Article
Spectroscopy
Tyler J. Williams, R. Kenneth Marcus
Summary: The study presented an integrated, single electrode design for LS-APGD system to reduce system components and simplify the ionization source. By optimizing operational parameters, maintaining stable plasma, improving analytical performance, and comparing with the previous design, it demonstrated higher sensitivity in detecting Rb, Ag, Tl, and U under optimal conditions.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Review
Spectroscopy
R. Kenneth Marcus, Edward D. Hoegg, Katja A. Hall, Tyler J. Williams, David W. Koppenaal
Summary: LS-APGD is an ionization method with diverse sample introduction methods and wide application in mass spectrometer platforms. It has the capabilities of a combined atomic and molecular ionization source, suitable for various analytical systems.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Chemistry, Applied
Krzysztof Greda, Pawel Pohl
Summary: A new method of optical emission spectrometry (OES) using micmplasma source was developed for the determination of Na, K, Mg, Ca, and Zn in wine, without the need for acid digestion. The study also found that red wines have higher levels of K and Mg, and different grape varieties can be distinguished based on the concentrations of K and Ca.
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: For the first time, a dispersive micro-solid phase extraction (D-mu SPE) based on graphene oxide was used for the ultrasensitive determination of Cd. With this method, Cd can be efficiently extracted from a mixture of alkali and alkaline earth metals without the need for an elution step. The combination of D-mu SPE and SAGD OES significantly reduces matrix effects and improves the tolerance of Cd to alkali metals. The method shows simplicity in the measurement system and the commercially available nanosorbent used.
MICROCHEMICAL JOURNAL
(2024)
Review
Spectroscopy
Brian T. Molnar, Jacob T. Shelley
Summary: Plasmas have been used as ionization sources in mass spectrometry experiments since the early days of Thomson and Aston. Plasma ion sources were chosen because they were one of the few known sources of gas-phase ions at the time and were relatively easy to set up and operate. The development of plasma ionization has led to advancements in mass spectrometry and laid the foundation for ionization approaches, mass analysis, and detection methods for very large molecules.
MASS SPECTROMETRY REVIEWS
(2021)
Article
Chemistry, Analytical
Shuang Liu, Xin-Xin Xue, Yong-Liang Yu, Jian-Hua Wang
Summary: The use of miniaturized optical emission spectrometry devices and activated carbon electrode tips allows for rapid preconcentration and quantitative analysis of heavy metals in water, significantly enhancing sensitivity and practicality.
ANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Jaime Orejas, Yinchenxi Zhang, Cristian Soto-Gancedo, Luis Javier Fernandez-Menendez, Jorge Pisonero, Nerea Bordel
Summary: The Solution-Cathode Glow Discharge (SCGD) is a plasma source that provides simplicity and low consumption for elemental analysis. When combined with Optical Emission Spectrometry (OES), it can achieve ng/mL limits of detection for multiple elements. This study focuses on fundamental plasma diagnostics of SCGD and investigates how dissolved ions in the sample solution affect the performance of the analysis.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Moritz Hitzemann, Christoph Schaefer, Ansgar T. Kirk, Alexander Nitschke, Martin Lippmann, Stefan Zimmermann
Summary: In this paper, a new and easy to assemble dielectric barrier discharge plasma ionization source is presented, which is based on printed circuit boards with two parallel isolated electrodes for generating plasma inside an inert fused silica capillary. The plasma source is coupled to an ion mobility spectrometer for demonstration. Different ionization pathways can be achieved by whether the analytes pass through the plasma or bypass it before entering the reaction region of the ion mobility spectrometer. The plasma source has been designed using electric field simulations and can reach detection limits in the mid pptv range.
ANALYTICA CHIMICA ACTA
(2023)
Article
Spectroscopy
Sunil P. Badal, Paul B. Farnsworth, George C-Y Chan, Brian T. Molnar, Jessica R. Hellinger, Jacob T. Shelley
Summary: Plasma-based ambient desorption/ionization sources often use helium as the primary discharge gas, but studies show advantages of mixed-gas plasmas. Adding H-2 to helium can decrease reagent-ion signals while preserving analyte-ion signals. Nitrogen addition increases negative reagent ions for enhanced ion signal of specific compounds. Various molecular gases impact emission characteristics and plasma parameters in mixed-gas systems.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Spectroscopy
Ashley A. Perkins, Edward D. Hoegg, R. Kenneth Marcus
Summary: The liquid sampling atmospheric pressure glow discharge (LS-APGD) microplasma technology shows potential in the fields of optical emission spectroscopy and mass spectrometry, allowing for applications in elemental/isotopic analysis and providing high resolution analyses. The SGC mode has been determined to perform the best in terms of elemental intensity, accuracy, and precision for isotope ratio measurements.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Monika Gorska, Pawel Pohl
Summary: Novel atmospheric pressure glow discharge microplasma systems were investigated for the direct determination of Br and Cl, showing resistance to foreign ions at relatively high concentrations in water and juices samples.
Article
Chemistry, Analytical
Krzysztof Greda, Maja Welna, Anna Szymczycha-Madeja, Pawel Pohl
Summary: The technique of vapor generation assisted by a microplasma improves the sensitivity and reduces the detection limits in ICP OES. The microplasma system produces higher analyte fluxes and less water vapor, resulting in boosted signal intensities. The method is characterized by higher resistance to matrix effects and eliminates the use of toxic reductants.
Review
Instruments & Instrumentation
Meiran Wang, Bing Qian, Qiaoxia Tian, Jingling Lin, Jing Zhao, Yue Zhang, Bingjun Han
Summary: This paper reviews the recent advances in analytical techniques based on microplasma sources and discusses their potential applications in miniaturized instruments.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Chemistry, Analytical
Monika Gorska, Krzysztof Greda, Pawel Pohl
Summary: A novel atmospheric pressure glow discharge microplasma system was combined with a hydride generation technique to improve the determination performance of As, Bi, Hg, Sb, and Se. The optimized conditions yielded improved detection limits for these elements, allowing for their quantification in wastewater and spiked water samples.
Article
Chemistry, Analytical
Monika Gorska, Pawel Pohl
Summary: Miniaturized atmospheric pressure glow discharge (APGD) microplasma devices operated in contact with a flowing liquid anode (FLA) or a flowing liquid cathode (FLC) and a He jet were used for determining the concentration of bromine (Br) through optical emission spectrometry (OES). The impact of crucial parameters on the intensity of the Br analytical line was studied and the analytical figures of merit were assessed under optimal conditions. The developed methods showed good endurance to matrix effects and were successfully applied for determining low concentrations of Br in water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Htoo W. Paing, Tyler J. Bryant, C. Derrick Quarles, R. Kenneth Marcus
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Catharina Erbacher, Nils Flothkoetter, Marcel Macke, C. Derrick Quarles, Michael Sperling, Jens Mueller, Uwe Karst
Summary: A fast and automated method for separation and quantification of bromide and 5-BrdU via IC and ICP-MS was developed, relevant for monitoring electron transfer efficiency along DNA. With a LOD of 30 ng/L, the method is suitable for screening applications with a multitude of samples.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Engineering, Environmental
Marcel Macke, C. Derrick Quarles, Michael Sperling, Uwe Karst
Summary: Gadolinium-based contrast agents are commonly used in MRI for improved image contrast, leading to significant environmental release of anthropogenic Gd. This study developed a rapid and efficient monitoring method utilizing a single platform system and ICP-MS for total metal analysis, successfully detecting and quantifying multiple GBCAs in surface water samples.
Article
Chemistry, Analytical
Paula Menero-Valdes, Ana Lores-Padin, Beatriz Fernandez, C. Derrick Quarles Jr, Montserrat Garcia, Hector Gonzalez-Iglesias, Rosario Pereiro
Summary: Single cell-inductively coupled plasma-mass spectrometry (sc-ICP-MS) and laser ablation (LA)-ICP-MS were used to comprehensively study the expression of APOE and claudin-1 in ARPE-19 cells treated with glucose. The introduction of microFAST Single Cell set-up improved cellular transport efficiency, and specific immunoprobes labelled with IrNCs were used for protein determination. The results obtained by sc-ICP-MS were validated with commercial ELISA kits, and the distribution of target proteins in individual cells was revealed by LA-ICP-MS with high resolution images.
Article
Chemistry, Multidisciplinary
Benjamin T. T. Manard, Veronica C. C. Bradley, C. Derrick Quarles, Lyndsey Hendriks, Daniel R. R. Dunlap, Cole R. R. Hexel, Patrick Sullivan, Hunter B. B. Andrews
Summary: This study developed an innovative autosampler to mix and transport the blanks, standards, and samples into a high-efficiency single particle introduction system for the analysis of gold nanoparticles (Au NPs) and silver shelled gold core nanospheres (Au/Ag NPs). The optimized transport efficiency into the inductively coupled plasma-time of flight-mass spectrometry (ICP-TOF-MS) was more than 80%, allowing for high-throughput sample analysis. The methodology displayed good long-term reproducibility, with a relative standard deviation (%RSD) of 3.54% for in-run variation and 9.52% for day-to-day variation.
Article
Chemistry, Analytical
Benjamin T. T. Manard, Hunter B. B. Andrews, C. Derrick Quarles Jr, Veronica C. C. Bradley, Peter Doyle, N. Alex Zirakparvar, Daniel R. R. Dunlap, R. R. Hexel
Summary: Laser-induced breakdown spectroscopy (LIBS) is used to characterize coatings on surrogate fuel particles. LIBS can directly analyze the sample surface, making it a viable technique for analyzing small, multilayered particles. In this study, LIBS successfully discerns small layers, detects the location of carbon and oxygen layers, and provides fast 2-D mapping and rapid depth profiling.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Matthias Elinkmann, Sarah Reuter, Michael Holtkamp, Steffen Heuckeroth, Alexander Koehrer, Katharina Kronenberg, Michael Sperling, Oliver Rubner, C. Derrick Quarles, Michael Hippler, Uwe Karst
Summary: This study presents a modular data processing workflow for single-particle and single-cell ICP-MS. The workflow improves the detection thresholds and addresses extra-Poisson variance in the experimental data. It also includes an outlier analysis and gate filter to reduce false-positive events. The application of this workflow in analyzing the distribution of endogenous elements in Chlamydomonas reinhardtii cell populations shows significant improvements in the accuracy of the results.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Jakob Willner, Lukas Brunnbauer, C. Derrick Quarles, Michael Nelhiebel, Silvia Larisegger, Andreas Limbeck
Summary: This study developed and optimized simultaneous 193 nm LA-ICP-MS & LIBS methods for spatially resolved analysis of polymer thin films. The methods were used to investigate polymer ageing and degradation in harsh environments. The results revealed spatially resolved information on oxidation behavior, sulfur diffusion profiles, and the influence of UV treatment on sulfur uptake in the films.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Biochemistry & Molecular Biology
Benjamin T. Manard, Christopher J. Hintz, C. Derrick Quarles, William Burns, N. Alex Zirakparvar, Daniel R. Dunlap, Toya Beiswenger, Alicia M. Cruz-Uribe, Joseph A. Petrus, Cole R. Hexel
Summary: Quantifying the chemical composition of fast-growing hard tissues in the environment can provide valuable information about ecosystems. Sharks teeth offer an opportunity to record environmental changes over a short period, and laser-induced breakdown spectroscopy (LIBS) can be used as a faster alternative to determine fluorine distribution. The results showed that LIBS can accurately map fluorine distribution within shark teeth and has the potential to transform current methods of determination.
Article
Chemistry, Analytical
C. Derrick Quarles, Nick Bohlim, Kevin Wiederin, Nathan Saetveit, Patrick Sullivan
Summary: Biomonitoring and clinical testing are crucial for improving human health, but most of the work in this field has been done manually. This study compares and validates the use of two different automation platforms for clinical analyses and calibrates the ICP-MS methods using different matrix options. The findings are based on the analysis of samples with known reference ranges.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
C. Derrick Quarles, Patrick Sullivan, Nick Bohlim, Nathan Saetveit
Summary: This study presents two fast and reliable separation methods for arsenic compounds. The recovery rate of both methods falls between 94% and 107%, and the accuracy was evaluated by analyzing proficiency samples. The detection limits in urine matrix for the two methods ranged from 2.8-6.0 ng L-1 As and 4.1-9.1 ng L-1 As, respectively.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
C. Derrick Quarles, Marcel Macke, Bernhard Michalke, Hans Zischka, Uwe Karst, Patrick Sullivan, M. Paul Field
Article
Chemistry, Analytical
C. Derrick Quarles, Andrew D. Toms, Ronald Smith, Patrick Sullivan, David Bass, John Leone
Article
Chemistry, Analytical
Jorge Pisonero, Jonatan Fandino, Jan Halvor Nordlien, Silke Richter, Jens Pfeifer, C. Derrick Quarles, Jhanis Gonzalez, Norbert Jakubowski, Nerea Bordel
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2019)
Article
Chemistry, Analytical
C. Derrick Quarles, Michael Szoltysik, Patrick Sullivan, Maurice Reijnen
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2019)