Review
Biochemistry & Molecular Biology
Rachana R. Borkute, Soeren Woelke, Gang Pei, Anca Dorhoi
Summary: Neutrophils play a complex role in tuberculosis, with both beneficial and detrimental effects on disease outcomes. Recent studies have revealed the phenotypic heterogeneity of neutrophils and their interactions with other cells in TB pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Preeti Kumari Chaudhary, Soochong Kim
Summary: G protein-coupled receptor kinases (GRKs) are a type of protein kinases that work together with arrestins to regulate G protein-coupled receptor signaling. Studies have shown the critical role of these kinases in cardiovascular biology, inflammation and immunity, neurodegeneration, thrombosis, and hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Ivy A. Rosales, Grace K. Mahowald, Kristen Tomaszewski, Kiyohiko Hotta, Naoya Iwahara, Takuya Otsuka, Takahiro Tsuji, Yusuke Takada, Ellen Acheampong, Milagros Araujo-Medina, Amy Bruce, Andrea Rios, Anthony Benedict Cosimi, Nahel Elias, Tatsuo Kawai, Hannah Gilligan, Kassem Safa, Leonardo V. Riella, Nina E. Tolkoff-Rubin, Winfred W. Williams Jr, Rex Neal Smith, Robert B. Colvin
Summary: In this study, mRNA analysis was performed to gain insights into the pathogenesis of chronic active antibody-mediated rejection (CAMR). The results showed that peritubular capillary inflammation and donor-specific antibodies (DSA) are the primary drivers of elevation in AMR pathway scores. Transcripts revealed subpathological evidence of both AMR and TCMR, which have predictive value for graft loss.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Hui Fang, Shuyan Sheng, Bangjie Chen, Jianpeng Wang, Deshen Mao, Yanxun Han, Yuchen Liu, Xinyi Wang, Siyu Gui, Tongyuan Zhang, Lizhi Zhang, Conghan Li, Xinyang Hu, Wanyu Deng, Xin Liu, Honghai Xu, Wentao Xu, Xingyu Wang, Rongqiang Liu, Weihao Kong
Summary: This study unraveled the oncogenic role of CDCA4 in different cancers and investigated its correlation with tumor immune infiltration and prognosis from the perspective of tumor immunity, providing new insights for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Kirsty Wells, Angela Lamrca, George Papaxoinis, Andrew Wallace, Anne Marie Quinn, Yvonne Summers, Daisuke Nonaka
Summary: Recent study has shown that GTF2I mutation is common in thymomas, with the highest frequency in types A and AB. This mutation is associated with a more indolent histology subtype and better prognosis.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Cell Biology
Zhiran Zou, Xiao Long, Qian Zhao, Yandong Zheng, Moshi Song, Shuai Ma, Yaobin Jing, Si Wang, Yifang He, Concepcion Rodriguez Esteban, Nanze Yu, Jiuzuo Huang, Piu Chan, Ting Chen, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu
Summary: Single-cell RNA sequencing of human eyelid skin revealed progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process showed early-onset decline during aging. Inhibition of key transcription factors HES1 and KLF6 compromised cell proliferation, increased inflammation, and accelerated cellular senescence during aging.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Vanessa Zaiatz-Bittencourt, Fiona Jones, Miriam Tosetto, Caitriona Scaife, Gerard Cagney, Evan Jones, Glen A. Doherty, Elizabeth J. Ryan
Summary: The gut microbiota plays a crucial role in regulating chronic inflammation and its involvement in the development of autoimmune diseases and cancer. Microbial short-chain fatty acids, such as butyrate, have immunomodulatory effects and are believed to mediate the host-microbiome interaction. This study demonstrates that butyrate has a strong anti-inflammatory effect on NK cells and restricts their function through downregulation of mTORC1 activity, c-Myc mRNA expression, and metabolism.
SCIENTIFIC REPORTS
(2023)
Article
Pathology
Louisa Bolm, Natalie Petruch, Shivan Sivakumar, Nicola E. Annels, Adam Enver Frampton
Summary: TIGIT, an immune modulator expressed in immune cells, plays a role in cancer progression by regulating T-cell function and cancer cell recognition. Multiple studies have found an association between TIGIT expression and poor survival. Blocking TIGIT can prevent tumor progression, distant metastasis, and tumor recurrence.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Genetics & Heredity
Luigi Santacroce, Ioannis A. Charitos, Domenico M. Carretta, Emanuele De Nitto, Roberto Lovero
Summary: Coronaviruses in humans can cause varying respiratory infections, from mild colds to severe conditions like SARS and MERS. The most recent SARS-CoV-2 outbreak is a new strain with genetic similarity to SARS-CoV, causing a global pandemic.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Editorial Material
Multidisciplinary Sciences
Felicia Kuperwaser, Itai Yanai
Summary: A comprehensive cell atlas of gene expression and regulation in human embryos has provided a unique opportunity for innovative investigation of development through multi-organ and multi-modal analysis.
Article
Plant Sciences
Arnaud Capron, Nicolas Feau, Renate Heinzelmann, Irene Barnes, Andy Benowicz, Rosie E. Bradshaw, Angela Dale, Kathy J. Lewis, Timothy J. Owen, Richard Reich, Tod D. Ramsfield, Alex J. Woods, Richard C. Hamelin
Summary: Many tree improvement programs are incorporating assisted gene flow strategies to match reforestation efforts with future climates. Study of the lodgepole pine pathogen populations in western Canada showed distinct genetic lineages diverged between 31.4 and 7.2 thousand years ago. The movement of planting material may have major consequences by facilitating secondary contact between genetically isolated pathogens.
News Item
Multidisciplinary Sciences
Philip Ball
Summary: A pair of studies highlight ethical and legal concerns surrounding the status of lab-grown human embryo models.
Review
Oncology
Carlos Murga-Zamalloa, Kedar Inamdar
Summary: Mature T-cell lymphomas are aggressive and challenging to diagnose tumors, and recent molecular and histopathological findings have improved understanding of their classification and diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Michael J. Gaudry, Martin Jastroch
Summary: The protein UCP1 in brown fat helps burn calories by releasing heat. The structures of human UCP1 provide important insights into its mechanism and can potentially aid in designing drugs for obesity and metabolic complications.
Editorial Material
Multidisciplinary Sciences
Jeffrey A. Farrell
Summary: CellOracle, a computational tool, can predict the interaction of gene networks in programming cell identity during embryonic development. This tool will contribute to a better understanding of the regulation of development.
