Journal
ANAEROBE
Volume 23, Issue -, Pages 5-8Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2013.07.006
Keywords
Roseburia faecis; Bacteriocin-like inhibitory substance (BLIS); Firmicutes anaerobe; Gut microbiota; Trypsin
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Funding
- Biotechnology and Biological Sciences Research Council
- Scottish Government RESAS programme
- BBSRC [BBS/E/F/00044453] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00044453] Funding Source: researchfish
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During screening of human gut isolates in search of novel antimicrobials, the butyrate-producing strain Roseburia faecis M72/1 was found to produce an inhibitory substance active against Bacillus subtilis. Partial purification of the antimicrobial was achieved and activity found to be heat labile. Our findings suggest that R. faecis M72/1 produces a proteinaceous inhibitor whose production may be triggered by trypsin in the gastrointestinal tract. (c) 2013 Elsevier Ltd. All rights reserved.
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