Article
Pathology
Shinji Kaba, Yoshitaka Kawai, Yuki Tanigami, Hiroe Ohnishi, Tomoko Kita, Masayoshi Yoshimatsu, Koichi Omori, Yo Kishimoto
Summary: This study aimed to evaluate the effects of pioglitazone on macrophage phenotype and fibrosis following vocal fold injury. The results showed that pioglitazone reduced the expression of Ccl2, inhibited the accumulation of inflammatory macrophages, and improved tissue repair in a PPARy-dependent manner, resulting in decreased fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Immunology
Kwangwook Kim, Minho Song, Yanhong Liu, Peng Ji
Summary: Enterotoxigenic Escherichia coli (ETEC) infection-induced post-weaning diarrhea is a major health issue in newly weaned pigs, leading to the overuse of antimicrobial drugs. Nutritional intervention is an effective alternative practice to reduce reliance on antibiotics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuankang Zhou, Yuheng Luo, Bing Yu, Ping Zheng, Jie Yu, Zhiqing Huang, Xiangbing Mao, Junqiu Luo, Hui Yan, Jun He
Summary: The study found that dietary beta-glucan (BGL) supplementation has a protective effect on intestinal epithelium exposed to enterotoxigenic Escherichia coli (ETEC). BGL supplementation improves intestinal absorption, reduces inflammation, enhances intestinal immunity and antioxidant capacity, and improves intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li
Summary: The study identified sanguinarine as a dual agonist of PPAR alpha and PPAR gamma, showing promising therapeutic potential in chronic diseases. It was found to upregulate PPAR alpha-target genes in hepatocytes and modulate key PPAR gamma-target genes to promote adipocyte differentiation. The unique ligand-binding mode of sanguinarine to PPAR alpha highlights its potential as a novel template for dual-targeting PPARs ligands.
Article
Microbiology
Jiali Chen, Fuchang Li, Weiren Yang, Shuzhen Jiang, Yang Li
Summary: The study demonstrated that dietary supplementation with exogenous catalase (CAT) can improve intestinal development and protect against LPS-induced intestinal mucosa injury in weaned pigs by enhancing intestinal antioxidant capacity and altering microbiota composition.
MICROBIOLOGY SPECTRUM
(2021)
Article
Pharmacology & Pharmacy
Dan Li, Huijuan Ma, Qi Shu, Tingqian Wang, Linyi Li, Ping Huang, Kaiyan Lou, Huan Xu
Summary: The study found that arsenite (As+3) inhibits M2a cell polarization by suppressing PPAR-gamma and leads to lipid accumulation. Rosiglitazone (RSG) can alleviate the inhibitory effects of As+3 on PPAR-gamma and M2a cell polarization.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Microbiology
Cynthia Jinno, Xunde Li, Yanhong Liu
Summary: This study aimed to characterize the effects of ETEC infection, supplementing B. subtilis DSM 25841, or carbadox on intestinal microbiota of pigs. The results indicated that AGP reduced the relative abundance of beneficial bacteria in the intestines, while DFM had higher relative abundance of beneficial bacteria in some intestinal segments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyejin Ko, Hongjun Jang, Seungchan An, In Guk Park, Sungjin Ahn, Junpyo Gong, Seok Young Hwang, Soyeon Oh, Soo Yeon Kwak, Won Jun Choi, Hyoungsu Kim, Minsoo Noh
Summary: The upregulation of adiponectin production is a potential therapeutic strategy for metabolic diseases. Galangin and its derivatives were found to promote adiponectin synthesis by binding to PPARγ and enhancing its activity while reducing the activity of ERβ. A novel galangin derivative, galangin 3-benzyl-5,7-dimethylether, showed the highest potency and selectively bound to PPARγ, suggesting its potential therapeutic use in various metabolic diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
May A. Abd El Fattah, Yasmine A. Abdelhamid, Mohammed F. Elyamany, Osama A. Badary, Ola A. Heikal
Summary: RBE administration was found to protect against the LPS-induced inflammatory effects by decreasing the inflammatory mediator expression in mice brains, potentially through PPAR-gamma activation. Additionally, RBE also decreased PPAR-gamma sumoylation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Microbiology
Shan-Shan Peng, Yingjie Li, Qiuhong Chen, Qi Hu, Ying He, Lianqiang Che, Ping-Ping Jiang
Summary: This study investigated the changes in mucosal microbiome and protein expression in the ileum induced by ETEC infection using pigs as a model. The results showed that ETEC infection caused inflammation, impaired bile acid circulation, and the mucosal microbiome may affect the expression of intestinal proteins.
Article
Microbiology
Cynthia Jinno, Kwangwook Kim, Braden Wong, Emma Wall, Ravichandran Sripathy, Yanhong Liu
Summary: The objective of this study was to investigate the effects of supplementation of botanical blends (BB) on the gut microbiota and metabolomic profiles in pigs infected with Escherichia coli. The results showed that supplementing 100 ppm BB1 increased the relative abundances of Enterobacteriaceae and Escherichia-Shigella in the ileum, and the relative abundances of Bacteroidota and Prevotellaceae in the cecum. Supplementing 100 ppm BB2 upregulated serum pinitol on day 4 post-inoculation and serum cholesterol and aminomalonic acids on day 21 post-inoculation. Addition of 50 ppm BB2 reduced asparagine in the ileal mucosa on day 5 post-inoculation.
Article
Cell Biology
Xiran Lin, Xianmin Meng, Zhiqi Song, Jingrong Lin
Summary: The pathophysiology of psoriasis is complex and not fully understood. Recent evidence suggests a potential causative relationship between altered peroxisome proliferator-activated receptor gamma (PPARγ) activity and psoriasis. PPARγ is involved in various aspects of psoriasis pathogenesis, making PPARγ agonists a promising option for treatment. However, potential side effects of these agonists need to be considered.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Jingwen Liu, Xiaoye Li, Hong Wang, Yan Ren, Yiming Li, Fujiang Guo
Summary: Researchers identified a selective PPARγ modulator called Bavachinin (BVC), which effectively regulates bone homeostasis and shows potential for the prevention and treatment of diabetes. The prodrug of BVC (BN) improves water solubility, absorption, and circulation time.
PHYTOTHERAPY RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Se Yeon Chang, Min Ho Song, Ji Hwan Lee, Han Jin Oh, Yong Ju Kim, Jae Woo An, Young Bin Go, Dong Cheol Song, Hyun Ah Cho, Seung Yeol Cho, Dong Jun Kim, Mi Suk Kim, Hyeun Bum Kim, Jin Ho Cho
Summary: This study investigated the effects of different phytogenic feed additives on weaned pigs infected with Escherichia coli. The results showed that supplementation of PFA improved the growth performance and immune response of pigs, with the mixed additive of bitter citrus extract, thymol, and carvacrol showing the most effective results.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A. A. M. Kamps, Daniel H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Summary: PPAR y agonists can ameliorate proteinuria by inhibiting the expression of glomerular HPSE, providing a potential mechanism for the renoprotective effects of these drugs.