Article
Biochemistry & Molecular Biology
George Jitca, Erzsebet Fogarasi, Bianca-Eugenia Osz, Camil Eugen Vari, Amelia Tero-Vescan, Amalia Miklos, Madalina-Georgiana Batrinu, Carmen Maria Rusz, Mircea Dumitru Croitoru, Maria Titica Dogaru
Summary: A HPLC/DAD method was developed for the determination and quantification of MDA in the brain of rodents, showing good linearity, precision, and accuracy. The method was successfully applied in a study of chronic toxicology following different treatment regimens, demonstrating its reliability and effectiveness.
Article
Chemistry, Analytical
Xin Wang, Di Su, Chunyu Liu, Ping Li, Ran Zhang, Wen Zhang, Wei Zhang, Bo Tang
Summary: This study developed a two-photon fluorescent agent, TFCH, to simultaneously visualize the presence of MDA and FA in living brains. By using TFCH, researchers observed the synchronous increase of MDA and FA in PC12 cells and the brains of mice with depression.
ANALYTICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Tanja Veljovic, Milanko Djuric, Jelena Mirnic, Ivana Gusic, Aleksandra Maletin, Bojana Ramic, Isidora Neskovic, Karolina Vukoje, Snezana Brkic
Summary: This study compared salivary and plasma MDA levels in periodontitis patients with healthy controls and evaluated the effectiveness of periodontal therapy. The results showed higher levels of salivary and plasma MDA in the periodontitis group, and a significant decrease in salivary MDA levels after periodontal therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Zhenzhen Xie, James D. Morris, Stephanie J. Mattingly, Saurin R. Sutaria, Jiapeng Huang, Michael H. Nantz, Xiao-An Fu
Summary: Analysis of volatile organic compounds (VOCs) in exhaled breath has great potential for disease detection, but the analysis of metabolic VOCs is still challenging. This study presents a method combining ultrahigh-performance liquid chromatography with high-resolution mass spectrometry for analyzing carbonyl metabolites in breath. A silicon microreactor was used to capture carbonyl compounds in exhaled breath, and six subgroups of carbonyl compounds were identified. This method may provide a quantitative approach for identifying disease markers in exhaled breath.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Min Peng, Quan-Rong Du, Xue Yao, Chun-Ni Li, Yang Tian, Yu Peng, Ya-Wen Wang
Summary: A simple fluorescein derivative was synthesized as a fluorescent probe for detecting malondialdehyde (MDA). The probe achieved ring-opening of fluorescein and formation of a benzohydrazide derivative through a synergistic reaction. It exhibited high sensitivity and selectivity for MDA detection, and could quickly and visually detect MDA within 60 s using UV-vis and fluorescent modes. Moreover, the probe showed excellent performance in imaging MDA in living cells and bacteria.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mark C. Chappell, Aja Duncan, Ana Clara Melo, Christopher L. Schaich, Nancy T. Pirro, Debra Diz, E. Ann Tallant, Patricia E. Gallagher
Summary: This study investigates the phenolic composition and concentration of commercial muscadine grape supplements and finds significant variations in antioxidant activity.
Article
Green & Sustainable Science & Technology
Ashutosh Bahuguna, Vishal Kumar, Srinivasan Ramalingam, Anil Kumar Yadav, Myunghee Kim
Summary: Ginger was found to effectively reduce aflatoxins and protect cells from toxicity.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Chemistry, Analytical
Abhishesh Kumar Mehata, M. Nikitha Lakshmi Suseela, Patharaj Gokul, Ankit Kumar Malik, Matte Kasi Viswanadh, Chandrashekhar Singh, Joseph Selvin, Madaswamy S. Muthu
Summary: Antibiotics play a crucial role in preventing and mitigating infectious diseases, but their mass production has led to the accelerated development of antimicrobial resistance. Conventional wastewater treatment methods are inefficient in removing antibiotics, and it is essential to develop highly efficient analytical methods for quantifying antibiotic residues in the environment. This review provides an overview of sampling techniques, purification and enrichment methods for antibiotics from environmental matrices, as well as various analytical methods for the quantification of extracted antibiotics.
MICROCHEMICAL JOURNAL
(2022)
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Elisabetta Zinellu, Sara S. Fois, Barbara Piras, Gianfranco Pintus, Ciriaco Carru, Arduino A. Mangoni, Alessandro G. Fois, Angelo Zinellu, Pietro Pirina
Summary: The study found that the MDA concentrations were significantly higher in patients with obstructive sleep apnea (OSA) compared to controls, indicating that MDA may be involved in the pathogenesis of OSA and providing insights for future research on its potential clinical use.
Review
Biochemistry & Molecular Biology
Niloufar Rasaei, Omid Asbaghi, Mahsa Samadi, Leila Setayesh, Reza Bagheri, Fatemeh Gholami, Neda Soveid, Krista Casazza, Alexei Wong, Katsuhiko Suzuki, Khadijeh Mirzaei
Summary: Green tea supplementation has significant effects on total antioxidant capacity (TAC) in adults, with heterogeneity between studies related to gender and BMI. Meta-regression analysis suggests a linear inverse association between the dosage of green tea and significant change in malondialdehyde (MDA). Further research is needed to validate these findings.
Article
Biochemistry & Molecular Biology
Maud Hemmendinger, Jean-Jacques Sauvain, Nancy B. Hopf, Pascal Wild, Guillaume Suarez, Irina Guseva Canu
Summary: The study optimized a method based on 2,4-dinitrophenylhydrazine for quantifying MDA in EBC, with analytical uncertainty at the LOQ level reaching 23%, yet still lower than the observed inter-individual variability.
Article
Biochemistry & Molecular Biology
George Jitca, Erzsebet Fogarasi, Bianca-Eugenia Osz, Camil Eugen Vari, Ibolya Fulop, Mircea Dumitru Croitoru, Carmen Maria Rusz, Maria Titica Dogaru
Summary: This study successfully developed an HPLC/DAD method for detecting and quantifying GSH and GSSG levels in the rat brain, meeting validation criteria. The method has been applied in a chronic toxicology study of haloperidol under different treatment regimens.
Article
Pediatrics
Gopal Agrawal, Sourabh Dutta, Rajendra Prasad, Mangat Ram Dogra
Summary: Fetal oxidative stress and micronutrient deficiencies are associated with retinopathy of prematurity, with high MDA levels and low micronutrients in cord and maternal blood being predictors of ROP.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Veterinary Sciences
Ana Patricia Alves Leao, Alexandre Vinhas de Souza, Nelson Fijamo Mesquita, Luciano Jose Pereira, Marcio Gilberto Zangeronimo
Summary: This systematic review evaluated the potential benefits of antioxidant enrichment of rooster semen extenders. The findings suggest that antioxidants can reduce oxidative stress and improve fertilizing capacity for roosters.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Ching-Chiang Lin, Hsiu-Shu Hsieh, Yu-Jie Huang, Yeou-Lih Huang, Ming-Kun Ku, Hsin-Chia Hung
Article
Biochemical Research Methods
Guan-Wen Cheng, Keng-Chaing Hsu, Cheng-Fa Lee, Hsin-Lung Wu, Yeou-Lih Huang
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2009)
Article
Biochemical Research Methods
Guan-Wen Cheng, Cheng-Fa Lee, Keng-Chang Hsu, Hsin-Lung Wu, Yeou-Li Huang
JOURNAL OF CHROMATOGRAPHY A
(2008)
Article
Chemistry, Multidisciplinary
Tong-Shung Tsay, Yeou-Lih Huang, Lei-Chang Tseng
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2009)
Article
Public, Environmental & Occupational Health
C-H Pan, C-C Chan, Y-L Huang, K-Y Wu
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2008)
Article
Chemistry, Analytical
Cheng-Fa Lee, Bai-Hsiun Chen, Yeou-Lih Huang
Article
Chemistry, Analytical
Guan-Wen Cheng, Hsin-Lung Wu, Yeou-Lih Huang
Article
Immunology
Ching-Chiang Lin, Chen-Kang Chang, Yeou-Lih Huang, Hung-Fu Tseng
Article
Chemistry, Analytical
Cheng-Hui Lin, Hsin-Lung Wu, Yeou-Lih Huang
ANALYTICA CHIMICA ACTA
(2007)
Meeting Abstract
Public, Environmental & Occupational Health
S. L. Wang, C. J. Chen, K. H. Chang, L. Y. Tsai, Y. L. Huang, W. F. Li
Article
Chemistry, Analytical
Wei-Chang Tseng, Po-Hua Chen, Tong-Shung Tsay, Bai-Hsiun Chen, Yeou-Lih Huang
ANALYTICA CHIMICA ACTA
(2006)
Article
Biochemistry & Molecular Biology
Shun-Jin Lin, Cheng-Fa Lee, Wei-Chang Tseng, Yeou-Lih Huang, Hsin-Lung Wu
BIOLOGICAL TRACE ELEMENT RESEARCH
(2006)
Article
Biochemistry & Molecular Biology
Min-Tzu Chen, Guan-Wen Cheng, Ching-Chiang Lin, Bai-Hsiun Chen, Yeou-Lih Huang
BIOLOGICAL TRACE ELEMENT RESEARCH
(2006)
Article
Biochemistry & Molecular Biology
CW Hu, CH Pan, YL Huang, MT Wu, LW Chang, CJ Wang, MR Chao
FREE RADICAL BIOLOGY AND MEDICINE
(2006)
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)