Review
Biochemistry & Molecular Biology
Alla Zorina, Vadim Zorin, Dmitry Kudlay, Pavel Kopnin
Summary: Skin aging is a multi-factorial process that involves impairment of skin structures and functions, particularly in the dermal extracellular matrix (ECM), leading to disrupted functioning of dermal fibroblasts (DFs). The integrity of the collagen matrix (CM) is crucial for proper adhesion and mechanical tension in DFs, allowing them to maintain collagen homeostasis. Impaired CM integrity disrupts mechanotransduction and impairs DF functioning, contributing to the progression of aging processes in skin tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Xiaocao Zhao, Xuejiao Zhang, Dengyong Liu
Summary: Bioactive peptides, particularly collagen peptides, have great potential in skin anti-aging due to their diverse biological activities and high security. These peptides can provide skin protection effects by affecting various physiological pathways of the skin, thereby improving skin health.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Engineering, Biomedical
Maria Chiara Munisso, Susumu Saito, Itaru Tsuge, Naoki Morimoto
Summary: Quantitative structural analysis of collagen fiber orientation is crucial for understanding connective tissue behavior. We developed a simplified method for comparing multiple human skin samples to analyze load-dependent changes using SHG microscopy. Our results showed that increased load led to more aligned fibers in the loading direction and revealed the presence of two preferred orientations in both perpendicular and parallel planes to the epidermis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Edda Russo, Leandro Di Gloria, Matteo Cerboneschi, Serena Smeazzetto, Gian Paolo Baruzzi, Francesca Romano, Matteo Ramazzotti, Amedeo Amedei
Summary: In this study, the variation in facial skin microbiome architecture through aging and its functional association with host genetic factors were investigated in a cohort of healthy women. The facial skin microbiota showed different composition in different age groups and between normal and dry skins. Functional variations associated with collagen biosynthesis and oxidative stress damage repair were observed in middle-aged women.
Article
Biochemistry & Molecular Biology
Michaela Sochorova, Christopher Kremslehner, Ionela-Mariana Nagelreiter, Francesca Ferrara, Maja Mitrovic Lisicin, Marie-Sophie Narzt, Christina Bauer, Alexandra Stiegler, Bahar Golabi, Katerina Vavrova, Florian Gruber
Summary: NRF2 serves as a critical regulator in protecting cells from oxidative damage and plays a role in the aging process and epidermal differentiation of mammalian skin. In the absence of extrinsic stressors, NRF2-deficient mice do not exhibit obvious skin phenotype even at old age. However, the aged NRF2-deficient mice show disturbed epidermal differentiation and altered lipid composition, suggesting compensatory adaptations in keratinocyte proliferation and barrier lipid synthesis.
Article
Pharmacology & Pharmacy
Lucia Nanic, Andrea Cedilak, Nikolina Skrobot Vidacek, Florian Gruber, Miljenko Huzak, Michael Bader, Ivica Rubelj
Summary: The study demonstrates that implantation of young fibroblasts in aging rats restores cell density, revitalizes cell proliferation, rejuvenates collagen I and III matrices, and boosts epidermal stem cell proliferation. The transplantation of skin stem cells also reduces blistering in rats with Dominant Dystrophic Epidermolysis Bulosa (DDEB). The findings suggest that this intervention can change tissue homeostasis, leading to overall skin restoration and rejuvenation as well as the healing of DDEB skin.
Article
Biotechnology & Applied Microbiology
Michael J. Blair, Kyle P. Quinn
Summary: Quantitative Polarized Light Imaging (QPLI) is a technique used to compute the orientation of collagen fibers. In this paper, a single shot QPLI system (ssQPLI) without moving parts is presented, which can accurately quantify the fiber orientation and quickly provide pixel-wise measurements during mechanical testing. The ssQPLI system utilizes four cameras to simultaneously collect linearly polarized light in four states.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Changwei Cao, Zhichao Xiao, Huiquan Tong, Yuntao Liu, Yinglong Wu, Changrong Ge
Summary: The study found that orally administered chicken bone collagen peptides have significant effects in alleviating skin aging by improving the composition and structure of aging skin, enhancing skin antioxidant levels, and inhibiting inflammation. The mechanism of action involves reducing skin oxidation, activating the TGF-beta/Smad signaling pathway for collagen synthesis, inhibiting collagen degradation, and suppressing skin inflammation. It was also discovered that lysosomes activation may play an important role in the anti-aging effects of orally administered collagen peptides.
Article
Engineering, Biomedical
Hongqian Lv, Nan Gao, Qixin Zhou, Yan Wang, Guixia Ling, Peng Zhang
Summary: This study develops rapidly dissolving microneedles (DMNs) using hydrolyzed collagen (HC) as the main raw material, which can deliver collagen to the skin in a simple and minimally invasive way. The DMNs dissolve completely in the skin within 15 min and release drug within approximately 8 h, without causing toxicity or irritation. The drug-loaded DMNs overcome the drawbacks of traditional methods, enabling efficient and safe treatment. The successful preparation and research of HC DMNs have innovative and practical significance in the field of transdermal drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Ryohei Ishige, Cai Li Song, Shohei Hara, Shinji Ando, Sergei G. Kazarian
Summary: In this study, molecular orientation of aromatic polyimides (PIs) and their precursor of poly(amic ester)s (PAE) in biaxially oriented films was analyzed by polarized microscopic attenuated-total-reflection Fourier-transform infrared absorption spectroscopy (micro pATR-FTIR) imaging. The results showed the heterogeneous distribution of aromatic imide plane in the films, with face-on and edge-on orientation domains coexisting. The study also successfully visualized cracks in the PI film and investigated the orientation distribution inside the cracks, validating the quantitative capability of the micro pATR-FTIR imaging method for analyzing highly oriented PI films and demonstrating its ability to investigate micrometer-scale heterogeneity.
Article
Geriatrics & Gerontology
Sela Marin, Ines Godet, Lolita S. Nidadavolu, Jing Tian, Laura E. Dickinson, Jeremy D. Walston, Daniele M. Gilkes, Peter M. Abadir
Summary: Collagen is crucial for the firmness and elasticity of the skin, but its production decreases as we age. In this study, we found that valsartan had the highest penetration in human skin among eight angiotensin receptor blockers (ARBs). Treating skin cells with valsartan and sacubitril increased collagen production significantly, suggesting a potential application of this drug combination for aging skin.
EXPERIMENTAL GERONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Taihao Quan
Summary: As the most extensive and abundant tissue in the human body, the skin undergoes gradual atrophy during the aging process, causing disruptions to its structure and functionality. Recent molecular discoveries related to skin aging emphasize the importance of preventive approaches, such as the use of topical retinoids, which show promise in enhancing skin texture and thickness.
Review
Biochemistry & Molecular Biology
Hyunji Lee, Yongjun Hong, Miri Kim
Summary: Skin aging is a complex process influenced by intrinsic and extrinsic factors, which affect the structure and function of the skin. Aging skin typically shows epidermal atrophy and decreased cell numbers in the dermis, affecting fibroblast function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Serena De Santis, Francesco Porcelli, Giovanni Sotgiu, Anna Crescenzi, Anita Ceccucci, Martina Verri, Marco Caricato, Chiara Taffon, Monica Orsini
Summary: Research has shown that in the genesis and progression of colon cancer, there is strong remodeling of collagen fibers in the tumor stroma, creating a microenvironment that supports cancer development. Micro-FTIR spectroscopy, focusing on collagen signals, can provide valuable chemical evidence for distinguishing malignant and normal stroma. This technique shows promise as a tool for colon cancer diagnosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cell Biology
Julie Rorteau, Fabien P. Chevalier, Sebastien Bonnet, Theo Barthelemy, Amandine Lopez-Gaydon, Lisa S. Martin, Nicolas Bechetoille, Jerome Lamartine
Summary: This study investigates whether primary normal human dermal fibroblasts retain age-related characteristics when cultured in 2D monolayer and if they can be used as a relevant model for aging research. The findings suggest that as age increases, the cells exhibit decreased population doubling capacities, reduced clonogenic ability, impairment in extracellular matrix production, and modifications in respiratory metabolism. These alterations of cell features are related to the signs of dermis aging.
Article
Toxicology
Alison Vanlaeys, Gregory Fouquet, Philippe Kischel, Frederic Hague, Sylvie Pasco-Brassart, Thibaut Lefebvre, Pierre Rybarczyk, Isabelle Dhennin-Duthille, Bertrand Brassart, Halima Ouadid-Ahidouch, Mathieu Gautier
ARCHIVES OF TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Florian Slimano, Zoubir Djerada, Juline Guerin, Morad Id Bellouch, Sylvie Brassart-Pasco, Sylvain Dukic
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Review
Oncology
Sylvie Brassart-Pasco, Stephane Brezillon, Bertrand Brassart, Laurent Ramont, Jean-Baptiste Oudart, Jean Claude Monboisse
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Catherine Feliu, Helene Peyret, Sylvie Brassart-Pasco, Floriane Oszust, Gael Poitevin, Philippe Nguyen, Herve Millart, Zoubir Djerada
Review
Pharmacology & Pharmacy
Sylvie Brassart-Pasco, Veronique Dalstein, Bertrand Brassart, Maxime Dewolf, Christine Clavel, Jean-Baptiste Oudart
Article
Cell Biology
Thibaut Lefebvre, Pierre Rybarczyk, Clara Bretaudeau, Alison Vanlaeys, Remi Cousin, Sylvie Brassart-Pasco, Denis Chatelain, Isabelle Dhennin-Duthille, Halima Ouadid-Ahidouch, Bertrand Brassart, Mathieu Gautier
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Alexia Vautrin-Glabik, Jerome Devy, Camille Bour, Stephanie Baud, Laurence Choulier, Anthony Hoarau, Aurelie Dupont-Deshorgue, Christele Sellier, Bertrand Brassart, Jean-Baptiste Oudart, Laurent Ramont, Jean Claude Monboisse, Sylvie Brassart-Pasco
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Oncology
Lise Nannan, Jean-Baptiste Oudart, Jean Claude Monboisse, Laurent Ramont, Sylvie Brassart-Pasco, Bertrand Brassart
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Clara Bretaudeau, Stephanie Baud, Aurelie Dupont-Deshorgue, Remi Cousin, Bertrand Brassart, Sylvie Brassart-Pasco
Summary: Oral tongue squamous cell carcinoma is a common head and neck cancer. In this study, a nonapeptide, AG-9, was found to stimulate invasive properties of tongue squamous cell carcinoma cells. The stimulatory effect of AG-9 was mediated through binding to the RPSA receptor, with overlapping interaction areas with EGCG, a green tea-derived polyphenol that can abolish AG-9-induced invasion.
Article
Oncology
Camille Mazza, Vincent Gaydou, Jean-Christophe Eymard, Philippe Birembaut, Valerie Untereiner, Jean-Francois Cote, Isabelle Brocheriou, David Coeffic, Philippe Villena, Stephane Larre, Vincent Vuiblet, Olivier Piot
Summary: Assessing the tumor response to chemotherapy is crucial for improving patient care. In this study, we used infrared spectroscopy to analyze tissue samples from muscle-invasive bladder cancer and developed a classification model to predict the response to chemotherapy. This study highlights the potential of infrared imaging for personalized treatment.
Article
Polymer Science
Katia Bacha, Julien Estager, Sylvie Brassart-Pasco, Catherine Chemotti, Antony E. Fernandes, Jean-Pierre Mbakidi, Magali Deleu, Sandrine Bouquillon
Summary: New dendrimers were synthesized from PPI and PAMAM dendrimers using an efficient acid-base reaction with various phenolic acids, and the syntheses were optimized in both microwave and microfluidic reactors. These dendrimers, which are ionic and hydrophilic, exhibited excellent antioxidant properties and showed cytotoxic effects on fibroblast dermal cells.
Article
Biochemistry & Molecular Biology
Katia Bacha, Catherine Chemotti, Jean-Claude Monboisse, Anthony Robert, Aurelien L. Furlan, Willy Smeralda, Christian Damblon, Julien Estager, Sylvie Brassart-Pasco, Jean-Pierre Mbakidi, Jelena Prsic, Sandrine Bouquillon, Magali Deleu
Summary: The dendrimer GD-PAMAM-3 is an efficient carrier for vitamin C, with high encapsulation capacity and no cytotoxicity, and the release of vitamin C is mainly pH dependent, with pH 5.0 being the most favorable condition.
Article
Cell Biology
Jean-Baptiste Oudart, Matthieu Villemin, Bertrand Brassart, Christele Sellier, Christine Terryn, Aurelie Dupont-Deshorgue, Jean Claude Monboisse, Francois-Xavier Maquart, Laurent Ramont, Sylvie Brassart-Pasco
Summary: In this study, we found that the F4 peptide derived from collagen XIX has anti-angiogenic properties by inhibiting VEGF-induced tube formation by endothelial cells and endothelial sprouting in aortic ring assay. We also identified integrins alpha v beta 3 and alpha 5 beta 1 as potential receptors for F4, suggesting a direct interaction between F4 and these integrins, which contributes to its antitumor effects.
CELL ADHESION & MIGRATION
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
E. Prado, C. Eklouh-Molinier, F. Enez, C. Blay, M. Dupont-Nivet, L. Labbe, V Petit, A. Moreac, G. Taupier, D. Guemene, P. Haffray, G. Corraze, D. Causeur, V Nazabal
2020 22ND INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS (ICTON 2020)
(2020)
Article
Pharmacology & Pharmacy
Yuri Dancik, Hichem Kichou, Christophe Eklouh-Molinier, Martin Souce, Emilie Munnier, Igor Chourpa, Franck Bonnier
