Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 86, Issue 2, Pages 246-253Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2012.11-0409
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Funding
- U.S. Department of Defense Global Emerging Infectious Systems (DoD-GEIS)
- U.S. Department of State
- U.S. Centers for Disease Control and Prevention
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The agents of human febrile illness can vary by region and country suggesting that diagnosis, treatment, and control programs need to be based on a methodical evaluation of area-specific etiologies. From December 2006 to December 2009, 9,997 individuals presenting with acute febrile illness at nine health care clinics in south-central Cambodia were enrolled in a study to elucidate the etiologies. Upon enrollment, respiratory specimens, whole blood, and serum were collected. Testing was performed for viral, bacterial, and parasitic pathogens. Etiologies were identified in 38.0% of patients. Influenza was the most frequent pathogen, followed by dengue, malaria, and bacterial pathogens isolated from blood culture. In addition, 3.5% of enrolled patients were infected with more than one pathogen. Our data provide the first systematic assessment of the etiologies of acute febrile illness in south-central Cambodia. Data from syndromic-based surveillance studies can help guide public health responses in developing nations.
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