Review
Polymer Science
Lin Xu, Yanan Liu, Wenhui Zhou, Dengguang Yu
Summary: This review discusses the preparation technology and influencing factors of nanofiber sutures, summarizes the related research on absorbable and non-absorbable sutures, and discusses the application prospects of sutures.
Review
Materials Science, Textiles
Hongbin Li, Zixuan Wang, Juan Antonio Robledo-Lara, Jinmei He, Yudong Huang, Feng Cheng
Summary: Surgical sutures are crucial medical devices for wound closure, but may cause inflammation and infection, leading to the development of antimicrobial surgical sutures. Most antimicrobial surgical sutures are still in the research stage, with limited applications in clinical trials.
FIBERS AND POLYMERS
(2021)
Article
Materials Science, Biomaterials
Xiaoxuan Deng, Maree Gould, M. Azam Ali
Summary: Diclofenac potassium loaded sutures based on PEG/PCL/chitosan-keratin blends were prepared using the hot-melt extrusion technique. Analysis showed that the presence of hydrogen bonds between polymers improved material miscibility, and the ratio of PCL/PEG/chitosan-keratin affected the tensile properties of the sutures.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Applied
Qian Zhang, Yuhang Zou, Liqin Tang, Xiaoli Liu, Meiqi Hu, Hui Han, Yan Li, Fujun Wang, Lu Wang, Jifu Mao
Summary: Antibacterial surgical sutures play a crucial role in preventing incision infections and promoting wound healing. However, the existing sutures do not meet the antibacterial requirements during different stages of wound healing. To address this issue, a simple and feasible strategy was proposed to decorate the suture surface with curcumin@zeolitic imidazolate framework-8 (Cur@ZIF-8), providing stage-controlled antibacterial properties.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Multidisciplinary Sciences
Phuoc Thien Phan, Trung Thien Hoang, Mai Thanh Thai, Harrison Low, James Davies, Nigel H. Lovell, Thanh Nho Do
Summary: This paper introduces a new concept of smart sutures that can be programmed to achieve desired and uniform tension distribution while offering self-tightening knots or automatically deploying secured anchors. The core technology is a soft hydraulic artificial muscle that can be elongated and contracted under applied fluid pressure. The puncturing and holding force for the smart sutures with anchors are examined.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Ruonan Dong, Baolin Guo
Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Review
Biochemistry & Molecular Biology
Kamila Raziyeva, Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kuat Kassymbek, Shiro Jimi, Arman Saparov
Summary: Skin wounds significantly impact the global healthcare system, with acute and chronic wounds being the two main types. The immune response is crucial for acute wound healing, but dysregulation can lead to chronic wounds characterized by persistent inflammation and delayed healing. Current research focuses on immunomodulatory therapeutic strategies to improve wound healing, targeting factors such as macrophage phenotype and inflammatory mediators.
Review
Biotechnology & Applied Microbiology
Shijie Guo, Pengyu Wang, Ping Song, Ning Li
Summary: This review introduces the application of botanicals in nanofibrous membranes and discusses their bioactivity in wound healing. Botanical electrospun membranes have great potential as drug carriers or coatings, but further research and development are needed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Ruchi Tiwari, Kamla Pathak
Summary: Wound healing is a specific biological process connected to growth and tissue regeneration. The present review paper focuses on the physiology of wound healing, medications used for treatment, and local drug delivery systems for skin wound therapy. Various cellular and matrix elements work together to restore injured tissue integrity. Enhanced local delivery methods, such as innovative systems and nanoparticles, may provide faster wound healing agents.
Article
Biochemistry & Molecular Biology
Muhammad Irfan, Hira Munir, Hammad Ismail
Summary: In this study, zinc oxide nanoparticles (ZnO-NPs) based surgical sutures were developed for accelerated wound healing. The synthesized NPs showed good antibacterial potential against Escherichia coli and Methicillin-resistant staphylococcus aureus (MRSA), and the coated suture exhibited good tensile strength. The designed suture demonstrated excellent wound healing potential in rats, with rapid epithelialization, wound contraction, mild inflammation, and absence of infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Camille Togo, Ana Paula Zidorio, Vivian Goncalves, Patricia Botelho, Kenia de Carvalho, Eliane Dutra
Summary: This systematic review summarizes the current evidence on the effect of oral or enteral probiotic therapy on wound healing in humans. The results indicate that probiotic therapy may have a positive impact on wound improvement, but strong evidence is still lacking. Further controlled clinical research is needed to explore the effects of specific probiotic strains, wound types, and target populations.
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
