Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 396, Issue 1, Pages 45-52Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-3223-9
Keywords
TERS; Raman; Near-field; Biological samples; tip-enhanced CARS
Funding
- Engineering and Physical Sciences Research Council, UK
- Advanced Research Fellowship
- Challenging Engineering Award [GR/S52155/01, GR/52148/01, EP/E007864/1]
- RCUK Academic Fellow in Biomedical Engineering
- Engineering and Physical Sciences Research Council [EP/E500145/1, EP/E007864/1] Funding Source: researchfish
- EPSRC [EP/E007864/1] Funding Source: UKRI
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Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.
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