Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 405, Issue 30, Pages 9617-9623Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-013-7340-0
Keywords
Doping; Circulating microRNAs; Biomarkers; Athlete biological passport
Funding
- Partnership for Clean Competition (PCC)
- World Anti-Doping Agency
- Exiqon grant program
Ask authors/readers for more resources
MicroRNAs (miRNAs) are small non-coding RNAs that regulate a variety of biological processes. Cell-free miRNAs detected in blood plasma are used as specific and sensitive markers of physiological processes and some diseases. Circulating miRNAs are highly stable in body fluids, for example plasma. Therefore, profiles of circulating miRNAs have been investigated for potential use as novel, non-invasive anti-doping biomarkers. This review describes the biological mechanisms underlying the variation of circulating miRNAs, revealing that they have great potential as a new class of biomarker for detection of doping substances. The latest developments in extraction and profiling technology, and the technical design of experiments useful for anti-doping, are also discussed. Longitudinal measurements of circulating miRNAs in the context of the athlete biological passport are proposed as an efficient strategy for the use of these new markers. The review also emphasizes potential challenges for the translation of circulating miRNAs from research into practical anti-doping applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available