Article
Biochemistry & Molecular Biology
Yoshie Haratake, Kohei Sano, Miki Tsuchiya, Kaori Minaki, Masayuki Munekane, Toshihide Yamasaki, Masayori Hagimori, Takahiro Mukai
Summary: This study designed and synthesized a novel radiolabeled amyloid imaging probe, demonstrating its potential for diagnosing amyloidosis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Urology & Nephrology
Maria M. Picken
Summary: Amyloidoses are rare diseases in which treatment depends on the type of amyloid protein, and delays in diagnosis lead to poor prognosis.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Article
Engineering, Environmental
Chao Liang, Shuzhen Qin, Hao Ai, Shasha Li, Kaifeng Du
Summary: A novel biosorbent with superadsorption ability for Congo red removal, porous lysozyme skeletons, was successfully prepared using an enhanced amyloidal denaturation protocol. The as-prepared superadsorbent showed rapid kinetics and high capacity for CR adsorption, as well as selectivity and recyclability.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Alessandra Monti, Chiara Bruckmann, Francesco Blasi, Menotti Ruvo, Luigi Vitagliano, Nunzianna Doti
Summary: Peptides based on PREP1 can form amyloid-like aggregates with unique spectral properties under physiological conditions, exhibiting pH-dependent and reversible fluorescence during the structural transition from beta-sheet rich aggregates to alpha-helix structures. These findings demonstrate that the non-canonical fluorescence exhibited by amyloids is a complex phenomenon.
CHEMICAL COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Anna Jagusiak, Katarzyna Chlopas, Grzegorz Zemanek, Izabela Koscik, Irena Roterman
Summary: The research aims to design a new drug carrier system by analyzing the interactions between CR-Dox complexes and proteins, with the goal of improving the safety and efficacy of targeted drug delivery.
Review
Medicine, General & Internal
Alexander J. Howie, Mared P. Owen-Casey
Summary: This article presents a systematic review of recent papers on the appearance of Congo red-stained amyloid under a microscope, revealing that not all images show green birefringence as commonly believed. The study also highlights the widespread inaccuracies in reporting and emphasizes the need for more accurate descriptions.
ANNALS OF MEDICINE
(2022)
Article
Plant Sciences
Georgia I. Nasi, Foteini D. Aktypi, Panagiotis M. Spatharas, Nikolaos N. Louros, Paraskevi L. Tsiolaki, Vassiliki Magafa, Ioannis P. Trougakos, Vassiliki A. Iconomidou
Summary: This study investigates the amyloidogenic properties of a 34-residue-long peptide in Arabidopsis thaliana under different pH conditions, and explores its association with other A. thaliana proteins using bioinformatics tools.
Review
Engineering, Environmental
Yingqiu Zheng, Bei Cheng, Jiajie Fan, Jiaguo Yu, Wingkei Ho
Summary: The excessive presence of synthetic dyestuffs in aquatic environments can lead to ecological and health issues that are harmful to sustainable development. Adsorption is considered an effective method for removing dye pollutants from water due to its efficiency, cost-effectiveness, ease of operation, and lack of secondary pollution. Among various dyes, Congo red is a commonly used azo dye. Nickel-based materials have been extensively studied for Congo red adsorption due to their diverse morphology, large specific surface area, and strong affinity towards Congo red. However, the challenge remains in creating nickel-based adsorbents with high efficiency, stability, and recyclability for practical applications.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemical Research Methods
Sharay E. Setti, James Raymick, Joseph Hanig, Sumit Sarkar
Summary: A new method for rapid and thorough amyloid plaque labeling using Congo Red via perfusion has been introduced, resulting in reduced labeling time and variability in staining procedures.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Engineering, Biomedical
Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y. Rebecca Chin, Chung Tin, Pik Kwan Lo
Summary: Compared with siRNAs or other ASOs, TNA has the advantages of chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability, which make it a promising tool in biomedical applications. This study investigates the pharmacokinetics and biosafety of TNAs in living organisms, finding that they exhibit excellent stability, low cytotoxicity, and substantial uptake in living cells without transfection. TNAs also show the ability to efficiently penetrate multicellular spheroids and can be safely administered in mice without causing pathological changes in the kidneys.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Ewelina Stefaniak, Elena Atrian-Blasco, Wojciech Goch, Laurent Sabater, Christelle Hureau, Wojciech Bal
Summary: This study investigated the effect of Cu-II on the aggregation of A beta(1-40) and A beta(4-40). It was found that substoichiometric Cu-II concentrations accelerated aggregation, while superstoichiometric Cu-II inhibited fibril formation. The interaction between Cu-II, A beta(4-40), and A beta(1-40) resulted in significant changes in the aggregation process.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Food Science & Technology
Yajuan Li, Jingbo Liu, Xiaoxia Shi, Hui Zhang, Leiyi Zhang, Ziang Xu, Ting Zhang, Yiding Yu, Zhiyang Du
Summary: In this study, zein-hyaluronic acid nanoparticles were used as templates to induce the self-assembly of egg white-derived peptides for the enhancement of curcumin. The resulting nanoparticles showed high encapsulation efficiency and improved solubility and stability of curcumin. The self-assembled peptides exhibited synergistic antioxidant activity with curcumin and enhanced its bioaccessibility.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Acoustics
Furong Hou, Danli Wang, Xiaobin Ma, Lihua Fan, Tian Ding, Xingqian Ye, Donghong Liu
Summary: Chitin suspensions treated with enzymolysis and sonoenzymolysis showed improved adsorption properties for Congo red dyes, with Langmuir isotherm and pseudo-second order model being more reliable in describing the adsorption process. Thermodynamic studies indicated a spontaneous adsorption process, with physical adsorption between chitin and CR confirmed through structural characterization before and after adsorption. Sonoenzymolysis resulted in a larger specific surface area and higher porosity, providing more active sites for adsorption.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Thorbjorn Sonderby, Nikolaos N. Louros, Ladan Khodaparast, Laleh Khodaparast, Daniel J. Madsen, William P. Olsen, Nele Moonen, Madhu Nagaraj, Vita Sereikaite, Kristian Stromgaard, Frederic Rousseau, Joost Schymkowitz, Daniel E. Otzen
Summary: Functional bacterial amyloid provides structural stability in biofilm, which can be targeted for anti-biofilm therapeutics. Aggregation-modulating peptides can be used to disrupt the stability and morphology of amyloid proteins, such as CsgA and FapC, resulting in reduced biofilm formation in E. coli and P. aeruginosa. This study demonstrates the potential of selective amyloid targeting in combating bacterial biofilm.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Pathology
Xuguang Lin, Masahiro Kuragano, Kenichi Watanabe, Kiyotaka Tokuraku
Summary: The study found that amyloid fibrils from different animal species exhibit similar genetic homology and morphology, despite differences in fibril width and crossover distance. Analysis of amyloid protein and serum amyloid A sequences demonstrated high homology, suggesting similar fibril characteristics across species.
VETERINARY PATHOLOGY
(2021)
Article
Surgery
R. Lewis, B. Forman, M. Preston, E. Heidel, B. Alvoid-Preston, B. Ramshaw
Summary: This study attempted to improve abdominal wall reconstruction surgery by using a resorbable synthetic scaffold. The results showed that there were no mesh-related complications and no mesh removals required, indicating an improvement in value and a durable repair.
Article
Dentistry, Oral Surgery & Medicine
Mina D. Fahmy, Devin Clegg, Alexandra Belcastro, Blaine D. Smith, R. Eric Heidel, Eric R. Carlson, Benjamin Hechler
Summary: This study aimed to determine the association between pain complaints and perineural invasion in patients with oropharyngeal squamous cell carcinoma. The results showed that otalgia is a preoperative predictor of perineural invasion and there is an increased occurrence of perineural invasion in patients with pain symptoms.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Information Science & Library Science
Kelsey Leonard Grabeel, R. Eric Heidel, Sandy Oelschlegel, Rima Rudd
Summary: A librarian-led task force at the University of Tennessee Medical Center evaluated the health literacy attributes of their medical center using a widely-used tool, which ultimately led to the tool's update. The collaborative process of updating the HLEHHC tool involved an extensive literature review, editing, and formulating changes to better assess the organization's accommodation of low health literacy patients. The assessment conducted by the task force is playing a role in shaping changes within the organization.
HEALTH INFORMATION AND LIBRARIES JOURNAL
(2022)
Article
Health Care Sciences & Services
R. Steve McCallum, Baileigh A. Kirkpatrick, Robert E. Heidel, Louis Rocconi, Chelsea N. Price, Kaylan N. Gee, James M. Lewis
Summary: This study constructed and validated a scale of emotional intelligence (EI) for the medical field, called SEF:MED. The scale was developed through surveys of resident physicians and found to have a three-factor solution. The SEF:MED scale provides valuable data for physicians and other medical professionals to consider their own well-being and its impact on patient care.
EVALUATION & THE HEALTH PROFESSIONS
(2022)
Article
Surgery
Skyler Brown, James McLoughlin, Andrew Russ, Mark Casillas, Jason Buehler, Robert E. Heidel, John R. Yates
Summary: This study retrospectively analyzed patients undergoing colorectal surgery and found that the use of alvimopan and lidocaine significantly improved gastrointestinal recovery time and reduced length of hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Sarah A. King, Christopher Harper, Lou M. Smith, David Crismon, Robert E. Heidel, Genevieve Hall, Zachary Beam, Brian J. Daley
Summary: This study retrospectively analyzed pain management and opioid use in patients with rib fractures. The study found that prescriber factors can affect the duration of opioid use, while lidocaine infusion can reduce dependence. It is recommended that prescribers pay attention to the daily equivalent opioid dose and number of pills in prescriptions, and early lidocaine infusion is recommended to reduce post-discharge opioid use.
Article
Primary Health Care
Rebecca K. Kemmet, Gregory H. Blake, Robert E. Heidel, G. Anthony Wilson
Summary: This study aimed to provide milestones for academic physicians and found significant associations between academic titles and competency domains, which could guide faculty development and mentorship.
Article
Pharmacology & Pharmacy
Blake R. Johnson, Andrea S. Franks, Laura N. Bullock, Danielle L. Dennis, R. Eric Heidel, Timothy H. Self
Summary: Pharmacist-led inhaler technique education leads to sustained improvements in inhaler administration skills among acute care pulmonary nursing staff.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2022)
Article
Information Science & Library Science
Alexandria Quesenberry Wilson, Courtney Wombles, R. Eric Heidel, Kelsey Leonard Grabeel
Summary: This study examines the characteristics of health literacy publications authored by librarians from 2000 to 2020. Results show that librarian involvement in health literacy research has exponentially increased over the past two decades, particularly after 2014. Librarians demonstrate high productivity, multidisciplinary collaboration efforts, and consistent growth in their literature. However, further research is needed to explore the impact of librarians on health literacy that may not be reflected in well-indexed, peer-reviewed publications.
JOURNAL OF THE MEDICAL LIBRARY ASSOCIATION
(2022)
Meeting Abstract
Critical Care Medicine
N. Sharma, M. K. Bhagat, T. M. Dudney, R. Dhand, B. T. Bevill, P. R. Branca, M. T. McCormack, R. E. Heidel, J. W. Green, F. J. Soto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
R. Dhand, P. Terry, G. Kumar, H. Worth, J. Ferris, D. Norwood, R. E. Heidel, L. Shali
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
S. Treat, C. Forsyth, K. Gayathri, I. N. Biney, J. Ferris, R. Heidel, P. Terry, R. Dhand
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jonathan Wall, R. Eric Heidel, Emily B. Martin, Alan Stuckey, Dustin Powell, Spencer Guthrie, Ronald Lands, Stephen J. Kennel
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Amy Weisman, Emily Martin, Robert Eric Heidel, Timothy G. Perk, Deepak Behera, Stephen Kennel, Jonathan Wall
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Education & Educational Research
Luci Olewinski, M. Alison Brooks, John Wilson, R. Eric Heidel, Andrew Watson
Summary: Most collegiate athletes do not wear helmets while riding scooters or mopeds, but helmet use is higher when there are coach's rules or laws in place.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2022)