Article
Polymer Science
Yi-Jung Lu, Han-Yun Hsieh, Wen-Chang Kuo, Pei-Kuen Wei, Horn-Jiunn Sheen, Hidetoshi Tahara, Te-Wei Chiu, Yu-Jui Fan
Summary: The study proposed a multiplex detection system by integrating LSPR sensing array and microfluidic channels, proving successful in detecting different targets in parallel channels.
Article
Nanoscience & Nanotechnology
Yuye Wang, Yurui Hu, Ruibin Xie, Qi Zeng, Yanhang Hong, Xi Chen, Pengcheng Zhang, Lin Zeng, Yi Zhang, Shuwen Zeng, Hui Yang
Summary: miRNAs are important biomarkers for the development and progression of various cancers. Detecting miRNAs is crucial for early-stage diagnostics and prognostics of multiple diseases. This study proposes a MXene-enhanced plasmonic biosensor for real-time and label-free detection of miRNA, with ultrasensitive detection limit and the ability to distinguish single-base mismatched miRNA. The biosensor can detect miRNA in complex media without the need for extra labels or amplification tags, holding great potential in biological applications and clinical diagnostics.
Article
Chemistry, Analytical
Jiri Slaby, Marketa Bockova, Jiri Homola
Summary: A new optical biosensor based on gold nanostripes array excited surface plasmons is presented, with theoretical analysis showing its improved detection sensitivity compared to conventional surface plasmon resonance biosensors. Experimental validation of the theoretical model demonstrates high refractive index sensitivity and resolution of the nanoplasmonic sensor. Additionally, the biosensor successfully detects microRNA biomarkers at low concentrations, showcasing its potential for sensitive and specific biomolecular detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
T. Schoenfeldova, H. Okur, V. Vezocnik, I. Iacovache, C. Cao, M. Dal Peraro, P. Macek, B. Zuber, S. Roke
Summary: This study demonstrates an ultrasensitive method for direct detection of protein binding to liposome membranes using high throughput second harmonic scattering (SHS). The approach allows label-free and noninvasive probing of protein-membrane interactions at sub-picomolar concentrations in 3D systems.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Analytical
Fahad Usman, John Ojur Dennis, A. I. Aljameel, M. K. M. Ali, O. Aldaghri, K. H. Ibnaouf, Zakariyya Uba Zango, Mahnoush Beygisangchin, Ahmed Alsadig, Fabrice Meriaudeau
Summary: Lung cancer is the most common and deadliest cancer globally, and early diagnosis is crucial for survival. Optical biosensors, particularly plasmonic sensors, offer a promising solution for detecting lung cancer biomarkers, providing high sensitivity, freedom from electrical hazards, and multiplexing capability.
Article
Biochemistry & Molecular Biology
Silvia Picciolini, Valentina Mangolini, Francesca Roda, Angelo Montesano, Francesca Arnaboldi, Piergiuseppe Liuzzi, Andrea Mannini, Marzia Bedoni, Alice Gualerzi
Summary: The lack of specific measurable markers of recovery makes it difficult to predict the response of stroke patients to treatment. This study identified a panel of Extracellular Vesicle (EV)-associated molecules that could be used to profile stroke patients at the beginning of rehabilitation and predict their response to treatment. The increased expression of vascular endothelial growth factor receptor 2 (VEGFR2) and translocator protein (TSPO) on small EVs in the blood of subacute ischemic stroke patients suggests their potential as tools for predicting recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Ning Xia, Gang Liu, Xinyao Yi
Summary: This study presented a heterogeneous surface plasmon resonance (SPR) method for protease detection by integrating homogeneous reaction, with enhanced sensitivity through signal amplification of streptavidin (SA)-conjugated immunoglobulin G (SA-IgG).
Review
Chemistry, Analytical
Hasan Kurt, Parsa Pishva, Zeki Semih Pehlivan, Elif Gul Arsoy, Qandeel Saleem, Mustafa Kemal Bayaz, Meral Yuce
Summary: Nanoplasmonic biosensing holds great promise in meeting the demands of the global health industry, offering advantages such as low cost, high sensitivity, real-time detection, and miniaturization. By discussing nanostructure design, material selection, and nanofabrication methods, this review highlights the wide range of clinically relevant applications of nanoplasmonic biosensors, along with the challenges and proposed strategies for clinical translation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nanoscience & Nanotechnology
Yang Xiong, Huatian Hu, Tianzhu Zhang, Yuhao Xu, Fei Gao, Wen Chen, Guangchao Zheng, Shunping Zhang, Hongxing Xu
Summary: We report a quantitative molecular detection method based on surface-enhanced Raman spectroscopy (SERS) that achieves ultrahigh sensitivity in detecting alpha fetoprotein in serum using a nanoparticle-on-mirror plasmonic sensor. By adjusting the gaps between the nanoparticles and the gold film, a uniform and strong SERS enhancement is achieved. The detection limit is 697 times higher than that of the normal excitation method and 7800 times higher than a commercial assay kit, providing a potential solution for the bottleneck in SERS-based biosensing.
Article
Biophysics
Abdelmonaim Azzouz, Lamia Hejji, Ki-Hyun Kim, Deepak Kukkar, Badredine Souhail, Neha Bhardwaj, Richard J. C. Brown, Wei Zhang
Summary: Surface plasmon resonance (SPR) technology is a valuable tool for the detection of cancer biomarkers, offering advantages such as low cost fabrication, sensitivity, label-free detection, and accuracy. Recent research has focused on utilizing SPR biosensing technology for diagnosing various cancer types, evaluating the performance of SPR biosensors in terms of quality assurance criteria. The limitations and future challenges associated with SPR biosensors for cancer biomarker detection are also discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Matthew N. Creyer, Zhicheng Jin, Maurice Retout, Wonjun Yim, Jiajing Zhou, Jesse V. Jokerst
Summary: This study investigates the optical shifts and color changes of gold-silver core-shell nanoparticles, as well as their application in enzyme concentration detection.
Article
Biochemical Research Methods
Xiaoyong Chen, Pin Xu, Wenwei Lin, Jin Jiang, Hang Qu, Xuehao Hu, Jinghua Sun, Yukun Cui
Summary: This study proposes a plasmonic titled fiber Bragg grating biosensor for the detection of breast cancer cells. Experimental results demonstrate that the biosensor has good detection performance, capable of detecting low concentrations of breast cancer cells in a short period of time. The sensor has a simple structure, easy manufacturing process, making it a promising choice for future cancer cell detection.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Analytical
Valentina Lucarelli, Damon Colbert, Shiwei Li, Mathew Cumming, Wayne Linklater, John Mitchell, Jadranka Travas-Sejdic, Andrew Kralicek
Summary: Rats, as invasive mammalian predators, pose a major threat to ecosystem functioning globally. This study developed a new sensing paradigm using a specific rat urine biomarker to detect and monitor the presence of rats more sensitively and at a lower cost. The researchers successfully selected aptamers and characterized their affinity and specificity towards the biomarker. The developed biosensor platforms showed high specificity and nanomolar range dissociation constants, indicating their potential for remote surveillance of rats.
Article
Chemistry, Multidisciplinary
Mengdi Lu, Wei Peng, Ming Lin, Fang Wang, Yang Zhang
Summary: A self-assembled templating technique using block copolymer layer was proposed for LSPR sensors, resulting in a high uniformity and density of gold nanoparticle monolayer. The performance in LSPR resonance wavelength and refractive index sensitivity significantly improved compared to conventional techniques, with a notable decrease in detection limit.
Article
Nanoscience & Nanotechnology
Jiacheng He, Siqi Wu, Wu Chen, Albert Kim, Wen Yang, Chuanyu Wang, Zhengyang Gu, Jialiang Shen, Siyuan Dai, Weiqiang Chen, Pengyu Chen
Summary: Immunomodulation therapies are crucial for immune-related diseases, and precise real-time detection of cytokines is essential. This study developed a label-free multiplex immunosensor using nanoplasmonic bioink, which can be easily fabricated and applied for real-time detection of multiple cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Optics
Harry Miyosi Silalahi, Yu-Hsuan Tsai, Kuang-Li Lee, Pei-Kuen Wei, Chia-Yi Huang
Summary: This study presents a simple design for shifting the resonance wavelength of silver nanoslits using an EWOD cell, demonstrating the ability to shift the resonance wavelength by moving a droplet with an electric field. The wavelength shift of 135 nm can be achieved by adjusting the electric field, making it suitable for high-performance electro-optical devices.
Article
Engineering, Electrical & Electronic
Yi-Hsin Tai, A. Syazwan A. Kamal, Young-Jae Park, Po-Cheng Tsai, Ya-Lun Ho, Pei-Kuen Wei, Hirofumi Daiguji, Jean-Jacques Delaunay
Summary: A tapered fiber sensor was developed to detect the presence of condensed water and frost, showing different responses to liquid water and frost by selectively scattering light and altering transmission intensity.
IEEE SENSORS JOURNAL
(2021)
Article
Biophysics
Han-Yun Hsieh, Ray Chang, Yung-Yu Huang, Po-Han Juan, Hidetoshi Tahara, Kuan-Yi Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This study successfully detected the DNA sequence of LMP1 using a combination of microfluidic PCR and gold nanoslit-based SPR sensor, achieving rapid and accurate analytical procedures, as well as enhancing the detection efficiency of DNA extracted from EBV-positive cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Sheng-Hann Wang, Chia-Wen Kuo, Shu-Cheng Lo, Wing Kiu Yeung, Ting-Wei Chang, Pei-Kuen Wei
Summary: In this study, a spectral image contrast-based flow digital nanoplasmon-metry method was developed to amplify and quickly detect the peak shift signal of gold nanoparticles (AuNPs) by comparing the scattering image brightness in two neighboring wavelength bands near the local surface plasmon resonance (LSPR) peak. The method provides an ultrahigh signal-to-noise ratio and has a lower sample volume requirement compared to conventional LSPR immunoassays. It demonstrates high sensitivity, selectivity, and a broad dynamic detection range.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Chuan Chen, Shu-Cheng Lo, Pei-Kuen Wei
Summary: Label-free detection of mercuric ions in aqueous solutions was achieved using capped gold nanoslit arrays combined with electrochemical sensing technique. The system showed high sensitivity and selectivity towards Hg2+ ions, with a detection range from 100 μM to 10 nM and a detection limit of 1 μM. The developed system has the potential to be applied in detecting various chemicals and biomolecules.
Article
Nanoscience & Nanotechnology
Chia-Wen Kuo, Sheng-Hann Wang, Shu-Cheng Lo, Wei-Han Yong, Ya-Lun Ho, Jean-Jacques Delaunay, Wan-Shao Tsai, Pei-Kuen Wei
Summary: The study proposes a method for sensitive detection of small molecules by coupling image dipoles of gold nanoparticles with Fano resonance of capped gold nanoslits. The coupling mechanism was verified through calculations and experiments, showing potential for detecting low concentrations of small molecules. This resonant coupling significantly pushes the sensitivity boundary, with the detection limit reported to be 3 orders of magnitude lower than prism-based SPR.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Prakhar Dutta, Ting-Yu Su, An-Ying Fu, Mei-Chi Chang, Yu-Jie Guo, I-Jung Tsai, Pei-Kuen Wei, Yu-Sheng Chang, Ching-Yu Lin, Yu-Jui Fan
Summary: In this study, a portable solar-powered centrifuge was developed to provide access to centrifugation in remote areas. The device showed high yield and plasma purity in a short time, and can be used for various purposes. The integration of smartphone reader and nanoplamonic chip allows for evaluation of autoantibodies through image analysis. The device can operate under different conditions with minimal energy requirement, making it suitable for areas without electricity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Optics
Yi-Ru Li, Kuang-Li Lee, Kuan-Ming Chen, Yun Cheng Lu, Pin Chieh Wu, Sy-Hann Chen, Jiun-Haw Lee, Pei-Kuen Wei
Summary: This paper proposes a measurement method for sensitive and label-free detection of virus-like particles (VLPs) using color images of nanoplasmonic sensing chips. The experimental results show that the image contrast method has good linearity and can achieve direct detection of SARS-CoV-2 VLPs in a short period of time.
Article
Chemistry, Analytical
Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan, Pei-Kuen Wei, Horn-Jiunn Sheen
Summary: This study developed a rapid and highly sensitive EBV screening method using a nanofluidic preconcentrator integrated with a nanoslit Fano resonance biosensor to detect latent membrane protein 1 (LMP1) for EBV diagnosis. Through nanoimprinting and aluminum deposition, a low-cost nanoslit plasmonic sensing chip was mass-produced, achieving a limit of detection of 100 pg/ml and a sensing range of 100 pg/ml to 10 μg/ml.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Wei-Che Huang, Chin-Dian Wei, Shimshon Belkin, Tung-Han Hsieh, Ji-Yen Cheng
Summary: With the widespread use of antibiotics, the detection and categorization of compounds with antibiotic activity has become increasingly important. Researchers have developed a new platform, BacSPA, which uses genetically modified Escherichia coli sensor strains to monitor the responses to different antibiotics. By using timelapse photography and a machine learning algorithm, the method can accurately identify and categorize antibiotics within three hours.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Wei-Ru Lu, Wen-Tse Yang, Justin Chu, Tung-Han Hsieh, Fu-Liang Yang
Summary: Through innovative deduction learning, the efficiency of personalized blood glucose modeling has been improved with limited data, and outlier predictions have been eliminated using an automatic screening algorithm. The DL model achieved significant improvements with limited training data, leading to precise noninvasive blood glucose measurements.
SCIENTIFIC REPORTS
(2022)
Article
Optics
Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, Pei-kuen Wei
Summary: In this work, high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures are presented. The hybrid Tamm-plasmon mode, resulting from the Fano coupling between higher order Tatum plasmon states and Bloch-wave surface plasmon polariton on the gold nanoslit array, demonstrates high surface sensitivity and resonant quality. The experimental results show that the hybrid mode has significantly higher sensitivity and better signal-to-noise ratios in biomolecular interaction measurement.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Chemistry, Analytical
Shu-Cheng Lo, Shao-Sian Li, Wen-Fai Yang, Kuang-Chong Wu, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This paper presents a new micro/nanostructure co-hot embossing technique for the integration of gold-capped nanostructures as localized surface plasmon resonance (SPR) sensors into a microfluidic channel. The advantage of this technique is that it eliminates the need for alignment between the SPR sensors and the microfluidic channel during bonding. The integrated SPR sensor and microfluidic channel were characterized, and the sensitivity of the SPR sensor to refractive index was determined using different concentrations of glycerol solutions. The SPR sensor was also used for quantifying latent membrane protein (LMP-1) by modifying anti-LMP-1 on its surface, and a calibration curve was created using different concentrations of LMP-1 samples.
Article
Astronomy & Astrophysics
Yu-Chih Chen, Ting-Wai Chiu, Tung -Han Hsieh
Summary: In this study, we perform hybrid Monte-Carlo simulation of lattice QCD with Nf = 2 + 1 + 1 domain-wall quarks at the physical point. The results provide a basis for studying finite temperature QCD with Nf = 2 + 1 + 1 domain-wall quarks. By measuring the topological charge and determining the topological susceptibility at different lattice spacings and temperatures, we are able to extract the topological susceptibility in the continuum limit.
