Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 84, Issue 1, Pages 91-98Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2011.10-0402
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Funding
- Swiss National Science Foundation [PPOOB 102883, PPOOB 119129]
- Imperial College London and Technologie Servier
- Wellcome Trust/Imperial College [PS1041]
- Chinese Academy of Sciences [KJXC2 YW W11]
- US National Science Foundation [DEB 0408083]
- Yale Institute of Biospheric Studies
- Novartis Stiftung fur medizmisch biologische Forschung
- University of Basel Fonds zur Forderung des akademischen Nachwuchses
- Medical Research Council [G0801056B] Funding Source: researchfish
- National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) [U62PS001041] Funding Source: NIH RePORTER
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Although co infections are common and can have important epidemiologic and evolutionary consequences, studies exploring biochemical effects of multiple strain infections remain scarce We studied metabolic responses of NMRI mice to Trypanosoma brucei brucei single (STIB777AE-Green1 or STIB246BA-Red1) and co infections using a H-1 nuclear magnetic resonance (NMR) spectroscopy-based metabolic profiling strategy All T b brucei infections caused an alteration in urinary biochemical composition by day 4 postinfection, characterized by increased concentrations of 2 oxoisocaproate, D 3 hydroxybutyrate, lactate, 4-hydroxyphenylacetate, phenylpyruvate, and 4-hydroxyphenylpyruvate, and decreased levels of hippurate Although there were no marked differences in metabolic signatures observed in the mouse infected with a single or dual strain of T b brucei, there was a slower metabolic response in mice infected with T b brucei green strain compared with mice infected with either the red strain or both strains concurrently Pyruvate phenylpyruvate and hippurate were correlated with parasitemia which might be useful in monitoring responses to therapeutic interventions
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