Article
Chemistry, Physical
Bazilah Awang Abd Manaf, Shyang Pei Hong, Mohammad Rizwan, Fareeha Arshad, Christopher Gwenin, Minhaz Uddin Ahmed
Summary: Carcinoembryonic antigen (CEA) is a prominent cancer biomarker that allows for early diagnosis of various cancers. Nanomaterial-based immunosensors have gained attention for their high specificity and low detection limit in detecting CEA biomarkers. Various nanomaterials like platinum, gold, silver, and carbon have shown promising results in the detection and diagnostics of CEA. This review explores the significance and recent developments of nanomaterial-based biosensors for detecting CEA biomarkers with high sensitivity, selectivity, and specificity.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Analytical
Xinmei Song, Huahui Gao, Ruo Yuan, Yun Xiang
Summary: This study developed a label-free and aptamer-based sensitive carcinoembryonic antigen (CEA) detection method, which achieved high sensitivity through cyclic cleavage and catalytic reduction.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Analytical
Changdong Chen, Ming La, Xinyao Yi, Mengjie Huang, Ning Xia, Yanbiao Zhou
Summary: Electrochemical immunosensors with alkaline phosphatase (ALP) as the signal reporter have shown great potential in various fields. This work summarizes the achievements of these immunosensors, focusing on detection principles, signal amplification strategies, and challenges for improving the performance of ALP-based immunoassays.
Review
Biotechnology & Applied Microbiology
Yanna Shao, Huan Zhou, Qingping Wu, Yonghua Xiong, Juan Wang, Yu Ding
Summary: This study systematically discusses the importance of enzyme-based signal transduction patterns in immunoassay, as well as different strategies for enhancing the output signals of enzymes to significantly improve the sensitivity of enzyme-based immunosensors. The article categorizes these strategies into three categories and discusses the current focus and future direction of enzyme-based immunoassays.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Chemistry, Analytical
Xiaoting Xu, Xuan Li, Juncong Miao, Lei Liu, Xinyi Huang, Qin Wei, Wei Cao
Summary: A label-free electrochemical immunosensor based on DPV and i-t dual-mode analysis was developed for early quantitative detection of PCT. Using materials with high stability and biocompatibility as sensing interface, the sensor showed wide linear response and low detection limit through an advanced sensing strategy.
Article
Chemistry, Analytical
Chochanon Moonla, Suphaporn Chenkhuruthum, Tik Ouiram, Anchana Preechaworapun, Weerinradah Tapala, Kamonwad Ngamchuea, Tanin Tangkuaram
Summary: In this study, a label-free immunosensor for rapid detection of CEA was developed using a biocomposite material. The immunosensor exhibited a wide linear range, high sensitivity, low detection limit, excellent selectivity, stability, and repeatability. The proposed method was successfully applied for CEA detection in whole blood samples, suggesting its potential for real sample analysis.
Article
Chemistry, Analytical
Qingmin Wei, Huakui Huang, Shulong Wang, Fa Liu, Jiayao Xu, Zhihui Luo
Summary: We designed and synthesized a fluorescent aptamer sensor with DNAzyme signal amplification for the detection of carcinoembryonic antigen (CEA) in blood. The experimental results showed that the sensor had high sensitivity and a wide detection range, and could be used for the analysis of complex biological samples such as blood.
Article
Chemistry, Analytical
Ruina Wang, Yun Huang, Yuwu Chi
Summary: An ECL immunosensor for the detection of carcinoembryonic antigen (CEA) was constructed using oxidized multi-walled carbon nanotube/nano-gold (AuNP-ox-MWCNT) composites with strong electrochemiluminescence (ECL) activity. The immunosensor showed a wide linear response range and a low detection limit, and was simple to fabricate and label-free.
Review
Chemistry, Multidisciplinary
Lei He, Rongrong Huang, Pengfeng Xiao, Yuan Liu, Lian Jin, Hongna Liu, Song Li, Yan Deng, Zhu Chen, Zhiyang Li, Nongyue He
Summary: Aptamers have high specificity and affinity toward various targets, making them widely used in analytical techniques. In order to improve biosensor sensitivity, different amplification strategies are being explored, such as using nanomaterials or enzyme mimics.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Meiqing Yang, Haozi Lu, Song Liu
Summary: This review focuses on the application of MXenes in electrochemical immunosensors. The composition, structure, and properties of MXenes are introduced, followed by a summary of recent advances in MXenes-based electrochemical immunosensors. The current problems and future research directions are also analyzed.
APPLIED SCIENCES-BASEL
(2022)
Article
Biophysics
Haiyang Wang, Xinyu Wan, Xin Wang, Meijin Li, Dianping Tang
Summary: In this study, a liposome-amplification photoelectrochemical (PEC) immunoassay was developed using ultrathin mesoporous bismuth chloride oxide nanosheets (BiOCl MSCN) for the highly selective and sensitive detection of carcinoembryonic antigen (CEA).
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Medicine, Research & Experimental
Rabia Khan, Fareeha Arshad, Israr U. Hassan, Gowhar A. Naikoo, Mona Z. Pedram, Mohammed Saeedi, Hamed Pourfarzad, Alaa A. A. Aljabali, Angel Serrando-Aroca, Yusuf Haggag, Vijay Mishra, Yachana Mishra, Martin Birkett, Murtaza M. Tambuwala
Summary: Prostate cancer is a common health hazard for men around the world, but rapid screening techniques and the use of nanomaterials in immunoassays have improved detection accuracy and diagnosis for prostate cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Hongying Jia, Siqi Yu, Lei Yang, Qin Wei, Huangxian Ju
Summary: The study introduces a dual-stabilizer-capped strategy for achieving red-shifted ECL in the near-infrared region using N-acetyl-L-cysteine and cysteamine as model capping agents. This method enables bioanalysis in aqueous medium and has successfully developed a signal on-genre NIR ECL immunosensing method.
ACS APPLIED NANO MATERIALS
(2021)
Article
Electrochemistry
Ping Wang, Huikai Ma, Yaoyao Xie, Sanqiang Li
Summary: The study proposes a ratiometric electrochemical aptasensor for highly sensitive detection of carcinoembryonic antigen (CEA) using exonuclease I (Exo I)-assisted target recycling amplification. The aptasensor shows a linear detection range from 10 pg mL(-1) to 100 ng mL(-1) with a detection limit of 4.1 pg mL(-1), and exhibits good stability, reproducibility, and selectivity.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fenglin Zhang, Zhiguang Liu, Yujie Han, Lifang Fan, Yujing Guo
Summary: An electrochemical aptasensor for CEA detection was developed based on PDA@Gr/Pd-PtNDs, which showed sensitivity and stability with a dynamic response range from 50 pg/mL to 1.0 μg/mL and a detection limit of 6.3 pg/mL. The sandwich-type specific reaction between CEA and corresponding aptamers allowed for proportional electrochemical signals with HQ concentrations, demonstrating good precision in real samples application.
BIOELECTROCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yinjun Tang, Yanjun Chen, Yu Wu, Weiqing Xu, Zhen Luo, Hua-Rong Ye, Wenling Gu, Weiyu Song, Chengzhou Zhu, Shaojun Guo
Summary: In this study, high-indexed intermetallic Pt3Sn (H-Pt3Sn) with high peroxidase-like activity and specificity was reported. H-Pt3Sn showed a specific activity of 345.3 U/mg, which was 1.82 times higher than Pt. It also exhibited negligible oxidase-like and catalase-like activities, indicating superior catalytic specificity towards H2O2 activation.
Article
Chemistry, Multidisciplinary
Rong Tan, Ying Qin, Mingwang Liu, Hengjia Wang, Jinli Li, Zhen Luo, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: A self-checking photoelectrochemical biosensor with dual photocurrent signals was developed to eliminate false-positive or false-negative signals. By introducing the iodide/tri-iodide redox couple, the photocurrent polarity-switchable behavior was achieved, which circumvented the inconvenience caused by the addition of different hole-and electron-trapping agents in the electrolyte. Moreover, the catalytic activity of nickel single-atom catalysts enhanced the photoelectric responsivity, enabling a more efficient iodide/tri-iodide redox reaction under low applied voltages. This proposed photocurrent polarity switching system offers new routes to sensitive and reliable biosensing.
Article
Chemistry, Analytical
Ruimin Li, Weiwei Guo, Zhijun Zhu, Yanling Zhai, Guanwen Wang, Zheng Liu, Lei Jiao, Chengzhou Zhu, Xiaoquan Lu
Summary: A single-atom indium anchored on nitrogen-doped carbon (In1-N-C) catalyst was prepared for sensitive electrochemical sensing of dopamine (DA). The In1-N-C catalyst exhibited high catalytic performance for DA oxidation, showing enhanced intrinsic activity with atomically dispersed In-N4 sites. The concept application of an electrochemical sensor for DA detection with high sensitivity and selectivity was established.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jinli Li, Hengjia Wang, Mingwang Liu, Ying Qin, Qie Fang, Rong Tan, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: Photoelectrochemical enzymatic biosensors have attracted attention due to their specificity and sensitivity, but the charge migration between enzymes and semiconductors is uncertain. This study successfully immobilized horseradish peroxidase (HRP) on ionic liquid-modified Cu@Cu2O aerogels to enhance charge transfer and interfacial redox reactions. The improved catalytic ability of HRP after immobilization was demonstrated through enhanced redox ability under light irradiation. By utilizing the excellent PEC activity and catalysis reaction of IL-Cu@Cu2O@HRP, an immunoassay platform was constructed for sensing prostate-specific antigens with a wide detection range and low limit of detection. A new perspective for designing advanced PEC sensing platforms is provided through a better understanding of direct electronic communication between photoactive materials and enzymes for boosted charge transfer and interfacial catalysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weiqing Xu, Yu Wu, Xiaosi Wang, Ying Qin, Hengjia Wang, Zhen Luo, Jing Wen, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: In this study, enzyme-inspired Fe-based single-atom catalysts were used to generate specific reactive oxygen species (ROS) for cathodic/anodic electrochemiluminescence (ECL) conversion. Mechanistic studies revealed that the FeN5 sites produced highly active hydroxyl radicals, enabling direct cathodic luminescence, while the FeN4 (c) sites produced superoxide radicals, resulting in inefficient anodic ECL. Based on the enhanced cathodic ECL, an FeN5 SAC-based immunosensor was developed for sensitive detection of cancer biomarkers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Guohai Yang, Fanglei Liu, Jiayi Zhao, Lijie Fu, Yingqiu Gu, Lulu Qu, Chengzhou Zhu, Jun-Jie Zhu, Yuehe Lin
Summary: In this review, the latest research on MXenes in the fields of biosensing and biomedicine is summarized. The synthesis strategies and unique properties of MXenes are introduced, and the biosensing applications of MXenes are divided into three subcategories based on the sensing mechanism: electrochemical, photochemical, and opto-electrochemical biosensors. The biomedical applications of MXenes are evaluated from four aspects: antibacterial activity, bioimaging, therapeutics, and theranostics. The specific chemical and physical properties of MXenes that influence the efficiency of biosensing and biomedicine are highlighted, as well as the structure-performance relationships determining detection sensitivity and material toxicity. The challenges, future prospects, and opportunities for MXenes are discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Xiao-Qian Zhang, Zhaoyuan Lyu, Shichao Ding, Shiyong Zhao, Guangyu Chen, Yuehe Lin, Jin-Cheng Li
Summary: A molten-salt-assisted pyrolysis strategy was used to prepare two-dimensional porous metal-nitrogen/carbon materials with exposed metal-nitrogen sites, which showed excellent performance in both liquid-state and solid-state Zn-air fuel cells.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Rong Tan, Ying Qin, Mingwang Liu, Hengjia Wang, Rina Su, Runshi Xiao, Jinli Li, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: Semiconductor-based photoelectrochemical (PEC) fuel cells convert solar and chemical energy into electrical energy, offering a sustainable and environmentally friendly energy production solution. However, their low PEC activities due to electron-hole recombination and slow reaction kinetics limit their practical application. To overcome this, a unique PEC fuel cell composed of dual photoelectrodes utilizing low-cost biomass as an organic fuel is reported. The integration of bifunctional iron single-atom catalysts (Fe SACs) and photoactive materials effectively enhances charge carrier transfer and boosts reaction kinetics and conversion efficiency.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Zhen Luo, Weiqing Xu, Zhichao Wu, Lei Jiao, Xin Luo, Mengzhen Xi, Rina Su, Liuyong Hu, Wenling Gu, Chengzhou Zhu
Summary: The Ru(bpy)(3)(2+)-tripropylamine ECL system is widely used in commercial bioanalysis, but the presence of amines in the biological environment causes unwanted anodic interference signals. To overcome this, a cathodic Ru(bpy)(3)(2+) ECL system is proposed, which utilizes the iron-nitrogen-carbon catalyst to activate the ECL signal. This innovative system shows great potential for practical applications, demonstrated by the successful development of an ECL biosensor for detecting alkaline phosphatase activity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xin Luo, Zhen Luo, Shentian Li, Qie Fang, Weiqing Xu, Hengjia Wang, Yongze Wang, Guang-Ming Bao, Wenling Gu, Chengzhou Zhu
Summary: Self-powered sensing system (SPSS) integrating nanozymatic biofuel cell enables sensitive detection of prostate-specific antigen (PSA) with a wide detection range and low detection limit. The nanozymatic biofuel cell exhibits higher power output and stability compared to the Pt/C-based counterpart, making it beneficial for the application of SPSS and broadening the application scenarios of nanozymes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Weiqing Xu, Yu Wu, Yuling Xu, Xiaoli Cai, Wenling Gu, Chengzhou Zhu
Summary: This study presents a spatially compartmentalized artificial organelle for correcting intratumoral metabolite analysis. The organelle consists of a zeolitic imidazolate framework-8 immobilized glucose oxidase-horseradish peroxidase cascade core and catalase-directed shell, which function as signal transduction and guarding rooms, respectively. The core and shell provide appropriate spaces to enhance biocatalytic efficiency and tolerate complex tumor microenvironments. Moreover, catalase decomposes endogenous H2O2 to O-2, overcoming interference in signal output and alleviating hypoxic states, thus maximizing glucose oxidation. The artificial organelle demonstrates great potential for accurate intratumoral metabolite analysis in vitro and in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Juan Liu, Xiaoxiao Guo, Zhaoyuan Lyu, Rong-Bin Song, Pengyu Zhou, Shichao Ding, Yang Zhou, Li-Ping Jiang, Yuehe Lin, Wenlei Zhu
Summary: By using copper electrocatalysts and microorganisms, an electro-bio tandem reactor was designed to convert CO2 into specific multicarbon compounds in both the gas and liquid phases. The reducing products from electrocatalysis can be consumed and recycled for selective acetate synthesis in Moorella thermoacetica. The results showed high faradaic selectivity for acetate in liquid products for Cu-based CO2 electroreduction and high electron conversion rate to ethylene and acetate for microbial electrosynthesis, presenting a green design for CO2 upcycling targeting multicarbon products through the parallel integration of electrocatalysis and fermentation.
Review
Chemistry, Multidisciplinary
Weiqing Xu, Yu Wu, Wenling Gu, Dan Du, Yuehe Lin, Chengzhou Zhu
Summary: Metal-organic frameworks (MOFs) have made significant advances as mimics of metalloenzymes in bioinspired catalysis, particularly in the field of active pocket engineering at the atomic level.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Na Tao, Lei Jiao, Huihuang Li, Liu Deng, Wei Wang, Senfeng Zhao, Wansong Chen, Limiao Chen, Chengzhou Zhu, You-Nian Liu
Summary: This study demonstrates a mild hyperthermia-enhanced pyroptosis-mediated immunotherapy based on hollow carbon nanozyme, which can amplify anticancer responses in the tumor microenvironment and has implications for clinical immunotherapy.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
