Article
Multidisciplinary Sciences
Shin-Hye Kim, Mi Jung Park, Sung Kyun Park
Summary: This study examined the association between urinary concentrations of polycyclic aromatic hydrocarbon (PAH) metabolites and obesity in the Korean pediatric population. The results showed that concentrations of 2-naphthol and 1-hydroxypyrene were associated with childhood obesity. This suggests that PAH exposure may be a risk factor for childhood obesity.
Article
Environmental Sciences
Inae Lee, Young Joo Park, Min Joo Kim, Sunmi Kim, Sohyeon Choi, Jeongim Park, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Hyunwoong Park, Gi Jeong Cheon, Kyungho Choi, Min Kyong Moon
Summary: This study in the adult Korean population found that the direction of associations between exposure to phthalates, BPA, and parabens and obesity and diabetes mellitus varied depending on the method used to adjust urinary dilution. It highlights the importance of choosing an appropriate adjustment method when studying the associations between these chemical exposures and health outcomes. Further research in other populations is needed to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Environmental Sciences
Radia Bousoumah, Veruscka Leso, Ivo Iavicoli, Pasi Huuskonen, Susana Viegas, Simo P. Porras, Tiina Santonen, Nadine Frery, Alain Robert, Sophie Ndaw
Summary: This study found a lack of recent occupational HBM studies on bisphenols, especially on BPS and BPF. Different methodological designs make comparisons between studies difficult. Few studies have been conducted on the industrial applications of bisphenols outside of Asia.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Martina Capriotti, Paolo Cocci, Luca Bracchetti, Erika Cottone, Rosaria Scandiffio, Giovanni Caprioli, Gianni Sagratini, Gilberto Mosconi, Patrizia Bovolin, Francesco Alessandro Palermo
Summary: This study presented environmental baseline data on floating microplastics in Italian coastal waters of the Central Adriatic Sea, revealing the presence of various organic pollutants on the surface of collected microplastics. Furthermore, the study indicated potential metabolic effects of microplastics on adipocytes, resulting in both adipogenesis and lipid uptake/storage.
Review
Pharmacology & Pharmacy
Ylenia Della Rocca, Enrico Matteo Traini, Francesca Diomede, Luigia Fonticoli, Oriana Trubiani, Alessia Paganelli, Jacopo Pizzicannella, Guya Diletta Marconi
Summary: Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is believed to be involved in the pathogenesis of various diseases, including immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. This review aims to analyze the mechanism of action of BPA, with a specific focus on mesenchymal stromal/stem cells (MSCs) and adipogenesis. The uses of BPA in dental, orthopedic, and industrial fields will be assessed, as well as the impact on different pathological or physiological conditions and related molecular pathways.
Article
Environmental Sciences
Kamila Rybczynska-Tkaczyk, Bartosz Skora, Konrad A. Szychowski
Summary: The aim of this study was to determine the toxicity of bisphenol A (BPA) and its derivatives on various organisms. The results showed that BPA, BPS, and BPF exhibited high toxicity on bacteria, reaching concentrations of 0.018-0.031 mg/L. These compounds also showed genotoxicity and cytotoxicity effects on human cells, as well as phytotoxicity effects on plants. The findings suggest that BPA and its derivatives have a negative impact on living organisms through apoptosis and genotoxic mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Ana Socorro Rodriguez-Baez, Susanna Edith Medellin-Garibay, Maribel Rodriguez-Aguilar, Julia Sagahon-Azua, Rosa Del Carmen Milan-Segoviaa, Rogelio Flores-Ramirez
Summary: The Indigenous women in Mexico are highly vulnerable to exposure to environmental endocrine disruptors, mainly from sources like plastic containers and burning garbage. This study highlights the significant exposure risks faced by Indigenous women and the urgent need for regulatory policies to mitigate these risks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Reproductive Biology
Elodie Person, Sandrine Bruel, Trishabelle I. Manzano, Emilien L. Jamin, Daniel Zalko, Catherine M. H. Combelles
Summary: Ovarian cells have the ability to metabolize bisphenols, such as BPA and BPS, into their respective sulfo-conjugates, with sulfation being the main metabolic route. The persistence of BPA residues is higher than that of BPS in theca cells, and only theca explants can deconjugate inactive BPA-glucuronide and BPS-glucuronide back into their biologically active forms. These findings raise concerns about the direct release of bisphenols in the ovary and highlight the importance of studying the biotransformation of bisphenols in different ovarian cells for risk assessment.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Environmental Sciences
Christoph Schmidtkunz, Katja Kuepper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring
Summary: A study in Germany analyzed the levels of two oxidized metabolites of 4-MBC in urine samples from young adults from 1995 to 2019. The results showed a decreasing trend in 4-MBC exposure in Germany in recent years, possibly due to reduced use of 4-MBC in the cosmetic industry.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Applied
Mereke Alimzhanova, Madina Mamedova, Kazhybek Ashimuly, Alham Alipuly, Yerlan Adilbekov
Summary: A simple and rapid method based on miniaturized solid-phase microextraction (mini-SPME) followed by gas chromatography-mass spectrometry was developed to identify eight endocrine disruptors in drinking water samples. The method showed high sensitivity and accuracy, and can be used for qualitative and quantitative analysis of analytes at extremely low concentrations.
Article
Toxicology
Dino Grgic, Andrea Betschler, Rebeka Fruholz, Barbara Novak, Elisabeth Varga, Doris Marko
Summary: In this study, the estrogenic potential of mycoestrogens and isoflavones was investigated, and it was found that their combination can enhance estrogenic response. Especially, the combination of low concentrations of mycoestrogens with low concentrations of isoflavones significantly increased the estrogenic response.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chiara Castellini, Mario Muselli, Antonio Parisi, Maria Totaro, Daniele Tienforti, Giuliana Cordeschi, Macro Giorgio Baroni, Mauro Maccarrone, Stefano Necozione, Sandro Francavilla, Arcangelo Barbonetti
Summary: This meta-analysis study found a weak negative association between urinary levels of BPA and sperm motility. The overall estimates of data produced by clinical studies indicate a clinically negligible association between urinary BPA concentrations and semen quality.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Environmental Sciences
A. Martinez-Ibarra, L. D. Martinez-Razo, K. MacDonald-Ramos, M. Morales-Pacheco, E. R. Vazquez-Martinez, M. Lopez-Lopez, M. Rodriguez Dorantes, M. Cerbon
Summary: Bisphenol A (BPA) and phthalates, as endocrine-disrupting chemicals, are widely distributed in the environment and can affect cellular proliferation, tissue development, and various physiological processes through interference with hormone synthesis and action. Exposure to these compounds is inevitable and unintentional for humans and living organisms, potentially leading to a wide range of chronic diseases later in life. Monitoring of EDC levels and their impact on human health is crucial for the general population and the healthcare system.
ENVIRONMENTAL POLLUTION
(2021)
Article
Reproductive Biology
Ophelie Teteau, Anais Vitorino Carvalho, Pascal Papillier, Beatrice Mandon-Pepin, Luc Jouneau, Peggy Jarrier-Gaillard, Alice Desmarchais, Marie-Emilie Lebachelier de la Riviere, Claire Vignault, Virginie Maillard, Aurelien Binet, Svetlana Uzbekova, Sebastien Elis
Summary: This study analyzed the effects of BPA and BPS on steroidogenesis in ovine granulosa cells in vitro and compared the effects of GPER agonist and antagonist. The results showed that both BPA and BPS affected progesterone secretion, while only BPS affected estradiol secretion. RNA-seq analysis revealed that BPA mainly disrupted the expression of genes involved in metabolism and transcription, while BPS mainly impaired cellular communication. These findings are important for further investigations on the temporal changes of these genes and the biological processes involved.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Environmental Sciences
Amber L. Cathey, Max T. Aung, Deborah J. Watkins, Zaira Y. Rosario, Carmen M. Velez Vega, Akram N. Alshawabkeh, Jose F. Cordero, Bhramar Mukherjee, John D. Meeker
Summary: This study provides introductory evidence of hormone disruption on the causal pathway between gestational phthalate mixture exposure and subsequent preterm birth. The findings also suggest differential endocrine pathways and susceptibility between male and female fetuses.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Hans G. J. Mol, Ingrid Elbers, Claudia Paelmke, Daniel Bury, Thomas Goeen, Marta Esteban Lopez, Stefanie Nuebler, Vincent Vaccher, Jean-Philippe Antignac, Darina Dvorakova, Jana Hajslova, Amrit Kaur Sakhi, Cathrine Thomsen, Katrin Vorkamp, Argelia Castano, Holger M. Koch
Summary: A quality assurance/quality control program was implemented in the HBM4EU project, which included four rounds of proficiency tests and involved 28 laboratories. The program resulted in a significant improvement in performance and the establishment of a network of competent laboratories capable of generating comparable and accurate data for biomarker analysis.
Article
Chemistry, Analytical
Corinna Fischer, Thomas Goeen
Summary: 2-(5-Chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is a compound used as an ultraviolet (UV) absorber in plastic materials and coatings. This study presents a method for the determination of UV-327 and its metabolites in human blood using protein precipitation, dispersive liquid-liquid microextraction (DLLME) and derivatization. The method has been validated and shown to have high sensitivity and reliability, allowing for the analysis of UV-327 and its metabolites and the assessment of exposure in potentially exposed individuals.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Kate Jones, Karen S. Galea, Bernice Scholten, Marika Loikala, Simo P. Porras, Radia Bousoumah, Sophie Ndaw, Elizabeth Leese, Henriqueta Louro, Maria Joao Silva, Susana Viegas, Lode Godderis, Jelle Verdonck, Katrien Poels, Thomas Goeen, Radu-Corneliu Duca, Tiina Santonen
Summary: This study aims to assess occupational exposure to diisocyanates in five European countries and test the usability of different biomarkers in the assessment of exposure. It also aims to provide background data for regulatory purposes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Goeen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria Joao Silva
Summary: This study conducted a mixture risk assessment (MRA) based on human biomonitoring (HBM) data in Europe to evaluate the co-exposure of hexavalent chromium, nickel, and polycyclic aromatic hydrocarbons. The results indicate that there is concern regarding the occupational health risk of co-exposure to these substances, particularly in welding activities and waste incineration settings. It highlights the importance of considering exposure to the mixture rather than the individual components to manage workplace risk and protect workers' health.
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Aline Murawski, Phillipp Schmidt, Maria Ruther, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Edda Dufthaksdottir, Kristin Olafsdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goen, Stefanie Nuebler, Moritz Schaefer, Karin H. A. Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: This report summarizes the results of the HBM4EU project and associated studies regarding acrylamide exposure levels. The findings show an increasing trend in acrylamide exposure in children, while the trend is less significant in adults and smokers. The average acrylamide exposure still exceeds suggested benchmark levels, raising specific concerns for children. Further research is needed to confirm the declining trend observed in recent years.
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Norman Zinne, Soeren Wiesner, Benno M. Ure, Claus Petersen, Joachim F. Kuebler
Summary: An analysis of the kinetics of metal contamination after minimally-invasive repair of pectus excavatum (MIRPE) and after bar removal revealed a rapid systemic increase of nickel and chromium in patients' blood, urine, and local tissue. These elevated levels of trace metals could cause irritative symptoms, and the prolonged elevated systemic nickel levels beyond bar removal require further investigation of the long-term side effects of MIRPE.
Review
Environmental Sciences
Henriqueta Louro, Bruno Costa Gomes, Anne Thoustrup Saber, Anna Laura Iamiceli, Thomas Goen, Kate Jones, Andromachi Katsonouri, Christiana M. Neophytou, Ulla Vogel, Celia Ventura, Axel Oberemm, Radu Corneliu Duca, Mariana F. Fernandez, Nicolas Olea, Tiina Santonen, Susana Viegas, Maria Joao Silva
Summary: This comprehensive review aims to provide regulators and policymakers with a comprehensive overview of occupational exposure to polycyclic aromatic hydrocarbons (PAHs), including the use of exposure and effect biomarkers, as well as the knowledge needs for regulation. The review highlights the importance of advancing harmonized approaches in data and sample collection, as well as the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure.
Article
Biochemical Research Methods
Heike Denghel, Thomas Goeen
Summary: A simple, reliable, and highly sensitive method for simultaneous monitoring of multiple endocrine disruptors in urine was developed. The method showed good sensitivity and accuracy, making it suitable for exploring the exposome of these disruptors in the general population.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Toxicology
Corinna Fischer, Edgar Leibold, Julia Hiller, Thomas Goeen
Summary: This study provides initial information on the human in vivo metabolism of UV-327 by administering it orally to volunteers. The results show that UV-327 is well-absorbed from the intestine but only partially metabolized. Biliary excretion may be the major route of elimination for UV-327 and its hydroxylated metabolites.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Julia Hiller, Thomas Goeen, Nina Seibold-Wulf, Sebastian Meyer, Hans Drexler
Summary: This study investigates whether a diet highly exposed to aluminum-containing food-contact materials (Al-FCM) leads to an increased aluminum load in humans. The results show that under real-world conditions, there is a measurable but fully reversible additional aluminum burden. The estimated increase from Al-FCM corresponds to 8% of the baseline concentration.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Michael Hoopmann, Aline Murawski, Michael Schuemann, Thomas Goeen, Petra Apel, Nina Vogel, Marike Kolossa-Gehring, Claudia Roehl
Summary: HBM reference values are statistically derived values that provide information on population exposure. A revision is needed to improve the standardization and transparency of the process. It is recommended to use the 95th percentile of the reference distribution as the HBM reference value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Caroline Fortmann, Thomas Goeen, Soeren Wiesner, Jan Hegermann, Rim Kiblawi, Martha Dohna, Benno M. Ure, Diane Miriam Renz, Claus Petersen, Joachim F. Kuebler
Summary: This study investigated the impact of titanium nitride coating on metal release and exposure in patients undergoing minimally invasive repair of pectus excavatum (MIRPE). The results showed that the use of titanium nitride coated pectus bars led to a significant increase in trace metal levels after MIRPE, compared to stainless steel bars, possibly due to wear of the coating and inter-component mobilization processes.
Article
Public, Environmental & Occupational Health
Katharina Schwarz, Katharina Bluemlein, Thomas Goeen, Stefan Hahn, Ralph Hebisch, Wolfgang Koch, Ulrich Poppek, Anja Schaeferhenrich, Urs Schlueter, Monika Krug
Summary: The application of biocidal products by foam as an alternative to droplet spraying has inhalation exposure to aerosols as a concern. The study quantified the formation of inhalable aerosols during foaming and measured the aerosol release fractions of the active substance. The results showed that the aerosol release fractions varied and could be correlated to the process and foam parameters.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anja Schaeferhenrich, Katharina Bluemlein, Wolfgang Koch, Stefan Hahn, Katharina Schwarz, Ulrich Poppek, Ralph Hebisch, Urs Schlueter, Monika Krug, Thomas Goeen
Summary: This study provides comparative exposure data for foam and spray applications of biocidal products in occupational settings, showing that potential dermal exposure is higher than inhalation exposure. While foam application reduces inhalation exposure, it does not significantly affect potential dermal exposure.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Chemistry, Analytical
Laura Kuhlmann, Frank Muench, Thomas Goeen, Elisabeth Eckert
Summary: An online SPE-LC-MS/MS method was developed for the simultaneous determination of DEHP and alternative plasticizers in urine samples. The method showed high sensitivity and a simple sample preparation procedure, making it suitable for analyzing background levels of plasticizer exposure in the general population and for monitoring studies.
ANALYTICAL METHODS
(2022)