Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 377, Issue -, Pages 188-200Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2014.07.004
Keywords
Surface-induced dissociation; Ion soft landing; Self-assembled monolayer surfaces
Funding
- U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Chemical Sciences, Geosciences & Biosciences Division
- DOE's Office of Biological and Environmental Research and located at Pacific Northwest National Laboratory (PNNL)
- DOE [DE-AC05-76RL01830]
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This article presents a personal perspective regarding the development of key concepts in understanding hyperthermal collisions of polyatomic ions with surfaces as a unique tool for mass spectrometry applications. In particular, this article provides a historic overview of studies focused on understanding the phenomena underlying surface-induced dissociation (SID) and mass-selected deposition of complex ions on surfaces. Fast energy transfer in ion-surface collisions makes SID especially advantageous for structural characterization of large complex molecules, such as peptides, proteins, and protein complexes. Soft, dissociative, and reactive landing of mass-selected ions provide the basis for preparatory mass spectrometry. These techniques enable precisely controlled deposition of ions on surfaces for a variety of applications. This perspective article shows how basic concepts developed in the 1920s and 1970s have evolved to advance promising mass-spectrometry-based applications. (C) 2014 Elsevier B.V. All rights reserved.
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