Article
Chemistry, Analytical
Mohammad Hossein Ghanbari, Zahra Norouzi, Bastian J. M. Etzold
Summary: In this study, a multinary nanocomposite was designed for the detection of theophylline (TP) and uric acid (UA) in blood serum, showing high sensitivity and selectivity. The multinary nanocomposite improved the electrochemically active surface area and electron transfer rate, leading to enhanced current response. The detection limits were found to be 0.18 nM for UA and 0.36 nM for TP, with sensitivities of 1.27 μA μM-1 cm-2 and 1.06 μA μM-1 cm-2, respectively.
MICROCHEMICAL JOURNAL
(2023)
Article
Polymer Science
Lidiia Kolzunova, Elena Shchitovskaya, Maxim Karpenko
Summary: The study demonstrates the advantages of the electrochemical approach in the formation of polymer/metal nanoparticle composites, simplifying the production process and reducing formation time. It also shows the possibility of single-stage formation of such composites and confirms the energetic favorability of including gold nanoparticles into the polymethylolacrylamide film.
Article
Chemistry, Multidisciplinary
Reza Moshrefi, Katelyn Ryan, Evan P. P. Connors, Joshua C. C. Walsh, Erika Merschrod, Graham J. J. Bodwell, Talia Jane Stockmann
Summary: In this study, highly reproducible electrogeneration of low dispersity Au nanocluster embedded ultra-thin conductive polymer films was achieved at a micro liquid|liquid interface. The miniaturized reaction facilitated external, potential control and limited the reaction pathway.
Article
Polymer Science
Saedah R. Al-Mhyawi, Riham K. Ahmed, Rasha M. El Nashar
Summary: This study demonstrated a facile electropolymerization of dl-methionine conducting polymeric film on a gold nanoparticle-modified glassy carbon electrode for sensitive detection of paroxetine HCl. The sensor showed a wide linear response range with a low detection limit, and successfully applied for PRX determination in different formulations with high percent recoveries.
Article
Chemistry, Analytical
Shimayali Kaushal, Anil Kumar, Sanjeev Soni, Nitin Kumar Singhal
Summary: A hybrid antibody biosensor based on graphene oxide-coated gold nanoparticles was developed for fast, specific, and high sensitivity foodborne bacterial detection. The biosensor showed colorimetric and spectrophotometric changes up to 10(3) and 10(2) CFU, respectively, when incubated with Escherichia coli and Salmonella typhimurium for 5 minutes. Immobilized antibodies on the hybrid nanoparticle biosensor were specific to bacteria and exhibited specific photoablation of bacteria upon infrared exposure. This antibody-functionalized biosensor allowed for rapid optical detection and extermination of foodborne bacteria.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Irina-Georgiana Munteanu, Constantin Apetrei
Summary: This study investigated the electrochemical properties of three screen-printed electrodes using different materials for the detection of chlorogenic acid, showing that graphene and gold nanoparticles modification can significantly improve sensitivity and reversibility of the electrodes. The method developed can be applied for the determination of chlorogenic acid in real samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Tugba Oren Varol, Sebahat Topal, Ozgul Hakli, Esma Sezer, Ulku Anik, Turan Ozturk
Summary: In this study, electropolymerization of pre-synthesized ThPDITh was conducted on Au button electrode and the properties of the resulting polymer P(ThPDITh) were investigated. The experimental results confirmed that P(ThPDITh) is capable of undergoing multiple reversible redox processes, making it a good candidate for enhancing the capacitance and energy density of electrode material. The capacitance values obtained from different measurements all showed good agreement with each other, indicating the reliability of the findings.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Spectroscopy
Shuyan Xiao, Jiping Lu, Liang Sun, Shengli An
Summary: A new colorimetric biosensor for specific detection of azlocillin was developed using DNA aptamer and unmodified gold nanoparticles. The biosensor showed a red solution in the absence of azlocillin and a color change from red to blue in the presence of azlocillin. The biosensor exhibited a linear relationship with a detection limit of 11.6 nM and was successfully used to detect azlocillin in milk and tap water samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Raksha Singh, Anurag Kumar Singh, Minu Yadav, Manish Sharma, Ida Tiwari, K. K. Upadhyay
Summary: This study presents simultaneous colorimetric detection of cysteine and homocysteine through the aggregation of citrate capped silver nanoparticles, and achieves categorical naked-eye detection of homocysteine through the conjugation with thiosulphate.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Geetika Bhardwaj, Randeep Kaur, Navneet Kaur, Narinder Singh
Summary: A new receptor R1 was synthesized and prepared as nanoparticles to detect azidothymidine. The nanoparticle probe showed better sensing performance for azidothymidine in various techniques such as cyclic voltammetry.
Article
Electrochemistry
Jaewon Chung, Habin Park, Cheolsoo Jung
Summary: This study polymerized an isocyanate-based electrolytic additive on activated carbon electrodes using two different methods to reduce the self-discharge of supercapacitors. Among them, the electropolymerization method demonstrated more effective results in retaining capacitance and suppressing self-discharge behavior.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Applied
Viktor Pogorilyy, Nikita Kirin, Andrey Mironov, Mikhail Grin
Summary: The study focuses on modifying the chlorine macrocycle with additional exocycles to enhance stability, improve spectral characteristics, and introduce chemically active groups. Replacing oxygen with sulfur in the purpurin-18 anhydride exocycle is proposed as a bioisosteric substitution, providing opportunities for new chemical modifications while minimally affecting the photosensitizer's properties. The synthesis pathway for a derivative of naturally occurring chlorin with an additional thioanhydride cycle is discussed, along with the immobilization of chlorin p(6) thioanhydride on gold nanoparticles.
Review
Biochemistry & Molecular Biology
Ian E. Cock, Matthew J. Cheesman
Summary: The development of new antimicrobial therapies is crucial in response to the rise of multiple-drug-resistant pathogens. Cyanobacteria, despite their potential environmental toxicity, have been found to contain compounds with significant inhibitory activity against various pathogens, making them promising targets for drug development.
Article
Chemistry, Medicinal
Zouher Amzil, Amelie Derrien, Aouregan Terre Terrillon, Veronique Savar, Thomas Bertin, Marion Peyrat, Audrey Duval, Korian Lhaute, Nathalie Arnich, Vincent Hort, Marina Nicolas
Summary: Shellfish in France are monitored for regulated toxins and other unregulated toxins. A monitoring program called EMERGTOX was set up in 2018 to detect emerging unregulated toxins in shellfish samples. The results of the monitoring plan from 2018 to 2022 showed the presence of various unregulated toxins, highlighting the need for further monitoring to protect consumers.
Article
Biochemistry & Molecular Biology
Mohzibudin Z. Quazi, Nokyoung Park
Summary: To address the side effects of chemotherapeutic drugs on healthy tissues, researchers have developed a cancer-specific peptide drug delivery system. By constructing a peptide drug delivery vehicle using a nanoscale DNA hydrogel, combined with gold nanoparticles for light-triggered drug release, the system can deliver anticancer peptides specifically to cancer cells, with no cytotoxicity and minimal impact on normal cells.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)