Article
Biophysics
Rimsha B. Jamal, Toni Vitasovic, Ulrich Gosewinkel, Elena E. Ferapontova
Summary: In this study, a sensitive and simple electrocatalytic amplification method for detecting Escherichia coli 23S ribosomal rRNA has been developed. The RNA sample was cleaved by RNase H enzyme, and then hybridized with a methylene-blue (MB) - labelled DNA probe. The formed duplex acted as an electrical wire for electron transfer, enabling the electrocatalytic reduction on the modified electrodes. This assay allowed the detection of synthetic E. coli DNA and 23S rRNA with a limit of 1 fM.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Joshua Reyes-Morales, Jeffrey E. Dick
Summary: Nanoparticles have experienced significant development in the past few decades due to their unique physicochemical properties. However, electrodeposition of nanoparticles has been challenged by a lack of control over size and morphology. This Account presents a new method using water nanodroplets to electrodeposit nanoparticles, allowing for greater control over macromorphology and microstructure. The use of nanodroplets also enables the electrodeposition of high entropy alloy nanoparticles at room temperature and the exploration of various electrochemical studies.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Elisabetta Mazzotta, Tiziano Di Giulio, Valentina Mastronardi, Pier Paolo Pompa, Mauro Moglianetti, Cosimino Malitesta
Summary: Platinum nanoparticles (PtNPs) of size-tunable nature were prepared in an aqueous environment without the use of catalyst-poisoning reagents, exhibiting excellent electrocatalytic properties for the detection of hydrogen peroxide. The nanoparticles were freed from the citrate capping agent by adjusting the pH to basic values, and then deposited on a glassy carbon electrode with high cleanliness and adherence, leading to enhanced electrocatalytic performances. The smaller PtNPs showed higher sensitivity in detecting hydrogen peroxide, with good results in terms of sensitivity, selectivity, repeatability, stability, and tests in real tap water samples.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Yan Dong, Zhenlan Li, Guocheng Zheng, Jiawei Zhang, Jiawei Zhou, Yuki Orikasa, Yoshiharu Uchimoto, Xiaoming Wang
Summary: The use of a quasi-monolayer Pt shell (Pt-qms) on a Pd core (Pd-c) can achieve cost and activity targets for the electrocatalytic oxygen-reduction reaction (ORR). In situ X-ray absorption spectroscopy was used to monitor the structural evolution of Pd(c)Pt(qms) during ORR, revealing that Pt-qms undergoes restructuring to form Pt clusters and holes while Pd-c remains stable. Protecting the structure of Pd-c is crucial in the development of high-performance Pd(c)Pt(qms) electrocatalysts.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Physical
Chunhui Wang, Xiutao Yang, Guopeng Zhu, Tianye Wang, Dengbin Yu, Yongzheng Lu, Hongwen Yu
Summary: In this work, Cu-Pt nanoparticles were successfully modified on a GCE for non-enzymatic glucose detection. The Cu-Pt NPs/GCE exhibited high sensitivity, good selectivity, reproducibility, long-term stability, and rapid response time. They were also able to detect glucose in artificial saliva and human serum samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Zhixin Liu, Zhengang Guo, Hailong He, Yuling Zhang, Mengnan Ruan, Zhifeng Liu
Summary: In this study, hybrid catalysts consisting of Pt quantum dots doped NiP nano-embroidery spheres and Co(OH)2 nanosheets were successfully prepared by a two-step electrodeposition method. The catalyst exhibited excellent catalytic performance, which can be attributed to the synergistic interaction between NiP and Pt quantum dots as well as the strong electronic interactions at the interface with Co(OH)2.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Biotechnology & Applied Microbiology
Qingyuan Zheng, Tong Wang, Xinmin Li, Husun Qian, Xintong Bian, Xingrong Li, Huijie Bai, Shijia Ding, Yurong Yan
Summary: A novel electrochemical biosensor was developed for ultrasensitive and locus-specific detection of m(6)A in DNA, showing a wide linear range and low detection limit. The biosensor demonstrated good applicability in quantitating m(6)A DNA at specific site in biological matrix.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Soumya P. Tripathy, Manvitha Ponnapati, Suhaas Bhat, Joseph Jacobson, Pranam Chatterjee
Summary: In this study, computational protein modeling tools were used to propose a molecular beacon architecture for high-sensitivity detection of the SARS-CoV-2 spike protein receptor binding domain. By integrating these beacons on a miniaturized total internal reflection fluorescence microscope, the SARS-CoV-2 and pseudotyped SARS-CoV-2 could be detected with limits of detection in the femtomolar range.
Article
Engineering, Environmental
Nilesh S. Dumore, Mausumi Mukhopadhyay
Summary: The PtNPs-SeNPs-FTO nanocomposites, developed as an electrochemical sensor via electrochemical deposition method, were used for hydrogen peroxide detection. Morphological and structural studies confirmed the synthesis and growth of the nanocomposites on FTO substrate. The synthesized PtNPs and SeNPs showed nano-flower and spherical morphology, respectively. The nanocomposites exhibited a wide range of linear concentration response and fast response time, with high selectivity towards hydrogen peroxide.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Lee Seul Oh, Ju Ye Kim, Hyun Woo Kim, Jeonghyun Han, Eunho Lim, Won Bae Kim, Jong Hyeok Park, Hyung Ju Kim
Summary: In this study, a simple synthesis strategy was utilized to prepare Pt-WOx hybrid nanostructures, which exhibited excellent catalytic hydrogen evolution reaction performance. The Pt mass activity was approximately 17 times higher than that of commercial Pt catalysts, and the turnover frequency was 7.4 times higher. The enhanced electrocatalytic performance is attributed to the creation of Pt-WOx interfacial sites.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Sakshi Gautam, Sachin Chugh, Byron D. Gates
Summary: Low concentrations of surfactants were used as templates during Pt electrodeposition to synthesize high-surface-area multifaceted Pt nanoparticles. The electrochemical active surface area (A (ecsa)) and activity for the oxygen reduction reaction (ORR) were evaluated. The use of surfactants as templates during electrodeposition led to an increase in A (ecsa) and mass activity of the Pt nanostructures.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Analytical
Antonella Miglione, Ada Raucci, Jussara Amato, Simona Marzano, Bruno Pagano, Tiziana Raia, Marco Lucarelli, Andrea Fuso, Stefano Cinti
Summary: This study developed an electrochemical printed strip for the detection of miRNA-29a at low levels, which showed good repeatability and selectivity. The research provides a way for the study and possible early diagnosis of Alzheimer's disease.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jin Wang, Jinhong Yu, Junjie Wang, Kaili Wang, Liuyingzi Yu, Chengcheng Zhu, Kun Gao, Zhongyan Gong, Zhuoyao Li, Rajkumar Devasenathipathy, Dongyu Cai, Haijiao Xie, Gang Lu
Summary: The electrocatalytic efficiency of platinum nanoparticles (PtNPs) in hydrogen evolution is improved through simple surface adsorption of sub-monolayer p-aminothiophenol (PATP) molecules. The overpotential is reduced to 86.1 mV, 50.2 mV lower than that on naked PtNPs. This surface adsorption strategy can also be utilized to improve the electrocatalytic activity of palladium, gold, and silver nanoparticles.
Review
Chemistry, Multidisciplinary
Quansong Zhu, Catherine J. Murphy, L. Robert Baker
Summary: This perspective summarizes recent advances and opportunities using surface ligands to enhance the performance of nanocatalysts for electrochemical CO2 reduction. Several mechanisms are discussed, including selective permeability, modulating interfacial solvation structure and electric fields, chemical activation, and templating active site selection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Yuki Akanuma, Takane Imaoka, Hiroyasu Sato, Kimihisa Yamamoto
Summary: Controversy surrounds the roles of metal core and shell in photoluminescence of ligand-protected metal nanoclusters. The inclusion of silver ions in a platinum-thiolate complex led to a significant increase in photoluminescent quantum yield. DFT calculations showed that LUMO, with contributions from Ag s-orbital and Pt d-orbitals, played a critical role in suppressing structural distortion in the excited state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Karmel S. Gkika, Sara Noorani, Naomi Walsh, Tia E. Keyes
Summary: This study shows that cell permeability can be promoted by non-contiguous sequences of arginine residues bridged across the metal center. The bis-tetraarginine conjugate exhibited excellent cellular uptake and accumulation in two 2D monolayer cell lines, as well as remarkable in-depth penetration of 3D MCTSs in pancreatic cancer cells.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Keshav Kumar Jha, Amrutha Prabhakaran, Christopher S. Burke, Marcus Schulze, Ulrich S. Schubert, Tia E. Keyes, Michael Jaeger, Benjamin Dietzek Ivansic
Summary: Triplet-triplet annihilation upconversion is an emerging technology that has the potential to convert long-wavelength photons to higher photon energies. Transferring the upconversion system from solution to solid matrices is a challenge, but various approaches have been established. This study investigates the effect of integrating molecular sensitizers into a PMMA polymer on the upconversion process, and compares the results to those using a monomeric annihilator.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Sean Hennessey, Christopher S. Burke, Roberto Gonzalez-Gomez, Debobroto Sensharma, Wenming Tong, Amal, Cherian Kathalikkattil, Fabio Cucinotta, Wolfgang Schmitt, Tia E. Keyes, Pau Farras
Summary: A new multimetallic photoactive coordination polymer with high photostability and unique optical properties has been successfully synthesized.
Article
Chemistry, Inorganic & Nuclear
Komala Pandurangan, Anthony B. Carter, Paulo N. Martinho, Brendan Gildea, Tibebe Lemma, Shang Shi, Aizuddin Sultan, Tia E. Keyes, Helge Mueller-Bunz, Grace G. Morgan
Summary: This study reports the structural and magnetic properties of a new spin crossover complex in lattices with different counterions. Comparison experiments show that alkylation effectively inhibits the thermal spin crossover pathway. Further investigations confirm the stability of the high spin state in dilute environments.
Article
Chemistry, Multidisciplinary
Nirod Kumar Sarangi, Amrutha Prabhakaran, Tia E. Keyes
Summary: Quinacrine is a versatile drug with antimalarial, antianthelmintic, antiprotozoan, and multidrug resistance combating properties. By using microcavity-suspended lipid bilayers as in vitro models, the influence of cholesterol and mixed-lipid composition on the membrane interactions of quinacrine was investigated. Label-free surface-sensitive techniques, such as electrochemical impedance spectroscopy and surface-enhanced Raman spectroscopy, were utilized to study drug permeability and binding behavior.
Review
Chemistry, Multidisciplinary
Karmel S. Gkika, David Cullinane, Tia E. Keyes
Summary: Metal complex luminophores have been widely applied as imaging probes in cell imaging due to the use of peptide-facilitated delivery. The conjugation of cell-permeating or signal peptides to metal complex luminophores allows efficient transportation across the cell membrane. This article discusses the rationale behind using metal complexes as probes and sensors in cell imaging and highlights the advantages of using peptides as carriers for complex luminophores. The article also presents progress in applying peptides in metal complex peptide-driven conjugates for cell permeation and targeting.
TOPICS IN CURRENT CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorcan Holden, Karmel S. Gkika, Christopher S. Burke, Conor Long, Tia E. Keyes
Summary: This study reports a Ru(II) complex (Ru-PDC3) that combines the light switch capability of a Ru(II) dipyridylphenazine complex with the well-known G4-selective ligand Phen-DC3 into a single structure. The complex exhibits the expected light switch effect and strong affinity for G4 structures, while also possessing a powerful G4 disrupting capability. Additionally, the complex is fully water-soluble and readily permeable to live cells.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Jack Robinson, Nirod Kumar Sarangi, Tia E. Keyes
Summary: The study shows that Aβ(1-42) induces oligomerization on the outer leaflet of membranes containing DOPS, leading to membrane damage and solute leakage, with the effects dependent on the concentrations of DOPS and Aβ(1-42) as well as time.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Ruben Arturo Arellano-Reyes, Amrutha Prabhakaran, Rengel Cane E. Sia, Julien Guthmuller, Keshav Kumar Jha, Tingxiang Yang, Benjamin Dietzek-Ivansic, Vickie McKee, Tia E. Keyes
Summary: BODIPY heterochromophores with perylene and/or iodine substituents at the 2 and 6 positions were investigated for their potential as sensitizers in triplet-triplet annihilation up conversion (TTA-UC). The compounds exhibited strong charge transfer absorption and emission properties, and were effective sensitizers for TTA-UC with perylene annihilator in dioxane and DMSO solvents. The emission profiles remained characteristic of charge transfer transition across all solvents tested.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Rafaela T. Marques, Liliana P. Ferreira, Clara S. B. Gomes, Catia S. D. Lopes, Carlos E. S. Bernardes, Nirod Kumar Sarangi, Tia E. Keyes, Paulo N. Martinho
Summary: The storage of guest molecules in nonporous single crystals is an important development in the field of smart materials. We describe the synthesis and characterization of the new spin crossover Fe(III) compound [Fe(3-Br,5-ClsalEen)2]BPh4 center dot CH3CN center dot H2O (salEen = N-ethyl-N-(2-aminoethyl)salicylaldiminate) and its reversible single-crystal-to-single-crystal transformation upon desolvation and resolvation of the crystals. This compound behaves as a spin crossover sponge, and the desolvation/resolvation dynamics were studied through kinetic analysis.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Physical
Arpita Roy, Nirod Kumar Sarangi, Surajit Ghosh, Amrutha Prabhakaran, Tia E. Keyes
Summary: Antimicrobial peptides (AMPs) have significant potential in combating antibiotic resistance by targeting microbial membrane without harming mammalian cells. This study investigated the interactions and synergistic effects of two AMPs, magainin 2 and PGLa, on bacterial and mammalian membrane models. The combined AMPs formed toroidal pores, while individual AMPs only affected the exterior leaflet of the bacterial model. The impact on a ternary, mammalian mimetic membrane was much weaker.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Rhianne C. C. Curley, Christopher S. S. Burke, Karmel S. S. Gkika, Sara Noorani, Naomi Walsh, Tia E. E. Keyes
Summary: Parent and peptide conjugates of bistridentate Ru(II) complexes with expanded bite angles demonstrate high phototoxicity and exceptional permeability in both 2D and 3D cell models for potential use in photodynamic therapy. The Ru(II) complexes show enhanced emission quantum yields and lifetimes, promoting their photoinduced singlet oxygen production. The complexes exhibit significant phototoxicity toward pancreatic cancer cell monolayers, with phototoxic indices ranging from 580 to 760.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Meenaxi Saini, Tia E. Keyes
Summary: Pt1 selectively emits luminescence when binding to G-quadruplex rather than duplex DNA, with enhanced effect on parallel and hybrid G-quadruplex structures. The kinetics of binding are studied for c-myc and the response is partially reversible in a displacement assay.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Chao-Yi Yao, Hong-Yu Lin, Philip Morgenfurt, Tia E. Keyes, A. Prasanna de Silva
Summary: This article introduces shape-switchable cyclophane hosts that can capture and release reactive polypyridineRu(ii) complexes in water. This leads to a network of host-guest binding, acid-base reactions, and chemical redox interconversions. The study of (2-(2'-pyridyl)imidazole)Ru(ii) complexes reveals the emergence of molecular logic gate arrays of varying complexity. The luminescence switching in neutral solution is attributed to the features of the aromatic hosts, including enhanced radiative decay and suppressed nonradiative decay involving deprotonation by reducing the water content within the deep host cavity. These findings demonstrate the control of nanometric coordination chemistry/physics through inclusion in an open box. The shape-switching mechanism of wall collapse/erection is also influenced by the aromatic units of the macrocycle.
