Article
Acoustics
Che-Chou Shen, Ri-Cheng Lin, Nien-Hung Wu
Summary: This study proposes a Golay-encoded ultrasound (US) monitoring method to address the difficulties in monitoring high-intensity focused ultrasound (HIFU) treatment caused by strong HIFU interference. By effectively removing HIFU interference patterns, this method improves the image quality metrics and increases the echo magnitude in real-time B-mode imaging. Experimental results show that Golay decoding significantly increases the PSNR of US monitoring images and improves the SSIM index, making the B-mode image with HIFU transmission visually indistinguishable from the one without HIFU transmission.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Medicine, Research & Experimental
Chao Li, Yao Lu, Lili Cheng, Xiaoge Zhang, Jun Yue, Jie Liu
Summary: Combining HIFU with nanodroplets showed enhanced anticancer efficacy by triggering anticancer immune responses, inducing immunogenic cell death, activating DCs maturation, and enhancing effector T-cell infiltration within tumors.
MOLECULAR PHARMACEUTICS
(2021)
Review
Oncology
Sin Yuin Yeo, Grischa Bratke, Holger Gruell
Summary: High Intensity Focused Ultrasound (HIFU) is a non-invasive method for ablating tumors and treating painful bone lesions. It has been used for pain relief in bone metastases and primary tumors for 20 years, as well as for local treatment of bone tumors. This review summarizes 20 years of literature on HIFU treatment of bone malignancies, focusing on pain palliation, treatment efficacy, and safety.
Article
Engineering, Biomedical
Molly Smallcomb, Julianna C. Simon
Summary: This study investigates ultrasonic atomization and erosion from planar healthy and tendinopathic tendon surfaces as we evaluate HIFU parameters for histotripsy in tendons. Results showed that tendons with chronic tendinopathies may be more susceptible than healthy tendons to erosion by HIFU atomization.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Sin Yuin Yeo, Grischa Bratke, Peter Knoell, Sebastian Gottfried Walter, David Maintz, Holger Gruell
Summary: Desmoid tumors are a rare form of cancer that can invade surrounding tissues and occur anywhere in the body. Treatment options include surgery, radiation therapy, chemotherapy, and thermal ablation with HIFU. This report presents a case of a desmoid tumor that was surgically resected twice and then treated with HIFU, leading to complete tumor remission and pain relief.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Matthew G. Parry, Arunan Sujenthiran, Julie Nossiter, Melanie Morris, Brendan Berry, Arjun Nathan, Ajay Aggarwal, Heather Payne, Jan van der Meulen, Noel W. Clarke
Summary: This observational cohort study examines the 5-year failure-free survival (FFS) of 1381 men who received high-intensity focused ultrasound (HIFU) for localized prostate cancer. The study finds that four in five men were free from local salvage treatment at 5 years, but treatment failure rates varied significantly based on ISUP Grade Group.
Article
Oncology
Mu Yao Tsai, Chih Tai Lin, Ping Hsuan Chiang, Po Hui Chiang, Ping Chia Chiang
Summary: This study reported preliminary outcomes of high-intensity focused ultrasound (HIFU) in combination with transurethral resection of the prostate for localized prostate cancer in Taiwan. The results showed that HIFU treatment achieved adequate short-term cancer control, excellent potency, and continence preservation, with low complication rates.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Kaiyuan Peng, Shima Shahab, Reza Mirzaeifar
Summary: Experiments have shown that high-intensity focused ultrasound (HIFU) is a promising stimulus for inducing localized heating in polymers with unique capabilities, but the origin of the difference in heating compared to direct heat sources is still unknown. Research suggests that the macroscopic response of polymers to HIFU depends greatly on factors such as chain structure and composition, with viscoelasticity, chain motion, and localized mobility all contributing to the observed thermal effects. This study sheds light on the mechanisms behind HIFU stimulation of polymers and highlights its potential for future applications.
Article
Medicine, General & Internal
Xin Liu, Jingxi Wang, Yanglu Liu, Shuang Luo, Gaowu Yan, Huaqi Yang, Lili Wan, Guohua Huang
Summary: Cystic adenomyosis, a rare type of uterine adenomyosis, primarily affects young women and is characterized by severe dysmenorrhea. Misdiagnosis and delayed treatment can significantly impact the quality of life and reproductive function of these women. This report presents two cases of young patients with cystic adenomyosis treated with high-intensity focused ultrasound (HIFU) ablation, demonstrating successful reduction in cyst size and improvement in dysmenorrhea symptoms. Reviewing 14 cases of juvenile cystic adenomyosis, the study suggests that HIFU or HIFU-combined drugs are safe and effective treatments, although further multicenter and prospective studies are warranted for validation.
Article
Chemistry, Multidisciplinary
Tingyu Sun, Jingnan Li, Yinglin Zhou, Chao Zeng, Chengyan Luo, Xirui Luo, Huanan Li
Summary: A versatile HIFU-specific metal-organic framework nanosystem (ADMOFs) is developed to enhance the accuracy of HIFU surgery and overcome drug resistance by utilizing the hypoxic tumor environment.
Article
Oncology
Jian-zhou Cao, Rui Su, Jin-feng Pan, Ze-jun Yan, Qi Ma
Summary: The study proposed a hypothesis of using a combination of HIFU and bicalutamide as the first-line salvage therapy for local recurrent PCa, due to its minimal invasiveness, better quality of life, and the option to preserve radiotherapy as the second-line treatment. More clinical trials are needed to confirm the effectiveness of this approach in treating recurrent PCa.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sung Kyu Hong, Hakmin Lee
Summary: PGA with HIFU is a safe and effective treatment option for clinically unilateral prostate cancer, providing satisfactory oncological control and preserving functional outcomes. Further prospective studies are needed to evaluate the oncological and functional outcomes of PGA with HIFU more accurately.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Chemistry, Analytical
Yufeng Zhou, Wei Chun Daniel Lim
Summary: High-intensity focused ultrasound (HIFU) was used to ablate solid tumors and cancers in this study. The interaction between HIFU bursts and blood vessels in hypervascular tumors was investigated to ensure efficiency and safety. Results showed that the presence of the artery led to a decrease in lesion size, with characteristics dependent on focus alignment. Acoustic and hydrodynamic cavitation played important roles in lesion production and interaction with the artery, with both thermal and mechanical effects found on the artery wall after HIFU ablation, but no vessel rupture was observed in this ex vivo study.
Article
Nanoscience & Nanotechnology
Hui Gao, Zhaoxia Wang, Mixiao Tan, Weiwei Liu, Liang Zhang, Ju Huang, Yang Cao, Pan Li, Zhigang Wang, Jiexin Wen, Tingting Shang, Haitao Ran
Summary: This study successfully constructed pH-responsive Ca@H nanoparticles for photoacoustic imaging-guided/monitored HIFUT combined with SDT therapy. This method has potential in the treatment of non-invasive tumors in the future.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Oncology
Jing Zhao, Hong Shen, Xiaoye Hu, Yuebing Wang, Ying Yuan
Summary: In this study, low-power cumulative HIFU treatment showed significantly higher pain relief rate and survival benefit compared to traditional HIFU treatment in patients with metastatic pancreatic cancer. Additionally, it also demonstrated a better safety profile with lower incidence of adverse events.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Editorial Material
Anesthesiology
C. C. Nestor, P. O. Sepulveda, M. G. Irwin
Review
Anesthesiology
R. L. H. Yim, K. M. M. Leung, C. C. M. Poon, M. G. Irwin
Summary: Parkinson's disease patients have a higher risk of peri-operative complications, necessitating multidisciplinary management and specialized care. Continuous dopaminergic treatment, peri-operative disease pathway development, and telemedicine are improving peri-operative care. Management for advanced Parkinson's disease is evolving with potential for integrated care and changes in anaesthetic management.
Review
Anesthesiology
C. C. Nestor, C. Ng, P. Sepulveda, M. G. Irwin
Summary: Mixing long- and short-acting local anaesthetics to hasten onset and extend duration may lead to ineffective solutions or potential harm due to pharmacokinetic principles; many local anaesthetic adjuncts are not approved for use, which can result in adverse events, and pharmaceutical compatibility needs to be confirmed before administration.
Review
Anesthesiology
C. K. E. Chung, C. C. M. Poon, M. G. Irwin
Summary: Surgery and anesthesia can cause stress to the brain, and monitoring with electroencephalography and cerebral oximetry can help assess anesthesia depth and cerebral metabolic activity. However, research results on the ability of these monitors to alleviate peri-operative neurocognitive complications have been contradictory. Understanding the changes in electroencephalography under anesthesia and those associated with aging is important for correctly interpreting anesthesia depth indices. Cerebral oximetry is useful for detecting cerebral desaturation and identifying higher-risk patients. An algorithm-based approach may be most effective in managing cerebral desaturation events.
Article
Anesthesiology
S. Agarwal, K. El-Boghdadly
Summary: This position statement highlights the importance of prioritising equity, diversity and inclusion in anaesthesia and medicine. The Anaesthesia Editors outline their policies and practices to achieve these goals, including transparent recruitment practices and removing barriers to leadership roles. They commit to regularly reviewing and improving their policies and embracing equity, diversity and inclusion.
Letter
Emergency Medicine
Wei Deng, Steven Wang, Rex Pui Kin Lam, Timothy Hudson Rainer, Michael Garnet Irwin
ANNALS OF EMERGENCY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Qiu Qiu, Joshua C. J. Chew, Michael G. Irwin
Summary: Opioids are still important in postoperative analgesia, but the focus is on using them as part of multimodal regimens to avoid their complete use. The development of new drugs with more favorable adverse effect profiles may increase safety while maintaining efficacy.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Anesthesiology
Wendong Chen, Li Ma, Jianlin Shao, Chun Bi, Yuchen Xie, Shuangyan Zhao
Summary: This study analyzed the position-specific morphological changes of the upper airway and assessed their impact on difficult airway during intubation. The results showed that difficult airway had lower upper airway filling volumes compared to normal airway. Furthermore, the airway volume increased as the body position changed.
BMC ANESTHESIOLOGY
(2022)
Review
Anesthesiology
L. M. Hughes, M. G. Irwin, C. C. Nestor
Summary: Propfol-remifentanil-based total intravenous anaesthesia is commonly used in clinical practice due to its favorable pharmacokinetic profile. However, interruption in remifentanil supply presents an opportunity to explore alternative opioids and consider adjuncts to propofol-based anaesthesia. This article provides an overview of different opioids and their administration methods, as well as the role of non-opioid adjuncts in total intravenous anaesthesia.
Article
Anesthesiology
L. Q. Yang, L. Zhu, X. Shi, C. H. Miao, H. B. Yuan, Z. Q. Liu, W. D. Gu, F. Liu, X. X. Hu, D. P. Shi, H. W. Duan, C. Y. Wang, H. Weng, Z. L. Huang, L. Z. Li, Z. Z. He, J. Li, Y. P. Hu, L. Lin, S. T. Pan, S. H. Xu, D. Tang, D. I. Sessler, J. Liu, M. G. Irwin, W. F. Yu, POLMA-EP Investigators
Summary: In a clinical study, it was found that using a supraglottic airway device rather than a tracheal tube can reduce postoperative pulmonary complications in older patients undergoing non-cardiothoracic surgery under general anesthesia.
Article
Anesthesiology
W. Deng, C. C. Nestor, K. M. M. Leung, J. Chew, H. Wang, S. Wang, M. G. Irwin
Summary: The amount of aerosol generation from positive pressure ventilation via supraglottic airway devices in low-risk patients was quantified and compared to aerosol levels during conversation and coughing. The study found that the aerosol concentration generated by supraglottic airway insertion and removal was significantly lower than that produced during talking and coughing. The proportion of easily inhaled and small particles was also much lower during insertion and removal compared to talking and coughing.
Review
Medicine, General & Internal
Abigail Silva, Barbara Costa, Irene Castro, Joana Mourao, Nuno Vale
Summary: This review aims to discuss the current information on drug interactions in the perioperative period. Drug interactions during this period can affect the efficacy and safety of treatment. There are three types of drug interactions. It is important to recognize that drug interactions may increase toxicity and reduce efficacy, increasing the risk of complications. Thoroughly reviewing a patient's medication list and vigilant monitoring are essential in minimizing risks.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Becem Trabelsi, Azza Yedes, Ghada Kharrat, Hadhami Abdouli, Issam Mahouachi, Mohamed Ridha Saied, Mechaal Ben Ali
Summary: Negative-pressure pulmonary edema (NPPE) is a rare respiratory complication caused by acute upper airway obstruction shortly after extubation. This case report highlights the importance of early recognition and management of NPPE in young healthy patients, focusing on the misdiagnosis and subsequent treatment. The patient achieved full recovery through mechanical ventilation and diuretics.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Letter
Medicine, General & Internal
Claire C. Nestor, Michael G. Irwin
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Anesthesiology
Filipa D. M. F. Pinto, Michael G. Irwin
Summary: Since 2000, day surgery has experienced rapid expansion, driven by the target set by the NHS to perform 75% of surgeries as day procedures. Initially limited to elective surgeries, it now includes a pathway for emergency surgeries as well. Ambulatory surgery offers numerous advantages, but clear selection criteria, adherence to enhanced recovery protocols, and optimization of the patient's preoperative medical conditions are crucial for achieving good outcomes and minimizing complications.
ANAESTHESIA AND INTENSIVE CARE MEDICINE
(2022)
