4.6 Article

Contact angle changes induced by immunocomplex formation

Journal

ANALYST
Volume 139, Issue 6, Pages 1340-1344

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3an02189k

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Funding

  1. NSF Career [ECCS-0846454]
  2. NIH NIAID [R01AI093418]
  3. Directorate For Engineering
  4. Div Of Electrical, Commun & Cyber Sys [0846454] Funding Source: National Science Foundation

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Immunoassays analyzing interactions between antigens and antibodies can be affected by capillary action together with binding affinity. This paper studies contact-angle changes of bacterial suspensions on antibody immobilized surfaces. The capillary action and the dried pattern of the bacterial suspensions are analyzed and correlated with specific- and nonspecific bindings between bacteria and antibodies.

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