Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 397, Issue 1, Pages 173-179Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-3483-4
Keywords
Adrenolytic drugs; Solid-phase microextraction; High-performance liquid chromatography; Mass spectrometry
Funding
- Foundation for Polish Sciences (FNP)
- Ministry of Science and Higher Education (Warsaw, Poland) [N204 268038]
- European Social Found
- Polish National Budget
- Kujawskopomorskie Voivodship Budget
Ask authors/readers for more resources
Five adrenolytic drugs have been analyzed by liquid chromatography-mass spectrometry (LC-MS). Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all the drugs investigated. Relative standard deviations (RSD), calculated for samples prepared in standard solutions, were in the range 2.5-13%, however RSD values for the drugs in human plasma were 2.5-4.5%. Using LC-MS the limit of detection (LOD) and the limit of quantification (LOQ) were in the ranges 0.11-0.18 and 0.39-0.54 ng mL(-1), respectively, for the five drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
