Article
Chemistry, Analytical
Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun
Summary: Schisandrol B, a lignan isolated from dried Schisandra chinensis fruits, has been shown to have protective effects on the liver, heart, kidneys, and memory. A sensitive HPLC-MS/MS method was developed to measure Schisandrol B levels in rat plasma and tissues, allowing for assessment of its pharmacokinetics, oral bioavailability, and tissue distribution. The results showed promising pharmacokinetic profiles and tissue distribution patterns of Schisandrol B, providing valuable insights for future studies on its pharmacological and biological characteristics.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Haihua Shang, Xiaohan Dai, Mi Li, Yueyi Kai, Zerong Liu, Min Wang, Quansheng Li, Yuan Gu, Changxiao Liu, Duanyun Si
Summary: This study provides the first systematic elucidation of the absorption and distribution characteristics of Rotundic acid (RA) in rats, which can provide valuable information for the further development and evaluation of RA in drug metabolism and pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Qinyan Zhang, Dongguo Li, Bihua Ma, Xueyan Wang, Junyi Yang, Donglin Chen, Liming Ye
Summary: Hupehenenine, a novel isosteroid alkaloid, showed inhibitory proliferation effects on various human cancer cell lines. A sensitive HPLC-MS/MS method was developed to quantify hupehenenine and its derivatives in rat plasma and tissues, revealing gender differences in the maximum plasma concentration in rats, as well as strong tissue affinity but inability to pass the blood-brain barrier for hupehenenine. These findings offer valuable insights for further research on hupehenenine and related alkaloid derivatives.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Pharmacology & Pharmacy
Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu
Summary: Licorice (Glycyrrhiza uralensis Fisch) is widely used in China as a food and herbal medication. The present study investigated the pharmacokinetic profile of Glycycoumarin (GCM), a major coumarin in licorice, in rats. The results showed that GCM was rapidly absorbed and transformed into its conjugated metabolites, with low bioavailability and widespread distribution in various tissues except the brain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Genbei Wang, Ruijia Hao, Yu Liu, Yu Wang, Shuli Man, Wenyuan Gao
Summary: The study aimed to investigate the metabolism and distribution of Paris polyphylla var yunnanensis saponins in rats. Through LC-MS/MS analysis and various experimental methods, the concentration distribution of metabolites in different tissues and the characteristics of permeability and recovery were determined. The results provided a theoretical basis for the future application of this medicinal plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Yue Zhang, Xiang-xiang Huo, Li-yuan Cheng, Meng-ying Chen, Lei Song, Ying-li Yu, Kun Zhou
Summary: 13-Elemonic acid, known for its potential anti-inflammatory and anti-cancer activities, has limited information on its pharmacokinetics and tissue distribution. A developed UHPLC-MS/MS method was successfully applied to determine the concentration of 13-elemonic acid in rat biological samples.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiangjun He, Zhi Zhong, Quan Wang, Zhenmao Jia, Jing Lu, Jianwen Chen, Peiqing Liu
Summary: Cryptotanshinone (CTS), derived from Salvia miltiorrhiza, has shown significant benefits in a rat model of pulmonary fibrosis induced by bleomycin. Pharmacokinetic studies revealed slow absorption, low bioavailability, and a slow clearance rate of CTS. Tissue distribution analysis showed higher exposure of CTS in the lungs and liver.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu
Summary: This study aimed to investigate the pharmacokinetic characteristics and tissue distribution of loganin after oral administration in rats. The results showed that loganin was quickly absorbed and eliminated in rats, with low bioavailability. Loganin was highly distributed in the cortex compared to the hippocampus.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Summary: Through a multicompound pharmacokinetic analysis, the tissue distribution and excretion characteristics of Radix Polygoni Multiflori (RPM) components were investigated. The findings showed that the active ingredients of RPM were quickly absorbed after oral administration and had high tissue distribution in the liver and kidney. These components were key contributors to the effectiveness and toxicity of RPM on the liver and kidney.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Imoh Etim, Benson Abasifreke, Rongjin Sun, Daniel Kuddabujja, Dong Liang, Ting Du, Song Gao
Summary: This study developed a sensitive LC-MS/MS method for simultaneous quantification of MMF, MPA, MPAG, and AcMPAG. The method showed good linearity and reproducibility, and was successfully applied in a rat PK study.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Zhaoxu Yang, Qingmei Sun, Sheng Wang, Bingbing Tang, Chenxing Yuan, Yue Wu, Jiabin Dai, Chen Yang, Lingkun Wang, Qian Zhou, Jincheng Wang, Qinjie Weng
Summary: This study characterized the pharmacokinetics, tissue distribution, and protein binding rates of curcumol in rats. The results showed that curcumol was rapidly absorbed and eliminated in rats. High accumulation of curcumol was found in the small intestine, colon, liver, and kidney. The protein binding rate of curcumol in rat plasma was high.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Ping Du, Guoyong Wang, Song Yang, Pengfei Li, Lihong Liu
Summary: A robust HPLC-MS/MS method was developed to determine Nuc concentrations in rat plasma samples, which was successfully applied in a rat pharmacokinetics study of remdesivir and can serve as a basis for further investigations in patients with COVID-19. The method met the requirements of the FDA guidelines and ensured robustness and reproducibility.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Longyun Wang, Qianqian Yin, Cun Liu, Ying Tang, Changgang Sun, Jing Zhuang
Summary: Ursolic acid (UA) is a natural compound with anticancer activity, but its clinical application is limited by poor solubility and bioavailability. Research on UA nanoformulations has shown promising results in improving its bioavailability, targeting ability, and solubility. Despite significant progress in the field of nanotechnology, there is still a long way to go before the clinical application of UA nanoformulations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Sun, Xin Meng, Di Huang, Zipeng Gong, Chunhua Liu, Ting Liu, Jie Pan, Yuan Lu, Lin Zheng
Summary: The study revealed that the pharmacokinetic behavior and tissue distribution characteristics of the four major active components of CA were altered under the pathological state of functional dyspepsia, providing an experimental basis for the role of CA in treating functional dyspepsia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhihua Liu, Yu Feng, Hang Zhao, Jinping Hu, Yanmin Chen, Dongdong Liu, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Xuejun Xia, Jun Ye, Yuling Liu
Summary: Ramulus Mori (Sangzhi) alkaloids (SZ-A) derived from mulberry twigs have been approved for the treatment of type 2 diabetes mellitus. SZ-A not only has hypoglycemic effects, but also protects pancreatic B-cell function and alleviates hepatic steatosis. Pharmacokinetic studies showed that SZ-A is rapidly absorbed, exhibits dose-linear pharmacokinetics, and is widely distributed in glycolipid metabolism-related tissues.
FRONTIERS IN PHARMACOLOGY
(2023)