Journal
ANALYTICA CHIMICA ACTA
Volume 655, Issue 1-2, Pages 1-7Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2009.09.038
Keywords
Spiropyran; Metal ions; Probe; Cooperative interaction
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Funding
- National Outstanding Youth Foundation of China [20525518]
- National Natural Foundation of China [20775005]
- Hong Kong Research Grant Council [HKBU 200407]
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Spiropyrans are an attractive starting point in design of optical approaches for metal ions sensing. However, the high background in aqueous solution and non-specific chelation of the spiropyran with heavy metal ions has hindered their application as reliable sensors for environmental and biological species. Here, we report on a new spiropyran-based approach for sensitive and selective sensing of Hg2+ in aqueous solution, based on cooperative ligation interactions among the spiropyran probe, an intermediate, cysteine, and the metal ion. To test the feasibility of this design, three spiropyran scaffolds, L1-L3, with different ligation functions at the 8'-position were examined as model systems. The results demonstrate that by using cysteine, a potential ligand of Hg2+, the spiropyran could detect 1.0 x 10(-7) M Hg2+ in aqueous solution. Due to the specific metal-amino acid interaction, the approach exhibits selective response toward Hg2+ over other metal ions and anions, although possible interference from Cu2+ has to be considered at the high level of the metal ion. This approach has been used for the determination of Hg2+ in water samples containing potential interferents with satisfactory recovery. (C) 2009 Elsevier B.V. All rights reserved.
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