Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 82, Issue 2, Pages 223-227Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0458
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Funding
- Fonds voor Wetenschappelijk Onderzoek
- Institute for the Promotion of Innovation by Science
- Technology in Flanders
- Institute of Tropical Medicine Antwerp
- Belgian Technical Cooperation
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Fourteen published and three newly identified polymorphic microsatellites were used to genotype 69 Plasmodium vivax samples obtained from 39 patients detected over a period of two years who lived in it rural community Of central Vietnam. All samples were polyclonal with in average expected heterozygosity of 0.86. Among the 39 patients, 16 experienced 1-5 recurrent episodes of P. vivax malaria, most of them (83%) with a different genotype profile compared with previous infections. The minimal Set of microsatellites required for differentiating the genotype profiles of the recurrent infections compared with the full set of 17 microsatellites was explored. A combination of five markers was sufficient to identify all recurrent infections with an unrelated or different genotype profile compared with an previous episodes.
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