Article
Biotechnology & Applied Microbiology
Sarabjot Kaur, Rushikesh Tambat, Vikas Pathania, Hemraj Nandanwar, Sanjeev Soni
Summary: This study demonstrates that photo-thermally enhanced triangular silver nanoplates have strong antimicrobial efficacy and can eradicate various pathogens in a short period of time, which is significant for a wide range of antibacterial and antifungal applications.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Guocheng Xie, Sijia Gao, Jinzhao Ou, Meng Zhu, Man Wu, Xiaoyan Ju, Zhuang Li, Ye Tian, Zhongwei Niu
Summary: By conjugating peptides onto tobacco mosaic virus, the resulting nanoparticles show significantly enhanced antibacterial effects against Gram-negative bacteria. The high osmotic pressure and reactive oxygen species generated by the peptide-TMV cause the death of Escherichia coli, while also downregulating biofilm-related genes to inhibit biofilm formation. This study opens up new possibilities for combating Gram-negative bacteria-related infections.
Review
Immunology
Jing Zhang, Ling Chen, Yang Yang, Xiao Liu, Yuan Yuan, Shi-rong Song, Yue Zhao, Jian Mao
Summary: The purpose of this study was to compare the clinical and laboratory characteristics of late-onset sepsis (LOS) caused by Gram-negative and Gram-positive bacteria in preterm neonates and evaluate the diagnostic accuracy of biomarkers. The results showed that LOS caused by Gram-negative bacteria in preterm neonates had higher levels of CRP and lower platelet counts. Therefore, platelet count and CRP values may be useful biomarkers to differentiate sepsis caused by Gram-negative and Gram-positive bacteria in preterm neonates.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Antonella Migliaccio, Maria Stabile, Maria Bagattini, Maria Triassi, Rita Berisio, Eliana De Gregorio, Raffaele Zarrilli
Summary: Resveratrol can reverse tolerance and restore susceptibility to CHX and BZK in the majority of microorganisms causing HAI. The efflux pump inhibitor reduced the MIC and MBC of CHX and BZK in most strains, while resveratrol dose-dependently decreased the MIC and MBC of the biocides.
Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Multidisciplinary Sciences
Aliya Fazal, Sajida Ara, Muhammad Tayab Ishaq, Kalsoom Sughra
Summary: The study focuses on the green synthesis of copper oxide nanoparticles using vegetable peels, with an ecofriendly approach and low fabrication temperature. It also explores the antibacterial efficacy of the nanoparticles, showing a more significant biocidal effect on Gram-negative bacteria compared to Gram-positive bacteria. The research highlights the potential of utilizing biowaste for the production of useful products.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Jianxing Wang, Jie Li, Zipeng Shen, Dong Wang, Ben Zhong Tang
Summary: In this study, phospholipid-mimetic aggregation induced emission luminogens (AIEgens) were developed to selectively eliminate both Gram-positive and Gram-negative bacteria. By utilizing the different structure of two bacterial membranes and the regulated length of substituted alkyl chains of AIEgens, these AIEgens can anchor onto the bacterial membrane and kill bacteria. AIEgens with short alkyl chains exhibit selective ablation to Gram-positive bacteria, while AIEgens with long alkyl chains selectively destroy the membranes of Gram-negative bacteria. Fluorescent imaging and in vitro/in vivo experiments confirm the extraordinary antibacterial selectivity of these AIEgens towards both types of bacteria. This research could contribute to the development of species-specific antibacterial agents.
Article
Food Science & Technology
Yi Kang, Yanmin Liang, Hao Sun, Jie Dan, Qiuping Zhang, Zehui Su, Jianlong Wang, Wentao Zhang
Summary: The emergence of magnetic nanotechnology has led to the development of novel sample preparation techniques. Phytic acid is a natural organophosphate compound that has a high affinity for multivalent metal ions as well as the ability to form complexes with molecules such as proteins. In this study, we describe a cost-effective method using phytic acid-modified Fe3O4 for the rapid concentration and isolation of foodborne pathogens, demonstrating its excellent selective ability towards Gram-positive bacteria with high capture efficiency for MRSA.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Microbiology
Edwin Esau Hernandez-Arvizu, Teresa Monserrat Silis-Moreno, Jose Alejandro Garcia-Arredondo, Angelina Rodriguez-Torres, Jose Antonio Cervantes-Chavez, Juan Mosqueda
Summary: Anti-microbial peptides play a crucial role in the defense mechanisms of various organisms. In this study, a cathelicidin-like peptide called Aquiluscidin was identified for the first time in Crotalus aquilus, exhibiting remarkable inhibitory activity against multiple bacteria. It has the potential to be a candidate for further antimicrobial research.
Review
Engineering, Environmental
Meera Varghese, Manoj Balachandran
Summary: CDs, known for their nontoxic characteristics and inherent antibacterial potency, have gained significant attention as potential alternative antibiotics due to the increasing antibiotic resistance of bacterial strains. The light-driven antibacterial action of CDs is safe and effective with minimal side effects, and their direct interaction with bacterial cells contributes to their overall antibacterial activity. The unique and complex mechanisms of antibacterial activity of CDs involve ROS generation, degeneration of cell structure, and cytoplasm leakage, among other factors, providing insights for significant future research in this area.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Applied
Yuanyuan Wang, Yang Xue, Qianqian Bi, Dingkui Qin, Qizhen Du, Peng Jin
Summary: The study demonstrated that ECL-NPs have significant antibacterial efficiency against gram-positive bacteria, with the synergistic effect of low-dose lysozyme enhancing their inhibitory effects. Scanning electron microscopy showed that ECL-NPs could completely break down the cellular structures of bacteria, while 100% microbial inhibition was observed in fresh fruits treated with ECL-NPs for 15 days.
Review
Fisheries
Hien Van Doan, Mehdi Soltani, Einar Ringo
Summary: Gram-positive probiotic bacteria have been shown to be effective in preventing disease outbreaks in aquaculture by producing bioactive compounds that can inhibit potential pathogenic Gram-negative bacteria. They can also enhance host immune-physiological functions and improve disease resistance. Further research is needed to optimize probiotic dosages and understand the in vivo effects of Gram-positive probiotics.
Article
Chemistry, Multidisciplinary
Guobin Qi, Yufu Tang, Leilei Shi, Jiahao Zhuang, Xianglong Liu, Bin Liu
Summary: This study discovers a new antimicrobial agent, a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte (PorHP), which exhibits high photodynamic bactericidal activity against Gram-negative bacteria and low cytotoxicity toward mammalian cells.
Article
Nanoscience & Nanotechnology
Chaoren Yan, Chaoli Wang, Tongtong Hou, Ping Guan, Youbei Qiao, Liulong Guo, Yonggang Teng, Xiaoling Hu, Hong Wu
Summary: T-SCQDs is a novel method that enables rapid discrimination of peptidoglycan, lasting tracking of bacteria, and nondestructive identification of Gram-positive bacteria within the range of 50-500 μg/mL.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Medicinal
Charlotte M. J. Wesseling, Nathaniel I. Martin
Summary: New approaches targeting Gram-negative bacteria are crucial in combating antibiotic resistance. This review focuses on peptide-based and small organic compounds that disrupt the outer membrane of Gram-negative bacteria and synergize with clinically used antibiotics. The review also assesses the hemolytic activity of these compounds and their selectivity towards Gram-negative bacteria.
ACS INFECTIOUS DISEASES
(2022)
Article
Immunology
Michal Krupka, Tereza Matusu, Helena Sutova, Katerina Wezdenkova, Renata Vecerova, Yvona Smesna, Milan Kolar, Hana Bilkova Frankova, Jana Krivankova, Miroslav Jorenek, Zdenek Novak, Milan Raska, Ondrej Holy
Summary: This study analyzed data from four laboratories in the Olomouc Region, Czech Republic, and found significant differences in measles positive results depending on the individual laboratories and detection methods used. However, individuals born before the introduction of vaccination showed higher levels of antibodies.
Article
Biology
Yuliya Morozova, Iva Voborna, Radovan Zizka, Katerina Bogdanova, Renata Vecerova, Dominik Rejman, Milan Kolar, Duy Dinh Do Pham, Pavel Holik, Roman Mostek, Matej Rosa, Lenka Pospisilova
Summary: The study focused on the ex vivo effects of second- and third-generation LPPOs on Enterococcus faecalis in root canal samples, comparing them with other disinfectants. Results showed that LPPOs demonstrated superior bactericidal effects compared to the tested disinfectants by reducing planktonic bacterial cells and inhibiting biofilm formation.
Article
Engineering, Biomedical
Martin Cernan, Tomas Szotkowski, Jaromir Hubacek, Milan Kolar, Edgar Faber, Karel Indrak, Tomas Papajik
Summary: This study retrospectively analyzed the incidence of infectious complications in AML patients without routine antibiotic prophylaxis in a clinical site in Czech Republic over a 15-year period. The results showed that infectious complications were common, but infectious mortality was comparable to patients with prophylaxis. Additionally, achieving complete remission had a significant effect on the duration of febrile episodes and overall survival, while infection or fever of unknown origin at diagnosis increased the colonization of multi-drug resistant bacterial strains and prolonged antibiotic therapy.
BIOMEDICAL PAPERS-OLOMOUC
(2023)
Article
Multidisciplinary Sciences
Lucie Hochvaldova, David Panacek, Lucie Valkova, Robert Prucek, Vera Kohlova, Renata Vecerova, Milan Kolar, Libor Kvitek, Ales Panacek
Summary: This study reports an effective way of enhancing and restoring the antibacterial activity of inactive antibiotics by using a cyanographene/Ag nanohybrid. The combined treatment showed synergistic and partial synergistic effects against multiresistant bacterial strains, indicating the potential of the nanohybrid in overcoming antibiotic resistance. The study also revealed that the interaction between the antibiotic's mode of action and the bacterial resistance mechanism strongly influenced the efficacy of the combined treatment.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Biology
Milan Kolar
Review
Chemistry, Multidisciplinary
Maomao Xie, Meng Gao, Yang Yun, Martin Malmsten, Vincent M. M. Rotello, Radek Zboril, Omid Akhavan, Aliaksandr Kraskouski, John Amalraj, Xiaoming Cai, Jianmei Lu, Huizhen Zheng, Ruibin Li
Summary: Antimicrobial resistance (AMR) is a major threat to the environment and health, and antimicrobial nanomaterials are being explored as alternatives to conventional antibiotics. Some antimicrobial nanomaterials show AMR-independent antimicrobial effects, while others trigger the evolution of AMR. This review compares the mechanisms and relationships of antibiotics and antimicrobial nanomaterials, examines nano-microbe interactions, and provides an outlook on future antimicrobial nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Robert Prucha, Vitezslav Hruby, Dagmar Zaoralova, Eva Otyepkova, Veronika Sedajova, Jan Kolarik, Radek Zboril, Miroslav Medved', Michal Otyepka
Summary: Anchoring single metal atoms on suitable substrates is a convenient route towards materials with unique electronic and magnetic properties. Cyanographene (GCN), a highly functionalized graphene containing nitrile groups, offers a favorable arrangement for anchoring metal atoms. In this study, density functional theory (DFT) calculations were used to analyze the coordination effects in the binding of late 3d cations to GCN in aqueous solutions. Copper cations were found to be the most tightly bonded to GCN. Coordination effects significantly reduced the binding affinities predicted by implicit solvation models.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Olivier Henrotte, Eva Yazmin Santiago, Artur Movsesyan, Luca Mascaretti, Morteza Afshar, Alessandro Minguzzi, Alberto Vertova, Zhiming M. Wang, Radek Zboril, Stepan Kment, Alexander O. Govorov, Alberto Naldoni
Summary: The investigation of photocatalytic systems at the nanoscale is crucial for understanding their fundamental principles, improving their design, and enhancing their applicability. A photochemical nanoscopy technique has been developed to detect the molecular products of plasmonic hot-carrier-driven photocatalytic reactions with nanometric precision. Applying this methodology to Au/TiO2 plasmonic photocatalysts, it was discovered that smaller and denser Au nanoparticle arrays have lower optical contribution but higher quantum efficiency in hot-hole-driven photocatalysis, which is closely related to population heterogeneity. This study also revealed the areas of oxidation and reduction product evolution in a single plasmonic nanodiode, demonstrating the bipolar behavior of such nanosystems. These findings enable quantitative investigations at the nanoscale to evaluate the photocatalytic reactivity of low-dimensional materials in various chemical reactions.
Review
Chemistry, Multidisciplinary
Iosif Tantis, Smita Talande, Vasileios Tzitzios, Georgia Basina, Vishal Shrivastav, Aristides Bakandritsos, Radek Zboril
Summary: This review focuses on recent advances in electrochemical energy storage (EES) technologies related to 2D crystals originating from non-layered 3D solids (non-van der Waals; nvdW) and their influence on the materials' features. The methods and challenges in top-down and bottom-up strategies towards nvdW 2D sheets and their applications in EES are discussed. Moreover, the opportunities and challenges of nvdW 2D systems in various applications are highlighted.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Tomas Malina, Cordula Hirsch, Alexandra Rippl, David Panacek, Katerina Polakova, Veronika Sedajova, Magdalena Scheibe, Radek Zboril, Peter Wick
Summary: Graphene oxide (GO) is a promising delivery nanoplatform, but its non-specific surface properties and heterogeneity in stability limit its commercial application. Evaluating the interaction of emerging graphene derivatives with endothelial and immune cells is important. The study demonstrated that graphene acid (GA) and cyanographene (GCN) have better biocompatibility and potential for drug/gene delivery compared to GO.
Review
Chemistry, Physical
En Zhao, Wenjun Zhang, Lin Dong, Radek Zboril, Zupeng Chen
Summary: Transfer hydrogenation using liquid hydrogen carriersas the direct proton sources under mild conditions has attracted considerable attention in the field of organic synthesis. Photocatalytic water-donating transfer hydrogenation (PWDTH) has emerged as an eco-friendly alternative to conventional hydrogenation technology. This paper discusses recent advances in PWDTH reactions, including the mechanism of hydrogen transfer and the design principles of efficient photocatalysts. It also explores the current challenges and future opportunities in this rapidly developing field.
Article
Infectious Diseases
Josef Chudacek, Petr Spicka, Milan Kolar, Martin Stasek, Stefan Kolcun, Dusan Klos, Kristyna Hricova, Patrik Mlynarcik, Vendula Pudova, Olga Klementova, Rostislav Horacek
Summary: This study extends the existing knowledge of hospital-acquired pneumonia (HAP) complicating secondary peritonitis by providing detailed microbiological characteristics, including the identification of isolated bacterial pathogens and their potential sources. The study emphasizes the importance of initial antibiotic therapy effective against enterobacteria, ESBL and AmpC β-lactamases producing strains, Pseudomonas aeruginosa, and Enterococcus faecalis in patients with secondary peritonitis complicated by HAP. Monitoring the respiratory tract bacterial microflora in these patients is also highlighted as important.
Article
Chemistry, Physical
Shashikant A. Kadam, Stefania Sandoval, Zdenek Bastl, Karolina Simkovicova, Libor Kvitek, Juraj Jasik, Joanna Elzbieta Olszowka, Stanislav Valtera, Mykhailo Vaidulych, Jaroslava Moravkova, Petr Sazama, David Kubicka, Arnaud Travert, Jeroen A. van Bokhoven, Alessandro Fortunelli, Armin Kleibert, Martin Kalbac, Stefan Vajda
Summary: In this study, the cyclohexane oxidative dehydrogenation (ODH) catalyzed by cobalt ferrite nanoparticles supported on reduced graphene oxide (RGO) was investigated. The active sites responsible for full and partial dehydrogenation were identified using advanced spectroscopic techniques and kinetic analysis. The study revealed the cooperativity between different sites and the role of the support in controlling the abundance of undesired active sites.
Review
Pharmacology & Pharmacy
Viktor Sebek, Pavel Anzenbacher, Dominik Rejman, Alena Spicakova, Milan Kolar
Summary: Lipophosphonoxins (LPPOs) are a new group of antibiotics that target bacterial cell membranes. They have bactericidal activity against both Gram-positive and Gram-negative bacteria, with better selectivity and less resistance compared to previous generations. LPPOs have shown potential therapeutic effects in bone cement infections and wound infections.
Review
Chemistry, Multidisciplinary
Virender K. Sharma, Xingmao Ma, Radek Zboril
Summary: Water is a crucial component of the United Nations' sustainable development goals, and water reuse is becoming increasingly accepted in response to global water scarcity. However, traditional treatment processes face challenges in treating low concentrations of pollutants in the presence of other chemicals. Advanced oxidation processes and the use of single atom catalysts offer promising solutions to these challenges.
CHEMICAL SOCIETY REVIEWS
(2023)
