Article
Biochemical Research Methods
Yuan Ding, He Chen, Lingfeng Zong, Panpan Cui, Xujin Wu, Minghua Wang, Xiude Hua
Summary: In this study, a peptide-based time-resolved fluoroimmunoassay (P-TRFIA) was developed with high sensitivity and specificity for detecting benzothiostrobin in environmental and agro-products samples. The method is more accurate than previous immunoassays and shows consistent results with high-performance liquid chromatography.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yalin Hu, Xin Lu, Liyue Shen, Jiahui Dong, Zhanwei Liang, Jie Xie, Tao Peng, Xiaoping Yu, Xinhua Dai
Summary: In this study, an immunochromatographic assay (ICA) based on magnetic nanoparticles (MNPs) was successfully developed for the sensitive detection of carcinoembryonic antigen (CEA). The developed method shows excellent performance, sensitivity, and efficiency, providing technical support for cancer diagnosis and prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yanmin Zhang, Chenfang Sun, Yuchen Duan, Shanshan Cheng, Wenping Hu
Summary: This study presents the design and fabrication of a carbon dots-functionalized organic field effect transistor for biosensing applications. By utilizing the advantages of carbon dots, low-abundance proteins were successfully detected while maintaining device performance.The experimental results demonstrate that this biosensor exhibits an extremely low limit of detection and high selectivity, highlighting its potential for early cancer detection.
Article
Environmental Sciences
Yuan Qin, Jiayu Li, Jiani Kuang, Sicheng Shen, Jingwen Jiang, Zhi Zhang, Chenhao Zhao, Xiumei Zhou, Biao Huang, Bingnan Han
Summary: This study established a highly sensitive OA detection method using TRFIA, which showed good correlation with HPLC results and exceeded the EU or US standards for shellfish toxin detection.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Engineering, Biomedical
Thais S. Correa, Anamelia L. Bocca, Florencio Figueiredo, Emilia C. O. Lima, Maria De Fatima M. Almeida Santos, Zulmira G. M. Lacava, Mariana Campos-da-Paz
Summary: Systemic therapy is essential for breast cancer treatment, but side effects and resistance are concerns, especially for TNBC. New nanoformulations targeting cancer cells and alternative biomarkers for TNBC management have been explored. In vivo study showed MFCEA nanoparticles effectively targeted CEA-positive TNBC tumors in mice, with promising potential for clinical application. Further research is needed to improve performance and ensure safety for future studies.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chaoqun Wang, Ziqiang Deng, Hu Zhang, Rui Liu, Yi Lv
Summary: Magnetic particles (MPs) are widely used in various biological applications, and this study discovered a novel function of commercialized MPs-internal standard for accurate quantification of biomolecules. The proposed MPs-based immunoassay greatly improves the accuracy and precision by eliminating potential MPs loss and intensity fluctuations during magnetic separation.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Pengli Li, Min Wang, Mingzhe Jiang, Wenjing Lai, Jiajia Li, Kailin Liu, Hongling Li, Chenglin Hong
Summary: The sensitive detection of carcinoembryonic antigen (CEA) was achieved using an electrochemical immunosensor loaded with gold nanoparticles and flower-shaped CuS nanoflowers with peroxidase-like activity. This immunosensor exhibited excellent analytical performance for the quantitative detection of CEA.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xue Liu, Xiuzhai Chen, Xu Zhu, Qing Lin, Xi Pan, Xiaolei Tan, Yongfeng Guo, Jun Qiu, Song Fang
Summary: In this study, ELISA and TRFIA methods were established for the detection and monitoring of quinclorac residue in the environment. The results of both methods were consistent with those of the referenced UPLC-MS/MS method, and they showed good detection performance that met the requirements of quinclorac quantitative determination.
Article
Biochemical Research Methods
Xiaomei Yu, Lingli Chen, Bo Lin, Li Zhang, Xue Yang, Xiaobin Liu, Pengguo Xia, Yueming Liu, Shaoxiong Zheng, Xiumei Zhou, Yigang Wang, Yuan Qin, Liang Wang, Zhigang Hu, Qiang He, Biao Huang
Summary: The aim of this study was to develop a wide detection range Gal-3-TRFIA assay and explore the elevated Gal-3 concentration in serum of patients with IMN.
JOURNAL OF FLUORESCENCE
(2022)
Article
Multidisciplinary Sciences
Archie F. A. Bott, Petros Tzeferacos, Laura Chen, Charlotte A. J. Palmer, Alexandra Rigby, Anthony R. Bell, Robert Bingham, Andrew Birkel, Carlo Graziani, Dustin H. Froula, Joseph Katz, Michel Koenig, Matthew W. Kunz, Chikang Li, Jena Meinecke, Francesco Miniati, Richard Petrasso, Hye-Sook Park, Bruce A. Remington, Brian Reville, J. Steven Ross, Dongsu Ryu, Dmitri Ryutov, Fredrick H. Seguin, Thomas G. White, Alexander A. Schekochihin, Donald Q. Lamb, Gianluca Gregori
Summary: Understanding magnetic field generation and amplification in turbulent plasma is crucial for explaining observations of magnetic fields in the universe. This study validates a theoretical framework for the origin and sustainment of these fields, and reports an experiment on laboratory plasma dynamo with Pm & 1. By characterizing plasma evolution and measuring various properties, it is shown that plasma turbulence from strong shear can generate fields more efficiently than previously thought, potentially explaining large-scale fields in astrophysical systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Xianxian Zhao, Ye Yuan, Xiaoya Liu, Fajiang Mao, Ge Xu, Qingzhong Liu
Summary: The development of a versatile and sensitive analytical biomarker detection platform is crucial for early disease diagnosis and treatment. In this study, a novel fluorescence-based, ultrasensitive, and label-free biomarker detection platform is proposed. This platform demonstrates high sensitivity and specificity, and shows great potential in clinical diagnosis and anticancer drug development.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mingjing Zou, Yan Gong, Xinxin Sun, Caifeng Ding
Summary: Simultaneous assay of multiple tumor marker proteins is important for accurate cancer diagnosis. In this study, yellow and blue carbon dots were prepared, and magnetic beads modified with aptamers were used for the simultaneous detection of CEA and CA125 in real samples. The fluorescence intensities of the carbon dots at specific wavelengths were measured to obtain the detection limits of the two proteins. This method showed good specificity, ease of operation, and correlation with existing electrochemiluminescent immunoassay results, making it a promising candidate for clinical diagnosis of ovarian cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biotechnology & Applied Microbiology
Yuan Ji, Liwei Hu, Wei Xiong, Ying Wang, Fei Yang, Mowen Shi, Haiyan Zhang, Jimin Shao, Canhua Lu, Dunhuang Fang, Huimin Deng, Zhaoyang Bian, Gangling Tang, Shili Liu, Ziyan Fan, Shanshan Liu
Summary: This study established a rapid and sensitive method for onsite detection of Alternaria longipes in tobacco samples. The method offers high accuracy, specificity, and repeatability, allowing quick responses towards disease control and elimination of phytopathogens.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Oncology
Hua-qiang Zhu, Dong-ye Wang, Lin-shen Xu, Jian-le Chen, Er-wei Chu, Cai-jin Zhou
Summary: This study aimed to investigate the diagnostic value of enhanced magnetic resonance imaging (MRI) combined with carcinoembryonic antigen (CEA) and carbohydrate antigen in detecting liver metastasis of colorectal cancer. The results showed that the combination of MRI and CEA had high specificity and positive predictive value, while the combination of MRI and parallel CEA had high sensitivity and negative predictive value. These combinations can exclude non-metastatic patients and identify colorectal cancer patients with liver metastasis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Analytical
Kexin Sun, Junlong Li
Summary: CEA is a widely used tumor marker, especially for gastrointestinal cancers like colorectal malignancy. The current methods for CEA detection are limited by high costs and long waiting times. By altering the secondary structure of fluorescent modified DNA, a new method for CEA detection was established, providing a simple, fast, and cheap sensing platform for biomarkers detection. This method shows great potential in tumor screening among populations and may have prospective effects on tumor treatment.
Article
Oncology
Qian Xie, Huiling Guo, Peirong He, Huan Deng, Yanjun Gao, Ningning Dong, Wenbo Niu, Tiancai Liu, Ming Li, Suihai Wang, Yingsong Wu, Ji-Liang Li
Summary: High expression of Tspan5 is significantly associated with clinicopathological features and poor survival in HCC patients, promoting cell migration and tumour metastasis. Mechanistically, Tspan5 enhances ADAM10 enzymatic activity, activates Notch signaling, and induces epithelial-mesenchymal transition in tumour cells. These findings highlight the pivotal role of Tspan5 in regulating Notch signaling, EMT, and tumour metastasis in HCC.
MOLECULAR ONCOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Yongjun Liang, Liping Huang, Tiancai Liu
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Tiancai Liu, Yongjun Liang, Liping Huang
Summary: mRNA vaccine development has made significant progress in individualized tumor vaccines. While the production process is simple and safety profiles are good, inherent limitations such as degradation and side effects still exist. Appropriate carriers can enhance immune responses, improve biocompatibility, and biosafety.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zibo Li, Qing Xu, Xuefeng Lin, Kunyi Yu, Ling Lin, Yangjia Liu, Zhiqiang Yu, Tiancai Liu, Dixian Luo
Summary: A promising liposomal drug CholesPt(IV)-Liposomes was synthesized to overcome the limitations of platinum-based anticancer agents, such as poor water-solubility and chemoresistance. The liposomes showed small particle size, rapid release of platinum ions, and significant apoptosis of cancer cells. In animal experiments, CholesPt(IV)-Liposomes demonstrated better therapeutic effect and reduced drug toxicity compared to traditional platinum drugs.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemical Research Methods
Lun Bian, Yufeng Xiong, Hui Zhao, Huiling Guo, Zhaoyue Li, Ke Ye, Zhigao Zhang, Tiancai Liu, Yingsong Wu, Guanfeng Lin
Summary: In this study, a Eu (III) chelate nanoparticles based lateral flow immunoassay was developed to achieve real-time monitoring of Cys C concentration in serum within 15 min. This method showed a wide detection range and a low limit of detection, and exhibited satisfactory correlation with chemiluminescence immunoassay.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Chemistry, Analytical
Yue Cao, Zhenhua Chen, Xijiu Li, Zhaoyue Li, Guanfeng Lin, Tiancai Liu, Yingsong Wu
Summary: The dual-color quantum dots-loaded nanoparticles based lateral flow biosensor offers high accuracy by eliminating heterogeneity caused by different membrane locations, showing success in detecting pepsinogen with ultra-low limits of detection. The capability and reliability of the multiplex biosensor are validated, demonstrating negligible crosstalk and cross-reaction during simultaneous detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Immunology
Lixia Gao, Jie Yang, Jutao Feng, Ziying Liu, Ying Dong, Jiangyan Luo, Liangzhentian Yu, Jiamei Wang, Hongying Fan, Weifeng Ma, Tiancai Liu
Summary: This study developed a novel strategy to suppress HBV DNA replication and eliminate cccDNA by preparing biomimetic nanoparticles with high targeting ability. The nanoparticles showed excellent stability and safety property, and exhibited significant inhibitory effects on various CHB-related markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Lun Bian, Zhaoyue Li, An He, Biru Wu, Hui Yang, Yingsong Wu, Fang Hu, Guanfeng Lin, Deqing Zhang
Summary: The researchers developed an ultrabright nanoparticles-based lateral flow immunoassay for rapid semi-quantitative detection of anti-SARS-CoV-2 neutralizing antibodies in serum samples. The method accurately identified negative and positive samples with high precision. The study highlights the practical value of the established assay in assessing acquired protective immunity against SARS-CoV-2.
Article
Biotechnology & Applied Microbiology
Xiaoyan Zhang, Jingxin Li, Tiancai Liu, Min Zhao, Baozhu Liang, Hong Chen, Zhen Zhang
Summary: This study analyzed the differential gene expression profiles of liver tissue after bariatric surgery, revealing the impact of surgery on gene expression. Functional enrichment analysis indicated the involvement of differentially expressed genes in immune response. Through the identification of hub genes and the analysis of immune cell infiltration, the study found that one gene, LCP1, was correlated with specific immune cells. These findings are of great significance in further understanding the therapeutic mechanisms of bariatric surgery in NAFLD and NASH and identifying new biomarkers and therapeutic targets.
Article
Medicine, Research & Experimental
Zhi-Wei Guo, Qing Liu, Xu Yang, Geng-Xi Cai, Bo-Wei Han, Li-Min Huang, Chun-Xi Li, Zhi-Kun Liang, Xiang-Ming Zhai, Li Lin, Kun Li, Min Zhang, Tian-Cai Liu, Rui-lin Pan, Ying-Song Wu, Xue-Xi Yang
Summary: The study found that promoter profiling based on nucleosome footprints of cell-free DNA (cfDNA) can be used to evaluate the axillary lymph node status in breast cancer patients. By developing a classifier with multiple machine learning models, it is possible to accurately distinguish between lymph node-positive and lymph node-negative patients and guide the choice of cancer treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zichang Dai, Qiyuan Huang, Xueran Huang, Chuiyu Zhu, Kashif Rafiq Zahid, Tiancai Liu, Qiuyan Li, Chunmei Wu, Minghui Peng, Xiangyan Xiao, Umar Raza, Nan Yu, Tao Zeng
Summary: The expression of KIN17 is significantly increased in HCC and is associated with tumor progression and metastasis. KIN17 promotes migration and invasion of HCC cells by stimulating the TGF-beta/Smad2 pathway. It could serve as a potential therapeutic target and prognostic biomarker in HCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Chemistry, Multidisciplinary
Chao-Qing Li, Xiao-Lin Hou, Dong-Xue Jiang, Bin Zhang, Meng-Wen Ma, Xiao-Ting Xie, Yuan-Di Zhao, Tian-Cai Liu, Bo Liu
Summary: PT has excellent photothermal conversion capacity, good biocompatibility, and efficient targeting ability after cell membrane coating, can effectively inhibit breast tumors and relieve inflammation.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Biao Li, Wan Li, Tiancai Liu, Longying Zha
Summary: Noncommunicable diseases (NCDs), such as diabetes, can be transmitted in vivo through extracellular vesicles (EVs), despite not being directly transmissible. Insulin resistance, a common issue caused by a long-term high-fat diet, can lead to various health problems like hyperlipidemia, type 2 diabetes mellitus (T2DM), and diabetic peripheral neuropathy (DPN). Current treatments focus on improving insulin sensitivity, but exploring the role of EVs in insulin resistance may provide new preventive and therapeutic strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Materials Science, Biomaterials
Chun Wu, Xuancheng Du, Bingqing Jia, Chengmei Zhang, Weifeng Li, Tian-Cai Liu, Yong-Qiang Li
Summary: The study introduces a synergistic strategy for potentiated cancer radiation/gene therapy using transformable gold nanocluster aggregates. By leveraging the size transformation of the nanocluster and survivin gene interference, the radio-sensitivity of tumor cells can be significantly improved, leading to enhanced tumor radiation therapy efficacy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)
