Article
Immunology
Marzia Caproni, Manuela Capone, Maria Caterina Rossi, Veronica Santarlasci, Laura Maggi, Alessio Mazzoni, Beatrice Rossettini, Daniela Renzi, Lavinia Quintarelli, Beatrice Bianchi, Alessandra Ninci, Gabriele Lami, Antonio Calabro, Lorenzo Cosmi, Francesco Annunziato, Francesco Liotta
Summary: The study suggests a role of TNF alpha and IL-17A producing cells in the development of dermatitis herpetiformis, with circulating T cells producing TNF alpha and IL-17A decreasing after a gluten-free diet. Furthermore, TG2 and TG3-specific T cells in dermatitis herpetiformis patients showed heightened reactivity to antigen stimulation. The data also showed a crossed T cell response towards the two transglutaminases isoforms in both groups of patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chiara Maria Trovato, Salvatore Oliva, Nicoletta Pietropaoli, Maria Gemma Pignataro, Silvia Berni, Andrea Tancredi, Salvatore Cucchiara, Carla Giordano, Monica Montuori
Summary: The study validated a double immunohistochemistry method for detecting intestinal TG2 IgA deposits on formalin-fixed paraffin-embedded biopsies. The results suggest that this method could be a promising diagnostic tool to improve the diagnosis of coeliac disease.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Juha Taavela, Kalle Kurppa, Tuija Jaaskelainen, Niina E. Kaartinen, Harri Rissanen, Heini Huhtala, Markku Maki, Katri Kaukinen
Summary: The prevalence of coeliac disease in Finland has been increasing over the years, with positive TGA without EmA, TGA values in the upper normal range, and pre-existing autoimmune diseases as predictors of developing the disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Immunology
Jordan Voisine, Valerie Abadie
Summary: Celiac disease is influenced by various factors like gluten antigen, HLA molecules, TG2 enzyme, and interactions between different types of T cells. These factors together lead to changes in immune pathways in specific gut compartments, ultimately resulting in the development of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gaetana Paolella, Silvia Sposito, Antonio Massimiliano Romanelli, Ivana Caputo
Summary: Type 2 transglutaminase (TG2) is the main autoantigen in coeliac disease (CD) and plays a significant role in its pathogenesis. Research has focused on finding specific and potent inhibitors for TG2, which could be used as alternative therapeutics for CD instead of a lifelong gluten-free diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Laura Kivela, Alberto Caminero, Daniel A. Leffler, Maria Ines Pinto-Sanchez, Jason A. Tye-Din, Katri Lindfors
Summary: A gluten-free diet is currently the only effective treatment for coeliac disease, but some patients face challenges such as high cost, strict restrictions, and perceived reduced quality of life. As a result, there is a need for alternative treatment forms to better control the disease.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Pediatrics
Maria Ulnes, Henrik Albrektsson, Ketil Stordal, Robert Saalman, Jonas F. Ludvigsson, Karl Marild
Summary: The aim of this study was to examine the clinical follow up of paediatric coeliac disease and the rate of loss of follow up during childhood. The results showed that 14% of the coeliac patients were lost to follow up after an average of 5.3 years since diagnosis. The patients who were lost to follow up were more often boys and had a slightly longer average disease duration.
Article
Chemistry, Analytical
C. Toyos-Rodriguez, A. Llamedo-Gonzalez, D. Pando, S. Garcia, J. A. Garcia, F. J. Garcia-Alonso, A. De la Escosura-Muniz
Summary: Magnetic beads (MBs) are widely used in biosensing platforms due to their magnetic behavior, simplifying sample purification and separation. In this study, novel, reliable, and low-cost MBs were synthesized and used as electrochemical immunosensing platforms, showing improved performance.
MICROCHEMICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Sunniva F. Amundsen, Jorunn Stamnaes, Knut E. A. Lundin, Ludvig M. Sollid
Summary: This study demonstrates the expression of transglutaminase 2 (TG2) in duodenal epithelial cells of healthy individuals. In untreated coeliac disease (CeD) patients, there is increased TG2 expression in epithelial cells, which may contribute to the pathogenic action of TG2 in the gut lumen.
Article
Pathology
Alexander Richardson, Stephanie Chu, Mary Agapides, Stephen Adelstein, Lucinda Wallman, Louise Wienholt
Summary: Coeliac disease is an autoimmune disorder caused by the ingestion of gluten containing foods in genetically susceptible individuals, with a worldwide prevalence of up to 1%. The only available treatment is a gluten-free diet. This study investigated the prevalence of a gluten-free diet in hospital clinic settings and the general population, and found that a significant number of individuals may be misdiagnosed for coeliac disease based on serological tests. Additionally, there was a higher proportion of females excluding gluten from their diet.
Article
Chemistry, Analytical
Pravanjan Malla, Hao-Ping Liao, Chi-Hsien Liu, Wei-Chi Wu
Summary: A highly sensitive magneto immunosensor for detecting parathyroid hormone (PTH) was successfully developed using MBs modified by APBA and a disposable electrode, allowing for rapid point-of-care testing for PTH. The sensor exhibited a linear detection range and low limits of detection by both voltammetry and impedance spectroscopy, showcasing its potential for practical diagnostic applications.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Gastroenterology & Hepatology
Lucia Treppiccione, Antonio Picarelli, Mauro Rossi
Summary: Coeliac disease is caused by intolerance to wheat gluten and related proteins, and the development of gluten-free products requires technological improvements. The use of microbial transglutaminase (mTG) has been suggested as a way to replace gluten in bakery products, but concerns have been raised about its immunogenicity. Recent studies found that mTG and gliadin can interact in the endoplasmic reticulum of enterocytes in coeliac disease patients. Although the pathogenic activity of mTG has not been found, its use has been shown to reduce the inflammatory immune response in coeliac disease.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Robert P. Anderson
Summary: Diagnostics are crucial in addressing the global prevalence of coeliac disease and promoting new non-dietary treatments. Non-biopsy diagnosis is gaining acceptance due to the better understanding of the immunopathogenesis of coeliac disease and the use of serology. Research methods for measuring gluten-specific CD4+ T cells and the acute recall response to gluten ingestion may further expand non-biopsy diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Govind K. Makharia, Ashish Chauhan, Prashant Singh, Vineet Ahuja
Summary: Coeliac disease is an immune-mediated disease caused by gluten ingestion, impacting not only Europeans but also people worldwide. The prevalence and incidence of coeliac disease have increased over the past three decades, potentially due to improved diagnostic methods, dietary changes, and increased awareness. In addition to genetic factors, early-life gluten intake has been shown to increase the risk of the disease.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Hugo A. Penny, Suneil A. Raju, Michelle S. Lau, Lauren J. S. Marks, Elisabeth M. R. Baggus, Julio C. Bai, Gabrio Bassotti, Hetty J. Bontkes, Antonio Carroccio, Mihai Danciu, Mohammad H. Derakhshan, Arzu Ensari, Azita Ganji, Peter H. R. Green, Matt W. Johnson, Sauid Ishaq, Benjamin Lebwohl, Adam Levene, Roxana Maxim, Hamid Mohaghegh Shalmani, Mohammad Rostami-Nejad, David Rowlands, Irene A. Spiridon, Amitabh Srivastava, Umberto Volta, Vincenzo Villanacci, Graeme Wild, Simon S. Cross, Kamran Rostami, David S. Sanders
Summary: The study aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury diagnostic of coeliac disease (CD) in adult patients. Results showed that IgA tTG levels of >= 10xULN have a strong predictive value at identifying adults with intestinal changes diagnostic of CD, supporting the use of a no-biopsy approach for the diagnosis of adult CD.
Article
Biophysics
Vincenzo Mazzaracchio, Daniela Neagu, Alessandro Porchetta, Eleonora Marcoccio, Alice Pomponi, Giovanni Faggioni, Nino D'Amore, Andrea Notargiacomo, MarialLilia Pea, Danila Moscone, Giuseppe Palleschi, Florigio Lista, Fabiana Arduini
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Biophysics
Neda Bagheri, Stefano Cinti, Veronica Caratelli, Renato Massoud, Mohammad Saraji, Danila Moscone, Fabiana Arduini
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Biophysics
F. Arduini, S. Cinti, V. Caratelli, L. Amendola, G. Palleschi, D. Moscone
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Engineering, Environmental
Viviana Scognamiglio, Amina Antonacci, Fabiana Arduini, Danila Moscone, Estefania V. R. Campos, Leonardo F. Fraceto, Giuseppe Palleschi
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Chemistry, Analytical
Maria Rita Tomei, Stefano Cinti, Nicolo Interino, Valeria Manovella, Danila Moscone, Fabiana Arduini
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Chemistry, Analytical
Noemi Colozza, Ilaria Cacciotti, Danila Moscone, Fabiana Arduini
Article
Chemistry, Analytical
Stefano Cinti, Giulia Cinotti, Claudio Parolo, Emily P. Nguyen, Veronica Caratelli, Danila Moscone, Fabiana Arduini, Arben Merkoci
ANALYTICAL CHEMISTRY
(2020)
Review
Biophysics
Fabiana Arduini, Stefano Cinti, Vincenzo Mazzaracchio, Viviana Scognamiglio, Aziz Amine, Danila Moscone
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Chemistry, Analytical
Maria Rita Tomei, Eleonora Marcoccio, Daniela Neagu, Danila Moscone, Fabiana Arduini
Article
Biophysics
Aldo Roda, Fabiana Arduini, Mara Mirasoli, Martina Zangheri, Laura Fabiani, Noemi Colozza, Elisa Marchegiani, Patrizia Simoni, Danila Moscone
BIOSENSORS & BIOELECTRONICS
(2020)
Review
Chemistry, Analytical
Cecilia Bartolucci, Amina Antonacci, Fabiana Arduini, Danila Moscone, Leonardo Fraceto, Estefania Campos, Raouia Attaallah, Aziz Amine, Chiara Zanardi, Laura M. Cubillana-Aguilera, Jose Maria Palacios Santander, Viviana Scognamiglio
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Ilaria Cacciotti, Francesca Pallotto, Viviana Scognamiglio, Danila Moscone, Fabiana Arduini
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Review
Chemistry, Analytical
Laura Fabiani, Veronica Caratelli, Luca Fiore, Viviana Scognamiglio, Amina Antonacci, Silvia Fillo, Riccardo De Santis, Anella Monte, Manfredo Bortone, Danila Moscone, Florigio Lista, Fabiana Arduini
Summary: The recent global events of COVID-19 have highlighted the importance of rapid virus detection in order to prevent spread. Efforts have been made to develop new, rapid, affordable, and accurate diagnostic tools. Researchers have focused on electrochemical and optical biosensors for specific detection of SARS-CoV-2 antigens.
Review
Chemistry, Analytical
Noemi Colozza, Veronica Caratelli, Danila Moscone, Fabiana Arduini
Summary: In the past decade, paper-based electrochemical biosensors have gained attention for their unique advantages and sustainability vision, offering features like solution flow management, reagent storage, and gas phase analyte detection. The foldability of paper has been utilized to design 3D multifarious biosensors, enhancing the development of self-powered devices and expanding the possibilities for smart and sustainable analytical tools.
Review
Materials Science, Biomaterials
Veronica Caratelli, Erika Di Meo, Noemi Colozza, Laura Fabiani, Luca Fiore, Danila Moscone, Fabiana Arduini
Summary: Nanomaterials have made significant advances in the field of biosensors, particularly in the integration with paper-based electrochemical biosensors. This integration enhances the performance of the sensors and has potential applications in the biomedical field.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)