Article
Environmental Sciences
Yueyue Li, Yashu Li, Guanxi Wang, Julin Li, Meihua Zhang, Jingyao Wu, Cheng Liang, Huayun Zhou, Jianxia Tang, Guoding Zhu
Summary: Insecticide resistance is a severe global problem for vector control. A recent study analysed the molecular metabolite changes in deltamethrin-resistant An. sinensis mosquitoes using liquid chromatography tandem mass spectrometry (LC-MS/MS) and found that the differential metabolites were mainly associated with glycerophospholipid metabolism. These findings provide further mechanistic understanding of insecticide resistance in An. sinensis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Entomology
Jiajun Zhang, Yongjie Zhang, Liang Qiao, Shulin He, Xingfei He, Chengyin He, Bin Chen, Yueqing Cao, Zhengbo He
Summary: Female adult anautogenous mosquitoes rely on diverse chemical stimuli to locate and discriminate hosts for feeding. Odorant binding protein AsOBP1 plays a crucial role in host-seeking behavior of Anopheles sinensis mosquitoes. The study identifies human odor compounds, such as 1-tetradecanol and heptanal, that enhance the attraction of mosquitoes, and provides a potential target for malaria control.
JOURNAL OF PEST SCIENCE
(2023)
Article
Parasitology
Zhengbo He, Zhengrong Yu, Xingfei He, Youjin Hao, Liang Qiao, Shihui Luo, Jingjing Zhang, Bin Chen
Summary: This study provides a genome-wide analysis of OR genes in An. sinensis, identifying 59 putative OR genes and investigating their expression patterns and characteristics. The findings suggest the involvement of ORs in odor reception in this species.
PARASITES & VECTORS
(2022)
Article
Computer Science, Artificial Intelligence
Yunpeng Ren, Wenxin Hu, Ziao Wang, Xiaofeng Zhang, Yiyuan Wang, Xuan Wang
Summary: Generating long macro reports from short text is a challenging task, and a hybrid deep generative neural model is proposed in this paper to tackle this issue. Experimental results show that the model performs well in evaluation criteria, but further efforts are needed to improve readability.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Congshan Liu, Jianping Cao, Haobing Zhang, Jiatong Wu, Jianhai Yin
Summary: Recent discoveries have revealed the potential regulatory functions of reversible N6-methyladenosine (m6A) methylation on messenger RNA (mRNA). This study profiles the transcriptome-wide m6A in Anopheles sinensis, a mosquito species, and identifies its conserved nature. The distribution pattern of m6A in this species is associated with sex-specific pathways and positively correlated with mRNA abundance, indicating a regulatory role in gene expression. The study also highlights the involvement of m6A methylation in spermatogenesis-related genes, providing insights for controlling disease transmission by this mosquito vector.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yan-Jun Kang, Guoding Zhu, Yang Cheng, Haitao Yang, Jun Cao
Summary: ISVs are considered ancestors to arboviruses. This study characterized the RNA viromes in different tissues of two mosquito species using a metatranscriptomics approach. The results provide important insights into the dynamics of viromes within individual mosquitoes and help understand the evolution, transmission routes, and maintenance modes of mosquito-specific viruses in nature.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Wen-Jian Xie, Xin-Ya Xu, Yi-Xuan Xia, Chu Shing Lam, Tie Chen, Yun-Shi Zhi, Kuan Ming Lee, Xun Song, Stephen T. Deyrup, Zhen-Dan He, Hong-Jie Zhang
Summary: Miliusanes, belonging to meroterpenoids, are anticancer lead molecules isolated from Miliusa plants. In this study, 20 compounds, including 12 new ones, were isolated and identified from M. sinensis. These compounds showed potent inhibition of cell growth in various human derived cancer cell lines. Compound 11 demonstrated stronger cytotoxic activity and contained a new unconjugated 1,4-diketone system.
BIOORGANIC CHEMISTRY
(2023)
Article
Agronomy
You Wang, Xingfei He, Liang Qiao, Zhengrong Yu, Bin Chen, Zhengbo He
Summary: This study successfully applied CRISPR/Cas9 mediated knock-in technology to achieve highly efficient, site-specific mutagenesis in Anopheles sinensis. The integration of the EGFP marker gene into the odorant receptor co-receptor (Orco) confirmed Orco as a key mediator of multiple olfactory-driven behaviors in the An. sinensis life cycle, emphasizing its importance as a key molecular target for malaria control. The results also demonstrated that CRISPR/Cas9 is a simple and highly efficient genome editing technique for An. sinensis and could be utilized in developing genetic control tools for this vector.
PEST MANAGEMENT SCIENCE
(2022)
Article
Parasitology
Zhi-quan He, Ya-bo Hu, Dan Wang, Yu-ting Liu, Cheng-yun Yang, Dan Qian, Rui-min Zhou, De-ling Lu, Su-hua Li, Ying Liu, Hong-wei Zhang
Summary: This study investigated the susceptibility profile and population genetic characteristics of Anopheles sinensis, the main vector of malaria in Henan Province, China, to provide data and guidance for the study of resistance mechanisms and the control of An. sinensis.
PARASITES & VECTORS
(2023)
Article
Environmental Sciences
Yanlong Guo, Zefang Zhao, Xin Li
Summary: Using a comprehensive niche modelling approach, the study predicted the spatial quality pattern of Ophiocordyceps sinensis, showing that with increasing temperature, suitable habitats for O. sinensis may shift to the high-latitude and high-altitude hinterland of the Tibetan Plateau.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Kinley Wangdi, Erica Wetzler, Paola Marchesini, Leopoldo Villegas, Sara Canavati
Summary: The study identifies risk factors for imported malaria in the border areas between Brazil and Venezuela and highlights the importance of targeted interventions tailored to occupation, age, and mobility status to achieve malaria elimination.
SCIENTIFIC REPORTS
(2022)
Article
Agronomy
Fei Tao, Feng-Ling Si, Rui Hong, Xiu He, Xiang-Ying Li, Liang Qiao, Zheng-Bo He, Zhen-Tian Yan, Shu-Lin He, Bin Chen
Summary: The study identified 32 putative cytosolic and three putative microsomal GST genes in An. sinensis. Transcriptome analysis showed high expression of GSTs in larvae and in specific tissues of adults. GSTd2 and GSTe2 were significantly upregulated in pyrethroid-resistant populations, and silencing these genes increased susceptibility to deltamethrin. Recombinant GSTd2 and GSTe2 showed high enzymatic activity in metabolizing certain chemicals.
PEST MANAGEMENT SCIENCE
(2022)
Article
Ecology
Jiangtao Liang, James M. Hodge, Igor V. Sharakhov
Summary: Haldane's rule of speciation states that hybrid male sterility or inviability is more likely to affect the heterogametic sex of inter-species hybrids. Darwin's corollary suggests that there are asymmetric phenotypes in inter-species hybrids from reciprocal crosses. By studying the phenotypes of F1 hybrids among closely related species of malaria mosquitoes, researchers have identified different genetic factors and molecular mechanisms responsible for reproductive isolation in reciprocal crosses among species of the An. gambiae complex.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Immunology
S. Ricci, S. Abu-Rumeileh, N. Campagna, F. Barbati, S. Stagi, C. Canessa, L. Lodi, B. Palterer, L. Maggi, A. Matucci, A. Vultaggio, F. Annunziato, C. Azzari
Summary: We present a case of a patient with common variable immunodeficiency (CVID) who exhibited short stature and was treated with recombinant human growth hormone (rhGH). Whole exome sequencing identified a novel pathogenic single-nucleotide duplication in the NFKB1 gene, leading to NFKB1 haploinsufficiency. This is the first reported case of CVID caused by an NFKB1 mutation presenting with short stature. The study also suggests a potential shared mechanism involving NFKB1 and GH-IGF-1 pathways for both CVID and short stature in this patient.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Information Systems
Tong Bao, Ni Ren, Rui Luo, Baojia Wang, Gengyu Shen, Ting Guo
Summary: The paper proposes a feature fusion framework based on BERT, where CNN captures static features, BiGRU captures contextual features, and an attention mechanism assigns weight to salient words. Experimental results show that the model outperforms other state-of-the-art baseline methods.
JOURNAL OF ORGANIZATIONAL AND END USER COMPUTING
(2021)
