Article
Optics
Anastasiia Kharcheva, Zinaida A. Charyshnikova, Nataliya E. Borisova, Tsagana B. Sumyanova, Oleg K. Farat, Dmitriy A. Kharitonov, Svetlana Patsaeva
Summary: The luminescence characteristics of a new water-soluble europium complex were studied, revealing the existence of different species of the complex in different pH environments. This finding has significant implications for the development of a multimodal pH sensor for aqueous environments.
JOURNAL OF LUMINESCENCE
(2022)
Article
Optics
Ekaterina Pshenay-Severin, Hyeonsoo Bae, Karl Reichwald, Gregor Matz, Jorg Bierlich, Jens Kobelke, Adrian Lorenz, Anka Schwuchow, Tobias Meyer-Zedler, Michael Schmitt, Bernhard Messerschmidt, Juergen Popp
Summary: Multimodal non-linear microscopy combining various techniques is a powerful tool for label-free investigation of tissue structure and molecular composition. Implementing this approach in an in vivo imaging endoscope presents challenges, but a new fiber-scanning endoscope platform offers a solution with efficient signal collection and high power laser delivery.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yongshan Ma, Yanzhao Xia, Yanyan Zhu, Fengxia Zhang, Jingcheng Cui, Tianyi Jiang, Xiangfeng Jia, Xuemei Li
Summary: The novel probe P1 based on a core-extended perylene tetra-(alkoxycarbonyl) (PTAC) derivative showed high sensitivity and selectivity for detecting fluoride ions, with a 1:1 stoichiometry and a detection limit of 0.97 RM. The probe exhibited a red-shift and fluorescence quenching response in the presence of F-, with emission intensity decreasing linearly with F- concentration. The mechanism of intermolecular proton transfer (IPT) and the theoretical DFT results of the P1-F- complex were also studied.
Article
Chemistry, Physical
Qin Zhang, Bingyao Wang, Yifei Zhang, Jie Yang, Bodan Deng, Bei Ding, Dongping Zhong
Summary: Transient amyloid intermediates play a crucial role in neurodegenerative diseases, and optical methods combined with site-specific tryptophan probes can elucidate the molecular mechanism of amyloid formation.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Zi-Yi Chen, Peng-Cheng Li, Cui Guo, Xiao-Huan Chen, Bing-Jie Liu, Hui-Jing Zou, Wen-Jie Liang, Hai Xu
Summary: Two-dimensional materials have been widely studied for their thickness-dependent physical and chemical properties. These materials have a large surface-to-volume ratio, allowing for easy functionalization, making them suitable for chemical sensors. In this study, two types of 2D metal-organic frameworks based on functionalized anthracene derivatives were synthesized and used as sensors for Fe3+ and ascorbic acid at low concentrations.
Article
Biochemistry & Molecular Biology
Cristina Amaral, Georgina Correia-da-Silva, Cristina Ferreira Almeida, Maria Joao Valente, Carla Varela, Elisiario Tavares-da-Silva, Anne Marie Vinggaard, Natercia Teixeira, Fernanda M. F. Roleira
Summary: This study investigates the anti-cancer properties and multi-target potential of compound 1 alpha,2 alpha-epoxy-6-methylenandrost-4-ene-3,17-dione (Oxy) in breast cancer cells. The results show that Oxy acts as an ER alpha antagonist and AR agonist, suggesting it could be a new multi-target drug. Furthermore, Oxy has the ability to sensitize AI-resistant breast cancer cells.
Article
Chemistry, Multidisciplinary
Sounderya Nagarajan, Florent Poyer, Laura Fourmois, Delphine Naud-Martin, Kadda Medjoubi, Andrea Somogyi, Gabrielle Schanne, Lucas Henry, Nicolas Delsuc, Clotilde Policar, Helene C. Bertrand, Florence Mahuteau-Betzer
Summary: In this study, two bimodal probes suitable for X-ray fluorescence imaging were designed, capable of labeling organelles. One probe altered the localization in live cells, while the other retained good photophysical properties and labeling ability in live cells. The influence of calcium channels on probe uptake was also investigated.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Engineering, Environmental
Agnes Rejasse, Jehan Waeytens, Ariane Deniset-Besseau, Nicolas Crapart, Christina Nielsen-Leroux, Christophe Sandt
Summary: The larvae of Greater Wax Moth, Galleria mellonella, can partially degrade polyethylene (PE) plastics but cannot fully metabolize them.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Juan Sanz Garcia, Marie Gaschard, Isabelle Navizet, Mehdi Sahihi, Siden Top, Yong Wang, Pascal Pigeon, Anne Vessieres, Michele Salmain, Gerard Jaouen
Summary: The family of ferrocifens, derived from the anti-oestrogen tamoxifen, exhibit a broad antitumor activity by generating reactive oxygen species and electrophilic quinone methides. In addition to their known targets, cathepsin B was unexpectedly identified as a new target for ferrocifens.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Clotilde Policar, Jean Bouvet, Helene C. Bertrand, Nicolas Delsuc
Summary: Superoxide dismutases (SODs) are metalloproteins that protect cells from oxidative stress by controlling the concentration of superoxide. Recent studies have shown that some SOD mimics designed to react with superoxide could indirectly enhance cellular antioxidant defenses. Understanding the bioactivity of these SOD mimics requires information on their cell-penetration, speciation, and subcellular location.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Cell Biology
Gabrielle Schanne, Martha Zoumpoulaki, Geraldine Gazzah, Amandine Vincent, Hugues Preud'homme, Ryszard Lobinski, Sylvie Demignot, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
Summary: Oxidative stress is important in the pathogenesis of inflammatory bowel diseases (IBDs). Superoxide dismutase (SOD) defenses are weakened in IBD patients. A Mn(II) complex SOD mimic (Mn1) based on an open-chain diaminoethane ligand has antioxidant and anti-inflammatory effects. Metal exchanges occur between the manganese center and metal ions in the biological environment. New Mn(II) complexes with cyclohexyl and/or propyl groups show improved SOD activity and kinetic inertness in metal ion exchange processes. They provide anti-inflammatory and antioxidant effects in cells at lower doses than Mn1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Multidisciplinary
Martha Zoumpoulaki, Gabrielle Schanne, Nicolas Delsuc, Hugues Preud'homme, Elodie Quevrain, Nicolas Eskenazi, Geraldine Gazzah, Regis Guillot, Philippe Seksik, Joelle Vinh, Ryszard Lobinski, Clotilde Policar
Summary: The detection and quantification of exogenous metal complexes are crucial in understanding their activity in complex biological media. This study used ion mobility spectrometry-mass spectrometry (IMS-MS) to demonstrate the intracellular presence and concentration of Mn1 and Mn1P complexes, which are superoxide dismutase (SOD) mimics, in cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Caroline Prieux-Klotz, Henri Chedotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chene, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frederic Batteux, Helene C. Bertrand, Carole Nicco, Romain Coriat
Summary: A new prodrug combining a Mn SOD mimic with oxaliplatin was designed and studied for its antitumoral effects. In vitro and in vivo experiments showed that this combination treatment increased ROS production, improved antitumoral efficacy, and decreased oxaliplatin-induced peripheral neuropathy without impairing the overall clinical tolerance to oxaliplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Charles Fayolle, Pascal Pigeon, Nathalie Fischer-Durand, Michele Salmain, Olivier Buriez, Anne Vessieres, Eric Labbe
Summary: The first fluorescent ferrociphenol derivative has been synthesized, and its fluorescence properties were found to be dependent on the redox state of the ferrocene group. This compound could serve as a useful tool to study the biodistribution and redox state of ferrociphenols in cancer cells.
Article
Chemistry, Analytical
Christophe Sandt, Ferenc Borondics
Summary: Human hair medulla and cortex were chemically mapped at the sub-micron scale using Optical Photothermal Infrared microspectroscopy (OPTIR) and a Quantum Cascade Laser (QCL) source. The study revealed heterogeneity in hair medulla, with the presence of calcium carboxylates, aliphatic lipids, and wax esters. OPTIR proved to be a reliable method for measuring, mapping, and imaging dark and photosensitive samples, although it may underestimate or fail to detect weaker peaks such as CH3, C--O, and S--O.
Article
Plant Sciences
Pjotr Meyvisch, Kenneth Neil Mertens, Pieter Roger Gurdebeke, Christophe Sandt, Vera Pospelova, Henk Vrielinck, Ferenc Borondics, Stephen Louwye
Summary: This study used ATR microscope FTIR spectroscopy to investigate the dinosporin composition in the walls of modern organic-walled dinoflagellate resting cysts. Variable cyst wall compositions were observed and four spectrochemical groups were identified. The study also discussed possible proxies derivable from the spectrochemical composition of modern and fossil dinocysts. The research filled a knowledge gap in understanding the chemical nature of dinocyst walls and provided new insights into the role of eumelanin in colored dinocysts, as well as the implications of different research methods on the structure of dinocyst walls.
JOURNAL OF PHYCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Lucie Ludvikova, Emma Simon, Mathieu Deygas, Thomas Panier, Marie-Aude Plamont, Jean Ollion, Alison Tebo, Matthieu Piel, Ludovic Jullien, Lydia Robert, Thomas Le Saux, Agathe Espagne
Summary: We present a method to reduce photobleaching and phototoxicity of fluorescent proteins by exploiting the photophysical process of reverse intersystem crossing. Dual illumination with near-infrared light during fluorophore excitation reduces photobleaching effects by 1.5-9.2-fold and can be easily implemented on commercial microscopes, making it effective in both eukaryotic and prokaryotic cells with various fluorescent proteins.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Leonard Piroska, Alexis Fenyi, Scott Thomas, Marie-Aude Plamont, Virginie Redeker, Ronald Melki, Zoher Gueroui
Summary: α-Synuclein aggregation is associated with various synucleinopathies. Recent studies suggest that α-Synuclein can form liquid condensates. This study investigates the interaction between condensates and fibrillar structures. The results show that fibrils can trigger the evolution of liquid condensates into solid-like structures with pathological features. α-Synuclein that did not undergo phase separation did not elicit such changes. The findings propose a model where α-Synuclein within condensates fuels the growth of exogenous fibrillar seeds, thereby accelerating the propagation of pathogenic aggregates.
Article
Chemistry, Analytical
Armin Mozhdehei, Aneta Slodczyk, Eirik Almklov Magnussen, Achim Kohler, Christophe Sandt, Ferenc Borondics, Lionel Mercury
Summary: Mid-infrared microspectroscopy is a non-invasive technique that can identify molecular structure and chemical composition at a small scale. High-resolution measurements are required for investigating small objects, and different protocols and machines were tested in this study.
Article
Chemistry, Multidisciplinary
Mrinal Mandal, Hessam Sepasi Tehrani, Qianhua Mai, Emma Simon, Marie-Aude Plamont, Christine Rampon, Sophie Vriz, Isabelle Aujard, Thomas Le Saux, Ludovic Jullien
Summary: In this study, a series of hydrophobic and hydrophilic caged fluorophores based on a robust pyranine backbone were reported. These fluorophores can be used for the absolute quantification of light intensity in chemical and biological samples. The brightness of these fluorophores increases upon illumination, and their uncaging cross-sections have been thoroughly characterized.
Article
Chemistry, Multidisciplinary
Marco Fabbiani, Sebastiano Romi, Frederico Alabarse, Anna Celeste, Francesco Capitani, Ferenc Borondics, Christophe Sandt, Sylvie Contreras, Leszek Konczewicz, Jerome Rouquette, Mario Santoro, Julien Haines
Summary: In this study, pi-conjugated polymer polydiphenylbutadiyne (PDPB) was prepared inside the 1.2 nm pores of aluminophosphate AlPO4-54 at the nanoscale. The confined PDPB exhibited complete polymerization and showed important photocatalytic properties and gas sensing capabilities.
