Article
Environmental Sciences
Fiorella Lucarini, Rocco Gasco, Davide Staedler
Summary: This study aimed to develop effective analytical methods to simultaneously quantify BPA and fifteen bisphenol analogues present in canned foods and beverages. The study found that BPA and BPS were present in the majority of samples, highlighting the need for further research on the extent of bisphenol contamination and associated toxicity in the food production chain.
Article
Biochemistry & Molecular Biology
Marcin Gruba, Emilia Jozwik, Mariusz Chmiel, Katarzyna Tyskiewicz, Marcin Konkol, Anna Watros, Krystyna Skalicka-Wozniak, Grzegorz Wozniakowski
Summary: A multi-residue determination method for pesticide residues in dried hops was developed, employing acetate buffered QuEChERS method and dSPE sorbents. The study revealed that mixtures containing Z-Sep+ sorbent provided the best clean-up results. LC-MS/MS analysis was used for quantification, and the method was validated according to SANTE/11813/2017 guidelines. The validated method was successfully applied to the analysis of 15 real dried hop samples, providing data on detected residues.
Article
Chemistry, Applied
Yudan Wang, Jia 'an Qin, Qian Lu, Jiao Tian, Tongwei Ke, Mengyue Guo, Jiaoyang Luo, Meihua Yang
Summary: In this study, a green analytical method was developed to extract and detect 20 analytes in edible herbs, including 10 neonicotinoid insecticides and their 10 major toxic metabolites. The QuEChERS and LC-MS/MS techniques were used for the analysis of these analytes in five edible herbs. Among the 109 herbal samples tested, 90 samples were found to be positive for the residues of the 20 neonicotinoid insecticides and their metabolites, with the range of total neonicotinoid insecticides residue being 0.26-139.28 μg/kg. Acetamiprid, imidacloprid, and their metabolites were the most frequently detected compounds in herbs. Positive correlations were observed between imidacloprid/acetamiprid and their metabolites in Lycii fructus and Citri reticulatae pericarpium. Therefore, the residue of neonicotinoid insecticides in edible herbs should be given more attention in the future.
Article
Environmental Sciences
Krystyna Makowska, Julia Martin, Andrzej Rychlik, Irene Aparicio, Juan Luis Santos, Esteban Alonso, Slawomir Gonkowski
Summary: This study evaluated the exposure of dogs to parabens using fur sample analysis, finding the presence of multiple parabens in canine fur. The analysis of fur may be a useful tool for monitoring paraben exposure in dogs, suggesting a potential role in veterinary toxicology.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Marica Erminia Schiano, Federica Sodano, Elisa Magli, Angela Corvino, Ferdinando Fiorino, Maria Grazia Rimoli, Serenella Seccia, Stefania Albrizio
Summary: The levels of BPA, BPB, BPF, and BPS were analyzed in canned legume samples from popular brands in Italy. BPA was detected in 91% of the samples, while the other three compounds were not found. The risk associated with BPA exposure was assessed using the RACE tool, and it was concluded that there is a real risk for all population groups when the new TDI value for BPA is used.
Article
Biochemical Research Methods
Hongkai Zhu, Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: The study introduces a method for monitoring 121 environmental chemicals in urine samples using solid-phase extraction (SPE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). The optimized method showed excellent variability, satisfactory recoveries, and high detection limits for a wide range of analytes. This validated method was successfully applied to the simultaneous determination of environmental chemicals in real urine samples.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Food Science & Technology
Xiu Yuan, Chang Jo Kim, Raekeun Lee, Min Kim, Hee Jeong Shin, Leesun Kim, Won Tae Jeong, Yongho Shin, Kee Sung Kyung, Hyun Ho Noh
Summary: This study optimized a method for the multi-residue analysis of 287 pesticide residues in mandarin orange and grapefruit using the quick, easy, cheap, effective, rugged, and safe (QuEChERS) technique combined with liquid chromatography-tandem mass spectrometry. The method was validated in terms of selectivity, LOQ, linearity, accuracy, precision, and matrix effect, showing satisfactory results for routine laboratory testing of citrus fruits for pesticide residue analyses.
Article
Chemistry, Applied
Kihwan Kim, Younghun Choi, Sori Mok, Hyo-Bang Moon, Junho Jeon
Summary: The aim of this study was to optimize a QuEChERS extraction method for simultaneous determination of organic pollutants in aquaculture products. It was found that the method was effective in extracting pesticides and pharmaceuticals, and it also confirmed the possibility of organic contamination in aquaculture products.
Article
Chemistry, Analytical
Sudip Bhattacharyya, Rajlakshmi Poi, Moni Baskey Sen, Dipak Kumar Hazra, Rajarshi Ghosh, Swagata Mandal, Rajib Karmakar
Summary: This study developed a modified QuEChERS method for the quick and accurate screening of multi-class multi-pesticide residues in betelvine. 9% of the collected market samples were found to be contaminated with non-recommended pesticides, but the human risk indexes were within the acceptable range.
MICROCHEMICAL JOURNAL
(2022)
Article
Food Science & Technology
Laia Sanchez Costa, Judit Pujol Boira, Miriam Arago Iglesias, Pilar Rodriguez Martinez, Mireia Medina Sala
Summary: This article presents a unified analytical methodology for determining the content of 181 pesticides in flowers, leaves, and tree trunks in compliance with current European legislation. The methodology was developed over a 7-year study, resulting in a Catalan agricultural production database that provides a comprehensive view of the use of phytosanitary products in crops prior to harvest. The methodology includes a multi-residue analysis method, modified QuEChERS protocol for pesticide extraction, and liquid and gas chromatography coupled to a triple quadrupole mass spectrometer for analysis. The methodology was validated according to SANTE/11312/2021 guidelines, demonstrating good sensitivity, selectivity, accuracy, precision, and linearity.
FOOD ANALYTICAL METHODS
(2023)
Article
Environmental Sciences
Shima Kouhi Dehkordi, Hamed Paknejad, Ludek Blaha, Helena Svecova, Roman Grabic, Zdenek Simek, Alena Otoupalikova, Michal Bittner
Summary: The study on the water quality of Zayandeh Rood river in central Iran revealed the presence of various pharmaceutical active compounds and hormone-like compounds, with higher concentrations detected in treated wastewater. Despite the presence of these compounds in surface water and drinking water, the overall human health risk is considered minor according to the relevant effect-based trigger values.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Tarik Balkan, Ozlem Yilmaz
Summary: In this study, the QuEChERS method was optimized and validated for the determination of 260 pesticides using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method showed suitable linearity, low limits of detection and quantification, and was used to detect pesticide residue levels in leafy vegetables.
Article
Food Science & Technology
Isidora Kecojevic, Sanja Dekic, Milana Lazovic, Danica Mrkajic, Rada Baosic, Aleksandar Lolic
Summary: A method using modified QuEChERS without clean-up step based on sample dilution approach coupled with LC-MS/MS has been established for determination of 179 pesticide residues in cabbage and rice samples. The method showed high recoveries and precision within certain concentration ranges.
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Lucas Victor Pereira de Freitas, Carlos Augusto Alvarenga da Mota, Marina Alves Damaceno, Juliana Grell Fernandes Silveira, Ana Carolina Vellosa Portela, Sarah Chagas Campanharo, Agnaldo Fernando Baldo da Silva, Inacio Mateus Assane, Fabiana Pilarski, James Jacob Sasanya, Jonas Augusto Rizzato Paschoal
Summary: The use of veterinary drugs in fish farms is necessary for maintaining animal health and improving productivity. This study investigated the residue depletion of sulfadimethoxine and ormetoprim in Nile tilapia after oral administration to estimate a safe withdrawal period. The medicated feed used was analyzed to ensure suitability for treatment and prevent environmental contamination.
Article
Environmental Sciences
Sylvain Slaby, Francois Le Cor, Vincent Dufour, Lucile Auger, Laure Pasquini, Olivier Cardoso, Laurence Curtet, Jean-Marc Baudoin, Laure Wiest, Emmanuelle Vulliet, Cyril Feidt, Xavier Dauchy, Damien Banas
Summary: The study revealed that small waterbodies at the head of basins are impacted by agricultural contaminants, with higher concentrations of transformation products compared to parent compounds. Multiple contaminants were detected in water and sediment, with a few accumulating in fish species.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Analytical
Alexandre Guironnet, Laure Wiest, Emmanuelle Vulliet
Summary: The use of beta-lactams in veterinary and human medicine has increased in the past decade, representing a significant portion of overall consumption. This study developed a modified QuEChERS method for extraction and analysis of beta-lactams from sewage treatment plant sludge, showing satisfactory performance for quantification and detection. Through optimization and validation, the method proved effective in extracting beta-lactams from solid environmental matrices.
Article
Hematology
Laurent Bertoletti, Gaelle Gusto, Artak Khachatryan, Nadia Quignot, Jose Chaves, Audrey Moniot, Ruth Mokgokong
Summary: DOACs have been found to be noninferior and safer than conventional therapy for treating VTE in clinical trials. This observational study compares the effectiveness and safety of DOACs and conventional therapy in a real-world setting, and finds that DOACs are associated with superior safety and effectiveness.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
Patrice Fardellone, Lianne Barnieh, Nadia Quignot, Gaelle Gusto, Artak Khachatryan, Doreen A. Kahangire, Gavin Worth, James O'Kelly, Gaelle Desamericq
Summary: The use of anti-osteoporosis treatment following a diagnosis of osteoporosis with fracture or a relevant fragility fracture remains low in France. Initiating an anti-resorptive treatment may reduce the risk of subsequent fracture by 60%.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Multidisciplinary Sciences
Jean-Luc Bertrand-Krajewski, Remy Bournique, Vivien Lecomte, Noemie Pernin, Laure Wiest, Christine Bazin, Agnes Bouchez, Elodie Brelot, Benoit Cournoyer, Teofana Chonova, Christophe Dagot, Pascal Di Majo, Adriana Gonzalez-Ospina, Audrey Klein, Jerome Labanowski, Yves Levi, Yves Perrodin, Sandra Rabello-Vargas, Liana Reuilly, Audrey Roch, Axel Wahl
Summary: The Bellecombe pilot site - SIPIBEL - was established in 2010 to study the characteristics, treatability, and impacts of hospital effluents in an urban wastewater treatment plant. The pilot site consists of a hospital, a wastewater treatment plant, and a receiving water body. The extensive database includes various measurements and indicators.
Article
Chemistry, Analytical
Alexandre Guironnet, Laure Wiest, Emmanuelle Vulliet
Summary: In this study, an enhanced method for analyzing five beta-lactams in wastewater treatment plant sludge was proposed, using a hybrid triple quadrupole-Linear Ion Trap spectrometer for triple stage MS acquisition. The method achieved improved sensitivity and specificity.
ANALYTICA CHIMICA ACTA
(2022)
Correction
Chemistry, Analytical
Laure Wiest, Barbara Giroud, Azziz Assoumani, Franois Lestremau, Emmanuelle Vulliet
Article
Chemistry, Analytical
Laure Wiest, Barbara Giroud, Maeva Fieu, Azziz Assoumani, Francois Lestremau, Emmanuelle Vulliet
Summary: Despite their wide use in various fields, the knowledge about surfactants in environmental solid matrices is generally limited. Aiming to develop an extraction method in sediments for the simultaneous analysis of anionic, cationic, and non-ionic surfactants, this study compared different extraction techniques, solvents, and additives. The optimized method, coupled with liquid chromatography and tandem mass spectrometry, was validated and applied to real samples, allowing the detection of 18 out of 27 targeted surfactants.
Article
Medicine, Research & Experimental
Ruth Mokgokong, Artak Khachatryan, Nadia Quignot, Jose Chaves, Audrey Moniot, Gaelle Gusto
Summary: Compared to VKAs, apixaban appears to be a cost-saving option for the treatment of patients with acute VTE in France, with lower all-cause costs in terms of outpatient visits, laboratory tests, and hospitalizations. However, the costs of overall drugs and medical procedures are higher compared to VKAs. Subgroup analyses also show that apixaban is associated with lower all-cause costs in patients with recurrent VTE and bleeding.
ADVANCES IN THERAPY
(2022)
Article
Environmental Sciences
Gaelle Daniele, Florent Lafay, Carine Arnaudguilhem, Sandra Mounicou, Alain Geffard, Isabelle Bonnard, Odile Dedourge-Geffard, Christelle Bonnefoy, Emmanuelle Vulliet
Summary: Mollusks are sensitive to environmental changes in water and are thus used as bio-indicators to monitor water contamination. Iodinated X-ray contrast media (ICMs) are widely present in aquatic environments due to their high consumption, low biodegradability, and low removal rates. Although assumed to have low toxicity, continuous exposure to ICMs can lead to adverse effects, making the evaluation of their environmental risk important.
Article
Environmental Sciences
Olivier Roques, Jean-Philippe Bedell, Julia Le Maux, Laure Wiest, Sylvie Nelieu, Christian Mougin, Nathalie Cheviron, Olivier Santini, Vivien Lecomte, Remy Bayard
Summary: Spreading organic wastes on soils in Europe is a common alternative to chemical fertilizers, promoting plant growth and agricultural production. However, these organic amendments may contain pollutants that require analysis to ensure their safety for soil and organisms. This study assessed the toxicity of three different organic amendments through chemical analysis and acute toxicity tests on earthworms, plants, and soil microbial communities.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Biophysics
David Michonneau, Nadia Quignot, Heng Jiang, Dawn Reichenbach, Maebh Kelly, Anita Burrell, Xiang Zhang, Kris Thiruvillakkat, Mohamad Mohty
Summary: This study comprehensively investigates the clinical and economic burden of graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation in France. The results demonstrate that patients with GVHD have a higher risk of severe infection, higher mortality rates, higher hospital admission rates, and higher direct costs compared to patients without GVHD.
BONE MARROW TRANSPLANTATION
(2023)
Article
Environmental Sciences
Lucie Pinasseau, Florian Mermillod-Blondin, Aurelie Fildier, Francois Fourel, Felix Vallier, Ludovic Guillard, Laure Wiest, Laurence Volatier
Summary: The use of passive sampling and suspect screening analysis can improve the understanding of groundwater origins and interactions with surface water, leading to a more realistic assessment of groundwater vulnerability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Health Care Sciences & Services
Nadia Quignot, Heng Jiang, Indraraj Umesh Doobaree, Jan Lehmann, Ola Ghatnekar
Summary: Intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC) patients treated with transurethral resection of the bladder tumour (TURBT) followed by intravesical Bacillus Calmette-Guerin (BCG) immunotherapy may become refractory or progress to muscle-invasive bladder cancer (MIBC). This study examines healthcare resource utilization (HCRU) and costs in these patient populations using data from a German health insurance database.
CLINICOECONOMICS AND OUTCOMES RESEARCH
(2023)
Meeting Abstract
Respiratory System
L. Bertoletti, G. Gusto, A. Khachatryan, N. Quignot, J. Chaves, A. Moniot, R. Mokgokong, I. Mahe
EUROPEAN RESPIRATORY JOURNAL
(2022)