Article
Chemistry, Analytical
Ming-Nan Chien, Yu-Jen Chen, Chin-Han Bai, Jung-Tung Huang
Summary: In this research, a continuous blood glucose monitoring system (CGMS) is developed, which includes a microneedle-array blood glucose sensor, a circuit module, and a transmission module placed in a wearable device. The system enables continuous blood glucose sensing and wireless data transmission. Through various experiments and analyses, the feasibility and effectiveness of the system are demonstrated.
Article
Biophysics
Xiaofeng Jin, Guanhua Li, Tailin Xu, Lei Su, Dan Yan, Xueji Zhang
Summary: Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Jian Yang, Xia Gong, Shuijin Chen, Ying Zheng, Lelun Peng, Bin Liu, Zhipeng Chen, Xi Xie, Changqing Yi, Lelun Jiang
Summary: Continuous glucose monitoring (CGM) is highly desirable for diabetes management to track blood glucose fluctuation and reduce the risk of hyperglycemia and hypoglycemia. In this study, a smartphone-controlled and microneedle-based wearable CGM system was developed for long-term glucose monitoring. The system, modified with a sandwich-type enzyme immobilization strategy, demonstrated good performance, costing less than $15 and correlating well with commercial glucometers and FDA-approved CGM systems. The intelligently wearable CGM system accurately monitored glucose fluctuations and provided valuable clinical information, offering an alternative solution for home-care diabetes management.
Article
Chemistry, Analytical
Lanjie Lei, Chengtao Xu, Xing Dong, Biao Ma, Yichen Chen, Qing Hao, Chao Zhao, Hong Liu
Summary: Conventional enzyme-based glucose sensors using dissolved oxygen as the electron-transfer mediator may cause biased detection results, affect sensor response, and compromise long-term stability due to fluctuation of oxygen and continuous production of corrosive hydrogen peroxide. In this study, we introduce an oxygen-independent nonenzymatic glucose sensor based on water splitting-assisted electrocatalysis, which shows acceptable sensitivity, reliability, and biocompatibility for continuous glucose monitoring in hypoxic environments. This technique holds promise for monitoring glucose in clinically hypoxic patients.
Article
Chemistry, Analytical
Lanjie Lei, Chao Zhao, Xiaofei Zhu, Shuai Yuan, Xing Dong, Yinxiu Zuo, Hong Liu
Summary: The study presents a nonenzymatic electrochemical sensor for wearable glucose monitoring, which demonstrates acceptable selectivity and reliability for continuous glucose detection up to 30 days, as well as good biocompatibility. A fully integrated wearable glucose monitoring system with wireless connectivity to a smartphone has been developed.
Article
Biophysics
Yanxiang Cheng, Xia Gong, Jian Yang, Guizhou Zheng, Ying Zheng, Yanjun Li, Yunsheng Xu, Gang Nie, Xi Xie, Meiwan Chen, Changqing Yi, Lelun Jiang
Summary: A touch-actuated biosensor was developed for monitoring glucose in interstitial fluid, using a combination of skin penetration and reverse iontophoresis extraction. The biosensor showed significant improvement in glucose extraction flux compared to traditional reverse iontophoresis, both in vitro and in vivo. The integration of this biosensor, a wireless electrochemical detector, and a smartphone application enabled the development of a wearable glucose monitoring system, which showed high correlation with commercially available blood glucometer results.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Qingmei Xu, Chongwei Zou, Chengtao Sun, Xingguo Zhang, Haixia Yu, Dachao Li
Summary: This paper presents a miniaturized and automatic optofluidic system for accurate and high-precision monitoring of glucose concentration in microvolume ISF samples. The system achieved high precision for automatic and continuous monitoring of glucose, showing great promise for continuous monitoring of blood glucose concentration.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Ernesto De la Paz, Tamoghna Saha, Rafael Del Cano, Sumeyye Seker, Nikhil Kshirsagar, Joseph Wang
Summary: A wearable epidermal adhesive patch was developed for non-invasive collection and analysis of interstitial fluid (ISF) lactate. The patch integrates a reverse iontophoretic system and an amperometric lactate biosensor, allowing simultaneous ISF lactate extraction and quantification. The device successfully collected lactate from rested individuals with no discomfort or irritation to the skin. This all-in-one platform represents the first demonstration of non-invasive collection and subsequent analysis of lactate from iontophoretically extracted ISF.
Article
Chemistry, Analytical
Yiqun Liu, Li Yang, Yue Cui
Summary: Diabetes is a prevalent and chronic metabolic disease, and continuous monitoring is crucial for its management. Transdermal glucose biosensors offer accurate monitoring, but face challenges in biosensing principles, device configuration, and material integration. This review aims to address these questions and explore the practical applications of transdermal glucose biosensors.
Article
Chemistry, Physical
Wenrui Zhang, Junlin Ma, Fanxing Meng, Yu Jiang, Liuxue Shen, Tongrui Sun, Yanan Qin, Nan Zhu, Minwei Zhang
Summary: The successfully synthesized core-shell Prussian blue nanomaterials with high electrochemical activity, water solubility, and stability were used to construct wearable sensors using screen printing technology for the detection of biomarkers with high sensitivities. The combination of microfluidic technology is expected to enable large-scale health management monitoring and clinical applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Biochemical Research Methods
Brince Paul Kunnel, Silvia Demuru
Summary: Simultaneous access to different biofluids allows for accurate analysis of multiple analytes, enabling precise diagnosis and appropriate medication. Establishing a relationship between markers in different biofluids and blood biomarkers aids in non-invasive diagnosis. However, the challenge lies in the advanced microfluidic coupled device design. To address this, an epidermal wearable bio-fluidic patch is presented, which enables simultaneous extraction, sampling, and storage of sweat and interstitial fluid, as well as monitoring of their corresponding counterions.
Article
Engineering, Electrical & Electronic
Jinze Li, Xin Liu, Hao Sun, Liming Wang, Jianqi Zhang, Xi Huang, Li Deng, Jiawei Xi, Tianhong Ma
Summary: The immobilization of enzymes is a key factor in biosensor development. This study successfully used the electrospinning method to immobilize enzymes on optical fiber sensors, demonstrating high sensitivity in detecting glucose with promising potential for further development.
IEEE SENSORS JOURNAL
(2021)
Review
Chemistry, Analytical
Xichen Yuan, Oumaima Ouaskioud, Xu Yin, Chen Li, Pengyi Ma, Yang Yang, Peng-Fei Yang, Li Xie, Li Ren
Summary: Healthcare technology enables individuals to monitor and track physiological and biological parameters. With the increasing use of the internet of things and big data, wearable biosensors have shown immense potential in accessing human body information and analyzing physiological and biochemical data, leading to improved personalized and efficient healthcare. This review summarizes biomarkers in interstitial fluid, discusses extraction methods, and explores the application of epidermal wearable biosensors for continuous monitoring of clinical biology markers. Current needs, development prospects, and challenges are briefly discussed.
Review
Chemistry, Multidisciplinary
Tamoghna Saha, Rafael Del Cano, Kuldeep Mahato, Ernesto De la Paz, Chuanrui Chen, Shichao Ding, Lu Yin, Joseph Wang
Summary: With the increasing diabetic population, the demand for glucose sensing devices has risen. Electrochemical biosensors show great potential for real-time glucose monitoring. Wearable devices have opened opportunities for noninvasive glucose monitoring. This review provides a comprehensive report on the status and potential of wearable electrochemical sensors for on-body glucose monitoring.
Article
Biotechnology & Applied Microbiology
Laila Hossain, Marisa De Francesco, Patricia Tedja, Joanne Tanner, Gil Garnier
Summary: This study presents a new generation of nanocellulose coated-paper sensors for measuring glucose concentration in blood. The sensors are rapid, easy to use, and robust, and utilize nanocellulose gel to store and stabilize enzymes. The sensors produce a color change from red to orange in response to changes in blood glucose concentration. The prototype device designed based on these sensors can instantly measure glucose concentration from blood.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)