Journal
ANALYST
Volume 136, Issue 7, Pages 1288-1297Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0an00969e
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Funding
- National Institute of Health [R21RR024397]
- Flight Attendant Medical Research Institute [FAMRI-082502]
- Defense Advanced Research Projects Agency (DARPA) via Micro/Nano Fluidics Fundamentals Focus Center at the University of California at Irvine
- National Science Foundation [OISE-0968313]
- NATIONAL CENTER FOR RESEARCH RESOURCES [R21RR024397] Funding Source: NIH RePORTER
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Microfluidics is a platform technology that has been used for genomics, proteomics, chemical synthesis, environment monitoring, cellular studies, and other applications. The fabrication materials of microfluidic devices have traditionally included silicon and glass, but plastics have gained increasing attention in the past few years. We focus this review on thermoplastic microfluidic devices and their applications in protein and DNA analysis. We outline the device design and fabrication methods, followed by discussion on the strategies of surface treatment. We then concentrate on several significant advancements in applying thermoplastic microfluidic devices to protein separation, immunoassays, and DNA analysis. Comparison among numerous efforts, as well as the discussion on the challenges and innovation associated with detection, is presented.
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