Journal
ANAESTHESIA
Volume 69, Issue 5, Pages 484-493Publisher
WILEY
DOI: 10.1111/anae.12635
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Funding
- MRC self-initiated research grant
- University of KwaZulu-Natal (Competitive Research Grant)
- South African Society of Anaesthesiologists (Jan Pretorius Research Fund)
- CIHR Scholarship (Canada-HOPE Scholarship)
- College of Medicine of South Africa (Phyllis Kocker/Bradlow Award)
- Heart and Stroke Foundation of Ontario Career Investigator Award
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B-Type natriuretic peptides and troponin measurements have potential in predicting risk in patients undergoing non-cardiac surgery. Using the American Heart Association framework for the evaluation of novel biomarkers, we review the current evidence supporting the peri-operative use of these two biomarkers. In patients having major non-cardiac surgery who are risk stratified using clinical risk scores, the measurement of natriuretic peptides and troponin, both before and after surgery, significantly improves risk stratification. However, only pre- and postoperative natriuretic peptide measurement and postoperative troponin measurement have shown clinical utility. It is now important for trials to be conducted to determine whether integrating pre- and postoperative natriuretic peptide and postoperative troponin measurement into clinical practice is able to improve clinical outcomes in patients undergoing non-cardiac surgery.
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