Article
Parasitology
Javier Gandasegui, Berta Grau-Pujol, Maria Cambra-Pelleja, Valdemiro Escola, Maria Antonietta Demontis, Anelsio Cossa, Jose Carlos Jamine, Rafael Balana-Fouce, Lisette van Lieshout, Jose Munoz, Maria Martinez-Valladares
Summary: This study optimized the sample processing methodology and standardized pyrosequencing in soil-transmitted helminth (STH) pooled eggs. The protocols developed in this study can be used for large-scale screenings or anthelmintic efficacy trials in STH populations. The results suggest that the new pyrosequencing assays designed in this study provided accurate SNP frequencies in simulated resistance levels.
PARASITES & VECTORS
(2021)
Article
Pathology
Jaco J. Verweij
Summary: This paper discusses setting tailor-made performance characteristics for the validation of laboratory developed tests (LDTs) for the molecular diagnosis of intestinal parasitic infections in compliance with ISO 15189 guidelines, emphasizing the importance of maintaining these tests through daily monitoring and reassessment of the test set-up. It highlights the necessity of modifying or adding additional characteristics based on personal insights to achieve continuous quality improvement in diagnostic laboratory practice.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Multidisciplinary Sciences
Yonas Alemu, Teshome Degefa, Mitiku Bajiro, Getachew Teshome
Summary: This study assessed the prevalence and intensity of soil-transmitted helminths (STH) infection among individuals in model and non-model households in Jimma zone. The study found that the prevalence and intensity of STH infection were higher in non-model households than in model households. Factors such as household training status, age of participants, and latrine use pattern were found to be significant predictors of STH infection prevalence.
Article
Infectious Diseases
Robert J. Hardwick, James E. Truscott, William E. Oswald, Marleen Werkman, Katherine E. Halliday, Rachel L. Pullan, Roy M. Anderson
Summary: This study presents a general framework to understand the impact of adherence and non-adherence behavior on mass drug administration (MDA) programs for neglected tropical diseases (NTDs). By developing probability models informed by observed adherence behavior, the study explores how different patterns influence the success of MDA programs. The analysis conducted on the TUMIKIA data highlights the importance of accurately capturing non-adherence patterns for effective control measures.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Patsy A. Zendejas-Heredia, Allison Crawley, Helen Byrnes, Rebecca J. Traub, Vito Colella
Summary: Soil-transmitted helminths are highly prevalent in the Asia-Pacific region, with a 96.5% prevalence in dogs in Kiribati. Urgent implementation of treatment and prevention programs is advocated to address these zoonotic pathogens, in accordance with the Kiribati-World Health Organization Cooperation Strategy 2018-2022.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Biology
Benjamin S. S. Collyer, James E. E. Truscott, Charles S. S. Mwandawiro, Sammy M. M. Njenga, Roy M. M. Anderson
Summary: Human mobility is a contributing factor to the spread of infectious diseases, and understanding this can aid in planning interventions. This study focuses on the spatial dynamics of hookworm, a common parasitic infection, and develops a transmission model based on data from Kenya. The model considers human mobility and successfully reproduces observed patterns of infection decline during a mass chemotherapy trial. The results highlight the importance of considering mobility in the design of elimination programs for helminth transmission.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Gabriela Matamoros, Ana Sanchez, Jose Antonio Gabrie, Marisa Juarez, Laura Ceballos, Andres Escalada, Carol Rodriguez, Helena Marti-Soler, Maria Mercedes Rueda, Maritza Canales, Carlos Lanusse, Pamela Cajal, Luis Alvarez, Ruben O. Cimino, Alejandro Krolewiecki
Summary: This study demonstrates that the combined use of ALB and high-dose IVM is highly effective and well tolerated for the treatment of Trichuris trichiura infections. Comparisons show that the efficacy of the IVM groups is significantly better than the ALB-only groups.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Mary Lorraine S. Mationg, Veronica L. Tallo, Gail M. Williams, Catherine A. Gordon, Archie C. A. Clements, Donald P. McManus, Darren J. Gray
Summary: Despite major efforts to control soil-transmitted helminth infections in the Philippines for nearly two decades, high prevalence rates persist due to suboptimal mass drug administration coverage, limited water, sanitation, and hygiene programs, and inadequate health education. Sustainable delivery of integrated control approaches is crucial for reducing the burden of soil-transmitted helminth infections in the Philippines.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Medicine, General & Internal
Lukas Ihnacik, Julia Smigova, Jindrich Soltys, Diana Bobikova, Zofia Kuzevicova, Stefan Kuzevic, Ingrid Schusterova, Ingrid Papajova
Summary: Roma people in Slovakia are at the highest risk for soil-transmitted helminths (STH) due to unsanitary living conditions. The study also found that soil and animals could be sources of STH eggs.
FRONTIERS IN MEDICINE
(2022)
Article
Parasitology
Ameyo M. Dorkenoo, Anna E. Phillips, Luke Klein, Fiali Lack, Essoham Ataba, Kossi Yakpa, Atna-Edi Tagba, Bozi-Esso Assoti, Efoe Sossou, Maweke Tchalim, Gbati Datagni, Anders Seim, Marie Denise Milord, Yao Kassankogno
Summary: After 10 years of high coverage integrated mass drug administration, Togo has achieved a low prevalence of schistosomiasis infection through sub-district implementation. However, soil-transmitted helminth (STH) infection remains a problem in some areas. additional measures such as improving treatment coverage among preschool age children and hygiene and sanitation practices are needed.
PARASITES & VECTORS
(2023)
Article
Microbiology
Hanchen Li, Ambily Abraham, David Gazzola, Yan Hu, Gillian Beamer, Kelly Flanagan, Ernesto Soto, Florentina Rus, Zeynep Mirza, Austin Draper, Sridhar Vakalapudi, Cheryl Stockman, Perry Bain, Joseph F. Urban, Gary R. Ostroff, Raffi Aroian
Summary: Gastrointestinal nematodes have a negative impact on childhood growth, cognition, nutrition, education, productivity, income, and pregnancy. The development of an anthelmintic for mass drug administration must be safe, effective, inexpensive, stable without a cold chain, and massively scalable. The Bacillus thuringiensis Cry5B (IBaCC) has been proven to be a safe, inexpensive, highly effective, easy-to-manufacture, and scalable anthelmintic for treating human GINs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Fan-Zhen Mao, Yu-Ying Chen, Xiang-Zhen Xu, Bi-Xian Ni, Xiao-Lin Jin, Yang Dai, Jun Cao
Summary: From 1989 to 2019, a multi-intervention integrated deworming approach in Jiangsu Province of China, including mass drug administration, health education, and environmental sanitation improvements, significantly reduced the infection rate of soil-transmitted helminths, demonstrating the effectiveness of comprehensive interventions in sustaining control efforts.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Chemistry, Medicinal
Jennifer Keiser, Cecile Haberli
Summary: Drug repurposing from veterinary to human medicine has been the main strategy to develop anthelminthics for the treatment of helminthiasis. A systematic comparison of the anthelminthic activity profile of derivatives of these drugs has not been conducted yet. The study reveals pronounced differences in activity against larval and adult stages among different classes of anthelminthics, highlighting the importance of evaluating drugs against different species and stages for potential candidates.
ACS INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Ernesto Candela, Carolina Goizueta, Leonardo Sandon, Carla Munoz-Antoli, Maria Victoria Periago
Summary: This study aimed to explore the socioeconomic and environmental factors related to soil-transmitted helminth (STH) infection in indigenous villages in Argentina. The study found that specific environmental factors, such as vegetation pattern and impervious surface density, played a major role in the transmission and distribution of STH. Furthermore, socioeconomic factors, such as walking barefoot and overcrowding, were significantly correlated with infection intensity.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Health Care Sciences & Services
Vito Colella, Virak Khieu, Andrew Worsley, Dammika Senevirathna, Sinuon Muth, Rekol Huy, Peter Odermatt, Rebecca J. Traub
Summary: The study found that in the Asia Pacific region, as age increases, the odds of hookworm infection increase faster for females than males; there is a significant difference in cure rates of hookworm infections under different detection methods following albendazole treatment; drinking boiled water can increase the likelihood of cure.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Microbiology
Amelia R. Woolums, Brandi B. Karisch, Jonathan G. Frye, William Epperson, David R. Smith, John Blanton, Frank Austin, Ray Kaplan, Lari Hiott, Tiffanie Woodley, Sushim K. Gupta, Charlene R. Jackson, Michael McClelland
VETERINARY MICROBIOLOGY
(2018)
Article
Parasitology
Grace VanHoy, Michelle Carman, Greg Habing, Jeffrey Lakritz, C. Austin Hinds, Andrew Niehaus, Ray M. Kaplan, Antoinette E. Marsh
VETERINARY PARASITOLOGY
(2018)
Article
Parasitology
Kelsey L. Paras, Melissa M. George, Anand N. Vidyashankar, Ray M. Kaplan
VETERINARY PARASITOLOGY
(2018)
Article
Parasitology
Bruno Levecke, Ray M. Kaplan, Stig M. Thamsborg, Paul R. Torgerson, Jozef Vercruysse, Robert J. Dobson
VETERINARY PARASITOLOGY
(2018)
Article
Parasitology
A. M. Becher, D. C. van Doorn, K. Pfister, R. M. Kaplan, M. Reist, M. K. Nielsen
VETERINARY PARASITOLOGY
(2018)
Article
Parasitology
Melissa M. George, Lorraine Lopez-Soberal, Bob E. Storey, Sue B. Howell, Ray M. Kaplan
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2018)
Review
Parasitology
Eric R. Morgan, Nor-Azlina A. Aziz, Alexandra Blanchard, Johannes Charlier, Claude Charvet, Edwin Claerebout, Peter Geldhof, Andrew W. Greer, Hubertus Hertzberg, Jane Hodgkinson, Johan Hoglund, Herve Hoste, Ray M. Kaplan, Maria Martinez-Valladares, Sian Mitchell, Harm W. Ploeger, Laura Rinaldi, Georg von Samson-Himmelstjerna, Smaragda Sotiraki, Manuela Schnyder, Philip Skuce, David Bartley, Fiona Kenyon, Stig M. Thamsborg, Hannah Rose Vineer, Theo de Waal, Andrew R. Williams, Jan A. van Wyk, Jozef Vercruysse
TRENDS IN PARASITOLOGY
(2019)
Article
Parasitology
Jane E. Hodgkinson, Ray M. Kaplan, Fiona Kenyon, Eric R. Morgan, Andrew W. Park, Steve Paterson, Simon A. Babayan, Nicola J. Beesley, Collette Britton, Umer Chaudhry, Stephen R. Doyle, Vanessa O. Ezenwa, Andy Fenton, Sue B. Howell, Roz Laing, Barbara K. Mable, Louise Matthews, Jennifer McIntyre, Catherine E. Milne, Thomas A. Morrison, Jamie C. Prentice, Neil D. Sargison, Diana J. L. Williams, Adrian J. Wolstenholme, Eileen Devaney
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2019)
Article
Parasitology
Julie Sanchez, Guha Dharmarajan, Melissa M. George, Cassan Pulaski, Adrian J. Wolstenholme, John S. Gilleard, Ray M. Kaplan
VETERINARY PARASITOLOGY
(2020)
Article
Parasitology
Kelsey L. Paras, Ray M. Kaplan
VETERINARY PARASITOLOGY
(2020)
Article
Parasitology
Abigail R. McCrea, Pablo D. Jimenez Castro, Ray M. Kaplan, Michael Povelones
VETERINARY PARASITOLOGY
(2020)
Article
Parasitology
Umer Chaudhry, E. M. Redman, Ray Kaplan, Thomas Yazwinski, Neil Sargison, John S. Gilleard
VETERINARY PARASITOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
James B. Collins, Brian Jordan, Anand N. Vidyashankar, Pablo Jimenez Castro, Justin Fowler, Ray M. Kaplan
Summary: This study identified resistance to fenbendazole in the common intestinal helminth of turkeys, Ascaridia dissimilis. In turkeys, infection with resistant isolates significantly impacted feed conversion and weight gain. The presence of fenbendazole-resistant worms could have significant economic implications for turkey production.
Article
Parasitology
Alistair Antonopoulos, Stephen R. Doyle, David J. Bartley, Alison A. Morrison, Ray Kaplan, Sue Howell, Cedric Neveu, Valentina Busin, Eileen Devaney, Roz Laing
Summary: Haemonchus contortus is a parasitic nematode that infects small ruminants and causes health issues and economic losses in the livestock industry. The treatment for this parasite primarily relies on broad-spectrum anthelmintics, but resistance has emerged. Levamisole (LEV) is an important treatment option, as resistance to LEV is less common. Genetic variation at the acr-8 locus has been implicated in LEV resistance.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2022)
Article
Parasitology
Martin K. Nielsen, Ray M. Kaplan, Ghazanfar Abbas, Abdul Jabbar
Summary: Long-term intensive use of anthelmintics has led to widespread anthelmintic resistance, but it can also select for other biological traits. This study highlights examples of changing parasite dynamics that don't fit the definition of anthelmintic resistance, and explores cases where anthelmintic resistance has occurred along with coselection for other traits. Suggestions are made for collecting more information and addressing these knowledge gaps.
TRENDS IN PARASITOLOGY
(2023)
