Article
Pediatrics
Modupeola Diyaolu, Jordan Taylor, John Austin, Michelle Gibson, R. J. Ramamurthi, Ban Tsui, Stephanie Chao
Summary: The study found that laparoscopic-guided TAP blocks are as effective as ultrasound-guided TAP blocks in managing postoperative pain in pediatric patients. The laparoscopic blocks were completed faster and may lead to less operating room and general anesthetic time for the pediatric patient.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Surgery
Nicholas F. Lombana, Reuben A. Falola, Kiumars Zolfaghari, Clark Roth, Jasson T. Abraham, Michel H. Saint-Cyr
Summary: Transversus abdominis plane blocks are an important component of pain control and opioid reduction in abdominally based autologous breast reconstruction. The use of a local analgesic cocktail for the blocks can provide excellent pain control and decrease postoperative opioid use.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Veterinary Sciences
Chris S. Burrows, Juliet C. Duncan, Fernando Martinez-Taboada
Summary: The transversus abdominis plane (TAP) block is a regional anesthesia technique that provides analgesia to the abdominal wall. This study aimed to determine the feasibility of performing ultrasound guided TAP blocks in rat cadavers and evaluate the effectiveness of two point injection technique compared to one point injection technique. The results showed low success rates for injections, indicating that the current technique cannot be recommended. However, the two point injection technique appeared to provide greater spread of the injectate.
LABORATORY ANIMALS
(2023)
Review
Surgery
G. Hubbard, C. Hubert, L. Vudayagiri, J. Tullington, K. Merino, A. Vaidya, R. Gemma
Summary: This paper provides a thorough literature review on the role of TAP blocks in laparoscopic inguinal hernia repairs. The majority of studies conclude that TAP blocks improve post-operative pain and mobility, decrease opiate usage, and are superior in pain control compared to other regional anesthesia modalities. Therefore, TAP blocks should be considered for routine use in laparoscopic inguinal hernia repair to improve post-operative outcomes and patient satisfaction.
Article
Surgery
Nicole L. Petcka, Katie Alter-Troilo, Emily Hetzel, Rana M. Higgins, Kathleen L. Lak, Jon C. Gould, Tammy L. Kindel, Andrew S. Kastenmeier, Matthew I. Goldblatt
Summary: TAP blocks with liposomal bupivacaine can reduce the length of stay for patients undergoing complex abdominal wall reconstruction for ventral hernias. There is no significant difference in post-operative complications compared to epidurals and intravenous narcotic pain medications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
D. J. Morrell, J. A. Doble, B. S. Hendriksen, C. M. Horne, C. S. Hollenbeak, E. M. Pauli
Summary: This study compared the effectiveness of epidural catheter and surgeon-performed TAP-block post ventral hernia repair, showing that surgeon-performed TAP-block is associated with shorter length of stay and time to regular diet compared to epidural catheter.
Article
Clinical Neurology
Qi Chen, Changyu Liang, Jingqiu Liang, Jiapeng Qiu, Bin Yang
Summary: This study demonstrated that the injectate spread extensively along the costal margin in the plane of the transverse abdominis muscle following the SE-TAP block, providing reliable analgesia for abdominal surgery. The cold stimulus assessment showed high rates of cutaneous sensory block in both anterior and lateral abdominal walls within 30 minutes after the SE-TAP block.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Veterinary Sciences
Andrea Paolini, Francesco Santoro, Amanda Bianchi, Francesco Collivignarelli, Massimo Vignoli, Silvia Scialanca, Salvatore Parrillo, Ilaria Falerno, Andrea De Bonis, Martina Rosto, Roberto Tamburro
Summary: The combination of TAP and intercostal blocks can be an effective analgesic protocol for bitches undergoing laparoscopic ovariectomy, reducing intra-operative nociception, post-operative pain, and peri-operative opioid requirement.
VETERINARY SCIENCES
(2022)
Article
Clinical Neurology
Sean M. Esmende, Matthew J. Solomito, Jesse Eisler, Kevin J. Finkel, Pranjali P. Kainkaryam, Carla L. Maffeo-Mitchell
Summary: This study investigated the effectiveness of combined transversus abdominis plane (TAP) and rectus sheath (RS) blocks in patients undergoing anterior lumbar interbody fusion (ALIF), and the results demonstrated that this combined block can significantly reduce opioid pain medication use, alleviate pain intensity, and shorten hospital stay.
Article
Gastroenterology & Hepatology
Guillaume S. Chevrollier, Aaron L. Klinger, Heather J. Green, Mariella M. Gastanaduy, W. Forrest Johnston, Herschel D. Vargas, Brian R. Kann, Charles B. Whitlow, Jennifer L. Paruch
Summary: This study aimed to determine whether using liposomal bupivacaine in transversus abdominis plane blocks improves postoperative pain and reduces opioid use after colorectal surgery. The results showed that patients receiving liposomal bupivacaine blocks had lower maximum pain scores on the day of surgery, but no other differences were found in pain scores, morphine milligram equivalents used, or length of stay between the two groups. Therefore, the use of liposomal bupivacaine in transversus abdominis plane blocks for colon and rectal resections is not justified.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Medicine, General & Internal
Dmitriy Viderman, Mina Aubakirova, Yerkin G. Abdildin
Summary: The aim of this meta-analysis was to compare the postoperative opioid requirements of patients in the TAP block group and the control group in colorectal surgery. The results showed that the TAP block group had significantly lower opioid requirements and pain intensity at rest after laparoscopic and combined surgeries. However, TAP block did not have a significant impact on overall postoperative opioid consumption, length of hospital stay, and postoperative nausea and vomiting.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Michael Drew Honaker, Casey Chinn Hawes, Dana Alina Vinter, Anne Montgomery, James Cole Parker, Betsy Epps Smith
Summary: The study found that continuous TAP blocks did not decrease the amount of MME used during the first 4 post-operative days compared to patients receiving traditional pain control measures.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Surgery
Kiara N. Jeffrey, Angela E. Thelen, Angelina M. Dreimiller, Luis E. Tollinche, Hemasat Alkhatib, Amelia Dorsey, Kevin M. El-Hayek
Summary: This study compared patients who underwent laparoscopic cholecystectomy with and without a transversus abdominis plane block. The results showed that patients who received the block had lower opioid requirements and were prescribed fewer opioids on discharge.
Article
Agriculture, Dairy & Animal Science
Caterina Di Bella, Luca Pennasilico, Francesco Staffieri, Federica Serino, Angela Palumbo Piccionello
Summary: This study described the ultrasonographic-guided lateral TAP block in rabbit cadavers and found that a single point injection was not sufficient to cover the nerve eminences of the cranial abdomen. It suggested that a two-point TAP block (lateral and subcostal) could be a better option.
Article
Veterinary Sciences
Jessica Sperandio Cavaco, Pablo Ezequiel Otero, Aline Magalhaes Ambrosio, Ieda Cristina Boni Neves, Felipe Montanheiro Perencin, Marco Aurelio Amador Pereira, Julia Maria Matera, Denise Tabacchi Fantoni
Summary: This study aimed to evaluate the analgesic efficacy of TAP block in female dogs undergoing ovariectomy. The results showed that using ultrasound-guided TAP block provided effective post-operative analgesia in these dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Letter
Critical Care Medicine
Vincenzo Russotto, Giacomo Bellani, John G. Laffey
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Anesthesiology
Louise Rose, Luigi Camporota, Gary H. Mills, John Laffey, Gavin D. Perkins, Manu Shankar-Hari, Tamas Szakmany, Danny McAuley, RELEASE Investigators
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Engineering, Industrial
Evismar Andrade, Leo R. Quinlan, Richard Harte, Bronwyn Reid-McDermott, Frank Kirrane, Enda Fallon, Martina Kelly, Tony Hall, Michael Scully, John Laffey, Patrick Pladys, Ethel Ryan, Dara Byrne, Gearoid OLaighin
Summary: This study developed an online training platform to train clinicians on the use of a critical care medical device and carried out a preliminary evaluation of the platform via a case study. The results showed that participants were able to use and interpret the device interface and were overall satisfied with the training platform, perceiving it as an efficient and effective method for training.
APPLIED ERGONOMICS
(2023)
Article
Multidisciplinary Sciences
Marie Le Berre, Terezia Paulovcakova, Carolina De Marco Verissimo, Sean Doyle, John P. Dalton, Claire Masterson, Eduardo Ribes Martinez, Laura Walsh, Conor Gormley, John G. Laffey, Bairbre McNicholas, Andrew J. Simpkin, Michelle Kilcoyne
Summary: Zoonotic spillover of SARS-CoV-2 to humans in December 2019 caused the COVID-19 pandemic. Serological monitoring is crucial for understanding immune responses and guiding therapeutic and vaccine strategies. Researchers developed a high throughput SARS-CoV-2 antigen microarray for assessing IgG, IgA, and IgM responses, which can be used for expanded humoral immunity studies and monoclonal antibody therapeutic studies.
Article
Biochemistry & Molecular Biology
Sean D. McCarthy, Christopher B. Rohde, Matt Angel, Claire H. Masterson, Ronan MacLoughlin, Juan Fandino, Hector E. Gonzalez, Declan Byrnes, John G. Laffey, Daniel O'Toole
Summary: ARDS is a rapid-onset inflammatory lung disease without effective specific therapy, for which pneumonia is a common pathogenic etiology. Previous studies have shown that prophylactic delivery of mRNA coding for NF-kappa B inhibitor alpha super-repressor (I kappa B alpha-SR) or extracellular superoxide dismutase 3 (SOD3) by viral vector can help reduce the severity of pneumonia. This study demonstrates that nebulized mRNA therapeutics, complexed with cationic lipid and delivered through a vibrating mesh nebulizer, have potential as a promising approach for ARDS therapy. The mRNA treatments resulted in rapid expression of proteins and observable improvement in pneumonia symptoms.
NUCLEIC ACID THERAPEUTICS
(2023)
Article
Cell & Tissue Engineering
Hector Gonzalez, Sean McCarthy, Claire Masterson, Declan Byrnes, Ignacio Sallent, Emma Horan, Stephen J. Elliman, Gabriele Vella, Adriele P. Mello, Johnatas D. Silva, Anna D. Krasnodembskaya, Ronan MacLoughlin, John G. Laffey, Daniel O'Toole
Summary: In this study, the therapeutic potential of directly nebulised MSC-EVs in mitigating Escherichiacoli-induced pneumonia was investigated. The results showed that MSC-EVs retained their immunomodulatory and wound healing capacity after nebulisation. Treatment with IV or nebulised MSC-EVs reduced the severity of LPS-induced lung injury and E. coli-induced pneumonia.
STEM CELL RESEARCH & THERAPY
(2023)
Letter
Critical Care Medicine
Tai Pham, Leo Heunks, Giacomo Bellani, Laurent Brochard, John Laffey
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Bruno Francois, Simon Lambden, Tom Fivez, Sebastien Gibot, Marc Derive, Jean-Marie Grouin, Margarita Salcedo-Magguilli, Jeremie Lemarie, Nicolas De Schryver, Ville Jalkanen, Tarik Hicheur, Jean-Jacques Garaud, Valerie Cuvier, Ricard Ferrer, Morten Bestle, Ville Pettila, Jean-Paul Mira, Camille Bouisse, Emmanuelle Mercier, Joris Vermassen, Vincent Huberlant, Isabelle Vinatier, Nadia Anguel, Mitchell Levy, Pierre-Francois Laterre
Summary: This study aimed to investigate whether the TREM-1 inhibitor nangibotide could improve outcomes in patients with septic shock. The findings suggest that both low and high doses of nangibotide did not significantly improve the condition of patients with septic shock compared to placebo.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Bairbre A. McNicholas, Miguel Ibarra-Estrada, Yonatan Perez, Jie Li, Ivan Pavlov, Aileen Kharat, David L. Vines, Oriol Roca, David Cosgrave, Claude Guerin, Stephan Ehrmann, John G. Laffey
Summary: Awake prone positioning (APP) gained attention during the COVID-19 pandemic for treating acute hypoxaemic respiratory failure. It improves oxygenation and has similar effects as invasive ventilation in patients with moderate-severe acute respiratory distress syndrome. Randomised controlled studies in COVID-19 patients have conflicting outcomes, but evidence suggests that more severe hypoxaemic patients benefit most from APP when managed in higher care environments and being prone for several hours.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Medicine, General & Internal
Hector E. Gonzalez, Sean D. McCarthy, Claire Masterson, John G. Laffey, Ronan MacLoughlin, Daniel O'Toole
Summary: Mesenchymal stem cell secretome has strong immunomodulatory effects and can be delivered to the lung through nebulization, showing therapeutic potential for inflammatory diseases such as pneumonia ARDS.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Rohit Saha, Tai Pham, Pratik Sinha, Manoj Maddali, Giacomo Bellani, Eddy Fan, Charlotte Summers, Abdel Douiri, Gordon D. Rubenfeld, Carolyn S. Calfee, John Gerard Laffey, Daniel Francis McAuley, Manu Shankar-Hari, LUNG SAFE Investigators
Summary: This study estimated the mortality rate of acute respiratory distress syndrome (ARDS) using a case-control matching method and analyzed it in different patient subgroups. The results showed that there were variations in the mortality rate of ARDS among different subgroups. Depending on the severity of hypoxemia, the number of lung quadrants involved, and the inflammatory phenotype, the mortality rate of ARDS ranged from 20.9% to 38.0%.
Article
Anesthesiology
David M. Hannon, Tim Jones, Jack Conolly, Conor Judge, Talha Iqbal, Atif Shahzad, Michael Madden, Frank Kirrane, Peter Conneely, Brian H. Harte, Martin O'Halloran, John G. Laffey
Summary: Developed and assessed a system for shared ventilation using clinically available components to individualize tidal volumes. The system allowed accurate and reproducible titration of tidal volumes to each limb over a range of ventilator settings and simulated lung conditions.
BMC ANESTHESIOLOGY
(2023)
Article
Critical Care Medicine
Marius Troseid, Jose R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzic, Fulvia Mazzaferri, Jesus Rodriguez Bano, Joe Eustace, Maya Hites, Michael Joannidis, Jose-Artur Paiva, Jean Reuter, Isabel Puentmann, Thale D. J. H. Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Borresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltan Peterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Unal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Moller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Balde, Lucie de Gastines, Marta del Alamo, Burc Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Rottingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola
Summary: The study conducted a placebo-controlled trial of baricitinib in severe/critical COVID cases. The results showed that baricitinib did not reduce mortality within 60 days, and there may be safety risks in vaccinated participants, which require further investigation.
Meeting Abstract
Critical Care Medicine
Jie Li, Jian Luo, Ivan Pavlov, Yonatan Perez, Aileen Kharat, Elsa Tavernier, David Vines, Oriol Roca, Bairbre McNicholas, Miguel Ibarra-Estrada, John Laffey, Claude Guerin, Stephan Ehrmann
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Bairbre A. A. McNicholas, Emanuele Rezoagli, Andrew J. J. Simpkin, Sankalp Khanna, Jacky Y. Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. F. Fraser, John Laffey
Summary: AKI is a common and serious complication in COVID-19 patients, with different characteristics and outcomes compared to non-COVID-19 ARDS patients.