Article
Neurosciences
Raquel Cardoso Brito, Thairyne Olivato, Takae Tamy Kitabatake, Kelly Zhang, Elaine Caldeira de Oliveira Guirro, Joao Eduardo de Araujo
Summary: Studies have found that psychotropic drugs can alter rat behavior in the elevated plus-maze test. This study aimed to investigate whether static magnetic fields could impact alprazolam-induced rat behavior in the same test. The results showed that the south magnetic pole of the static magnetic field blocked the effect of alprazolam on the space-time variables of the open arms and ethological anxiolytic-like behavior in the elevated plus-maze test.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Gabriela Starowicz, Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This study aimed to investigate the role of glutamatergic and GABAergic system activation in TC-G 1008 antidepressant-like effects and the disruptions caused by a low-zinc diet. The results showed that the antidepressant-like effect of TC-G 1008 was blocked by NMDA and picrotoxin, and joint administration with muscimol or SCH50911 showed a trend towards decreased immobility time. A zinc-deficient diet resulted in dysregulation of GluN1, PSD95, and KCC2 protein expression. These findings suggest the important role of glutamate/GABA signaling in the antidepressant-like effect of TC-G 1008 and imply that GPR39 may be a novel target for the development of antidepressants.
PHARMACOLOGICAL REPORTS
(2023)
Article
Neurosciences
Joe R. Hilton, Susannah R. Simpson, Emily R. Sherman, Will Raby-Smith, Keemia Azvine, Maite Arribas, Jiaqi Zhou, Serena Deiana, Bastian Hengerer, Emma N. Cahill
Summary: This study investigated whether recalling unpleasant memories in different contextual, olfactory, or auditory conditions would enhance anxiety-like behavior in the elevated plus maze. However, the data did not support the idea that memory recall could influence behavior in the elevated plus maze.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Plant Sciences
Taiwo G. Olubodun-Obadun, Ismail O. Ishola, Timisola P. Adesokan, Blessing O. Anih, Olufunmilayo O. Adeyemi
Summary: This study investigates the antidepressant and anxiolytic effects of ethanol seed extract of Cajanus cajan in mice. The extract shows potential in treating anxiety and other neurological disorders, possibly through the involvement of monoaminergic systems and GABA receptors.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Mariah Mesquita de Figueiredo Cerqueira, Micaele Maria Lopes Castro, Amanda Almeida Vieira, Juliana Ayumi Azevedo Kurosawa, Fabio Leite do Amaral Junior, Fabiola de Carvalho Chaves de Siqueira Mendes, Marcia Consentino Kronka Sosthenes
Summary: Anxiety is increasingly being diagnosed in the elderly, and it is associated with cognitive decline, morbidity, and even mortality. The environment and age have an impact on anxiety-like behavior in mice, as assessed by the Elevated Plus Maze (EPM) and Open Field (OF) tests. The results from these tests suggest the need for a better evaluation of the parameters analyzed in each test.
Article
Behavioral Sciences
Parker Knight, Ranjithkumar Chellian, Ryann Wilson, Azin Behnood-Rod, Stefany Panunzio, Adriaan W. Bruijnzeel
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Vandna, Shruti Ahlawat, Krishna Kant Sharma, Hari Mohan
Summary: This study found that the co-administration of ketoprofen with Yersinia enterocolitica can cause significant damage to the rat gut, leading to altered expression of gut proteins and profound effects on the NF-kB signaling pathway, immune system, dysbiosis, and gut injury. Additionally, the biochemical and histopathological analysis of treated rats showed evidence of liver enzyme activity alteration and behavioral response changes, indicating the detrimental effects of the co-administration.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Lauren Gaspar, Sydney Bartman, Giuseppe Coppotelli, Jaime M. Ross
Summary: The incidence of anxiety-like disorders in humans decreases with aging, but it is unclear whether this is also true in mice. Mouse models can be used to understand the changes in neuronal networks that regulate anxiety-like behavior in aging. The elevated plus maze (EPM) test is commonly used to assess anxiety-like behavior, but it is unknown how the construction of the apparatus affects the behavior of younger and older mice. This study found that the distance traveled during the EPM test was most affected by the apparatus characteristics, and that old mice spent more time and had more entries in the open arms compared to young mice, suggesting a decrease in anxiety-like behavior with age.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Tais da Silva Teixeira Rech, Dianer Nornberg Strelow, Leticia Devantier Kruger, Jose Sebastiao Santos Neto, Gustavo Bierhals Blodorn, Diego Alves, Cesar Augusto Bruning, Cristiani Folharini Bortolatto
Summary: This study aimed to evaluate the relationship between the antidepressant-like effect of 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) and the glutamate pathway. The results showed that pretreatment of mice with drugs targeting glutamate receptors inhibited the antidepressant-like effect of SeBZF1. These findings contribute to a better understanding of the pharmacological effects of SeBZF1.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Nicolas Cordeiro, Jose Augusto Pochapski, William Sanchez Luna, Gabriel Baltazar, Rainer K. Schwarting, Roberto Andreatini, Claudio Da Cunha
Summary: Ultrasonic vocalizations play a role in conveying emotional states in both young pups and adult rats, with differences observed between genders and developmental stages. Pup vocalizations can predict adult behaviors, while adult vocalizations are influenced by stimulants.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Gabriel Guillen-Ruiz, Jonathan Cueto-Escobedo, Fabiola Hernandez-Lopez, Lina E. Rivera-Aburto, Emma Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: The study found that the effects of caffeine intake vary during different stages of the ovarian cycle in rats. In female rats during metestrus-diestrus, all doses of caffeine increased anxiety-like behavior, while during proestrus-estrus, only high doses had a slight increase in anxiety behavior. The observed effects may be associated with the naturally occurring low and high concentrations of steroid hormones during these phases.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
A. N. M. Tanvir, Md R. U. Ahsan, Gijeong Seo, Brian Bates, Chanho Lee, Peter K. Liaw, Mark Noakes, Andrzej Nycz, Changwook Ji, Duck Bong Kim
Summary: WAAM technology is used to manufacture AISI H13 tool steel in this study, which is then comprehensively analyzed for its microstructural and mechanical properties. The study finds that the combinations of phases at different locations and the periodic microhardness profile are correlated with the temperature distribution of the part.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Behavioral Sciences
Beatriz Moreno-Santos, Camila Marchi-Coelho, Willian Costa-Ferreira, Carlos C. Crestani
Summary: This study demonstrates the presence of different angiotensinergic mechanisms within the MeA controlling behavioral responses in the forced swimming test and elevated plus-maze.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychology, Biological
Patricia Gonzalez-Gaspar, Monserrat Macias-Carballo, Teresa Cadena-Mejia, Miguel A. Landa-Jimenez, Fernando M. Montes-Gonzalez, Maria Leonor Lopez-Meraz, Luis Beltran-Parrazal, Consuelo Morgado-Valle
Summary: Analixity is a video processing software designed for the elevated plus maze test (EPM) that automatically quantifies behavioral parameters, reducing analysis time and variability issues. Comparison with manual analysis and a commercial software showed that Analixity is as reliable and effective as the latter.
BEHAVIOURAL PROCESSES
(2021)
Article
Neurosciences
Kim Dore, Roberto Malinow
Summary: The study showed that NMDA receptors can signal through conformational change independently of ion flux, leading to long-term depression of synaptic transmission. PSD-95 overexpression was found to block agonist-induced conformational changes in the NMDAR intracellular domain and NMDAR-dependent, ion-flux independent LTD. This suggests that ion-flux independent LTD may be predominant in young animals due to lower levels of PSD-95 at synapses.
Review
Behavioral Sciences
C. P. Murphy, N. Singewald
GENES BRAIN AND BEHAVIOR
(2018)
Article
Clinical Neurology
Anupam Sah, Sergey Sotnikov, Maria Kharitonova, Claudia Schmuckermair, Rebekka P. Diepold, Rainer Landgraf, Nigel Whittle, Nicolas Singewald
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Neurosciences
Nicolas Singewald, Andrew Holmes
PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Ines Schoberleitner, Anna Mutti, Anupam Sah, Alexandra Wille, Francisco Gimeno-Valiente, Paolo Piatti, Maria Kharitonova, Luis Torres, Gerardo Lopez-Rodas, Jeffrey J. Liu, Nicolas Singewald, Christoph Schwarzer, Alexandra Lusser
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Judith Camats-Perna, Predrag Kalaba, Karl Ebner, Simone B. Sartori, Harish Vuyyuru, Nilima Y. Aher, Vladimir Dragacevic, Nicolas Singewald, Mario Engelmann, Gert Lubec
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Yu Kasugai, Elisabeth Vogel, Heide Hoertnagl, Sabine Schoenherr, Enrica Paradiso, Markus Hauschild, Georg Goebel, Ivan Milenkovic, Yvan Peterschmitt, Ramon Tasan, Guenther Sperk, Ryuichi Shigemoto, Werner Sieghart, Nicolas Singewald, Andreas Luethi, Francesco Ferraguti
Review
Pharmacology & Pharmacy
Simone B. Sartori, Nicolas Singewald
PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Cristina Lemos, Ahmad Salti, Ines M. Amaral, Veronica Fontebasso, Nicolas Singewald, Georg Dechant, Alex Hofer, Rana El Rawas
Summary: Social interaction can be beneficial in preventing drug abuse by reducing stress levels. The study found that social interaction decreased stress levels and reversed the preference for cocaine induced by stress. This suggests that social interaction could be an important component in the treatment of substance use disorders.
Article
Biochemistry & Molecular Biology
Anouk Pierre, Andries Van Schuerbeek, Wissal Allaoui, Sven Van Laere, Nicolas Singewald, Ann Van Eeckhaut, Ilse Smolders, Dimitri De Bundel
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Endocrinology & Metabolism
A. Pierre, Y. Regin, A. Van Schuerbeek, E. M. Fritz, K. Muylle, T. Beckers, I. J. Smolders, N. Singewald, D. De Bundel
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shima Kouhnavardi, Maureen Cabatic, M. Carmen Manas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Munoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec, Estela Castilla-Ortega, Francisco J. Monje
Summary: Cortisol is a steroid hormone that affects the central nervous system and plays important roles in brain neuronal synaptic plasticity and emotional and behavioral responses. Dysregulation of cortisol is associated with conditions such as Alzheimer's Disease, chronic stress, anxiety, and depression. The effects of cortisol on hippocampal functions and the mechanisms involved in fine-tuning synaptic responses are poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nicolas Singewald, Simone B. Sartori, Andreas Reif, Andrew Holmes
Summary: Psychiatric disorders associated with trauma, stress, and anxiety are increasing worldwide, leading to significant morbidity. Current medication-based therapeutic approaches for anxiety disorders and PTSD are effective but have unwanted side effects and do not address underlying pathophysiology. There is renewed interest in designing novel drug treatments in this field, targeting various neurochemical systems. This article provides an overview of the current state of drug development, highlighting the importance of neurobiology and neuroplasticity in achieving lasting therapeutic effects.
Article
Biochemistry & Molecular Biology
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Hoeger, Gert Lubec
Summary: The worldwide increase in cognitive decline calls for the search of pharmacological treatment. Current dopamine transporter (DAT) inhibitors have unwanted side effects due to lack of specificity. A highly specific DAT inhibitor, S-CE-123, was synthesized and tested for its potential to enhance cognitive functions in rats. S-CE-123 showed good bioavailability and improved the performance of aged rats.
Article
Biochemistry & Molecular Biology
Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec
Summary: The high structural similarity among dopamine, norepinephrine, and serotonin transporters, especially in transmembrane regions, presents a challenge for specifically targeting individual transporters. Ligand design is limited by chemists' tendency to modify lead compounds in a way that reduces the number of chiral centers, thus limiting the chemical space of synthetic ligands. However, increasing molecular complexity by introducing additional chiral centers has been shown to lead to more selective and potent dopamine reuptake inhibitors. The establishment of a compound library with defined absolute configurations lays the foundation for computational chemists to optimize and design specific monoamine transporter reuptake inhibitors.
Article
Psychiatry
Sinead Rooney, Anupam Sah, Michael S. Unger, Maria Kharitonova, Simone B. Sartori, Christoph Schwarzer, Ludwig Aigner, Helmut Kettenmann, Susanne A. Wolf, Nicolas Singewald
TRANSLATIONAL PSYCHIATRY
(2020)
