Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

(2012) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine and mTORC1: a complex relationship

(2012) Kayleigh M. Dodd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated

(2012) Agus Suryawan et al.   AMINO ACIDS

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

(2012) Margrét H. Ögmundsdóttir et al.   PLoS One

Mechanisms Involved in the Coordinate Regulation of mTORC1 by Insulin and Amino Acids

(2011) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTor Signaling in Skeletal Muscle During Sepsis and Inflammation: Where Does It All Go Wrong?

(2011) Robert A. Frost et al.   PHYSIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine

(2010) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle

(2010) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Sepsis-induced myopathy

(2010) Leigh Ann Callahan et al.   CRITICAL CARE MEDICINE

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

(2010) S Heublein et al.   ONCOGENE

Sepsis-Induced Alterations in Protein-Protein Interactions Within mTOR Complex 1 and the Modulating Effect of Leucine on Muscle Protein Synthesis

(2010) Abid A. Kazi et al.   SHOCK

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

(2009) Harinder S. Hundal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amino acid sensing and mTOR regulation: inside or out?: Figure 1

(2009) Deborah C.I. Goberdhan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM