Article
Environmental Sciences
Caitlin G. Howe, Birgit Claus Henn, Shohreh F. Farzan, Rima Habre, Sandrah P. Eckel, Brendan H. Grubbs, Thomas A. Chavez, Dema Faham, Laila Al-Marayati, Deborah Lerner, Alyssa Quimby, Sara Twogood, Michael J. Richards, John D. Meeker, Theresa M. Bastain, Carrie V. Breton
Summary: This study investigated the impact of a mixture of metals on fetal size in mid-pregnancy among predominantly lower income Hispanic pregnant women in Los Angeles. Results showed molybdenum (Mo) and barium (Ba) were the components that contributed most to fetal size, with Mo associated with higher estimated fetal weight (EFW) and Ba associated with lower EFW. The study also found a possible interaction between Ba and Mo in relation to head circumference.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Charalampos Kolvatzis, Paris Christodoulou, Ioannis Kalogiannidis, Konstantinos Tsiantas, Ioannis Tsakiridis, Charikleia Kyrkou, Antigoni Cheilari, Nikolaos S. Thomaidis, Panagiotis Zoumpoulakis, Apostolos Athanasiadis, Alexandra-Maria Michaelidou
Summary: This study analyzed the metabolic composition of amniotic fluid collected from pregnant women during the second trimester and identified potential biomarkers for predicting and diagnosing preterm delivery. Pathway analysis also revealed the metabolic pathways associated with the risk of preterm delivery.
Article
Genetics & Heredity
Maayke A. de Koning, Mariette J. Hoffer, Esther A. R. Nibbeling, Emilia K. Bijlsma, Menno J. P. Toirkens, Phebe N. Adama-Scheltema, E. Joanne Verweij, Marieke B. Veenhof, Gijs W. E. Santen, Cacha M. P. C. D. Peeters-Scholte
Summary: Prenatal exome sequencing (pES) shows a high diagnostic yield in cases of central nervous system anomalies, aiding parental decision making, guiding perinatal management, and approving late termination of pregnancy requests. The study suggests that pES has the potential to become a routine care modality for fetal neurologists.
Article
Environmental Sciences
Mauro Mecozzi, Riccardo Delle Fratte, Marco Pietroletti, Fabrizio Novelli, Umberto Scacco
Summary: In this study, FTIR and FTNIR spectroscopy were used to investigate the structural characteristics of different mollusc shells sampled from various sites. The results showed that the structural differences in these shells were related to local environmental conditions. FTIR spectra were able to detect the role of amorphous calcium carbonate in the shell structure, and FTNIR spectroscopy could detect the presence of protein structures in the shells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Analytical
Shengrong Du, Qun Zhang, Haohao Guan, Guannan Chen, Sisi Wang, Yan Sun, Yuling Li, Rong Chen, Youwu He, Zufang Huang
Summary: This study presents a Raman spectroscopy method combined with EMSC for the assessment of sperm DNA integrity directly on glass slides. The Raman results were validated with clinical sperm staining, and although there were similarities in overall spectral patterns, specific differences were observed. By employing multivariate statistical analysis, the PLS-DA model demonstrated better diagnostic sensitivity, specificity, and classification rate compared to PCA-LDA. The results suggest the potential of Raman-based label-free DNA assessment of sperm cells as a simple method for clinical applications.
Article
Medicine, General & Internal
Joanna Suliburska, Jakub Pankiewicz, Adam Sajnog, Magdalena Paczkowska, Beata Nowakowska, Ewa Bakinowska, Danuta Baralkiewicz, Rafal Kocylowski
Summary: This study investigated the relationship between the concentrations of elements in amniotic fluid and fetal chromosomal abnormalities. The results showed that fetuses with chromosomal abnormalities had lower manganese concentration and higher iron levels in the amniotic fluid.
Article
Pediatrics
Noah H. Hillman, Matthew W. Kemp, Erin Fee, Judith Rittenschober-Boehm, Emily Royse, Leenah Abugisisa, Fabrizio Salomone, Gabrielle C. Musk, Alan H. Jobe
Summary: The addition of budesonide to surfactant in preterm lambs exposed to intra-amniotic LPS improved physiology and markers of lung and systemic inflammation, showing potential for decreasing lung inflammation in preterm infants with chorioamnionitis.
PEDIATRIC RESEARCH
(2021)
Review
Developmental Biology
Nardhy Gomez-Lopez, Jose Galaz, Derek Miller, Marcelo Farias-Jofre, Zhenjie Liu, Marcia Arenas-Hernandez, Valeria Garcia-Flores, Zachary Shaffer, Jonathan M. Greenberg, Kevin R. Theis, Roberto Romero
Summary: This review summarizes the immune mechanisms involved in preterm birth, including intra-amniotic inflammation and novel etiologies. Intra-amniotic infection can be treated with antibiotics, while sterile inflammation may require anti-inflammatory drugs. Recent evidence suggests that fetal T-cell activation may be a new trigger for idiopathic preterm birth. Additionally, impaired maternal Treg function and the absence of homeostatic macrophages are also associated with preterm birth.
Article
Medicine, General & Internal
Longwei Qiao, XiaoJu Cao, Haoyu Tang, Zheng Yu, Jingye Shi, Ying Xue, Ting Wang, Yuting Liang, Chao Huang, Jiucun Wang
Summary: Increased white blood cell (WBC) count is associated with lower fetal fraction (FF) and higher test failure rates in noninvasive prenatal screening (NIPS). This study found that WBC count negatively correlated with FF and positively correlated with BMI, alanine aminotransferase (ALT), IVF conceptions, and gestational age. High WBC count significantly increased the risk of test failure. These findings highlight the importance of considering WBC count in genetic counseling for pregnant women.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Lauren S. Richardson, Nkechinyere Emezienna, Irina Burd, Brandie D. Taylor, Morgan R. Peltier, Arum Han, Ramkumar Menon
Summary: A study using an organ-on-chip model has found that race/ethnicity differences play a role in perinatal brain injury, but the fetal sex of neonates does not affect susceptibility to intraamniotic inflammation leading to neuroinflammation.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Instruments & Instrumentation
Margherita Tonolini, Klavs Martin Sorensen, Peter B. Skou, Colin Ray, Soren Balling Engelsen
Summary: Characterization and quantification of individual whey proteins are crucial to industrial dairy processes. This study investigates the utility of Fourier transform mid-infrared spectroscopy and Fourier transform near-infrared spectroscopy for rapid quantification of beta-lactoglobulin and alpha-lactalbumin in whey solutions. The results demonstrate the potential of NIR spectroscopy for accurate in-line protein quantification in industrial applications.
APPLIED SPECTROSCOPY
(2021)
Article
Acoustics
Lutfiye Uygur, Oya Demirci, Aysenur Celayir
Summary: This article presents three cases of female fetuses with hydrometrocolpos and discusses the prenatal differential diagnoses based on ultrasound findings, as well as postnatal diagnoses and outcomes.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Agriculture, Multidisciplinary
Emmanouil Orfanakis, Michail Markoulidakis, Aggelos Philippidis, Aikaterini Zoumi, Michalis Velegrakis
Summary: This study demonstrates that optical spectroscopic techniques combined with multivariate statistical analysis can effectively differentiate different types of honey based on their botanical origins, providing a rapid, low-cost, and easy-to-use approach for determining the botanical origin of honey without sample pretreatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Spectroscopy
Haohao Guan, Chunyan Huang, Dechan Lu, Guannan Chen, Juqiang Lin, Jianzhang Hu, Youwu He, Zufang Huang
Summary: Raman spectroscopy shows potential in investigating diabetic keratopathy and differentiating the biochemical differences between normal and diabetic corneal tissues; advanced statistical analysis methods such as principal component analysis and partial least squares discriminant analysis can enhance the diagnostic accuracy of diabetes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Obstetrics & Gynecology
Zhaomin Zeng, Hua Liao, Fan Hu, Fumin Zhao, Hongyan Liu, Qing Hu, Haiyan Yu
Summary: This article reports a case of a giant fetal neck lymphatic malformation, which achieved a favorable outcome through accurate prenatal diagnosis and evaluation and treatment by a multidisciplinary team.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)
Article
Environmental Sciences
Celia Alves, Margarita Evtyugina, Estela Vicente, Ana Vicente, Ismael Casotti Rienda, Ana Sanchez de la Campa, Mario Tome, Iola Duarte
Summary: This study collected PM2.5 samples near an industrial chemical pole and analyzed their OC, EC, trace elements, and organic constituents. The results showed that organic compounds, elemental carbon, and trace elements mainly originated from industrial emissions, nearby roads, and biomass burning. Some organic constituents were likely related to plasticizer ingredients and thermal stabilizers in industrial emissions. Additionally, principal component analysis revealed the contributions of different emission sources.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Mariana R. Silva, Gualter S. Silva, Sara Fernandes, Joao Almeida, Paulo Fonseca, Marco Oliveira, Helena Goncalves, Francisca Saraiva, Antonio S. Barros, Pedro G. Teixeira, Ricardo L. Lopes, Francisco Sampaio, Silvia O. Diaz, Joao Primo, Ricardo Fontes-Carvalho
Summary: This study aimed to determine the predictors of early recurrence (ER) and late recurrence (LR) after catheter ablation (CA) for atrial fibrillation (AF) and establish the risk of LR in patients who experience ER. The results showed that the risk of LR after CA was significantly higher in patients with ER (five-fold increased risk). These findings highlight the importance of clarifying the clinical role of the blanking period.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Monica Emili Garcia-Segura, Brenan R. Durainayagam, Sonia Liggi, Goncalo Graca, Beatriz Jimenez, Abbas Dehghan, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Julian L. Griffin
Summary: This study analyzed the differentially expressed multi-omics elements in mouse models of Alzheimer's disease (AD) using genome-wide association studies (GWAS), transcriptomics, and proteomics data. It identified lipid and bioenergetic metabolic pathways that are significantly enriched in the AD multi-omics data sets. Microglia and astrocytes were found to be significantly enriched in the lipid-predominant AD-metabolic transcriptome.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Sara Lopes Fernandes, Ricardo Ladeiras-Lopes, Mariana Silva, Gualter Silva, Ines Cruz, Silvia O. Diaz, Antonio S. Barros, Francisca Saraiva, Rita Faria, Joao Almeida, Paulo Fonseca, Helena Goncalves, Marco Oliveira, Nuno Ferreira, Joao Primo, Ricardo Fontes-Carvalho
Summary: Coronary artery calcium score (CACS) is associated with an increased risk of atrial fibrillation (AF) recurrence, particularly when the score exceeds 100.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Ines Cruz, Sara Lopes Fernandes, Silvia O. Diaz, Francisca Saraiva, Antonio S. Barros, Joao Primo, Francisco Sampaio, Ricardo Ladeiras-Lopes, Ricardo Fontes-Carvalho
Summary: There is no independent association between epicardial adipose tissue (EAT) volume and attenuation and the risk of atrial fibrillation (AF) recurrence after AF ablation.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Biochemistry & Molecular Biology
Maite Garcia-Guasch, Eduard Escrich, Raquel Moral, Iola F. Duarte
Summary: The aim of this study was to investigate the effects of two phenolic compounds, hydroxytyrosol (HT) and luteolin (LUT), on the metabolism of breast cancer cells of different molecular subtypes. The researchers used untargeted metabolomics to study the metabolic responses of MDA-MB-231 and MCF-7 cells to treatment with these phenols. The results showed that the effects of the phenolic compounds varied depending on the cell type and included changes in mitochondrial metabolism, glycolysis, lipid metabolism, and cellular redox status.
Article
Oncology
Ana S. Dias, Catarina R. Almeida, Luisa A. Helguero, Iola F. Duarte
Summary: Tumor-associated macrophages (TAMs) are the most abundant immune cells in the breast tumor microenvironment, and their immune-suppressive functions promote breast cancer progression. The metabolic crosstalk between tumor cells and TAMs is important in modulating the tumor microenvironment towards anti-tumor immunity. This study investigates how tumor-educated macrophages (TEM) reprogram their metabolism and phenotype in response to different metabolic conditions imposed by breast cancer cell subtypes, providing new insights into the metabolic plasticity of TEM in the breast cancer microenvironment.
Article
Oncology
Fernando Osorio, Antonio S. Barros, Barbara Peleteiro, Isabel Amendoeira, Jose Luis Fougo
Summary: In this study, we compared the outcomes of breast cancer among three age groups and found that older patients were more susceptible to suboptimal treatment and had a lower overall survival rate. This was not associated with the cancer itself, but rather with undertreatment. The study suggests that tumor characteristics and treatment compliance are better predictors of survival than chronological age.
Article
Cardiac & Cardiovascular Systems
Marta Leite, Francisco Sampaio, Francisca A. Saraiva, Silvia O. Diaz, Antonio S. Barros, Ricardo Fontes-Carvalho
Summary: Recently, HF guidelines have re-classified HF patients with LVEF between 41% and 49% as HFmrEF. The treatment of HFmrEF patients is often considered a grey zone due to the lack of RCTs exclusively conducted on this population. A network meta-analysis was conducted to compare the treatment effect of different medications in HFmrEF cardiovascular outcomes.
Article
Chemistry, Multidisciplinary
Maria V. Monteiro, Margarida Henriques-Pereira, Bruno M. Neves, Iola D. Duarte, Vitor M. Gaspar, Joao F. Mano
Summary: Tissue-derived decellularized extracellular matrix (dECM) combined with hyaluronic acid (HA) and tyramine can create highly physiomimetic tumor models for studying tumor-stroma interaction, which can be used for screening pancreatic cancer therapies.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rita Nogueira-Ferreira, Ines Santos, Rita Ferreira, Dulce Fontoura, Claudia Sousa-Mendes, Ines Falcao-Pires, Andre P. Lourenco, Adelino Leite-Moreira, Iola F. Duarte, Daniel Moreira-Goncalves
Summary: Exercise training has positive effects on the management of metabolic syndrome, improving inflammation, exercise capacity, and muscle metabolism. It reduces muscle atrophy and fibrosis and enhances oxidative metabolism, reducing fatigue susceptibility.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Joao A. Rodrigues, Daniela S. C. Bispo, Monica G. Silva, Rita Araujo, Amadeu M. V. M. Soares, Rosa Freitas, Ana M. Gil
Summary: This study investigates the effects of exposure to 17-α-ethinylestradiol (EE2) on lipophilic extracts of Ruditapes philippinarum clams at 17 degrees C and 21 degrees C. The results show that EE2 exposure at 17 degrees C leads to a slight increase in membrane rigidity at low concentrations, while at higher concentrations, lipid metabolism stabilizes. In contrast, at 21 degrees C, lipid metabolism responds to EE2 at 125 ng/L, with the antioxidant docosahexaenoic acid (DHA) helping to mitigate oxidative stress. The study also identifies new potential markers of stress mitigation, such as high levels of phosphatidylcholine (PtdCho), polyunsaturated fatty acids (PUFAs), and linoleic acid, as well as low PUFA/glycine ratios.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Biochemical Research Methods
Rita Araujo, Victoria Fabris, Caroline A. Lamb, Andres Elia, Claudia Lanari, Luisa A. Helguero, Ana M. Gil
Summary: The lipid metabolism adaptations of estrogen and progesteronereceptor-positive breast cancer tumors in relation to HD to HI tumor growth transition and HIR tumor acquisition of ET resistance were investigated. Results showed increased nonesterified cholesterol forms and phospholipids, and decreased triglycerides and fatty acids during tumor progression. These changes suggest a shift toward more activated cholesterol synthesis, β-oxidation, and phospholipid biosynthesis to sustain tumor growth. Certain compound levels and ratios were identified as potential markers for HD-HI-HIR progression.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Microbiology
Rita Almeida Teixeira, Claudia Silva, Antonio Carlos Ferreira, Diana Martins, Adelino Leite-Moreira, Isabel M. Miranda, Antonio S. Barros
Summary: Gestational diabetes, affecting 10% of pregnancies, has implications for both mother and child. This study reviewed the literature on the differences in microbiota composition between pregnant women with gestational diabetes and healthy pregnancies. The findings suggest that certain bacteria are more abundant in healthy pregnancies, while others are more abundant in gestational diabetes. The study also highlighted the potential of microbiome-targeted therapies for gestational diabetes.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
