Article
Biochemical Research Methods
Vijay Kumar Yadav, Tanurup Das, Abhimanyu Harshey, Murali Manohar Yadav, Kriti Nigam, Ankit Srivastava
Summary: This study examined the efficiency of different matrices and solvents in detecting diesel residue, finding that diethylether extracted more diesel residues compared to hexane. Tiles and cotton were found to be better matrices for extraction in hexane, while diethylether was able to significantly detect diesel residues in tiles, wood, and cotton. These findings can assist investigators in choosing suitable matrices and solvents for diesel residue extraction in forensic arson investigation.
Article
Chemistry, Applied
Maribel Alexandra Quelal-Vasconez, Riccardo Macchioni, Greta Livi, Edgar Perez-Esteve, Maria Jesus Lerma-Garcia, Pau Talens, Jose Manuel Barat, Mikael Agerlin Petersen, Rasmus Bro
Summary: This study utilized a non-target approach and chemical analysis techniques to analyze and evaluate the volatile compounds in natural and alkalized cocoa powders, aiming to understand their characteristics and differentiate between different samples. The results showed that the proposed comprehensive analysis method is effective for quality control of cocoa powders, with significant time and cost savings.
Article
Food Science & Technology
Jian Liang, Jianghao Sun, Pei Chen, Jared Frazier, Virginia Benefield, Mengliang Zhang
Summary: This study applied various analytical methods to analyze black pepper samples and successfully classified them based on their origins. The application of TD-DART-MS in analyzing plant-based food materials was demonstrated as a simple and high throughput method for classification studies.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Berta Baca-Bocanegra, Leticia Martinez-Lapuente, Julio Nogales-Bueno, Jose Miguel Hernandez-Hierro, Raill Ferrer-Gallego
Summary: Polysaccharides play a critical role in stabilizing and modifying the properties of wines. This study evaluates the use of Fourier transform infrared spectroscopy (FTIR) as a fast and non-destructive method for determining wine polysaccharides. The developed models show the potential of FTIR analysis for routine screening of different types of polysaccharides in wine samples.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Yuling Wu, Zhanming Li, Hui Zhu, Run Zi, Fang Xue, Yue Yu
Summary: Tartary buckwheat has attracted more attention due to its unique chemical composition and higher efficacy in disease prevention. However, counterfeiting and adulteration of Tartary buckwheat with common buckwheat is common, leading to consumer harm and market disruption. This study used metabolomics technology to develop a new and simple identification method for Tartary buckwheat and common buckwheat, revealing differential metabolic pathways between the two. This research has important implications for quality control of related agricultural products.
Article
Chemistry, Analytical
Maciej Tankiewicz, Andrzej Berg
Summary: In this study, an enhanced methodology for the determination of 31 currently used pesticides in food samples was proposed. The method involves the use of QuEChERS coupled with GC-MS/MS, and an additional extract preconcentration step to improve the limits of quantification. The validated procedure has been successfully applied to various fruit and vegetable samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Juliana Melo Duarte, Nadia Gabrielle Silva Sales, Jez Willian Batista Braga, Candice Bridge, Mark Maric, Marcelo Henrique Sousa, Juliano de Andrade Gomes
Summary: The aim of this study was to develop a methodology to distinguish automotive paint samples based on the make of the vehicle and its color shade. In-situ analysis of 143 white samples was conducted using Fourier transform infrared spectroscopy and coupled microscopy. Principal component analysis and partial least squares discriminant analysis were used for data analysis, resulting in high classification accuracy.
Article
Chemistry, Applied
Mostafa H. Baky, Samir Nabhan Shamma, Jianbo Xiao, Mohamed Farag
Summary: This study explored the aroma and nutrient profiles of six cruciferous vegetables and found extensive variation among them. The differences provided a basis for distinguishing these vegetables, and several new markers were discovered. Additionally, this study compared the edible and inedible parts of cruciferous vegetables for the first time, suggesting new potential uses as functional foods.
Article
Spectroscopy
Ana Luisa de Queiroz Baddini, Jorge Luiz Victor de Paula Santos, Raquel Reiner Tavares, Leticia Silva de Paula, Hiram da Costa Araujo Filho, Renato P. Freitas
Summary: In this study, historical pigments of green hue were analyzed using various spectroscopic techniques, and classification models were developed to automate the characterization of pigments in mixtures. The fusion of data from three spectroscopic techniques allowed for effective classification of the pigments in samples, providing fingerprints that may not be obtained using only one or two techniques.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Sara M. de Cripan, Adria Cereto-Massague, Pol Herrero, Andrei Barcaru, Nuria Canela, Xavier Domingo-Almenara
Summary: In this study, a rationalized framework for machine learning-based retention time prediction of trimethylsilyl derivatives of metabolites in gas chromatography was developed. Different machine learning paradigms were compared, and the influence of computational molecular structure representation on the prediction models was explored. The study demonstrated that machine learning can accurately predict retention time, providing insights into the true structure of unknown metabolites, and set the guidelines to assess confidence in metabolite identification using predicted retention time data.
Article
Biochemistry & Molecular Biology
Mohamed A. Farag, Tarik A. Mohamed, Enas A. El-Hawary, Amr Abdelwareth
Summary: Luwak coffee, known as civet coffee, is a precious and exotic type of coffee. This study used a comparative metabolomics approach to analyze the secondary and aroma metabolites of Luwak coffee and other coffee products. The results showed that Luwak coffee is derived from C. arabica and identified several new markers. Aroma analysis revealed higher levels of guaiacol derivatives, pyrazines, and furans in roasted Luwak coffee compared to roasted C. arabica. Quantification using NMR found lower levels of alkaloids in Luwak coffee compared to C. arabica.
Article
Chemistry, Applied
Dai-xin Yu, Xia Zhang, Sheng Guo, Hui Yan, Jie-mei Wang, Jia-qi Zhou, Jian Yang, Jin-Ao Duan
Summary: This study used headspace gas chromatography-mass spectrometry and fast gas chromatography electronic nose to distinguish the varieties and geographical origins of dried gingers from seven major production areas in China. The results showed that the combination of chemometric analysis and flavor information extracted by fast GC e-nose can accurately identify the varieties and geographical origins of ginger.
Article
Chemistry, Analytical
Hui-Dan Hou, Cheng-Ying Wu, Jing Zhou, Jin-Di Xu, Fang Long, Jin-Hao Zhu, Shan-Shan Zhou, Wei Zhang, Qian Mao, Hong Shen, Zi-Qi Shi, Ying-Jie Wei, Song-Lin Li
Summary: A comprehensive strategy integrating multiple chromatographic and chemometric methods was developed to evaluate the holistic quality of commercial Agastache rugosa. The study revealed differences in the composition and content of volatile components among commercial samples, while the compositions of non-volatile components were generally similar with some variations in content. The classification of commercial samples was primarily determined by the volatile components. Further investigation is needed to determine the impact of holistic quality variations on the efficacy of Agastache rugosa.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Applied
Ahmed Zayed, Amr Abdelwareth, Tarik A. Mohamed, Heba A. Fahmy, Andrea Porzel, Ludger A. Wessjohann, Mohamed A. Farag
Summary: This study used a metabolomics approach to analyze commercial coffee products in the Middle East region, revealing changes in metabolites in these products which can aid in evaluating and standardizing coffee quality.
Article
Chemistry, Analytical
Daniele C. G. C. Kunze, Tereza C. M. Pastore, Hugo S. Rocha, Priscila Veras Dos Anjos Lopes, Rafaela Dornelas Vieira, Vera T. R. Coradin, Jez W. B. Braga
Summary: The combination of NIRS technology and multivariate methods can differentiate wood from different forest species and determine their provenance. By using external parameter orthogonalization (EPO), the effect of moisture on wood spectra can be minimized, resulting in improved analysis efficiency and reduced outlier rates. EPO and soft-PLS-DA are effective strategies for enabling the application of NIR technology in field conditions, such as in monitoring illegal timber trade.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Seo Lin Nam, A. Paulina de la Mata, Ryan P. Dias, James J. Harynuk
Article
Automation & Control Systems
Michael Sorochan Armstrong, A. Paulina de la Mata, James J. Harynuk
Summary: Cluster resolution (CR) is a useful metric for guiding automated feature selection in classification models, measuring class separation through confidence ellipses of variable subsets. This study introduces a numerical determination method for the CR metric, reducing computation time significantly and simplifying the operating principles of the FS-CR algorithm.
JOURNAL OF CHEMOMETRICS
(2021)
Article
Chemistry, Analytical
Lawrence A. Adutwum, Joanna Koryo Kwao, James J. Harynuk
Summary: Comprehensive gas chromatography with time of flight mass spectrometry is a powerful tool for analyzing complex samples. Chemometric analysis of raw chromatographic data is more useful in one- and two-dimensional separations. Data reduction tools are necessary due to the volume of data generated by such experiments. The unique ion filter reduces data redundancy and increases model prediction accuracy.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Chemistry, Analytical
Seo Lin Nam, A. Paulina de la Mata, James J. Harynuk
Summary: Comprehensive two-dimensional gas chromatography mass spectrometry is a powerful tool for analyzing complex mixtures, but there may be matching issues when using unit mass resolution mass spectrometers. Scripting tools can be used to quickly classify major compound groups.
Article
Polymer Science
Christina Anna Braun, Seo Lin Nam, Aidee Paulina de la Mata, James Harynuk, Hyun-Joong Chung, Patricia Isabelle Dolez
Summary: This study investigates the hydrothermal aging process of a commercial polyimide film and reveals the mechanism of property loss in the presence of moisture. Through measurements of ATR-FTIR, ultimate tensile strength, and percent elongation at break at different temperatures, the study identifies significant trends and degradation mechanisms of the aging process.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Chungyeon Cho, Seo Lin Nam, A. Paulina de la Mata, James J. Harynuk, Anastasia L. Elias, Hyun-Joong Chung, Patricia I. Dolez
Summary: This study investigates the thermal aging behavior of a high-temperature resistance polymer, polyetherimide (PEI), at elevated temperatures in air. Changes in the ultimate tensile strength (UTS), glass transition temperature, and surface properties are observed, with an activation energy of 112 kJ mol(-1) identified for the effect of thermal aging on the mechanical strength of PEI. These findings suggest the potential use of PEI as a sensing material for the development of end-of-life sensors for fire-protective fabrics.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Max Loebel Roson, Ryan Duruisseau-Kuntz, Meng Wang, Keifer Klimchuk, Robin J. Abel, James J. Harynuk, Ran Zhao
Summary: Biomass burning is a major source of ultrafine particulate matter in the atmosphere, contributing to global health risks and climate change. Chemical analyses of emissions from biomass burning show that emissions from cow dung are consistently lower in levoglucosan than emissions from wood. The study highlights the need for further research on biomass types less common in Western contexts.
ACS EARTH AND SPACE CHEMISTRY
(2021)
Article
Engineering, Environmental
Shuang Wu, Siti K. Hayati, Erica Kim, A. Paulina de la Mata, James J. Harynuk, Chen Wang, Ran Zhao
Summary: Microbial volatile organic compounds (MVOCs) play a significant role in indoor air quality. The involvement of surface reservoirs in indoor chemistry has been recognized, but reliable partition coefficients are lacking for many MVOCs. This study experimentally determines the H values and their temperature dependence for key MVOCs, predicting the indoor phase distribution and potential exposure pathways.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Natalie E. Diether, Seo Lin Nam, Janelle Fouhse, Bich Le Thanh, Paul Stothard, Ruurd T. Zijlstra, James Harynuk, Paulina de la Mata, Benjamin P. Willing
Summary: Addition of benzoic acid and enzymes in pig diets can impact gut microbiota and metabolome, potentially supporting health and reducing diarrhea incidence in weaned pigs.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemical Research Methods
Ryland T. Giebelhaus, Michael D. Sorochan Armstrong, A. Paulina de la Mata, James J. Harynuk
Summary: Analyzing gas chromatography - mass spectrometry (GC-MS) data comes with many challenges, such as the difficulty in recovering molecular information due to electron ionization, the presence of common fragment ions among closely-eluting peaks, and the need for expert user intervention. This article proposes a new method for automated region of interest selection that considers the multivariate information in GC-MS data. The algorithm achieved high sensitivity in detecting features in a chromatogram at low concentrations.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemistry & Molecular Biology
Lea Farouil, Ryan P. Dias, Gianni Popotte-Julisson, Garrick Bibian, Ahissan Innocent Adou, A. Paulina de la Mata, Muriel Sylvestre, James J. Harynuk, Gerardo Cebrian-Torrejon
Summary: This study analyzed the essential oil from the leaves of Zanthoxylum caribaeum growing in Guadeloupe. Thirty molecules were identified, some of which showed antimetabolic effects. This research is significant for further exploring the application of this plant and its essential oil in metabolic diseases.
Article
Chemistry, Applied
Ryland T. Giebelhaus, Kieran Tarazona Carrillo, Seo Lin Nam, A. Paulina de la Mata, Juan F. Araneda, Paul Hui, Jonathan Ma, James J. Harynuk
Summary: Olive oil, commonly used in cooking, cosmetics, and soaps, is sometimes adulterated with cheaper non-olive oils to increase profitability. This study explores the use of low-field benchtop NMR with a chemometrics workflow to quantify non-olive oils in authentic extra virgin olive oil samples. 17 different varieties of non-olive oils were investigated and the models showed high linearity, accuracy, and precision, detecting most adulterant oils below 10% v/v in olive oil samples.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Forestry
Isabelle Duchesne, Dikshya Dixit Lamichhane, Ryan P. Dias, Paulina de la Mata, Martin Williams, Manuel Lamothe, James J. Harynuk, Nathalie Isabel, Alain Cloutier
Summary: Illegal logging and trade are increasing globally, posing a major threat to forests and society. Wood identification methods are needed to prevent illegal imports and differentiate regulated tree species. This study explored the use of metabolomic profiling and wood anatomy to identify CITES-regulated wood specimens. The findings suggest that GC3GC-TOFMS-based metabolomic profiles could complement wood anatomy in differentiating genus and species.
WOOD AND FIBER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Seo Lin Nam, Kieran Tarazona Carrillo, A. Paulina de la Mata, James J. J. Harynuk
Summary: The metabolic profiles of human feces, which can be used for early detection of gut diseases, are influenced by various genetic and environmental factors. However, there is a lack of consensus on methods to collect, prepare, and analyze feces. To accelerate the field, a metabolomics stool reference material is needed.
Article
Endocrinology & Metabolism
Seo Lin Nam, Kieran Tarazona Carrillo, A. Paulina de la Mata, Olle M. de Bruin, Evgueni Doukhanine, James Harynuk
Summary: This study investigated the effects of sample handling conditions on fecal metabolite profiles and abundances using GCxGC-TOFMS. The results showed that sample handling and processing conditions had a significant impact on the metabolic profiles of fecal samples, with a more pronounced effect on results obtained by SPME than by TMS derivatization. Overall, lyophilization resulted in a greater amount of total and class-specific metabolites. Therefore, snap-freezing at -80 degrees C would be preferred over lyophilization for handling fecal samples in the field of fecal metabolomics as this imparts the least change from the fresh condition.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)