Article
Biochemistry & Molecular Biology
Erika T. Rhone, Elissa Bardhi, Sai Vineela Bontha, Patrick D. Walker, Jorge A. Almenara, Catherine I. Dumur, Helen Cathro, Daniel Maluf, Valeria Mas
Summary: The study evaluated gene expression profiles in pediatric kidney transplant recipients and found oxidative phosphorylation and mitochondrial dysfunction, decreased ATP synthesis, and other toxicology pathways in CNIT patients. An integrative analysis identified a panel of 13 significant miRNAs and their 33 CNIT-specific gene targets, which may serve as future molecular markers for CNIT diagnosis and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Benas Prusinskas, Sinja Ohlsson, Simone Kathemann, Denisa Pilic, Kristina Kampmann, Rainer Buescher, Andreas Paul, Lars Pape, Peter F. Hoyer, Elke Lainka
Summary: Calculating the individual weight-adjusted TAC C/D ratio can help estimate the risk of therapy-associated complications in pediatric liver transplant patients. Lower TAC levels may be tolerable in fast metabolizers, especially in certain conditions such as EBV infection or reduced renal function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Xiang Zheng, Weijie Zhang, Hua Zhou, Ronghua Cao, Zhangfei Shou, Shuwei Zhang, Ying Cheng, Xuchun Chen, Chenguang Ding, Zuofu Tang, Ning Li, Shaohua Shi, Qiang Zhou, Qiuyuan Chen, Gang Chen, Zheng Chen, Peijun Zhou, Xiaopeng Hu, Xiaodong Zhang, Ning Na, Wei Wang
Summary: The study aims to investigate the effects of early conversion to low-dose CNIs combined with SRL on the long-term prognosis of renal transplant patients through a multicenter prospective randomized controlled study. Patients will undergo specific medication adjustments and monitoring to assess the efficacy and safety of this new treatment approach.
CHINESE MEDICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Pil Soo Sung, Ji Won Han, Changho Seo, Joseph Ahn, Soon Kyu Lee, Hee Chul Nam, Ho Joong Choi, Young Kyoung You, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon
Summary: This study demonstrated that mTOR inhibitors can help preserve renal function in liver transplantation recipients, especially in patients with renal impairment, without serious adverse events. Regardless of the timing of initiation, a switch to mTOR inhibitors showed significant improvement in kidney function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Andrea Karolin, Genevieve Escher, Stefan Rudloff, Daniel Sidler
Summary: The study revealed that cyclosporine A acts independently of NFAT on kidney epithelial cells. Moreover, inhibition of serine/threonine protein kinases mimics cyclosporine A's activity on kidney epithelial cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rongrong Qin, Jiwei Qin, Xuefeng Li, Zhijun Xu, Peiqi He, Xiaodong Yuan, Cheng Sun, Bjoern Nashan
Summary: This study analyzed the number and phenotypes of NK cells in liver transplant recipients and simulated the immunosuppressive microenvironment in vitro. It found that cyclosporine A, sirolimus/everolimus, and tacrolimus significantly impaired NK cell cytolytic activity and cytokine secretion. The MMF-containing regimen increased the expression of suppressive genes, while mTOR inhibitors had less impact on NK cell function.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Diego Martinelli, Giulio Catesini, Benedetta Greco, Alessia Guarnera, Chiara Parrillo, Evelina Maines, Daniela Longo, Antonio Napolitano, Francesca De Nictolis, Sara Cairoli, Daniela Liccardo, Stefania Caviglia, Anna Sidorina, Giorgia Olivieri, Barbara Siri, Roberto Bianchi, Gionata Spagnoletti, Luca Dello Strologo, Marco Spada, Carlo Dionisi-Vici
Summary: Liver and liver/kidney transplantation have positive effects on the neurological outcome of patients with methylmalonic aciduria. Improved biomarkers were observed in plasma, while biomarkers of mitochondrial dysfunction decreased in cerebrospinal fluid. Neurocognitive evaluation showed significant cognitive improvement and brain changes at MRI. Early transplantation is recommended due to long-term complications and low quality of life.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Medicine, General & Internal
Thibault Letellier, Delphine Kervella, Abderrahmane Sadek, Christophe Masset, Claire Garandeau, Cynthia Fourgeux, Victor Gourain, Jeremie Poschmann, Gilles Blancho, Simon Ville
Summary: This study analyzed the effects of a time-limited strategy of belatacept therapy/withdrawal of calcineurin inhibitors in kidney transplant recipients. The results showed that eGFR remained stable after belatacept withdrawal, and patients who resumed belatacept had a better eGFR trend. Additionally, the withdrawal of belatacept did not lead to rebound in alloimmune response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Transplantation
V. E. Syutkin, A. A. Salienko, S. Zhuravel, M. S. Novruzbekov
Summary: Changes in estimated glomerular filtration rate (eGFR) in liver recipients receiving everolimus with low-dose calcineurin inhibitors after immunosuppression conversion depend on baseline eGFR and are multidirectional. The use of immunosuppression conversion in the early post-liver transplantation period led to a more pronounced improvement in eGFR, with maximum changes observed by 3-6 months after conversion.
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV
(2021)
Article
Virology
Karel Krejci, Tomas Tichy, Jana Bednarikova, Margita Bartkova, Kamil Zamboch, Jiri Orsag, Josef Zadrazil
Summary: BK polyomavirus-associated nephropathy (PyVAN) is a significant cause of premature kidney function termination in transplanted kidneys, closely related to the intensity of immunosuppressive therapy. Nephrotoxicity score can serve as an indicator of excessive immunosuppression. The study found that nephrotoxicity is associated with BK polyomavirus activation and PyVAN occurrence.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Surgery
Steven Ivulich, Eldho Paul, Carl Kirkpatrick, Michael Dooley, Greg Snell
Summary: Everolimus (EVE) is an alternative immunosuppressive agent for lung transplant recipients (LTR) who cannot tolerate conventional immunosuppression. It can be used as part of a calcineurin inhibitor (CNI) minimization or elimination strategy. This study compared the safety and efficacy outcomes of EVE in LTR receiving either a CNI minimization or elimination regimen. The results showed that LTR receiving EVE as part of the CNI elimination strategy had poorer survival outcomes, while the utilization of EVE for renal preservation was associated with improved survival. The study highlighted the importance of retaining a low dose CNI in immunosuppressive regimens for superior survival outcomes.
TRANSPLANT INTERNATIONAL
(2023)
Review
Immunology
Jun Zeng, Qiang Zhong, Xiaobing Feng, Linde Li, Shijian Feng, Yu Fan, Turun Song, Zhongli Huang, Xianding Wang, Tao Lin
Summary: Conversion from CNIs to mTORi therapy in kidney transplant recipients can improve renal function and reduce the incidence of malignancy, but is associated with a higher risk of adverse events such as acute rejection, infection, proteinuria, leukopenia, acne, and mouth ulcer, leading to increased drug discontinuation rates. The conversion strategy may be suitable for selected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Haijiao Jin, Yuehan Wei, Yongbing Qian, Jiang Zhang, Yao Xu, Hang Zhou, Minfang Zhang, Wenyan Zhou, Chaojun Qi, Wei Jin, Shan Mou, Qin Wang, Jianjun Zhang
Summary: The etiology of CKD after liver transplantation might be more complex than originally thought and should not be diagnosed simply as calcineurin inhibitors(CNI)-related nephropathy. Renal biopsy plays a potentially important role in the diagnosis and treatment of CKD after liver transplantation and might not be fully substituted by urine or blood tests. It may help avoid unnecessary changes to the immunosuppressants and inadequate treatment of primary diseases.
Article
Surgery
Yusuke Takada, Tatsu Tanabe, Hajime Sasaki, Takashi Tsujimoto, Kiyohiko Hotta, Kazufumi Okada, Yutaka Shiono, Keita Minami, Hiroshi Tanaka, Hiroshi Harada
Summary: The study revealed that the incidence of CNI-T increases in donors aged 50 years and older, impacting renal function ten years after transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Jin Deng, Yi Lu, Lihong He, Jihong Ou, Hongping Xie
Summary: This study conducted a systematic review and meta-analysis to compare the effects of MMF and CNI as maintenance immunosuppression for kidney transplant recipients. The results showed that MMF improved glomerular filtration rate and may increase the risk of acute rejection.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Micol Ferrara, Jessica Cusato, Elena Salvador, Alice Trentalange, Chiara Alcantarini, Mattia Trunfio, Elvira Stefania Cannizzo, Valeria Bono, Silvia Nozza, Amedeo De Nicolo, Alice Ianniello, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora, Giulia Marchetti, Andrea Calcagno
Summary: This study aimed to investigate the correlation between inflammation markers and antiretroviral drug concentrations in HIV-positive patients. The results showed that there was a correlation between plasma inflammation markers and antiretroviral drug concentrations, suggesting an interplay between drug penetration and persistent inflammation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marybeth A. Nedrud, Mohammad Chaudhry, Michael S. Middleton, Cynthia A. Moylan, Reginald Lerebours, Sheng Luo, Alfredo Farjat, Cynthia Guy, Rohit Loomba, Manal F. Abdelmalek, Claude B. Sirlin, Mustafa R. Bashir
Summary: This study analyzed the change in PDFF values among 187 NASH patients after placebo treatment. It found that placebo treatment led to a decrease in PDFF values, known as the placebo effect. To accurately evaluate the results of future clinical trials, it is suggested to consider the placebo effect in sample size calculations.
Article
Medicine, General & Internal
Bastian N. Ruijter, Ron Wolterbeek, Mitchell Hew, Marjolein van Reeven, Danny van der Helm, Jeroen Dubbeld, Maarten E. Tushuizen, Herold Metselaar, Ann C. T. M. Vossen, Bart van Hoek
Summary: This study examined the effect of an EBV VL monitoring strategy on the incidence of PTLD after liver transplant in adults. The results suggest that monitoring EBV VL may reduce PTLD incidence, but larger studies are needed to confirm these findings.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Immunology
Savino Sciascia, Marta Arbrile, Mattia Trunfio, Andrea Calcagno, Massimo Radin, Dario Roccatello, David Lembo, Andrea Civra
Summary: The etiology of Behcet syndrome (BS), a rare immune-mediated form of vasculitis, is still unclear due to a lack of understanding about the interaction between genetic susceptibility, environmental triggers, and abnormal immune response. One theory suggests that infectious organisms can trigger an aberrant immune response through molecular mimicry. It has also been shown that BS phenotypes are linked to dysbiosis in the oral and gut microbiome, which contains proteins and metabolites that can mimic autoantigens. Infections, including viral pathogens, may play a role in triggering inflammation and symptoms of BS. This review aims to discuss the evidence on the relationship between BS and infections, and its potential clinical implications and therapeutic targets.
AUTOIMMUNITY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Francesco Venuti, Mattia Trunfio, Anne-Grete Martson, Filippo Lipani, Sabrina Audagnotto, Giovanni Di Perri, Andrea Calcagno
Summary: Consolidated data from pharmacokinetic and pharmacodynamic studies support the administration of beta-lactam antibiotics in prolonged infusion to optimize therapeutic efficacy. Novel beta-lactam/beta-lactamase inhibitor combinations have shown promising roles in treating MDR Gram-negative bacteria. This review summarizes available pharmacological and clinical data, future perspectives, and limitations of prolonged infusion of these novel protected beta-lactams.
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Mitchell L. Shiffman, Aliya Gulamhusein, Kris Kowdley, John M. Vierling, Cynthia Levy, Andreas E. Kremer, Ehud Zigmond, Pietro Andreone, Stuart C. Gordon, Christopher L. Bowlus, Eric J. Lawitz, Richard J. Aspinall, Daniel S. Pratt, Karina Raikhelson, Maria S. Gonzalez-Huezo, Michael A. Heneghan, Sook-Hyang Jeong, Alma L. Ladron de Guevara, Marlyn J. Mayo, George N. Dalekos, Joost P. H. Drenth, Ewa Janczewska, Barbara A. Leggett, Frederik Nevens, Victor Vargas, Eli Zuckerman, Christophe Corpechot, Eduardo Fassio, Holger Hinrichsen, Pietro Invernizzi, Palak J. Trivedi, Lisa Forman, David E. J. Jones, Stephen D. Ryder, Mark G. Swain, Alexandra Steinberg, Pol F. Boudes, Yun-Jung Choi, Charles A. McWherter
Summary: This study evaluated the efficacy and safety of seladelpar in patients with primary biliary cholangitis who had inadequate response or intolerance to ursodeoxycholic acid. The results showed that seladelpar significantly improved liver biochemistry and pruritus in these patients, and it was well tolerated.
Letter
Gastroenterology & Hepatology
Mary E. Rinella, Norah Terrault, Brent Neuschwander-Tetri, Rohit Loomba, Manal Abdelmalek
Review
Gastroenterology & Hepatology
Raluca Pais, Bertrand Cariou, Mazen Noureddin, Sven Francque, Joern M. Schattenberg, Manal F. Abdelmalek, Gadi Lalazar, Sharat Varma, Julie Dietrich, Veronica Miller, Arun Sanyal, Vlad Ratziu
Summary: This document, developed by the Liver Forum and the NAFLD-Associated Comorbidities Working Group, aims to provide guidance for the management of comorbidities in NASH therapeutic trials. The document discusses the analysis and stabilization of patients before inclusion in the trial and the management of comorbidities during the trial. It includes recommendations for specific interventions and the management of concomitant drug intake.
JOURNAL OF HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Daphne Bot, Suzanne Klerks, Eva Leistra, Maarten E. E. Tushuizen, Bart van Hoek
Summary: Liver transplantation is the only cure for end-stage liver disease. Loss of muscle quantity (SMI) and muscle attenuation (MA) are associated with post-transplant mortality, complications, and length of ICU and hospital stay.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Virology
Filippo Gabrielli, Francesco Alberti, Cristina Russo, Carmela Cursaro, Hajrie Seferi, Marzia Margotti, Pietro Andreone
Summary: Hepatitis A and hepatitis E are common causes of liver disease transmitted through the faecal-oral route. Both viruses can cause acute disease with mild liver injury, but severe disease or chronic manifestations can occur in vulnerable patients. Treatment mainly focuses on supportive measures, with limited evidence for aetiological treatment and additional agents in severe cases. Corticosteroid therapy and certain molecules have shown potential for improving outcomes in HAV infection, while ribavirin is the main therapeutic option for HEV infection. Vaccines for HAV have been successful in reducing disease prevalence, and vaccines for HEV are currently being developed.
Article
Gastroenterology & Hepatology
Bastian N. Ruijter, Akin Inderson, Aad P. van den Berg, Herold J. Metselaar, Jeroen Dubbeld, Maarten E. Tushuizen, Robert J. Porte, Wojciech Polak, Danny van der Helm, Marjolein van Reeven, Mar Rodriguez-Girondo, Bart van Hoek
Summary: This study compared the efficacy of cyclosporine and tacrolimus after liver transplantation, and found that tacrolimus (T0) had a lower incidence of acute rejection, higher patient and graft survival rates, and similar tolerability and safety compared to cyclosporine (C2). Therefore, tacrolimus might be a better choice after liver transplantation.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Surgery
Frederik J. H. Hoogwater, Hendrien Kuipers, Vincent E. de Meijer, Charlotte Maulat, Fabrice Muscari, Wojciech G. Polak, Bart van Hoek, Caroline Jezequel, Ian P. J. Alwayn, Jan N. M. Ijzermans, Kayvan Mohkam, Jean-Yves Mabrut, Frederike G. Van Vilsteren, Jean-Philippe Adam, Laurence Chiche, Alexandre Chebaro, Emmanuel Boleslawski, Jeroen Dubbeld, Sarwa Darwish Murad, Michel Rayar, Robert J. Porte
Summary: This study compared outcomes after liver transplantation for perihilar cholangiocarcinoma using strict selection criteria, with or without neoadjuvant chemoradiotherapy. The results showed that patients who received neoadjuvant chemoradiotherapy had lower post-transplant survival rates but lower tumor recurrence rates. Adjustments in neoadjuvant chemoradiotherapy may improve outcomes in these patients. Rating: 7 out of 10.
Article
Nutrition & Dietetics
Daphne Bot, Claudia Lucassen, Maarten Werkman, Sylvia van Dijk, Shirin Shahbazi Feshtali, Maarten E. Tushuizen, Bart van Hoek
Summary: The main purpose of this study was to investigate the association between low skeletal muscle index (SMI) and myosteatosis with physical fitness in patients with end-stage liver disease (ESLD). The results showed that myosteatosis was significantly associated with decreased cardiorespiratory fitness (CRF), while SMI had no significant association with physical fitness. Therefore, physical exercise training may be particularly beneficial for LT candidates with myosteatosis.
CLINICAL NUTRITION ESPEN
(2023)
Article
Cardiac & Cardiovascular Systems
Gabrielle Alblas, Hildo J. Lamb, Frits R. Rosendaal, Bart van Hoek, Minneke J. Coenraad, Renee de Mutsert
Summary: The prevalence of NAFLD in middle-aged population in the Netherlands in 2010 was 27%, with significantly higher rates in individuals with diabetes, obesity, and hypertriglyceridemia. NAFLD was also found in a proportion of participants without being overweight.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Filippo Gabrielli, Simonetta Lugari, Alessia Cavicchioli, Amedeo Lonardo, Cristina Felicani, Antonia Rudilosso, Chiara Pacchioni, Carla Greco, Chiara Valenti, Luigi Valerio, Mario Bondi, Daniele Santi, Giorgia Spaggiari, Stefano Ballestri, Tommaso Trenti, Valentina Pecoraro, Manuela Simoni, Pietro Andreone, Fabio Nascimbeni
JOURNAL OF HEPATOLOGY
(2023)