductively coupled plasma mass spectrometry.
Article
Chemistry, Analytical
Daniel Torregrosa, Carlos Gomez-Pertusa, Guillermo Grindlay, Luis Gras, Juan Mora
Summary: The number of studies on nanomaterial characterization in organic matrices using spICP-MS is increasing, but limited knowledge exists about the non-spectral interferences caused by this matrix. This study aims to investigate non-spectral interferences on nanoparticle characterization (number concentration and size distribution) by organic materials with spICP-MS. The results show that 10% w/w ethanol causes positive matrix effects on the number concentration, while the size distribution can be affected positively or negatively depending on the plasma conditions, instrument characteristics, and nanoparticle composition. Internal standardization can help mitigate these organic non-spectral interferences.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
C. Derrick Quarles, Patrick Sullivan, Nick Bohlim, Nathan Saetveit
Summary: This study presents two fast and reliable separation methods for arsenic compounds. The recovery rate of both methods falls between 94% and 107%, and the accuracy was evaluated by analyzing proficiency samples. The detection limits in urine matrix for the two methods ranged from 2.8-6.0 ng L-1 As and 4.1-9.1 ng L-1 As, respectively.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Engineering, Environmental
A. Arias-Borrego, M. Selma-Royo, M. C. Collado, N. Abril, T. Garcia-Barrera
Summary: Biological systems are exposed to a complex environment where pollutants can interact through synergistic or antagonistic mechanisms. This study investigates the effects of selenium supplementation on gut microbiota, plasma selenoproteome, metabolome, and arsenic metabolization using different models and methods. The results show that selenium reduces the concentration of the antioxidant glutathione peroxidase in plasma and increases the arsenic methylation rate. Furthermore, synergistic deleterious effects were observed between pollutants, antibiotics, and selenium.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemical Research Methods
Prasad Phapale, Andrew Palmer, Rose Muthoni Gathungu, Dipali Kale, Britta Brugger, Theodore Alexandrov
Summary: EMBL-MCF is an open LC-MS/MS spectral library with over 1600 fragmentation spectra from 435 authentic standards of endogenous metabolites and lipids. It features chromatographic profiles acquired with different LC-MS methods and coverage of different adduct ions. The library contains many biologically important metabolites and unique metabolites and lipids compared to other public libraries.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Analytical
Yanbei Zhu, Akihide Itoh
Summary: A practical method called pseudo isotope dilution (PID) was proposed to correct barium-related spectral interferences on the measurement of europium. Results confirmed its validity by determining europium in standard solutions with different concentrations of barium.
ANALYTICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Sara Hamid Kargari, Fatemeh Ahour, Mehdi Mahmoudian
Summary: The aim of this research is to develop an electrochemical sensor based on a conducting polymer, polyaniline, and a cationic polymer, poly(diallyldimethylammonium chloride), reinforced with graphene oxide nanosheets functionalized with acrylic acid. The presence of acrylic acid functionalized graphene oxide nanosheets increases the surface area due to the nano size effect and better dispersion of this nanomaterial, poly(diallyldimethylammonium chloride), increases the adsorption capacity of the analyte due to electrostatic interaction between the negatively charged analyte and positively charged surface, and polyanilin increases the charge transfer rate due to the good conductivity. The results show that the prepared electrode has a sensitivity equal to 1.79 A/M with 0.12 mu M as the detection limit. The proposed sensor could be used for the determination of total inorganic arsenic by first oxidative pretreatment for conversion of As(III) to As(V).
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Karas, Anetta Ziola-Frankowska, Marcin Frankowski
Summary: This paper presents a new method for simultaneous speciation analysis of arsenic and selenium forms using HPLC-ICP-MS technique, with successful separation achieved on ion exchange columns, applicable to seafood and onion samples.
Article
Biochemical Research Methods
Jiaxuan Zhang, Yang Zhou, Dongliang Zuo, Limin Yang, Xiaowen Yan, Pingguo Liu, Qiuquan Wang
Summary: A new method has been developed for quantifying active selenols in cells through specific recognition and signal switching, with a low limit of detection. Experimental results indicate significant differences in the levels of active selenols between liver cancer cells and normal cells, with a positive correlation to the degree of hepatic disease.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Nwabisa Takata, Angelique Botha, Philiswa N. Nomngongo
Summary: This study developed and validated methods for determining the total selenium concentration in soil, maize plants, and maize flour. The methods demonstrated acceptable accuracy and repeatability, and the performance characteristics were comparable to previously reported methods.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Analytical
Ka -Him Chun, Judy Tsz-Shan Lum, Kelvin Sze -Yin Leung
Summary: The study utilized single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS) to analyze single particles/cells, and developed a method to optimize quadrupole voltages for expanded analytical capabilities while minimizing spectral interference. This technique successfully achieved accurate analysis of various particles and biological cells despite severe interference, showing great potential for practical applications.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Yuki Itaya, Kenji Kuninishi, Yohey Hashimoto
Summary: Arsenic, selenium, and chromium can be harmful at certain concentrations and may be eluted from coal ash discharged from coal-fired power plants. Arsenic and selenium are eluted in forms that can be readily insolubilized, while chromium is eluted in the form of carcinogenic hexavalent chromium.
JOURNAL OF MATERIAL CYCLES AND WASTE MANAGEMENT
(2022)
Article
Environmental Sciences
Fernanda Pollo Paniz, Tatiana Pedron, Vitoria Aparecida Procopio, Camila Neves Lange, Bruna Moreira Freire, Bruno Lemos Batista
Summary: The study found that selenium has the potential to regulate the toxicity of arsenic and cadmium in rice plants, reducing their accumulation in grains and the risks associated with human consumption. However, different rice cultivars may show different responses to arsenic and selenium exposure under the same growing conditions.
Article
Spectroscopy
Yanbei Zhu, Kazumi Nakano, Yasuyuki Shikamori, Akihide Itoh
Summary: Rare earth elements (REEs) in natural water samples were measured using ICP-MS/MS with oxygen as the reaction gas, achieving low detection limits and confirming the effectiveness and accuracy of the method through optimization of operating conditions. The results of REEs in multiple river and lake water samples were evaluated by normalization to the concentrations of REEs in post Archean Australian shale (PAAS).
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Environmental Sciences
Cindy Ka Y. Law, Kankana Kundu, Luiza Bonin, Lorena Penacoba-Antona, Eduardo Bolea-Fernandez, Frank Vanhaecke, Korneel Rabaey, Abraham Esteve-Nunez, Bart De Gusseme, Nico Boon
Summary: In this study, biogenic palladium nanoparticles were used for the reductive transformation and/or dehalogenation of persistent micropollutants. The size of the nanoparticles and their catalytic activity could be controlled by adjusting the H-2 flow rate. The results showed that the nanoparticles with larger sizes exhibited higher catalytic activity and more efficient removal of micropollutants.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Analytical
Ryoga Maeda, Thibaut Van Acker, Frank Vanhaecke, Akira Yamaguchi, Vinciane Debaille, Phillippe Claeys, Steven Goderis
Summary: This study applied the fast elemental mapping technique LA-ICP-TOF-MS to analyze chondritic meteorite samples. The technique allows for the visualization of element distribution maps at sub-micrometer spatial resolution and semi-quantitative analysis of major and trace elements. The accuracy and precision of this method were compared to conventional spot analysis methods, and good agreement was found. However, there are limitations to LA-ICP-TOF-MS mapping, such as limited ablated yield when using a small laser spot size and lower sensitivity compared to LA-ICP-SF-MS.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
M. Carmen Garcia-Poyo, Sylvain Berail, Anne Laure Ronzani, Luis Rello, Elena Garcia-Gonzalez, Flavio V. Nakadi, Maite Aramendia, Javier Resano, Martin Resano, Christophe Pecheyran
Summary: This article investigates the importance of Cu fractionation and Cu isotopic composition in understanding Wilson's disease (WD) and proposes a machine learning model for diagnosis. The study finds that the relative exchangeable Cu (REC) parameter is crucial for distinguishing WD patients from others, and machine learning can achieve accurate and reliable diagnosis.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Multidisciplinary
Antonio Bazo, Maite Aramendia, Flavio V. Nakadi, Martin Resano
Summary: This paper proposes a novel approach using internal standards and bandpass mode in single particle ICP-MS for the characterization of Au nanoparticles in complex matrices. The method was validated for different matrices and the sensitivity of the nanoparticles was affected by matrix effects. Two methods, particle size method and dynamic mass flow method, were used to determine the transport efficiency and achieve accurate results. The use of bandpass mode provided flexibility in tuning the sensitivity for each nanoparticle type to ensure accurate characterization.
Article
Biology
Kasper Hobin, Marta Costas-Rodriguez, Elien Van Wonterghem, Roosmarijn E. Vandenbroucke, Frank Vanhaecke
Summary: Alzheimer's disease is associated with protein aggregations and altered copper metabolism. Two ICP-MS analysis techniques were used to determine the copper concentration and isotope ratio in blood plasma and brain regions of Alzheimer's mice. The concentration of copper in blood plasma was significantly altered in response to age and Alzheimer's-related effects, while the isotope ratio was affected by Alzheimer's disease only. Both the brain stem and cerebellum showed changes in copper concentration and isotope ratio. The determination of copper concentration and isotope ratio is relevant for understanding the role of copper in aging and Alzheimer's disease.
Article
Nanoscience & Nanotechnology
Helena Braet, Peter-Paul Fransen, Remco Marien, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Christian Vanhove, Stefan van der Vegte, Elke Gasthuys, An Vermeulen, Patricia Y. W. Dankers, Stefaan C. De Smedt, Katrien Remaut
Summary: This study aimed to improve the treatment of peritoneal metastasis from ovarian cancer by evaluating a nanoparticle-loaded, pH-switchable supramolecular polymer hydrogel as a controlled release drug delivery system. The research demonstrated that acidifying the nebulized hydrogel solution with carbon dioxide stimulated in situ gelation, prolonging the retention of the hydrogel in the peritoneal cavity. In vitro experiments showed that the drug was gradually released from the hydrogel and maintained cytotoxicity for 10 days. Furthermore, aerosolization of the hydrogel delayed tumor progression and significantly increased overall survival time in a xenograft model of peritoneal metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jari Leemans, Dobromil Respekta, Jing Bai, Simone Braeuer, Frank Vanhaecke, Zeger Hens
Summary: This study demonstrates a one-size-one-batch synthetic protocol for colloidal InAs quantum dots (QDs) with adjustable sizes by adjusting temperature profiles. By accelerating temperature transition and reducing synthesis concentration, larger QDs can be obtained.
Article
Biochemistry & Molecular Biology
Kaj Vaughan Sullivan, Yasmina Assantuh, Rosa Grigoryan, Marta Costas-Rodriguez, Eduardo Bolea-Fernandez, Bruno Lapauw, Steven Van Laecke, Frank Vanhaecke
Summary: Hypomagnesemia, a condition often found in type 1 diabetes mellitus (T1DM) patients, has become less prevalent due to improved treatment. However, a recent study found that disruptions to magnesium homeostasis still persist in T1DM patients. This study aimed to investigate the temporal variability in serum magnesium isotopic composition before and after insulin injection or meal consumption. The results showed a significant difference in serum magnesium isotopic composition between T1DM patients and controls, but no significant difference was observed before and after insulin injection/meal consumption. This suggests that the timing of the most recent meal may not affect serum magnesium isotopic composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geochemistry & Geophysics
Lidia Pittarello, Ludovic Ferriere, Stepan M. Chernonozhkin, Frank Vanhaecke, Steven Goderis
Summary: This study investigates the petrographic and geochemical characteristics of Diogenites meteorite, focusing on an anomalous vesiculated layer. The research reveals that the vesiculated layer shows distinct features and may have originated from in situ melting induced by a large impact event.
METEORITICS & PLANETARY SCIENCE
(2023)
Article
Geochemistry & Geophysics
Ryoga Maeda, Steven Goderis, Akira Yamaguchi, Thibaut Van Acker, Frank Vanhaecke, Vinciane Debaille, Phillippe Claeys
Summary: The chemical effects of terrestrial alteration were studied on a set of H chondrites, focusing on lithophile trace elements. It was found that rare earth elements, thorium, and uranium accumulate in cracks observed in weathered meteorite specimens. These features are interpreted to have been caused by terrestrial weathering following chemical leaching. However, the overall effects on the bulk chemical composition remain limited.
METEORITICS & PLANETARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lyndsey Hendriks, Robert Bruenjes, Sara Taskula, Jovana Kocic, Bodo Hattendorf, Garret Bland, Gregory Lowry, Eduardo Bolea-Fernandez, Frank Vanhaecke, Jingjing Wang, Mohammed Baalousha, Marcus von der Au, Bjoern Meermann, Timothy Ronald Holbrook, Stephan Wagner, Stasia Harycki, Alexander Gundlach-Graham, Frank von der Kammer
Summary: This study conducted an interlaboratory comparison to evaluate and validate the SOP for sp-ICP-TOFMS. Two Pt NP suspensions were characterized and showed good agreement among participating labs in terms of particle mass. However, the particle number concentration results were more scattered. The study also discussed the potential for particle density determination and assessed the precision and trueness of isotope ratio determinations.
Article
Chemistry, Analytical
Thibaut Van Acker, Ana Rua-Ibarz, Frank Vanhaecke, Eduardo Bolea-Fernandez
Summary: In this study, laser ablation was investigated as a method for introducing microplastic particles into an inductively coupled plasma for monitoring using a mass spectrometer. Different types and sizes of microplastic particles were successfully introduced intact. The laser energy density did not affect particle sampling, and better performance was observed with a smaller laser beam diameter and a higher repetition rate. The C-13(+) signal intensity showed a linear correlation with the absolute carbon mass, and the linear range could be extended by using helium. Laser ablation generated narrower signal distributions compared to the traditional solution-based approach and was successful for analyzing mixed suspensions and sampling microplastic particles from filters.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Dominika Berdecka, Manon Minsart, Tao Lu, Deep Punj, Riet De Rycke, Mina Nikolic, Eduardo Bolea-Fernandez, Frank Vanhaecke, Ranhua Xiong, Stefaan C. De Smedt, Peter Dubruel, Winnok H. De Vos, Kevin Braeckmans
Summary: Cell therapies often require modification of cells with external substances to enhance their therapeutic effectiveness. The study investigates the potential of using PEN photoporation to deliver macromolecules into unstimulated T cells. The results show that PEN treatment has minimal impact on T cell proliferation and activation, making it a promising and safe delivery strategy for genetic modification of minimally differentiated T cells.
APPLIED MATERIALS TODAY
(2023)
Article
Materials Science, Multidisciplinary
Omar Martinez-Mora, Luis F. Leon-Fernandez, Milica Velimirovic, Frank Vanhaecke, Kristof Tirez, Jan Fransaer, Xochitl Dominguez-Benetton
Summary: The development of high-performance electrocatalysts is crucial for improving the performance and commercial viability of direct methanol fuel cells (DMFCs). This study utilized the gas-diffusion electrocrystallization process (GDEx) to synthesize platinum nanoclusters (NCs) stabilized by polyvinylpyrrolidone (PVP). The electrocatalytic activity of the Pt NCs for methanol oxidation was successfully evaluated, with PVP-stabilized GDEx-made Pt NCs demonstrating superior performance due to their porous structure and high effective surface area.
MATERIALS ADVANCES
(2023)