Article
Chemistry, Analytical
Raji V. Nair, Parvathy R. Chandran, A. Peer Mohamed, Saju Pillai
Summary: The development of selective, ultra-sensitive, rapid and facile detection methods for toxic pesticides and hazardous chemicals residues is important for food safety, environmental monitoring and public health. A fluorescent turn-on aptasensor based on sulphur-doped graphene quantum dot (S-GQD) was presented for the ultra-sensitive and selective detection of omethoate. The detection method relies on the tuning aggregation-disaggregation mechanism of S-GQD and conformational alteration of the recognition probe.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Ying Wang, Fuyan Zhu, Li Yin, Guangxu Qu, Dik-Lung Ma, Chung-Hang Leung, Lihua Lu
Summary: Pesticide residues pose a serious threat to human health and the sustainable development of the environment. The establishment of an efficient detection platform for pesticides is crucial. Researchers have successfully developed a novel ratiometric fluorescent aptasensor for the sensitive determination of pesticides. This sensor offers a label-free and enzyme-free detection of isocarbophos (ICP) with high sensitivity and specificity, providing new ways for pesticide assays in agricultural products or environmental samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemical Research Methods
Qiming Kou, Ping Wu, Qi Sun, Chenxi Li, Lei Zhang, Haixing Shi, Juan Wu, Yarong Wang, Xueling Yan, Tao Le
Summary: A fluorescent aptamer/GO-based biosensor was developed for detecting SMZ residues in animal-derived foods, showing high affinity and specificity. The sensor has low detection limits and a wide dynamic linear range, allowing for accurate detection of SMZ residues in foods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Weidao Yu, Aiyue Hao, Yanzhen Mei, Yaqiong Yang, Chuanchao Dai
Summary: In this study, a novel fluorescent aptasensor based on CdTe quantum dots (QDs) and gold nanoparticles (Ag NPs) was developed for the detection of ampicillin. The aptasensor exhibited a good linear range and low detection limit, and it showed high recovery rate when applied to milk samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
Xiuxia Wei, Ming Yin, Li Zhang, Yiwei Sun, Yuting Luo, Dongpo Xu
Summary: A novel label-free electrochemical biosensor based on octahedral Cu2O @ Au nanocomposites was developed for the detection of tetracycline. The biosensor exhibited good electrochemical performance and specific binding ability, providing a synergistic effect of signal amplification and recognition strategy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Analytical
Pravin Savata Gade, Rutuja Murlidhar Sonkar, Praveena Bhatt
Summary: This study proposes a graphene oxide-mediated aptasensor platform for the one-step detection of Sterigmatocystin (STC). Through experiments and simulations, a high-affinity aptamer was obtained, and a simple and user-friendly fluorescence turn-on aptasensor was developed. The aptasensor showed linear detection in the concentration range of 80-720 ppb with low limits of detection and quantification. It demonstrated minimal interference from salts and detergents, as well as negligible cross-reactivity with other structurally similar mycotoxins. Recovery studies in simulated contaminated samples indicated satisfactory recoveries, making it useful for the measurement and monitoring of STC in real samples.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Kai Li, Zhan Lei, Chen Zhang, Longjiao Zhu, Kunlun Huang, Ying Shang, Wentao Xu
Summary: This paper preliminarily verifies that graphene oxide (GO) nanomaterials enhance the recombinase polymerase amplification (RPA). The GO nanosheets improve the efficiency of RPA amplification by inducing local aggregation. Based on this enhancement effect, an isothermal fluorescence biosensor is developed for detecting RNA interference (RNAi) transgenic plants and exhibits high sensitivity and selectivity. The biosensor provides significant potential for molecular detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Poonam Singh, Sandeep Kumar, Sanjay Kumar Verma
Summary: A fluorescent graphene oxide based aptasensing platform was developed for sensitive and accurate detection of acephate. The screened aptamer AAPT3 demonstrated high affinity and selectivity, and the aptasensor showed low detection limit and wide linear range.
Article
Pharmacology & Pharmacy
Nan Zhang, Jingrong Li, Boshi Liu, Haixia Wang, Di Zhang, Zheng Li
Summary: A fluorescence aptasensor based on fluorescence resonance energy transfer (FRET) was developed for simultaneous detection of patulin and zearalenone in traditional Chinese medicine. The aptasensor exhibited satisfactory selectivity and reliability, and showed great potential in fast and cost-effective simultaneous detection of multiple targets.
Article
Biochemical Research Methods
Yunwei Zhao, Hui Zhang, Ying Wang, Yanfang Zhao, Yaowei Li, Lei Han, Lihua Lu
Summary: A simple fluorescence detection platform based on DNA three-way junctions has been developed for the assay of acetamiprid, tripling the fluorescence signal without the need for any other amplification. This platform utilizes G-quadruplex assembly to achieve sensitive detection of acetamiprid and demonstrates high potential for applications in food control and environmental monitoring.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Xiuxia Wei, Yiwei Sun, Yuting Luo, Ruxin Shu, Huaqing Lin, Dongpo Xu
Summary: The widespread use of antibiotics can lead to residues in the environment and food, which in turn affects health problems. Therefore, it is crucial to detect antibiotic residues. In this study, an efficient and sensitive AMP electrochemical ensemble sensor was successfully prepared, and by optimizing the experimental conditions, AMP can be detected in real samples.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemical Research Methods
Guiyin Li, Wei Chen, Danhong Mi, Bo Wang, HaiMei Li, Guangxiong Wu, Ping Ding, Jintao Liang, Zhide Zhou
Summary: In this study, a highly sensitive apatasensor for detecting GPC3 was designed based on FRET. The GPC3 aptamer labelled gold carbon dots were used as a donor and magnetic graphene oxide nanosheets were used as an acceptor. The detection method showed a linear correlation between the fluorescence recovery rate and the concentration of GPC3, with a low detection limit. Real human serum samples demonstrated good recovery rates, indicating the potential application of this method for early diagnosis of HCC.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Qing Zhang, Linzhi Kang, Pengfei Yue, Linchun Shi, Meng Wang, Lidong Zhou, Haiping Zhao, Weijun Kong
Summary: A fluorescent aptasensor based on graphene oxide nanosheet and double-stranded DNA structure was developed for OTA detection. The sensor exhibited outstanding sensitivity and selectivity, making it a promising tool for food safety applications.
Article
Chemistry, Analytical
Luis Pla, M. Carmen Martinez-Bisbal, Elena Aznar, Felix Sancenon, Ramon Martinez-Manez, Sara Santiago-Felipe
Summary: Celiac disease is a global disorder affecting nearly 1% of the population, with no effective treatment available yet, resulting in the need to manage the disease by eliminating gluten from the diet. To combat food industry fraud and prevent inadvertent ingestion by celiac patients, clear labeling of food items and smart gluten detection methods are required. A novel gluten detection system utilizing nanoporous anodic alumina films and fluorescent dye has been developed, providing a rapid detection time of approximately 60 minutes with good selectivity and a detection limit of 100 μg kg(-1) in real food samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Food Science & Technology
Zhijun Guo, Jing Tian, Chengbi Cui, Yan Wang, Huanhuan Yang, Ming Yuan, Hansong Yu
Summary: This study demonstrated a new detection system for OTA using fluorescence biosensing based on an anti-OTA aptamer and fluorescence quencher, using single-walled carbon nanohorns. The detection limit of OTA was 2.3 ng/ml with a linear detection range of 5-500 ng/ml. The aptasensor was found suitable for the quantification of OTA in food samples.
Article
Chemistry, Applied
Chenxia Hao, Yunfeng Bai, Lu Zhao, Yayan Bao, Jinai Bian, Hui Xu, Tao Zhou, Feng Feng
Summary: Developing durable room temperature phosphorescent carbon dot-based materials with high stability and easy preparation has been a challenge. Through a one-step hydrolysis-assisted carbonization treatment, nitrogen-doped carbon dots encapsulated in silica (N-CDs@silica) were obtained, exhibiting outstanding stability and durable room temperature phosphorescence. The unique optical properties of NCDs@silica were utilized to develop RTP strip probes for selective Fe3+ detection and as security ink for advanced anti-counterfeiting. This work not only provides a strategy to optimize the structural and luminescent properties of N-CDs@silica, but also opens a new perspective for developing simple RTP strip probes for sensor applications.
Article
Chemistry, Applied
Chenxia Hao, Yunfeng Bai, Zezhong Chen, Fanshen Geng, Jun Qin, Tao Zhou, Feng Feng
Summary: A facile one-step hydrothermal method was presented to promote ultralong room-temperature phosphorescence (URTP) emission in an aqueous medium by confining polymer carbon dots in silica nanospheres. The polymer carbon dots-silica nanosphere composites exhibited the longest RTP lifetime of carbon dot-based materials in aqueous media to date, showing potential for applications in bioimaging without autoluminescence.
Article
Chemistry, Applied
Lizhen Liu, Zhi Mi, Xingyan Huo, Lin Yuan, Yayan Bao, Zhixiong Liu, Feng Feng
Summary: This paper reports an innovative method for the sensitive detection of new coccine using N, P-doped carbon quantum dots as fluorescent nanosensor. The developed nanosensor has good precision and high accuracy for the determination of new coccine in food samples, highlighting economic, rapid, simple, selective and ultra-sensitive features.
Article
Chemistry, Analytical
Xingyan Huo, Lizhen Liu, Yunfeng Bai, Jun Qin, Lin Yuan, Feng Feng
Summary: A novel fluorescent probe based on CQDs for phoxim detection was developed, showing good sensitivity, selectivity, and recoveries. The method has significant potential applications in the biological field.
ANALYTICA CHIMICA ACTA
(2022)
Article
Oncology
Xiaoliang Chen, Lili Yin, Hui Xu, Jie Rong, Miao Feng, Di Jiang, Yunfeng Bai
Summary: This study investigated the role of RhoA in enzalutamide-resistant prostate cancer and found that inhibition of RhoA can reverse enzalutamide resistance, potentially increasing its efficacy in castration-resistant prostate cancer.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2023)
Article
Chemistry, Applied
Yuehua Yuan, Wenfa Zhou, Yongjun Zhu, Maozhong Tian, Yutao Zheng, Zefeng Shi, Feng Feng, Yinglin Song
Summary: Two novel ethyne-linked polymers (P1 and P2) were synthesized and their nonlinear optical properties were investigated. The results showed that both polymers exhibit reverse saturable absorption and self-defocusing, with two photon absorption being the dominant nonlinear absorption mechanism. Additionally, the polymers also display negative excited-state refraction.
Article
Chemistry, Analytical
Lin Yuan, Lizhen Liu, Yunfeng Bai, Jun Qin, Meng Chen, Feng Feng
Summary: In this article, the use of dual-emission carbon dots (CDs) with orange-yellow fluorescence for the detection of L-glutamic acid (L-Glu) is reported for the first time. The CDs were synthesized through a facile hydrothermal route and showed changes in fluorescence intensity in the presence of L-Glu. These findings suggest that CDs have potential applications in biomedical research.
Article
Chemistry, Physical
Lu Zhao, Jie Liu, Yunfeng Bai, Yaqiong Wen, Xiaoming Yang
Summary: In this study, red-fluorescence gold nanoclusters (AuNCs@nisin) were synthesized using nisin as the template. The synthesized AuNCs@nisin showed uniform particle size and exhibited significant fluorescence response to thiourea, making it a potential fluorescent probe for thiourea detection.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Spectroscopy
Wen Juan Liang, Wen Xin Wu, Zhen Lu, Yun Feng Bai, Feng Feng, Wei Jun Jin
Summary: By studying the optical properties and stimulus responsive luminescence characteristics of two luminescence molecular rotors, it has been found that they can be applied to the preparation of water writable film materials.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Haidi Feng, Lu Zhao, Zhiqiang Bai, Zhihui Xin, Chaoyu Wang, Lizhen Liu, Jinping Song, Haifei Zhang, Yunfeng Bai, Feng Feng
Summary: In this study, an aptamer modified nanoplatform was designed for active-targeted chemo-photodynamic therapy of tumors. The nanoplatform showed enhanced therapeutic effect and active targeting efficiency under 808 nm laser irradiation.
Article
Chemistry, Analytical
Lu Zhao, Yunfeng Bai, Yaqiong Wen, Xiaoming Yang
Summary: In this study, we successfully developed carbon dots that emitted orange-fluorescence using the hydrothermal method. The carbon dots had multiple functional groups, allowing them to interact with potential targets. The introduction of silver ions quenched the fluorescence of the carbon dots, while the addition of glyphosine gradually recovered the fluorescence. The prepared carbon dots showed potential for detecting Ag+ and glyphosine.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Hong Zhai, Mengmeng Gao, Yunfeng Bai, Jun Qin, Qing Song, Zhixiong Liu, Haiyan Wang, Feng Feng
Summary: Two kinds of copper-based metal fluorescent nanoclusters were prepared using chemical reduction method, one by direct reduction of copper sulfate and the other by stepwise addition of copper salt and chloroauric acid. CuNCs were used for fluorescence resonance energy transfer (FRET) system with NR, while CuAuNCs acted as fluorescent probes for vanillin detection through quenching mechanism.
ANALYTICAL METHODS
(2022)
