Article
Biophysics
Tennyson Mathai, Tathagata Pal, Nayan Prakash, Soumyo Mukherji
Summary: Enrofloxacin (ENR) and its metabolite Ciprofloxacin (CIP) are effective against a broad-spectrum microbial infection, but their increased consumption has led to drug-resistant pathogens. To tackle this issue, a portable device has been developed to accurately detect the presence of CIP and ENR antibiotics in ppb concentrations.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Yuan Cheng, Hongliang Wang, Yuxin Zhuo, Dan Song, Chunsheng Li, Anna Zhu, Feng Long
Summary: This paper presents an innovative reusable smartphone-facilitated mobile fluorescence biosensor that combines optical system, microfluidic system, and smartphone to achieve rapid detection and quantitative analysis of toxic pollutants.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
A. Prasanth, Selamawit Getachew, Tseganesh Shewa, M. Velumani, S. R. Meher, Z. C. Alex
Summary: This study developed two sets of fiber optic sensors for detecting acetone concentrations, using SnO2 thin film and a bilayer of SnO2/MoS2 as the sensing layers. The SnO2/MoS2-coated sensor showed enhanced response and recovery time, indicating its potential for creating a handheld sensor system for monitoring diabetes.
Article
Chemistry, Analytical
Yue Zhou, Hongliang Wang, Dan Song, Zhanguo Li, Shitong Han, Feng Long, Anna Zhu
Summary: This study introduces a portable evanescent wave optofluidic biosensor for rapid and sensitive detection of Hg2+, utilizing fluorescence labeled poly-A DNA strand (CY-A14) and quencher labeled poly-T DNA strand (BQ-T14) for signal detection. The biosensor demonstrates high selectivity and a low detection limit of 8.5 nM for Hg2+, making it a powerful tool for on-site detection of Hg2+ in real water samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Jisoo Kim, Bumjoon Jang, Julian Gargiulo, Johannes Buerger, Jiangbo Zhao, Swaathi Upendar, Thomas Weiss, Stefan A. Maier, Markus A. Schmidt
Summary: The optofluidic light cage concept introduced in this study utilizes a novel on-chip hollow core waveguide platform achieved through 3D nanoprinting, allowing for fast and reliable integrated spectroscopy with unique structural features and performance. This light cage is not only limited to absorption spectroscopy, but can also be applied in other spectroscopy applications, opening up new avenues for highly integrated sensing devices.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Pan Tao, Kaixin Ge, Xing Dai, Danni Xue, Yang Luo, Shixun Dai, Tiefeng Xu, Tao Jiang, Peiqing Zhang
Summary: This paper proposes a fiber optic SERS sensor excited by evanescent waves for efficient detection of thiram. Silver nanocubes (Ag NCs) were prepared as SERS active substrates, which had much stronger electromagnetic field intensity than nanospheres. The combination of evanescent waves and SERS provides a new direction for the application of SERS sensors, which had great application potential in the field of pesticide residue detection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Electrical & Electronic
A. Prasanth, S. R. Meher, Z. C. Alex
Summary: This paper presents an experimental analysis of a fiber optic sensor for volatile organic compounds (VOC) based on evanescent wave and clad modification technique. Different metal oxide thin films were deposited on the optical fiber and characterized using various testing methods. The results show that the SnO2 coated sensor probe exhibits the highest sensor response rate and wavelength shift when detecting IPA.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Review
Chemistry, Analytical
Zheng Wang, Xinhui Lou
Summary: Fiber optic evanescent wave (FOEW) sensor using functional nucleic acids (FNAs) as specific recognition ligands has shown great potential in the onsite and continuous detection of various targets. This review summarizes the progress of fluorescent FNA-based FOEW biosensor and its sensing mechanisms for different types of targets, including small molecules, heavy metal ions, proteins, nucleic acids, and pathogens. The challenges and prospects for the development of FOEW biosensors capable of onsite and continuous detection are also discussed.
Article
Chemistry, Physical
Xudong Zhao, Ni Yao, Xianghua Zhang, Lei Zhang, Guangming Tao, Zijian Li, Quan Liu, Xiujian Zhao, Yinsheng Xu
Summary: This study proposes a new approach of tapered-fiber geometry optimization to improve the evanescent efficiency of mid-infrared chalcogenide fiber sensors. The influence of fiber geometry on sensing performance is discussed, and the analysis reveals that a smaller waist radius and longer taper length lead to higher evanescent efficiency. Additionally, the investigation of waist deformation shows that increasing the waist boundary radius can decrease the sensing performance.
Article
Chemistry, Applied
Yunhai Zhou, Leizi Jiao, Jianwei Wu, Yunhe Zhang, Qingzhen Zhu, Daming Dong
Summary: There is a growing interest in non-destructive and rapid determination of food freshness. This study applied mid-infrared fiber-optic evanescent wave spectroscopy to monitor shrimp freshness. By evaluating protein, chitin, and calcite contents and using a Partial Least Squares Discriminant Analysis model, the freshness of shrimp could be quickly and nondestructively assessed. The results showed that the spectroscopy method achieved high recognition rates for shrimp freshness compared to the standard indicator, making it a feasible method for non-destructive and in-site detection of shrimp freshness.
Article
Materials Science, Ceramics
A. P. Velmuzhov, V. S. Shiryaev, M. Sukhanov, T. Kotereva, B. S. Stepanov, G. E. Snopatin
Summary: Optical fibers based on pure Ge20Se80 and Ga10Ge15Te73I2 glasses are used as sensing elements, and flexible fibers based on polycrystalline silver halides and As-Se glasses are used to connect the sensing elements to an IR Fourier spectrometer. Fiber-optic probes with different combinations of materials are manufactured and tested for FEWS analysis of organic mixtures, showing promising results.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Biophysics
Jinchuan Liu, Yunpeng Xing, Xiaohong Zhou, George Y. Chen, Hanchang Shi
Summary: A novel U-shaped fiber-optic evanescent-wave fluorescent immunosensor was designed for real-time detection of microcystin-LR using light-sheet excitation of skew rays. The sensor showed enhanced sensitivity with the use of light-sheet skew rays, leading to successful establishment of a sensitive real-time MC-LR detection method. The system demonstrated high recovery rates for MC-LR detection in environmental water samples, showing potential for on-site environmental monitoring and clinical diagnostics.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Electrical & Electronic
Jixuan Wu, Bo Wang, Binbin Song, Mingqiang Qiao, Bo Liu, Hao Zhang, Wei Lin, Shaoxiang Duan
Summary: A bioimmunoassay method based on hydrophobin self-assembly in a Whispering Gallery Mode optofluidic microresonator has been proposed and experimentally demonstrated. The method shows potential advantages in terms of cost-effectiveness, simplicity in fabrication, label-free detection, and miniaturization for applications in biochemical and biomedical fields.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Engineering, Environmental
Qian Zhu, Lanhua Liu, Ruoyu Wang, Xiaohong Zhou
Summary: A sensitive EWF biosensor for STR detection using SPA has been developed, showing good selectivity and reuse capability. The detection steps are simple and the recovery rate for water samples is high.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Xin Xin, Huimin Liu, Nianbing Zhong, Mingfu Zhao, Dengjie Zhong, Haixing Chang, Bin Tang, Yuanyuan He, Cunling Peng, Xuefeng He
Summary: In this study, a plastic optical fiber evanescent wave sensor was developed for the selective detection of 4-chlorophenol in water. The sensor exhibited high sensitivity and a low limit of detection, making it a promising method for accurate detection of 4-chlorophenol.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)