Journal
AMYOTROPHIC LATERAL SCLEROSIS
Volume 11, Issue 4, Pages 389-391Publisher
INFORMA HEALTHCARE
DOI: 10.3109/17482960903358857
Keywords
Amyotrophic lateral sclerosis; genetics; genome-wide association studies; DPP6; FGGY
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Funding
- Canadian Institutes of Health Research (CIHR)
- Muscular Dystrophy Association USA (MDA)
- ALS Association (ALSA)
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DPP6 and FGGY genes have been recently associated with an increased susceptibility for sporadic amyotrophic lateral sclerosis. Here, we evaluated the role of these genes in ALS pathogenesis by undertaking a sequence analysis of a cohort of 190 ALS patients from France and Quebec. We did not observe any evidence that mutations in DPP6 and FGGY genes are involved in ALS. Our data indicate that mutations in these genes are unlikely to be a common cause of ALS in the French and French Canadian populations.
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