Journal
ANAEROBE
Volume 16, Issue 6, Pages 555-559Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.anaerobe.2010.10.002
Keywords
Antibiotic resistance; Anaerobic bacteria; cepA gene; Nim gene; Van gene
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The purpose of this article is to set out some important considerations on the main emerging antibiotic resistance patterns among anaerobic bacteria. The first point concerns the Bacteroides fragilis group and its resistance to the combination of beta-lactam + beta-lactamase inhibitor. When there is overproduction of cephalosporinase, it results in increased resistance to the beta-lactams while maintaining susceptibility to beta-lactams/beta-lactamase inhibitor combinations. However, if another resistance mechanism is added, such as a loss of porin, resistances to beta-lactam + beta-lactamase inhibitor combinations may occur. The second point is resistance to metronidazole occurring due to nim genes. PCR detection of nim genes alone is not sufficient for predicting resistance to metronidazole; actual MIC determinations are required. Therefore, it can be assumed that other resistance mechanisms can also be involved. Although metronidazole resistance remains rare for the B. fragilis group, it has nevertheless been detected worldwide and also been observed spreading to other species. In some cases where there is only a decreased susceptibility, clinical failures may occur. The last point concerns resistance of Clostridium species to glycopeptides and lipopeptides. Low levels of resistance have been detected with these antibiotics. Van genes have been detected not only in clostridia but also in other species. In conclusion, antibiotic resistance involves different mechanisms and affects many anaerobic species and is spreading worldwide. This demonstrates the need to continue with antibiotic resistance testing and surveys in anaerobic bacteria. (C) 2010 Elsevier Ltd. All rights reserved.
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