Journal
ANALYTICA CHIMICA ACTA
Volume 761, Issue -, Pages 201-208Publisher
ELSEVIER
DOI: 10.1016/j.aca.2012.11.028
Keywords
Electrospinning; Nanofibers; Chromatography; Ultra-thin layer chromatography; Alignment; Drug analysis
Categories
Funding
- National Science Foundation
- Nanoscale Science and Engineering Center
- Directorate For Engineering
- Div Of Engineering Education and Centers [914790] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012279] Funding Source: National Science Foundation
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The fabrication and implementation of aligned electrospun polyacrylonitrile (PAN) nanofibers as a stationary phase for ultra-thin layer chromatography (UTLC) is described. The aligned electrospun UTLC plates (AE-UTLC) were characterized to give an optimized electrospun mat consisting of high nanofiber alignment and a mat thickness of similar to 25 mu m. The AE-UTLC devices were used to separate a mixture of beta-blockers and steroidal compounds to illustrate the properties of AE-UTLC. The AE-UTLC plates provided shorter analysis time (similar to 2-2.5 times faster) with improved reproducibility (as high as 2 times) as well as an improvement in efficiency (up to100 times greater) relative to non-aligned electrospun-UTLC (E-UTLC) devices. (C) 2012 Elsevier B.V. All rights reserved.
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