Review
Chemistry, Analytical
Daniel G. Delafield, Gaoyuan Lu, Cameron J. Kaminsky, Lingjun Li
Summary: Mass spectrometry-based biomolecular analyses have become popular in research settings. Gas phase ion separation techniques provide a fourth dimension of analysis, enabling rapid characterization and high throughput profiling. This review highlights the latest developments and applications of high-end ion-mobility enabled instruments and their advantages for biomolecular research.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Karen E. Butler, Yoshihiko Takinami, Adam Rainczuk, Erin S. Baker, Blaine R. Roberts
Summary: Native mass spectrometry combined with IMS-MS technology can be used to study the tertiary and quaternary structure of proteins, validate other structural determination methods, and provide more comprehensive structural information.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
David S. Roberts, Morgan Mann, Jake A. Melby, Eli J. Larson, Yanlong Zhu, Allan R. Brasier, Song Jin, Ying Ge
Summary: Researchers have successfully elucidated the complete structure of newly discovered O-glycans on the S protein regional-binding domain (SR-BD) of the SARS-CoV-2 virus through a hybrid mass spectrometry approach. This method can provide insights into the interactions between the virus and host cells, laying a foundation for understanding the functional roles of O-glycans in SARS-CoV-2 and other glycoproteins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Brian C. Hauck, Bradley R. Ruprecht, Patrick C. Riley
Summary: Additive manufacturing is increasingly used in the fabrication of components for analytical instrumentation and chemical sensors. This study demonstrates a print-in-place and non-modular ion mobility spectrometer, and evaluates the accuracy of FDM as a manufacturing method.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Fabianowski, Miroslaw Maziejuk, Monika Szyposzynska, Monika Wisnik-Sawka
Summary: The article presents a technique of differential ion mobility spectrometry (DMS) for the detection and identification of volatile organic compounds (VOCs) from various categories. It analyzes the possibility of mixture identification using only the DMS spectrometer and provides several examples. The article also discusses the analysis of different compounds, their mechanisms of fragmentation, influence on effective ion temperature, and high electric field intensity.
Article
Chemistry, Physical
Younes Valadbeigi, Vahideh Ilbeigi, Zahra Khodabandeh
Summary: The ionization of glycerol, triethanolamine, and tris(hydroxymethyl)aminomethane was investigated using ion mobility spectrometry in an atmospheric pressure corona discharge ion source. The ionization process of the triols involves both deprotonation and anion attachment, while the thermodynamics of the reactions were studied using density functional theory. The presence of chloroform and bromoform as dopants resulted in the ionization mechanism of the triols being only halide attachment due to the lower basicity of Cl- and Br-.
CHEMICAL PHYSICS LETTERS
(2021)
Review
Spectroscopy
Fangbo Xia, Jian-Bo Wan
Summary: Lipids play essential roles in biological functions and mass spectrometry is the preferred method for lipid analysis. However, untargeted qualitative profiling and absolute quantitation of lipids are still challenging due to their structural diversity and similarity. Chemical derivatization techniques have been developed to improve lipidomic analysis, providing more structural information and better analytical performance.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Environmental Sciences
Alexandra C. Cordova, William D. Klaren, Lucie C. Ford, Fabian A. Grimm, Erin S. Baker, Yi-Hui Zhou, Fred A. Wright, Ivan Rusyn
Summary: This study used representative high production volume categories of petroleum UVCBs to compare the chemical composition and bioactivity data, finding that existing categories are not accurate enough and identifying specific constituents that influence these associations. This suggests that combining chemical composition and bioactivity data is a promising approach to better characterize the variability within manufacturing categories of petroleum UVCBs.
Article
Chemistry, Physical
Marwa Abdelmouleh, Mathieu Lalande, Edith Nicol, Gilles Frison, Guillaume van der Rest, Jean-Christophe Poully
Summary: It has been shown that 18-crown-6-ether plays a more active role in chemical processes during activation in mass spectrometers, abstracting protons or protonated molecules from peptides and potentially changing binding sites. Experimental and theoretical results support this new perspective.
Article
Biochemical Research Methods
Christoph Schaefer, Florian Schlottmann, Ansgar T. Kirk, Stefan Zimmermann
Summary: High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) chemically ionize gaseous samples and separate ions under high reduced electric field strengths. Increasing sample gas humidity shifts the mechanism of product ion formation from charge transfer to proton transfer. For HiKE-IMS, increasing sample gas humidity benefits the ionization yield of most analytes.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Ludwig R. Sinn, Sven H. Giese, Marchel Stuiver, Juri Rappsilber
Summary: Ion-mobility spectrometry has the potential to solve analytically challenging research questions by adding an extra separation dimension to liquid chromatography-mass spectrometry. By using machine learning, the understanding of field asymmetric waveform ion-mobility spectrometry for the analysis of cross-linked peptides has been deepened and ideal compensation voltages correlating with chromatography fraction number have been identified.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jiaxin Feng, Hansen Zhao, Xiaoyun Gong, Meng-Chan Xia, Lesi Cai, Huan Yao, Xu Zhao, Zihe Yan, Zhanping Li, Honggang Nie, Xiaoxiao Ma, Sichun Zhang
Summary: Research has shown that small MPs are highly toxic and current methods for detection and analysis are inadequate. A new method using SIMS imaging allows for rapid and accurate identification and spatial mapping of small MPs in organisms, offering a new approach to study their biological effects.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Hector Guillen-Alonso, Ignacio Rosas-Roman, Robert Winkler
Summary: 3D-printing has revolutionized rapid prototyping in analytical chemistry, particularly in ion studies where custom components and gadgets significantly enhance existing mass spectrometry systems. The fast turnover of design improvements enabled by permissive licenses has led to a community-driven development, offering economic advantages for public research and education.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Multidisciplinary
Yao Qian, Xiangyu Guo, Yunfang Wang, Zheng Ouyang, Xiaoxiao Ma
Summary: A mobility-modulated sequential dissociation (MMSD) strategy was developed for mass spectrometry imaging, enabling spatial lipidomics capable of multiplexed MS/MS imaging of 24 structurally distinct lipids. The method revealed a potential biomarker in a human hepatocellular carcinoma tissue.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Xin Meng, Junpeng Xing, Shu Liu, Zhiqiang Liu, Fengrui Song
Summary: This study successfully identified the chemical components of Tribulus terrestris and revealed the potential of its steroidal saponins for diabetes treatment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Engineering, Environmental
Sergio Montoya-Suarez, Fredy Colpas-Castillo, Edgardo Meza-Fuentes, Johana Rodriguez-Ruiz, Roberto Fernandez-Maestre
WATER SCIENCE AND TECHNOLOGY
(2016)
Article
Physics, Atomic, Molecular & Chemical
Roberto Fernandez-Maestre, Dairo Meza-Morelos, Ching Wu
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2016)
Article
Biochemical Research Methods
Roberto Fernandez-Maestre, Dairo Meza-Morelos, Ching Wu
JOURNAL OF MASS SPECTROMETRY
(2016)
Article
Chemistry, Analytical
Roberto Fernandez-Maestre, Dairo Meza-Morelos, Ching Wu
MICROCHEMICAL JOURNAL
(2016)
Article
Physics, Atomic, Molecular & Chemical
Roberto Fernandez-Maestre
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2017)
Article
Biochemical Research Methods
Dairo Meza-Morelos, Roberto Fernandez-Maestre
JOURNAL OF MASS SPECTROMETRY
(2017)
Article
Instruments & Instrumentation
R. Fernandez-Maestre
REVIEW OF SCIENTIFIC INSTRUMENTS
(2017)
Article
Environmental Sciences
Roberto Fernandez-Maestre, Boris Johnson-Restrepo, Jesus Olivero-Verbel
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH
(2018)
Review
Biochemical Research Methods
Roberto Fernandez-Maestre
JOURNAL OF MASS SPECTROMETRY
(2018)
Article
Biochemical Research Methods
Roberto Fernandez-Maestre, Mahmoud Tabrizchi, Dairo Meza-Morelos
Summary: This study investigated the effects of interaction energy, intermolecular bonds, and analyte size on ion mobility shifts by introducing different shift reagents and using electrospray ionization-IMS-mass spectrometry. The results showed that shift reagents can effectively discriminate false positives caused by overlapping peaks, which is important for resolving interferences and improving the accuracy of detection methods.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Roberto Fernandez-Maestre, Markus Doerr
Summary: Drift tube ion mobility spectrometry (IMS)-quadrupole mass spectrometry (QMS) was used to test the separation of enantiomers in racemic mixtures of twelve alpha-amino acids and three chiral drugs. Chiral selectors were introduced into the buffer gas of the IMS instrument. However, the racemic mixtures could not be separated, and several explanations were analyzed. Recommendations for potential enantiomer separations by IMS were proposed.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Roberto Fernandez-Maestre, Martha C. Daza
Summary: The study investigated the effect of 2-butanol as a contaminant in ion mobility spectrometry (IMS) and found that at different temperatures, the addition of 2-butanol influenced the ion mobilities of amino acid substances, with the most significant impact occurring at lower temperatures. Therefore, for accurate reduced mobilities, it is recommended to conduct drift-tube ion mobility measurements at high temperatures.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Roberto Fernandez Maestre
ANALYTICAL METHODS
(2017)
Article
Spectroscopy
Roberto Fernandez-Maestre
INTERNATIONAL JOURNAL FOR ION MOBILITY SPECTROMETRY
(2017)
Review
Medicine, General & Internal
Katiuska I. Romero, Roberto Fernandez-Maestre
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2018)